Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

Informazioni relative al progetto

SPHERES

ID dell’accordo di sovvenzione: 856404

DOI

10.3030/856404

Data della firma CE 18 Marzo 2020

Data di avvio 1 Settembre 2020

Data di completamento 31 Agosto 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 9 741 774,25

Contributo UE

€ 9 741 774,00

Coordinato da

UNIVERSITE DE TOULOUSE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (36)

Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting

Autori: Dávid Kovács, Anne-Sophie Gay, Delphine Debayle, Sophie Abélanet, Amanda Patel, Bruno Mesmin, Frédéric Luton, Bruno Antonny
Pubblicato in: Journal of Cell Biology, Numero 223, 2023, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202307051

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

Autori: Joanne X. Shen, Morgane Couchet, Jérémy Dufau, Thais de Castro Barbosa, Marie-Adeline Marques, Niklas Mejhert, Volker M. Lauschke
Pubblicato in: Advanced Science, Numero Vol. 8 Numero 16, 2021, ISSN 2198-3844
Editore: John Wiley & Sons, Ltd
DOI: 10.1002/advs.202100106

Metabolic and cardiovascular adaptations to an 8-wk lifestyle weight loss intervention in younger and older obese men

Autori: Julie Vion, Veronika Sramkova, Emilie Montastier, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Thibaut Duparc, Laurent O Martinez , Virginie Bourlier, Isabelle Harant, Dominique Larrouy, Nabila Moussaoui, Sophie Bonnel, Cécile Vindis, Cédric Dray, Philippe Valet, Jean-Sébastien Saulnier-Blache, Joost P Schanstra, Claire Thalamas, Nathalie Viguerie, Cedric Moro, Dominique Lan
Pubblicato in: American journal of physiology. Endocrinology and metabolism., Numero 2021 Sep 1, 2021, ISSN 0193-1849
Editore: American Physiological Society
DOI: 10.1152/ajpendo.00109.2021

Baseline gene expression in subcutaneous adipose tissue predicts diet-induced weight loss in individuals with obesity

Autori: Oghabian, A., van der Kolk, B. W., Marttinen, P., Valsesia, A., Saris, W. H., Astrup, A., Blaak, E. E. & Pietilainen, K. H.
Pubblicato in: PeerJ - Life and Environment, 2023, ISSN 2167-8359
Editore: PeerJ
DOI: 10.7717/peerj.15100

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

Autori: Omer Keinan, Joseph M. Valentine, Haopeng Xiao, Sushil K. Mahata, Shannon M. Reilly, Mohammad Abu-Odeh, Julia H. Deluca, Benyamin Dadpey, Leslie Cho, Austin Pan, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Aldons J. Lusis, Markku Laakso, Edward T. Chouchani, Mikael Rydén, Alan R. Saltiel
Pubblicato in: Nature, Numero 599, 2022, Pagina/e 296-301, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-04019-8

Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes

Autori: Etienne Mouisel, Anaïs Bodon, Christophe Noll, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Remy Flores-Flores, Elodie Riant, Camille Bergoglio, Pierre Vezin, Sylvie Caspar-Bauguil, Camille Fournes-Fraresso, Geneviève Tavernier, Khalil Acheikh Ibn Oumar, Pierre Gourdy, Denis P. Blondin, Pierre-Damien Denechaud, André C. Carpentier, Dominique Langin
Pubblicato in: Cell Metabolism, Numero 37, 2025, Pagina/e 429-440.e5, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2024.10.018

Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation

Autori: Gianluca Renzi, Ivan Vlassakev, Mattias Hansen, Romane Higos, Simon Lecoutre, Merve Elmastas, Ondrej Hodek, Thomas Moritz, Lynn M. Alaeddine, Scott Frendo–Cumbo, Ingrid Dahlman, Alastair Kerr, Salwan Maqdasy, Niklas Mejhert, Mikael Rydén
Pubblicato in: Molecular Metabolism, Numero 92, 2025, Pagina/e 102082, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.102082

