Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Informazioni relative al progetto

ANIMATE

ID dell’accordo di sovvenzione: 853425

DOI

10.3030/853425

Progetto chiuso

Data della firma CE 22 Ottobre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 946,25

Contributo UE

€ 1 499 946,00

Coordinato da

UNIVERSITAETSKLINIKUM FREIBURG
Germany

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I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (17)

Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice

Autori: Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Härdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N Dankel, Gunnar Me
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 15244636, 2021, Pagina/e 2563-2574, ISSN 1524-4636
Editore: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.316677

The Role of Tumor Necrosis Factor Associated Factors (TRAFs) in Vascular Inflammation and Atherosclerosis

Autori: Mark Colin Gissler, Peter Stachon, Dennis Wolf, Timoteo Marchini
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 9, 2023, ISSN 2297-055X
Editore: Frontiers
DOI: 10.3389/fcvm.2022.826630

Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe−/− mice

Autori: Marco Orecchioni; Dennis Wolf; Vasantika Suryawanshi; Holger Winkels; Kouji Kobiyama; Jeffrey Makings; William B. Kiosses; Klaus Ley
Pubblicato in: Cell Mol Life Sci ., Numero 1, 2022, ISSN 1420-9071
Editore: Springer Nature
DOI: 10.1007/s00018-022-04649-9

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Autori: Patrick M. Siegel, István Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto‐Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, Maximilian Mauler, Laura Hollederer, Martin Moser, Christoph Bode
Pubblicato in: Basic Research in Cardiology, Numero 14351803, 2021, ISSN 1435-1803
Editore: Springer
DOI: 10.1007/s00395-021-00849-9

Circulating Autoantibodies Recognizing Immunodominant Epitopes From Human Apolipoprotein B Associate With Cardiometabolic Risk Factors, but Not With Atherosclerotic Disease

Autori: Timoteo Marchini; Sara Malchow; Lourdes Caceres; Abed Al Hadi El Rabih; Sophie Hansen; Timothy Mwinyella; Lisa Spiga; Sven Piepenburg; Hauke Horstmann; Tijani Olawale; Xiaowei Li; Lucia Sol Mitre; Mark Colin Gissler; Heiko Bugger; Andreas Zirlik; Timo Heidt; Ingo Hilgendorf; Peter Stachon; Constantin von zur Muehlen; Christoph Bode; Dennis Wolf
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 1, 2022, Pagina/e 826729, ISSN 2297-055X
Editore: Frontiers, S.A.
DOI: 10.3389/fcvm.2022.826729

Longitudinal Assessment of Subclinical Arterial Inflammation in Patients Receiving Immune Checkpoint Inhibitors by Sequential [ ¹⁸ F]FDG PET Scans

Autori: Lucas Bacmeister, Niklas Hempfling, Alexander Maier, Susanne Weber, Annette Buellesbach, Adrian Heidenreich, Istvan Bojti, Mark Colin Gissler, Ingo Hilgendorf, Constantin von zur Muehlen, Dirk Westermann, Philipp Tobias Meyer, Christian Goetz, Dennis Wolf
Pubblicato in: Circulation: Cardiovascular Imaging, Numero 18, 2025, ISSN 1941-9651
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circimaging.124.016851

Break on Through to the Other Side: How Trained Monocytes Promote Recovery From Hind Limb Ischemia

Autori: Zhang, H. Wolf, D.
Pubblicato in: Arterioscler Thromb Vasc Biol, Numero 15244636, 2021, Pagina/e 189-192, ISSN 1524-4636
Editore: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.317257

Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis

Autori: Hauke Horstmann, Nathaly Anto Michel, Xia Sheng, Sophie Hansen, Alexandra Lindau, Katharina Pfeil, Marbely C Fernández, Timoteo Marchini, Holger Winkels, Lucia Sol Mitre, Tijani Abogunloko, Xiaowei Li, Timothy Bon-Nawul Mwinyella, Mark Colin Gissler, Heiko Bugger, Timo Heidt, Konrad Buscher, Ingo Hilgendorf, Peter Stachon, Sven Piepenburg, Nicolas Verheyen, Thomas Rathner, Teresa Gerhardt, Patric
Pubblicato in: Cardiovascular Research, 2024, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvae154

