Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Informations projet

ANIMATE

N° de convention de subvention: 853425

DOI 10.3030/853425

Date de signature de la CE 22 Octobre 2019

Date de début 1 Janvier 2020

Date de fin 31 Decembre 2024

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total € 1 499 946,25

Contribution de l’UE € 1 499 946,00

Coordonné par

UNIVERSITAETSKLINIKUM FREIBURG
Germany

Publications

Peer reviewed articles (12)

Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice

Auteurs: Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Härdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N Dankel, Gunnar Me
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 15244636, 2021, Page(s) 2563-2574, ISSN 1524-4636
Éditeur: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.316677

Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe−/− mice

Auteurs: Marco Orecchioni; Dennis Wolf; Vasantika Suryawanshi; Holger Winkels; Kouji Kobiyama; Jeffrey Makings; William B. Kiosses; Klaus Ley
Publié dans: Crossref, Numéro 1, 2022, ISSN 1420-9071
Éditeur: Springer Nature
DOI: 10.1007/s00018-022-04649-9

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Auteurs: Patrick M. Siegel, István Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto‐Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, Maximilian Mauler, Laura Hollederer, Martin Moser, Christoph Bode
Publié dans: Basic Research in Cardiology, Numéro 14351803, 2021, ISSN 1435-1803
Éditeur: Springer
DOI: 10.1007/s00395-021-00849-9

Circulating Autoantibodies Recognizing Immunodominant Epitopes From Human Apolipoprotein B Associate With Cardiometabolic Risk Factors, but Not With Atherosclerotic Disease

Auteurs: Timoteo Marchini; Sara Malchow; Lourdes Caceres; Abed Al Hadi El Rabih; Sophie Hansen; Timothy Mwinyella; Lisa Spiga; Sven Piepenburg; Hauke Horstmann; Tijani Olawale; Xiaowei Li; Lucia Sol Mitre; Mark Colin Gissler; Heiko Bugger; Andreas Zirlik; Timo Heidt; Ingo Hilgendorf; Peter Stachon; Constantin von zur Muehlen; Christoph Bode; Dennis Wolf
Publié dans: Frontiers in Cardiovascular Medicine, Numéro 1, 2022, Page(s) 826729, ISSN 2297-055X
Éditeur: Frontiers, S.A.
DOI: 10.3389/fcvm.2022.826729

Break on Through to the Other Side: How Trained Monocytes Promote Recovery From Hind Limb Ischemia

Auteurs: Zhang, H. Wolf, D.
Publié dans: Arterioscler Thromb Vasc Biol, Numéro 15244636, 2021, Page(s) 189-192, ISSN 1524-4636
Éditeur: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.317257

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

Auteurs: Alma Zernecke, Holger Winkels, Clément Cochain, Jesse W. Williams, Dennis Wolf, Oliver Soehnlein, Clint S. Robbins, Claudia Monaco, Inhye Park, Coleen A. McNamara, Christoph J. Binder, Myron I. Cybulsky, Corey A. Scipione, Catherine C. Hedrick, Elena V. Galkina, Tin Kyaw, Yanal Ghosheh, Huy Q. Dinh, Klaus Ley
Publié dans: Circulation Research, Numéro 127/3, 2020, Page(s) 402-426, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316903

Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis

Auteurs: Timoteo Marchini, Tijani Abogunloko, Dennis Wolf
Publié dans: Hamostaseologie, Numéro 25675761, 2022, Page(s) 447–457, ISSN 2567-5761
Éditeur: Thieme
DOI: 10.1055/a-1661-1908

Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight

Auteurs: Holger Winkels, Dennis Wolf
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.312137

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 –Reactive CD4 + T-Regulatory Cells

Auteurs: Dennis Wolf, Teresa Gerhardt, Holger Winkels, Nathaly Anto Michel, Akula Bala Pramod, Yanal Ghosheh, Simon Brunel, Konrad Buscher, Jacqueline Miller, Sara McArdle, Livia Baas, Kouji Kobiyama, Melanie Vassallo, Erik Ehinger, Thamotharampillai Dileepan, Amal Ali, Maximilian Schell, Zbigniew Mikulski, Daniel Sidler, Takayuki Kimura, Xia Sheng, Hauke Horstmann, Sophie Hansen, Lucia Sol Mitre, Peter St
Publié dans: Circulation, Numéro 142/13, 2020, Page(s) 1279-1293, ISSN 0009-7322
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042863

Editorial: Immune and autoimmune mechanisms in cardiovascular disease

Auteurs: Holger Winkels, Norbert Gerdes, Florian Kahles, Partha Dutta, Chiara Giannarelli, Dennis Wolf
Publié dans: Front Cardiovasc Med, 2023, ISSN 2297-055X
Éditeur: Frontiers
DOI: 10.3389/fcvm.2022.1125959

ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis

Auteurs: Timoteo Marchini, Sophie Hansen, Dennis Wolf
Publié dans: Cells, Numéro 10/2, 2021, Page(s) 446, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells10020446

Inflammatory Cell Recruitment in Cardiovascular Disease

Auteurs: Timoteo Marchini, Lucía Sol Mitre, Dennis Wolf
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 9, 2021, ISSN 2296-634X
Éditeur: Frontiers Media SA
DOI: 10.3389/fcell.2021.635527