Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Project Information

ANIMATE

Grant agreement ID: 853425

DOI

10.3030/853425

Project closed

EC signature date 22 October 2019

Start date 1 January 2020

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 946,25

EU contribution

€ 1 499 946,00

Coordinated by

UNIVERSITAETSKLINIKUM FREIBURG
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice

Author(s): Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Härdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N Dankel, Gunnar Me
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, Issue 15244636, 2021, Page(s) 2563-2574, ISSN 1524-4636
Publisher: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.316677

The Role of Tumor Necrosis Factor Associated Factors (TRAFs) in Vascular Inflammation and Atherosclerosis

Author(s): Mark Colin Gissler, Peter Stachon, Dennis Wolf, Timoteo Marchini
Published in: Frontiers in Cardiovascular Medicine, Issue 9, 2023, ISSN 2297-055X
Publisher: Frontiers
DOI: 10.3389/fcvm.2022.826630

Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe−/− mice

Author(s): Marco Orecchioni; Dennis Wolf; Vasantika Suryawanshi; Holger Winkels; Kouji Kobiyama; Jeffrey Makings; William B. Kiosses; Klaus Ley
Published in: Cell Mol Life Sci ., Issue 1, 2022, ISSN 1420-9071
Publisher: Springer Nature
DOI: 10.1007/s00018-022-04649-9

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Author(s): Patrick M. Siegel, István Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto‐Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, Maximilian Mauler, Laura Hollederer, Martin Moser, Christoph Bode
Published in: Basic Research in Cardiology, Issue 14351803, 2021, ISSN 1435-1803
Publisher: Springer
DOI: 10.1007/s00395-021-00849-9

Circulating Autoantibodies Recognizing Immunodominant Epitopes From Human Apolipoprotein B Associate With Cardiometabolic Risk Factors, but Not With Atherosclerotic Disease

Author(s): Timoteo Marchini; Sara Malchow; Lourdes Caceres; Abed Al Hadi El Rabih; Sophie Hansen; Timothy Mwinyella; Lisa Spiga; Sven Piepenburg; Hauke Horstmann; Tijani Olawale; Xiaowei Li; Lucia Sol Mitre; Mark Colin Gissler; Heiko Bugger; Andreas Zirlik; Timo Heidt; Ingo Hilgendorf; Peter Stachon; Constantin von zur Muehlen; Christoph Bode; Dennis Wolf
Published in: Frontiers in Cardiovascular Medicine, Issue 1, 2022, Page(s) 826729, ISSN 2297-055X
Publisher: Frontiers, S.A.
DOI: 10.3389/fcvm.2022.826729

Longitudinal Assessment of Subclinical Arterial Inflammation in Patients Receiving Immune Checkpoint Inhibitors by Sequential [ ¹⁸ F]FDG PET Scans

Author(s): Lucas Bacmeister, Niklas Hempfling, Alexander Maier, Susanne Weber, Annette Buellesbach, Adrian Heidenreich, Istvan Bojti, Mark Colin Gissler, Ingo Hilgendorf, Constantin von zur Muehlen, Dirk Westermann, Philipp Tobias Meyer, Christian Goetz, Dennis Wolf
Published in: Circulation: Cardiovascular Imaging, Issue 18, 2025, ISSN 1941-9651
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circimaging.124.016851

Break on Through to the Other Side: How Trained Monocytes Promote Recovery From Hind Limb Ischemia

Author(s): Zhang, H. Wolf, D.
Published in: Arterioscler Thromb Vasc Biol, Issue 15244636, 2021, Page(s) 189-192, ISSN 1524-4636
Publisher: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.317257