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

Autori: Alma Zernecke, Holger Winkels, Clément Cochain, Jesse W. Williams, Dennis Wolf, Oliver Soehnlein, Clint S. Robbins, Claudia Monaco, Inhye Park, Coleen A. McNamara, Christoph J. Binder, Myron I. Cybulsky, Corey A. Scipione, Catherine C. Hedrick, Elena V. Galkina, Tin Kyaw, Yanal Ghosheh, Huy Q. Dinh, Klaus Ley
Pubblicato in: Circulation Research, Numero 127/3, 2020, Pagina/e 402-426, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316903

Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding

Autori: Johannes Hoch, Niklas Burkhard, Shanshan Zhang, Marina Rieder, Timoteo Marchini, Vincent Geest, Krystin Krauel, Timm Zahn, Nicolas Schommer, Muataz Ali Hamad, Carolina Bauer, Nadine Gauchel, Daniela Stallmann, Claus Normann, Dennis Wolf, Rüdiger Eberhard Scharf, Daniel Duerschmied, Nancy Schanze
Pubblicato in: Frontiers in Immunology, Numero 14, 2023, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2023.1184010

Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis

Autori: Timoteo Marchini, Tijani Abogunloko, Dennis Wolf
Pubblicato in: Hamostaseologie, Numero 25675761, 2022, Pagina/e 447–457, ISSN 2567-5761
Editore: Thieme
DOI: 10.1055/a-1661-1908

Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight

Autori: Holger Winkels, Dennis Wolf
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.312137

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 –Reactive CD4 + T-Regulatory Cells

Autori: Dennis Wolf, Teresa Gerhardt, Holger Winkels, Nathaly Anto Michel, Akula Bala Pramod, Yanal Ghosheh, Simon Brunel, Konrad Buscher, Jacqueline Miller, Sara McArdle, Livia Baas, Kouji Kobiyama, Melanie Vassallo, Erik Ehinger, Thamotharampillai Dileepan, Amal Ali, Maximilian Schell, Zbigniew Mikulski, Daniel Sidler, Takayuki Kimura, Xia Sheng, Hauke Horstmann, Sophie Hansen, Lucia Sol Mitre, Peter St
Pubblicato in: Circulation, Numero 142/13, 2020, Pagina/e 1279-1293, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042863

Molecular mechanisms underlying NLRP3 inflammasome activation and IL-1β production in air pollution fine particulate matter (PM2.5)-primed macrophages

Autori: Lourdes Caceres, Tijani Abogunloko, Sara Malchow, Fabienne Ehret, Julian Merz, Xiaowei Li, Lucia Sol Mitre, Natalia Magnani, Deborah Tasat, Timothy Mwinyella, Lisa Spiga, Dymphie Suchanek, Larissa Fischer, Oliver Gorka, Mark Colin Gissler, Ingo Hilgendorf, Peter Stachon, Eva Rog-Zielinska, Olaf Groß, Dirk Westermann, Pablo Evelson, Dennis Wolf, Timoteo Marchini
Pubblicato in: Environmental Pollution, Numero 341, 2024, Pagina/e 122997, ISSN 0269-7491
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2023.122997

Editorial: Immune and autoimmune mechanisms in cardiovascular disease

Autori: Holger Winkels, Norbert Gerdes, Florian Kahles, Partha Dutta, Chiara Giannarelli, Dennis Wolf
Pubblicato in: Front Cardiovasc Med, 2023, ISSN 2297-055X
Editore: Frontiers
DOI: 10.3389/fcvm.2022.1125959

ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis

Autori: Timoteo Marchini, Sophie Hansen, Dennis Wolf
Pubblicato in: Cells, Numero 10/2, 2021, Pagina/e 446, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10020446

Inflammatory Cell Recruitment in Cardiovascular Disease

Autori: Timoteo Marchini, Lucía Sol Mitre, Dennis Wolf
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2021.635527