Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Información del proyecto

ANIMATE

Identificador del acuerdo de subvención: 853425

DOI

10.3030/853425

Proyecto cerrado

Fecha de la firma de la CE 22 Octubre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 946,25

Aportación de la UE

€ 1 499 946,00

Coordinado por

UNIVERSITAETSKLINIKUM FREIBURG
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (17)

Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice

Autores: Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Härdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N Dankel, Gunnar Me
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 15244636, 2021, Página(s) 2563-2574, ISSN 1524-4636
Editor: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.316677

The Role of Tumor Necrosis Factor Associated Factors (TRAFs) in Vascular Inflammation and Atherosclerosis

Autores: Mark Colin Gissler, Peter Stachon, Dennis Wolf, Timoteo Marchini
Publicado en: Frontiers in Cardiovascular Medicine, Edición 9, 2023, ISSN 2297-055X
Editor: Frontiers
DOI: 10.3389/fcvm.2022.826630

Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe−/− mice

Autores: Marco Orecchioni; Dennis Wolf; Vasantika Suryawanshi; Holger Winkels; Kouji Kobiyama; Jeffrey Makings; William B. Kiosses; Klaus Ley
Publicado en: Cell Mol Life Sci ., Edición 1, 2022, ISSN 1420-9071
Editor: Springer Nature
DOI: 10.1007/s00018-022-04649-9

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Autores: Patrick M. Siegel, István Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto‐Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, Maximilian Mauler, Laura Hollederer, Martin Moser, Christoph Bode
Publicado en: Basic Research in Cardiology, Edición 14351803, 2021, ISSN 1435-1803
Editor: Springer
DOI: 10.1007/s00395-021-00849-9

Circulating Autoantibodies Recognizing Immunodominant Epitopes From Human Apolipoprotein B Associate With Cardiometabolic Risk Factors, but Not With Atherosclerotic Disease

Autores: Timoteo Marchini; Sara Malchow; Lourdes Caceres; Abed Al Hadi El Rabih; Sophie Hansen; Timothy Mwinyella; Lisa Spiga; Sven Piepenburg; Hauke Horstmann; Tijani Olawale; Xiaowei Li; Lucia Sol Mitre; Mark Colin Gissler; Heiko Bugger; Andreas Zirlik; Timo Heidt; Ingo Hilgendorf; Peter Stachon; Constantin von zur Muehlen; Christoph Bode; Dennis Wolf
Publicado en: Frontiers in Cardiovascular Medicine, Edición 1, 2022, Página(s) 826729, ISSN 2297-055X
Editor: Frontiers, S.A.
DOI: 10.3389/fcvm.2022.826729

Longitudinal Assessment of Subclinical Arterial Inflammation in Patients Receiving Immune Checkpoint Inhibitors by Sequential [ ¹⁸ F]FDG PET Scans

Autores: Lucas Bacmeister, Niklas Hempfling, Alexander Maier, Susanne Weber, Annette Buellesbach, Adrian Heidenreich, Istvan Bojti, Mark Colin Gissler, Ingo Hilgendorf, Constantin von zur Muehlen, Dirk Westermann, Philipp Tobias Meyer, Christian Goetz, Dennis Wolf
Publicado en: Circulation: Cardiovascular Imaging, Edición 18, 2025, ISSN 1941-9651
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circimaging.124.016851

Break on Through to the Other Side: How Trained Monocytes Promote Recovery From Hind Limb Ischemia

Autores: Zhang, H. Wolf, D.
Publicado en: Arterioscler Thromb Vasc Biol, Edición 15244636, 2021, Página(s) 189-192, ISSN 1524-4636
Editor: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.317257

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis

Autores: Hauke Horstmann, Nathaly Anto Michel, Xia Sheng, Sophie Hansen, Alexandra Lindau, Katharina Pfeil, Marbely C Fernández, Timoteo Marchini, Holger Winkels, Lucia Sol Mitre, Tijani Abogunloko, Xiaowei Li, Timothy Bon-Nawul Mwinyella, Mark Colin Gissler, Heiko Bugger, Timo Heidt, Konrad Buscher, Ingo Hilgendorf, Peter Stachon, Sven Piepenburg, Nicolas Verheyen, Thomas Rathner, Teresa Gerhardt, Patric
Publicado en: Cardiovascular Research, 2024, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvae154