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis

Author(s): Hauke Horstmann, Nathaly Anto Michel, Xia Sheng, Sophie Hansen, Alexandra Lindau, Katharina Pfeil, Marbely C Fernández, Timoteo Marchini, Holger Winkels, Lucia Sol Mitre, Tijani Abogunloko, Xiaowei Li, Timothy Bon-Nawul Mwinyella, Mark Colin Gissler, Heiko Bugger, Timo Heidt, Konrad Buscher, Ingo Hilgendorf, Peter Stachon, Sven Piepenburg, Nicolas Verheyen, Thomas Rathner, Teresa Gerhardt, Patric
Published in: Cardiovascular Research, 2024, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvae154

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

Author(s): Alma Zernecke, Holger Winkels, Clément Cochain, Jesse W. Williams, Dennis Wolf, Oliver Soehnlein, Clint S. Robbins, Claudia Monaco, Inhye Park, Coleen A. McNamara, Christoph J. Binder, Myron I. Cybulsky, Corey A. Scipione, Catherine C. Hedrick, Elena V. Galkina, Tin Kyaw, Yanal Ghosheh, Huy Q. Dinh, Klaus Ley
Published in: Circulation Research, Issue 127/3, 2020, Page(s) 402-426, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316903

Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding

Author(s): Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Rüdiger Eberhard Scharf, Daniel Duerschmied, Nancy Schanze
Published in: Frontiers in Immunology, Issue 14, 2023, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2023.1184010

Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis

Author(s): Timoteo Marchini, Tijani Abogunloko, Dennis Wolf
Published in: Hamostaseologie, Issue 25675761, 2022, Page(s) 447–457, ISSN 2567-5761
Publisher: Thieme
DOI: 10.1055/a-1661-1908

Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight

Author(s): Holger Winkels, Dennis Wolf
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.312137

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 –Reactive CD4 + T-Regulatory Cells

Author(s): Dennis Wolf, Teresa Gerhardt, Holger Winkels, Nathaly Anto Michel, Akula Bala Pramod, Yanal Ghosheh, Simon Brunel, Konrad Buscher, Jacqueline Miller, Sara McArdle, Livia Baas, Kouji Kobiyama, Melanie Vassallo, Erik Ehinger, Thamotharampillai Dileepan, Amal Ali, Maximilian Schell, Zbigniew Mikulski, Daniel Sidler, Takayuki Kimura, Xia Sheng, Hauke Horstmann, Sophie Hansen, Lucia Sol Mitre, Peter St
Published in: Circulation, Issue 142/13, 2020, Page(s) 1279-1293, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042863

Molecular mechanisms underlying NLRP3 inflammasome activation and IL-1β production in air pollution fine particulate matter (PM2.5)-primed macrophages

Author(s): Lourdes Caceres, Tijani Abogunloko, Sara Malchow, Fabienne Ehret, Julian Merz, Xiaowei Li, Lucia Sol Mitre, Natalia Magnani, Deborah Tasat, Timothy Mwinyella, Lisa Spiga, Dymphie Suchanek, Larissa Fischer, Oliver Gorka, Mark Colin Gissler, Ingo Hilgendorf, Peter Stachon, Eva Rog-Zielinska, Olaf Groß, Dirk Westermann, Pablo Evelson, Dennis Wolf, Timoteo Marchini
Published in: Environmental Pollution, Issue 341, 2024, Page(s) 122997, ISSN 0269-7491
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122997

Editorial: Immune and autoimmune mechanisms in cardiovascular disease

Author(s): Holger Winkels, Norbert Gerdes, Florian Kahles, Partha Dutta, Chiara Giannarelli, Dennis Wolf
Published in: Front Cardiovasc Med, 2023, ISSN 2297-055X
Publisher: Frontiers
DOI: 10.3389/fcvm.2022.1125959

ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis

Author(s): Timoteo Marchini, Sophie Hansen, Dennis Wolf
Published in: Cells, Issue 10/2, 2021, Page(s) 446, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10020446

Inflammatory Cell Recruitment in Cardiovascular Disease

Author(s): Timoteo Marchini, Lucía Sol Mitre, Dennis Wolf
Published in: Frontiers in Cell and Developmental Biology, Issue 9, 2021, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2021.635527