Projektbeschreibung
Innovative 3D-Modellierung neuronaler Zellnetzwerke
Bisher beruhten kreative Ansätze zur Erstellung von dreidimensionalen neuronalen Netzen meist auf biologischen Matrizen oder Gelen, die zufällige Verbindungen generieren. Das Gastlabor entwickelte in leitfähige Elektroden integrierte 3D-Gerüste, die die elektrische Stimulation der Netzwerkentwicklung und Aufzeichnung der Aktivität der neuronalen Netzwerke ermöglichen. Das Ziel des EU-finanzierten Projekts SCAFFOLD-NEEDS ist die Kommerzialisierung der 3D-Gerüste und 3D-Gerüst-Plattformen mit integrierten Elektroden mithilfe von Industriepartnern. Die innovativen 3D-Gerüst-Plattformen können in der Wissenschaft und der Medizin für eine Vielzahl von Untersuchungen wie 3D-Modelle neuronaler Zellen zur Erforschung grundlegender Mechanismen der neuronalen Aktivität des Menschen, Tests mit pharmakologischen und toxikologischen Verbindungen oder die Modellierung neuronaler Erkrankungen verwendet werden.
Ziel
The ongoing MESO-BRAIN project aims at the development of functional three-dimensional (3D) human stem cell derived neural networks on laser fabricated artificial scaffold platforms. Previous and contemporaneous attempts at generating 3D neural networks usually rely on biological matrices or gels providing randomly connected networks. In MESO-BRAIN, 3D scaffolds are integrated with conductive electrodes that enable both electrical stimulation of the network development and recording of the neural network activity. The development of such technological platform will be foundational for a new era of biological and medical research. In this FET Launchpad “Scaffold-Needs” project, we aim to make 3D scaffolds and 3D scaffold platforms with integrated electrodes commercially available via MESO-BRAIN spin-off company Laser nanoFab GmbH. We envisage that the 3D scaffold platforms will enable scientific and medical researchers to use them for a variety of studies e.g. as 3D neuronal cell models for investigations of fundamental mechanisms of human neuronal activity; in tests of pharmacological and toxicological compounds, in modelling of neuronal diseases, etc. There is a unique opportunity for the creation of a marketable product stemming from the work already performed and intended in MESO-BRAIN project. The commercialisation of MESO-BRAIN 3D scaffolds in collaboration with Laser nanoFab GmbH with FET Launchpad support represents an added value innovation which will raise the TRL level to TRL 5 and provide a solid basis for continued exploitation in the industrial sector. Depending upon the market analysis feedback, a 2nd round of optimisation and modification of the 3D scaffold platforms may be essential based upon special needs of potential customers to better target the market. A business plan for production and commercialisation of the 3D scaffolds and 3D scaffold platforms with integrated electrodes will be developed based upon the market analysis.
Wissenschaftliches Gebiet
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenUnterauftrag
H2020-FETOPEN-2018-2019-2020-03
Finanzierungsplan
CSA - Coordination and support actionKoordinator
B4 7ET Birmingham
Vereinigtes Königreich