Tracing the origin and early evolution of animal cell type regulation with genomics and single-cell approaches

Project Information

EvoCellMap

Grant agreement ID: 851647

DOI

10.3030/851647

Project closed

EC signature date 13 November 2019

Start date 1 January 2020

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 498 070,00

EU contribution

€ 1 498 070,00

Coordinated by

FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan (DMP)

The DMP will explainathe handling of research data during after the end of the projectbwhat data will be collected processed andor generatedcwhich methodology standards will be applieddwhether data will be sharedmade open access andehow data will be curated preserved including after the end of the project

Publications

Peer reviewed articles (12)

Evolutionary cell type mapping with single-cell genomics

Author(s): Amos Tanay, Arnau Sebé-Pedrós
Published in: Trends in Genetics, Issue 10, 2021, Page(s) 919-932, ISSN 0168-9525
Publisher: Elsevier BV
DOI: 10.1016/j.tig.2021.04.008

A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity

Author(s): Shani Levy, Anamaria Elek, Xavier Grau-Bové, Simón Menéndez-Bravo, Marta Iglesias, Amos Tanay, Tali Mass, Arnau Sebé-Pedrós
Published in: Cell, Issue 184/11, 2021, Page(s) 2973-2987.e18, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.04.005

The evolution of facultative symbiosis in stony corals

Author(s): Shani Levy, Xavier Grau-Bové, Iana V. Kim, Sebastian R. Najle, Ewa Księżopolska, Anamaria Elek, Laia Montes-Espuña, Sean A. Montgomery, Tali Mass, Arnau Sebé-Pedrós
Published in: Nature, Issue 648, 2025, Page(s) 368-376, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-09623-6

An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm

Author(s): Xavier Grau-Bové, Lucie Subirana, Lydvina Meister, Anaël Soubigou, Ana Neto, Anamaria Elek, Silvia Naranjo, Oscar Fornas, Jose Luis Gomez-Skarmeta, Juan J. Tena, Manuel Irimia, Stéphanie Bertrand,
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-48774-4

Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

Author(s): Irene Miguel-Escalada, Miguel Ángel Maestro, Diego Balboa, Anamaria Elek, Aina Bernal, Edgar Bernardo, Vanessa Grau, Javier García-Hurtado, Arnau Sebé-Pedrós, Jorge Ferrer
Published in: Developmental Cell, Issue 57, 2024, Page(s) 1922-1936.e9, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2022.07.014

cGLRs are a diverse family of pattern recognition receptors in innate immunity

Author(s): Yao Li, Kailey M. Slavik, Hunter C. Toyoda, Benjamin R. Morehouse, Carina C. de Oliveira Mann, Anamaria Elek, Shani Levy, Zhenwei Wang, Kepler S. Mears, Jingjing Liu, Dmitry Kashin, Ximing Guo, Tali Mass, Arnau Sebé-Pedrós, Frank Schwede, Philip J. Kranzusch
Published in: Cell, Issue 186, 2024, Page(s) 3261-3276.e20, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.05.038

A phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution

Author(s): Xavier Grau-Bové, Cristina Navarrete, Cristina Chiva, Thomas Pribasnig, Meritxell Antó, Guifré Torruella, Luis Javier Galindo, Bernd Franz Lang, David Moreira, Purificación López-Garcia, Iñaki R
Published in: Nature Ecology & Evolution, Issue 6, 2022, Page(s) pages1007–1023, ISSN 2397-334X
Publisher: Nature Portfolio
DOI: 10.1038/s41559-022-01771-6

DNA methylation enables recurrent endogenization of giant viruses in an animal relative

Author(s): Luke A. Sarre, Iana V. Kim, Vladimir Ovchinnikov, Marine Olivetta, Hiroshi Suga, Omaya Dudin, Arnau Sebé-Pedrós, Alex de Mendoza
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.ado6406

Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity

Author(s): Helen E. Robertson, Arnau Sebé-Pedrós, Baptiste Saudemont, Yann Loe-Mie, Anne-C. Zakrzewski, Xavier Grau-Bové, Marie-Pierre Mailhe, Philipp Schiffer, Maximilian J. Telford, Heather Marlow
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-45956-y

Orthology clusters from gene trees with Possvm

Author(s): Xavier Grau-Bové; Arnau Sebé-Pedrós
Published in: Molecular Biology and Evolution, Issue 38, 2021, Page(s) 5204-5208, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1101/2021.05.03.442399

Chromatin loops are an ancestral hallmark of the animal regulatory genome

Author(s): Iana V. Kim, Cristina Navarrete, Xavier Grau-Bové, Marta Iglesias, Anamaria Elek, Grygoriy Zolotarov, Nikolai S. Bykov, Sean A. Montgomery, Ewa Ksiezopolska, Didac Cañas-Armenteros, Joan J. Soto-Ang
Published in: Nature, Issue 642, 2025, Page(s) 1097-1105, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-08960-w

Stepwise emergence of the neuronal gene expression program in early animal evolution

Author(s): Sebastián R. Najle, Xavier Grau-Bové, Anamaria Elek, Cristina Navarrete, Damiano Cianferoni, Cristina Chiva, Didac Cañas-Armenteros, Arrate Mallabiabarrena, Kai Kamm, Eduard Sabidó, Harald Gruber-Vodicka, Bernd Schierwater, Luis Serrano, Arnau Sebé-Pedrós
Published in: Cell, Issue 186, 2024, Page(s) 4676-4693.e29, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2023.08.027