Understanding the impact of nanoplastics on the development of neurological disorders

Informazioni relative al progetto

NanoGlia

ID dell’accordo di sovvenzione: 851257

DOI

10.3030/851257

Progetto chiuso

Data della firma CE 23 Gennaio 2020

Data di avvio 1 Aprile 2020

Data di completamento 31 Marzo 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 497 193,00

Contributo UE

€ 1 497 193,00

Coordinato da

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Pubblicazioni

Peer reviewed articles (17)

BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue

Autori: Katharina Sieckmann, Nora Winnerling, Dalila Juliana Silva Ribeiro, Seniz Yüksel, Ronja Kardinal, Lisa Maria Steinheuer, Fabian Frechen, Luis Henrique Corrêa, Geza Schermann, Christina Klausen, Nelli Blank-Stein, Jonas Schulte-Schrepping, Collins Osei-Sarpong, Matthias Becker, Lorenzo Bonaguro, Marc Beyer, Helen Louise May-Simera, Jelena Zurkovic, Christoph Thiele, Kevin Thurley, Lydia Sorokin,
Pubblicato in: The EMBO Journal, Numero 44, 2026, Pagina/e 5315-5336, ISSN 1460-2075
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44318-025-00524-y

Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism

Autori: Nikola Makdissi, Maria Francesca Viola, Lisa Maria Steinheuer, Nelli Blank-Stein, Ronja Kardinal, Fabrizio Musacchio, Eliana Franco Taveras, Virginia Aliprandi, Katharina Sieckmann, Akram Abdulkadyrov, Marina L. Mayer, Marie-Louise Diefenbach-Wilke, Diana Fink, Hannes Beckert, Stefan Böhmdorfer, Quentin Deveuve, Frederike J. Graelmann, Katharina Mauel, Nele Kronau, Jake Thomas, David Bejarano, An
Pubblicato in: Nature Metabolism, 2026, ISSN 2522-5812
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42255-026-01615-8

Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner

Autori: Seyhmus Bayar, Lea Seep, Karolína Doubková, Jelena Zurkovic, Margret H. Bülow, Katrin Kierdorf, Reinhard Bauer, Christoph Thiele, Gaia Tavosanis, Jan Hasenauer, Elvira Mass
Pubblicato in: Cells & Development, Numero 183, 2026, Pagina/e 204040, ISSN 2667-2901
Editore: Elsevier BV
DOI: 10.1016/j.cdev.2025.204040

Emerging principles of primary cilia dynamics in controlling tissue organization and function

Autori: Jay Gopalakrishnan, Kerstin Feistel, Benjamin M Friedrich, Anne Grapin‐Botton, Nathalie Jurisch‐Yaksi, Elvira Mass, David U Mick, Roman‐Ulrich Müller, Helen May‐Simera, Bernhard Schermer, Miriam Schmidts, Peter Walentek, Dagmar Wachten
Pubblicato in: The EMBO Journal, Numero 42, 2026, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2023113891

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Autori: Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Mel
Pubblicato in: Nature Cell Biology, Numero 23, 2023, Pagina/e 1224-1239, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-021-00774-y

CD163+ red pulp macrophages interact with marginal metallophilic macrophages during blood-stage malaria to maintain splenic architecture

Autori: Katharina Mauel, Daria Hirschmann, Nelli Blank-Stein, Marie-Louise Diefenbach-Wilke, Theresa Eulgem, Shirley Le, Samuel N. Breit, Miguel P. Soares, Vicky Wang-Wei Tsai, Florent Ginhoux, William R. Heath, Lynette Beattie, Elvira Mass
Pubblicato in: Immunity, 2026, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2026.07.006

From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists

Autori: Lea Seep, Stephan Grein, Iva Splichalova, Danli Ran, Mickel Mikhael, Staffan Hildebrand, Mario Lauterbach, Karsten Hiller, Dalila Juliana Silva Ribeiro, Katharina Sieckmann, Ronja Kardinal, Hao Huang, Jiangyan Yu, Sebastian Kallabis, Janina Behrens, Andreas Till, Viktoriya Peeva, Akim Strohmeyer, Johanna Bruder, Tobias Blum, Ana Soriano-Arroquia, Dominik Tischer, Katharina Kuellmer, Yuanfang Li, M
Pubblicato in: Scientific Data, Numero 11, 2026, ISSN 2052-4463
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41597-024-03349-2

Tissue-specific macrophages: how they develop and choreograph tissue biology

Autori: Elvira Mass, Falk Nimmerjahn, Katrin Kierdorf & Andreas Schlitzer
Pubblicato in: Nature Reviews Immunology, 2023, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/s41577-023-00848-y

Kupffer cell programming by maternal obesity triggers fatty liver disease

Autori: Hao Huang, Nora R. Balzer, Lea Seep, Iva Splichalova, Nelli Blank-Stein, Maria Francesca Viola, Eliana Franco Taveras, Kerim Acil, Diana Fink, Franzisca Petrovic, Nikola Makdissi, Seyhmus Bayar, Katharina Mauel, Carolin Radwaniak, Jelena Zurkovic, Amir H. Kayvanjoo, Klaus Wunderling, Malin Jessen, Mohamed H. Yaghmour, Lukas Kenner, Thomas Ulas, Stephan Grein, Joachim L. Schultze, Charlotte L. Scot
Pubblicato in: Nature, Numero 644, 2025, Pagina/e 790-798, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-025-09190-w

