Descripción del proyecto
Definición del papel del claustro en la función encefálica
El claustro es una de las estructuras menos estudiadas y más enigmáticas del encéfalo; aunque unos informes recientes sugieren que podría ser una de las más importantes. El claustro es una estructura delgada, irregular y parecida a una lámina situada bajo la superficie interna de la neocorteza. Posee muy pocos tipos de células y ninguna estratificación. La parte destacable es que recibe y envía proyecciones a casi todas las regiones de la corteza. Esto lo coloca en una posición única para integrar la información sensomotora multimodal relacionada con la experiencia consciente. El proyecto CLAUSTRUM, financiado con fondos europeos, se propone lograr avances significativos al definir el papel del claustro en la función encefálica a través del desarrollo y la aplicación de técnicas novedosas para su supervisión y manipulación.
Objetivo
How does the brain integrate inputs from the environment to generate perception and drive decisions? An enigmatic brain region called the claustrum has been suggested to play a role by integrating inputs from multiple brain regions. There is strong interconnectivity between claustrum and nearly every neocortical brain region, indicating that it exerts widespread influence on brain function. However, approaches to specifically record from or manipulate activity in the claustrum have been hindered by the inability to target it selectively. This has been difficult due to the anatomy of the claustrum: it is a long, thin bilateral nucleus buried between the neocortex and the striatum. This proposal aims to understand the role of the claustrum in multisensory integration and behaviour by developing new approaches for monitoring and manipulating the activity of the claustrum. We will harness recent advances in electrophysiological, genetic, optical, and behavioural tools to probe its connectivity, activity, and function in a precise manner. Understanding the role of the claustrum in brain function will provide fundamental insight into information processing in the neocortex, which is a major goal in neuroscience. The claustrum is unique because of its dense reciprocal connectivity with neocortex but nearly complete lack of direct subcortical sensory input. This particular anatomical structure indicates the possibility of a unique function, but none has been observed yet. This proposal will rectify the paucity of data on this distinctive structure by applying a battery of modern tools to address the function of the claustrum. Experiments will address the following key questions:
1. How are claustrocortical inputs integrated and what is the effect of corticoclaustral feedback?
2. What is the activity of claustral neurons during sensory stimulation and motor output?
3. What are the causal relationships between claustrum activity and animal behaviour?
Ámbito científico
Palabras clave
Programa(s)
Régimen de financiación
ERC-STG - Starting GrantInstitución de acogida
OX1 2JD Oxford
Reino Unido