Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Informazioni relative al progetto

ANIMATE

ID dell’accordo di sovvenzione: 853425

DOI 10.3030/853425

Data della firma CE 22 Ottobre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 499 946,25

Contributo UE € 1 499 946,00

Coordinato da

UNIVERSITAETSKLINIKUM FREIBURG
Germany

Pubblicazioni

Peer reviewed articles (12)

Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice

Autori: Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Härdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N Dankel, Gunnar Me
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 15244636, 2021, Pagina/e 2563-2574, ISSN 1524-4636
Editore: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.316677

Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe−/− mice

Autori: Marco Orecchioni; Dennis Wolf; Vasantika Suryawanshi; Holger Winkels; Kouji Kobiyama; Jeffrey Makings; William B. Kiosses; Klaus Ley
Pubblicato in: Crossref, Numero 1, 2022, ISSN 1420-9071
Editore: Springer Nature
DOI: 10.1007/s00018-022-04649-9

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Autori: Patrick M. Siegel, István Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto‐Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, Maximilian Mauler, Laura Hollederer, Martin Moser, Christoph Bode
Pubblicato in: Basic Research in Cardiology, Numero 14351803, 2021, ISSN 1435-1803
Editore: Springer
DOI: 10.1007/s00395-021-00849-9

Circulating Autoantibodies Recognizing Immunodominant Epitopes From Human Apolipoprotein B Associate With Cardiometabolic Risk Factors, but Not With Atherosclerotic Disease

Autori: Timoteo Marchini; Sara Malchow; Lourdes Caceres; Abed Al Hadi El Rabih; Sophie Hansen; Timothy Mwinyella; Lisa Spiga; Sven Piepenburg; Hauke Horstmann; Tijani Olawale; Xiaowei Li; Lucia Sol Mitre; Mark Colin Gissler; Heiko Bugger; Andreas Zirlik; Timo Heidt; Ingo Hilgendorf; Peter Stachon; Constantin von zur Muehlen; Christoph Bode; Dennis Wolf
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 1, 2022, Pagina/e 826729, ISSN 2297-055X
Editore: Frontiers, S.A.
DOI: 10.3389/fcvm.2022.826729

Break on Through to the Other Side: How Trained Monocytes Promote Recovery From Hind Limb Ischemia

Autori: Zhang, H. Wolf, D.
Pubblicato in: Arterioscler Thromb Vasc Biol, Numero 15244636, 2021, Pagina/e 189-192, ISSN 1524-4636
Editore: Lippincott Williams & Wilkins
DOI: 10.1161/atvbaha.121.317257

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

Autori: Alma Zernecke, Holger Winkels, Clément Cochain, Jesse W. Williams, Dennis Wolf, Oliver Soehnlein, Clint S. Robbins, Claudia Monaco, Inhye Park, Coleen A. McNamara, Christoph J. Binder, Myron I. Cybulsky, Corey A. Scipione, Catherine C. Hedrick, Elena V. Galkina, Tin Kyaw, Yanal Ghosheh, Huy Q. Dinh, Klaus Ley
Pubblicato in: Circulation Research, Numero 127/3, 2020, Pagina/e 402-426, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316903

Modulating Autoimmunity against LDL: Development of a Vaccine against Atherosclerosis

Autori: Timoteo Marchini, Tijani Abogunloko, Dennis Wolf
Pubblicato in: Hamostaseologie, Numero 25675761, 2022, Pagina/e 447–457, ISSN 2567-5761
Editore: Thieme
DOI: 10.1055/a-1661-1908

Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight

Autori: Holger Winkels, Dennis Wolf
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.312137

Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 –Reactive CD4 + T-Regulatory Cells

Autori: Dennis Wolf, Teresa Gerhardt, Holger Winkels, Nathaly Anto Michel, Akula Bala Pramod, Yanal Ghosheh, Simon Brunel, Konrad Buscher, Jacqueline Miller, Sara McArdle, Livia Baas, Kouji Kobiyama, Melanie Vassallo, Erik Ehinger, Thamotharampillai Dileepan, Amal Ali, Maximilian Schell, Zbigniew Mikulski, Daniel Sidler, Takayuki Kimura, Xia Sheng, Hauke Horstmann, Sophie Hansen, Lucia Sol Mitre, Peter St
Pubblicato in: Circulation, Numero 142/13, 2020, Pagina/e 1279-1293, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.042863

Editorial: Immune and autoimmune mechanisms in cardiovascular disease

Autori: Holger Winkels, Norbert Gerdes, Florian Kahles, Partha Dutta, Chiara Giannarelli, Dennis Wolf
Pubblicato in: Front Cardiovasc Med, 2023, ISSN 2297-055X
Editore: Frontiers
DOI: 10.3389/fcvm.2022.1125959

ApoB-Specific CD4+ T Cells in Mouse and Human Atherosclerosis

Autori: Timoteo Marchini, Sophie Hansen, Dennis Wolf
Pubblicato in: Cells, Numero 10/2, 2021, Pagina/e 446, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells10020446

Inflammatory Cell Recruitment in Cardiovascular Disease

Autori: Timoteo Marchini, Lucía Sol Mitre, Dennis Wolf
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 9, 2021, ISSN 2296-634X
Editore: Frontiers Media SA
DOI: 10.3389/fcell.2021.635527