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

Autores: Alma Zernecke, Holger Winkels, Clément Cochain, Jesse W. Williams, Dennis Wolf, Oliver Soehnlein, Clint S. Robbins, Claudia Monaco, Inhye Park, Coleen A. McNamara, Christoph J. Binder, Myron I. Cybulsky, Corey A. Scipione, Catherine C. Hedrick, Elena V. Galkina, Tin Kyaw, Yanal Ghosheh, Huy Q. Dinh, Klaus Ley
Publicado en: Circulation Research, Edición 127/3, 2020, Página(s) 402-426, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316903

Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding

Autores: Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Rüdiger Eberhard Scharf, Daniel Duerschmied, Nancy Schanze
Publicado en: Frontiers in Immunology, Edición 14, 2023, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2023.1184010

Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis

Autores: Timoteo Marchini, Tijani Abogunloko, Dennis Wolf
Publicado en: Hamostaseologie, Edición 25675761, 2022, Página(s) 447–457, ISSN 2567-5761
Editor: Thieme
DOI: 10.1055/a-1661-1908

Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight

Autores: Holger Winkels, Dennis Wolf
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.312137

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 –Reactive CD4 + T-Regulatory Cells

Autores: Dennis Wolf, Teresa Gerhardt, Holger Winkels, Nathaly Anto Michel, Akula Bala Pramod, Yanal Ghosheh, Simon Brunel, Konrad Buscher, Jacqueline Miller, Sara McArdle, Livia Baas, Kouji Kobiyama, Melanie Vassallo, Erik Ehinger, Thamotharampillai Dileepan, Amal Ali, Maximilian Schell, Zbigniew Mikulski, Daniel Sidler, Takayuki Kimura, Xia Sheng, Hauke Horstmann, Sophie Hansen, Lucia Sol Mitre, Peter St
Publicado en: Circulation, Edición 142/13, 2020, Página(s) 1279-1293, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042863

Molecular mechanisms underlying NLRP3 inflammasome activation and IL-1β production in air pollution fine particulate matter (PM2.5)-primed macrophages

Autores: Lourdes Caceres, Tijani Abogunloko, Sara Malchow, Fabienne Ehret, Julian Merz, Xiaowei Li, Lucia Sol Mitre, Natalia Magnani, Deborah Tasat, Timothy Mwinyella, Lisa Spiga, Dymphie Suchanek, Larissa Fischer, Oliver Gorka, Mark Colin Gissler, Ingo Hilgendorf, Peter Stachon, Eva Rog-Zielinska, Olaf Groß, Dirk Westermann, Pablo Evelson, Dennis Wolf, Timoteo Marchini
Publicado en: Environmental Pollution, Edición 341, 2024, Página(s) 122997, ISSN 0269-7491
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122997

Editorial: Immune and autoimmune mechanisms in cardiovascular disease

Autores: Holger Winkels, Norbert Gerdes, Florian Kahles, Partha Dutta, Chiara Giannarelli, Dennis Wolf
Publicado en: Front Cardiovasc Med, 2023, ISSN 2297-055X
Editor: Frontiers
DOI: 10.3389/fcvm.2022.1125959

ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis

Autores: Timoteo Marchini, Sophie Hansen, Dennis Wolf
Publicado en: Cells, Edición 10/2, 2021, Página(s) 446, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10020446

Inflammatory Cell Recruitment in Cardiovascular Disease

Autores: Timoteo Marchini, Lucía Sol Mitre, Dennis Wolf
Publicado en: Frontiers in Cell and Developmental Biology, Edición 9, 2021, ISSN 2296-634X
Editor: Frontiers Media SA
DOI: 10.3389/fcell.2021.635527