Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Información del proyecto

ANIMATE

Identificador del acuerdo de subvención: 853425

DOI 10.3030/853425

Fecha de la firma de la CE 22 Octubre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 499 946,25

Aportación de la UE € 1 499 946,00

Coordinado por

UNIVERSITAETSKLINIKUM FREIBURG
Germany

Publicaciones

Peer reviewed articles (12)

Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice

Autores: Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Härdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N Dankel, Gunnar Me
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 15244636, 2021, Página(s) 2563-2574, ISSN 1524-4636
Editor: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.316677

Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe−/− mice

Autores: Marco Orecchioni; Dennis Wolf; Vasantika Suryawanshi; Holger Winkels; Kouji Kobiyama; Jeffrey Makings; William B. Kiosses; Klaus Ley
Publicado en: Crossref, Edición 1, 2022, ISSN 1420-9071
Editor: Springer Nature
DOI: 10.1007/s00018-022-04649-9

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Autores: Patrick M. Siegel, István Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto‐Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, Maximilian Mauler, Laura Hollederer, Martin Moser, Christoph Bode
Publicado en: Basic Research in Cardiology, Edición 14351803, 2021, ISSN 1435-1803
Editor: Springer
DOI: 10.1007/s00395-021-00849-9

Circulating Autoantibodies Recognizing Immunodominant Epitopes From Human Apolipoprotein B Associate With Cardiometabolic Risk Factors, but Not With Atherosclerotic Disease

Autores: Timoteo Marchini; Sara Malchow; Lourdes Caceres; Abed Al Hadi El Rabih; Sophie Hansen; Timothy Mwinyella; Lisa Spiga; Sven Piepenburg; Hauke Horstmann; Tijani Olawale; Xiaowei Li; Lucia Sol Mitre; Mark Colin Gissler; Heiko Bugger; Andreas Zirlik; Timo Heidt; Ingo Hilgendorf; Peter Stachon; Constantin von zur Muehlen; Christoph Bode; Dennis Wolf
Publicado en: Frontiers in Cardiovascular Medicine, Edición 1, 2022, Página(s) 826729, ISSN 2297-055X
Editor: Frontiers, S.A.
DOI: 10.3389/fcvm.2022.826729

Break on Through to the Other Side: How Trained Monocytes Promote Recovery From Hind Limb Ischemia

Autores: Zhang, H. Wolf, D.
Publicado en: Arterioscler Thromb Vasc Biol, Edición 15244636, 2021, Página(s) 189-192, ISSN 1524-4636
Editor: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.317257

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

Autores: Alma Zernecke, Holger Winkels, Clément Cochain, Jesse W. Williams, Dennis Wolf, Oliver Soehnlein, Clint S. Robbins, Claudia Monaco, Inhye Park, Coleen A. McNamara, Christoph J. Binder, Myron I. Cybulsky, Corey A. Scipione, Catherine C. Hedrick, Elena V. Galkina, Tin Kyaw, Yanal Ghosheh, Huy Q. Dinh, Klaus Ley
Publicado en: Circulation Research, Edición 127/3, 2020, Página(s) 402-426, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316903

Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis

Autores: Timoteo Marchini, Tijani Abogunloko, Dennis Wolf
Publicado en: Hamostaseologie, Edición 25675761, 2022, Página(s) 447–457, ISSN 2567-5761
Editor: Thieme
DOI: 10.1055/a-1661-1908

Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight

Autores: Holger Winkels, Dennis Wolf
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.312137

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 –Reactive CD4 + T-Regulatory Cells

Autores: Dennis Wolf, Teresa Gerhardt, Holger Winkels, Nathaly Anto Michel, Akula Bala Pramod, Yanal Ghosheh, Simon Brunel, Konrad Buscher, Jacqueline Miller, Sara McArdle, Livia Baas, Kouji Kobiyama, Melanie Vassallo, Erik Ehinger, Thamotharampillai Dileepan, Amal Ali, Maximilian Schell, Zbigniew Mikulski, Daniel Sidler, Takayuki Kimura, Xia Sheng, Hauke Horstmann, Sophie Hansen, Lucia Sol Mitre, Peter St
Publicado en: Circulation, Edición 142/13, 2020, Página(s) 1279-1293, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042863

Editorial: Immune and autoimmune mechanisms in cardiovascular disease

Autores: Holger Winkels, Norbert Gerdes, Florian Kahles, Partha Dutta, Chiara Giannarelli, Dennis Wolf
Publicado en: Front Cardiovasc Med, 2023, ISSN 2297-055X
Editor: Frontiers
DOI: 10.3389/fcvm.2022.1125959

ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis

Autores: Timoteo Marchini, Sophie Hansen, Dennis Wolf
Publicado en: Cells, Edición 10/2, 2021, Página(s) 446, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10020446

Inflammatory Cell Recruitment in Cardiovascular Disease

Autores: Timoteo Marchini, Lucía Sol Mitre, Dennis Wolf
Publicado en: Frontiers in Cell and Developmental Biology, Edición 9, 2021, ISSN 2296-634X
Editor: Frontiers Media SA
DOI: 10.3389/fcell.2021.635527