Macrophage and monocyte subsets in response to ischemic stroke

Autori: Nelli Blank‐Stein, Elvira Mass
Pubblicato in: European Journal of Immunology, Numero 53, 2024, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250233

Kupffer cells control neonatal hepatic metabolism via Igf1 signaling

Autori: Nikola Makdissi, Daria J. Hirschmann, Aleksej Frolov, Inaam Sado, Bastian Bennühr, Fabian Nikolka, Jingyuan Cheng, Nelli Blank-Stein, Maria Francesca Viola, Mohamed Yaghmour, Philipp Arnold, Lorenzo Bonaguro, Matthias Becker, Christoph Thiele, Felix Meissner, Karsten Hiller, Marc D. Beyer, Elvira Mass
Pubblicato in: Development, Numero 153, 2026, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.204962

Differential impact of high-salt levels in vitro and in vivo on macrophage core functions

Autori: Linda Müller, Aya Rafea Nasr, Bettina Jux, Nikola Makdissi, Justin Wayne Trowbridge, Susanne V. Schmidt, Joachim L. Schultze, Thomas Quast, Jonas Schulte-Schrepping, Waldemar Kolanus, Elvira Mass
Pubblicato in: Molecular Biology Reports, Numero 343, 2024, Pagina/e Volume 51, Numero 1, ISSN 1573-4978
Editore: Springer Nature
DOI: 10.21203/rs.3.rs-3768163/v1

Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease

Autori: Rudolfo Karl, Arsila Palliyulla Kariat Ashraf, Maria Francesca Viola, Katharina Hopp, Elvira Mass, Dagmar Wachten
Pubblicato in: Journal of Cell Science, Numero 138, 2025, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.263992

From macrophage biology to macrophage-based cellular immunotherapies

Autori: Elvira Mass, Nico Lachmann
Pubblicato in: Gene Therapy, Numero 28/9, 2021, Pagina/e 473-476, ISSN 0969-7128
Editore: Nature Publishing Group
DOI: 10.1038/s41434-021-00221-5

Validation and refinement of existing methods for timed mating and early pregnancy detection in guinea pigs

Autori: Marina Luisa Mayer, Ilja Finkelberg, Elvira Mass
Pubblicato in: PLOS One, Numero 21, 2026, Pagina/e e0347318, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0347318

Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Autori: Aleksej Frolov, Hao Huang, Dagmar Schütz, Maren Köhne, Nelli Blank-Stein, Collins Osei-Sarpong, Maren Büttner, Tarek Elmzzahi, Mukhran Khundadze, Marina Zahid, Michael Reuter, Matthias Becker, Elena De Domenico, Lorenzo Bonaguro, Axel Kallies, Helen Morrison, Christian A. Hübner, Kristian Händler, Ralf Stumm, Elvira Mass, Marc D. Beyer
Pubblicato in: Journal of Experimental Medicine, Numero 222, 2025, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20232357

Developmental programming of tissue-resident macrophages

Autori: Maria Francesca Viola, Eliana Franco Taveras, Elvira Mass
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1475369

Non-peer reviewed articles (1)

How much plastic is too much for our brain?

Autori: Elvira Mass
Pubblicato in: The Project Repository journal, Numero 6, 2020, Pagina/e 8–11, ISSN 2632-4067
Editore: European Dissemination Media Agency

Book chapters (4)

Ontogeny and function of microglia and nerve-associated macrophages

Autori: Marina Mayer, Eliana Franco Taveras, Elvira Mass
Pubblicato in: Advances in Immunology, 2025, Pagina/e 91-122
Editore: Elsevier
DOI: 10.1016/bs.ai.2025.04.002

The development and physiological and pathophysiological functions of resident macrophages and glial cells

Autori: Nelli Blank, Marina Mayer, Elvira Mass
Pubblicato in: Advances in Immunology volume 151, Numero 151, 2021, Pagina/e 1-47, ISBN 9780128245996
Editore: Elsevier
DOI: 10.1016/bs.ai.2021.08.001

Fate-Mapping of Yolk Sac-Derived Macrophages

Autori: Iva Splichalova, Elvira Mass
Pubblicato in: Methods in Molecular Biology, Tissue-Resident Macrophages, 2023, Pagina/e 129-137
Editore: Springer US
DOI: 10.1007/978-1-0716-3437-0_8

Fate-Mapping of Hematopoietic Stem Cell-Derived Macrophages

Autori: Katharina Mauel, Elvira Mass
Pubblicato in: Methods in Molecular Biology, Tissue-Resident Macrophages, 2023, Pagina/e 139-148
Editore: Springer US
DOI: 10.1007/978-1-0716-3437-0_9

Conference proceedings (1)

THE IMPACT OF PLASTIC POLLUTION ON HUMAN NEURODEVELOPMENT AND NEUROINFLAMMATION

Autori: Nelli Blank-Stein, Marina L. Mayer, Maria Francesca Viola, Elvira Mass
Pubblicato in: GLIA (Meeting Abstract Supplement), Numero Volume 73, Supplement S1, 26. Juni 2025, 2025, Pagina/e 852, ISSN 0894-1491
Editore: John Wiley & Sons, Inc.

Other (1)

Our plastic world – what does it mean for our health?

Autori: Marina Mayer, Nikola Makdissi, Maria Francesca Viola, Elvira Mass
Pubblicato in: The Project Repository Journal (PRj), Numero Volume 19, November 2023, 2023, ISSN 2632-4113
Editore: European Dissemination Media Agency (EDMA)