Transcriptional determinants of lipid mobilization in human adipocytes

Autori: Alison C. Ludzki, Mattias Hansen, Danae Zareifi, Jutta Jalkanen, Zhiqiang Huang, Muhmmad Omar-Hmeadi, Gianluca Renzi, Felix Klingelhuber, Sebastian Boland, Yohannes A. Ambaw, Na Wang, Anastasios Damdimopoulos, Jianping Liu, Tomas Jernberg, Paul Petrus, Peter Arner, Natalie Krahmer, Rongrong Fan, Eckardt Treuter, Hui Gao, Mikael Rydén, Niklas Mejhert
Pubblicato in: Science Advances, Numero 10, 2024, ISSN 2375-2548
Editore: American Association for the Advancement of Science's
DOI: 10.1126/sciadv.adi2689

In vitro and ex vivo models of adipocytes

Autori: Jérémy Dufau, Joanne X. Shen, Morgane Couchet, Thais De Castro Barbosa, Niklas Mejhert, Lucas Massier, Elena Griseti, Etienne Mouisel, Ez-Zoubir Amri, Volker M. Lauschke, Mikael Rydén, and Dominique Langin
Pubblicato in: Cell Physiology, Numero Vol. 320 Numero 5, 2021, ISSN 0363-6143
Editore: American Physiological Society
DOI: 10.1152/ajpcell.00519.2020

Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function

Autori: Harayama, T.
Pubblicato in: Cold Spring Harbor Perspectives in Biology, 2023, ISSN 1943-0264
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041409

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Autori: Jesper Bäckdahl, Lovisa Franzén, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Rydén, Patrik L. Ståhl, Niklas Mejhert
Pubblicato in: Cell Metabolism, Numero Volume 33, Numero 9, 2021, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.07.018

ChREBPβ is dispensable for the control of glucose homeostasis and energy balance

Autori: Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, Dominique Langin
Pubblicato in: JCI Insight, Numero Vol. 7, Numero 4, 2022, ISSN 2379-3708
Editore: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.153431

Adipocyte heterogeneity revealed by spatial transcriptomics of human adipose tissue: Painting and more

Autori: Dominique Langin
Pubblicato in: Cell Metabolism, Numero Vol 33 Numero 9, 2021, Pagina/e 1869-1882, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2021.08.011

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Autori: Hui Gao, Peter Arner, Gallic Beauchef, Christelle Guéré, Katell Vie, Ingrid Dahlman, Niklas Mejhert, Mikael Rydén
Pubblicato in: Cell Metabolism, Numero 32, 2022, Pagina/e 1-3, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.06.007

New insights into the OSBP‒VAP cycle

Autori: Subra M., Mesmin, B.
Pubblicato in: Current Opinion in Cell Biology, 2023, ISSN 0955-0674
Editore: Elsevier BV
DOI: 10.1016/j.ceb.2023.102172

Adipogenic characterization of immortalized CD55 ⁺ progenitor cells from human white adipose tissue

Autori: Morgane Couchet, Hui Gao, Felix Klingelhuber, Jutta Jalkanen, Thais De Castro Barbosa, Muhmmad Omar-Hmeadi, Lucas Massier, Natalie Krahmer, Niklas Mejhert, Mikael Rydén
Pubblicato in: Adipocyte, 2024, ISSN 2162-3945
Editore: Taylor & Francis Online
DOI: 10.1080/21623945.2023.2283213

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Autori: Valerio Azzimato, Ping Chen, Emelie Barreby, Cecilia Morgantini, Laura Levi, Ana Vankova, Jennifer Jager, André Sulen, Marina Diotallevi, Joanne X. Shen, Anne Miller, Ewa Ellis, Mikael Rydén, Erik Näslund, Anders Thorell, Volker M. Lauschke, Keith M. Channon, Mark J. Crabtree, Arvand Haschemi, Siobhan M. Craige, Mattia Mori, Francesco Spallotta, and Myriam Aouadi
Pubblicato in: Gastroenterology, Numero Volume 161, Numero 6, 2021, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.08.030

Separation of polar and neutral lipids from mammalian cell lines by high-performance thin-layer chromatography

Autori: Ana Rita Dias Araújo, Océane Buvry, Bruno Antonny, Delphine Debayle
Pubblicato in: Journal of Chromatography A, Numero 1741, 2025, Pagina/e 465610, ISSN 0021-9673
Editore: Elsevier BV
DOI: 10.1016/j.chroma.2024.465610

Surface tension-driven sorting of human perilipins on lipid droplets

Autori: Ana Rita Dias Araujo, Abdoul Akim Bello, Joëlle Bigay, Céline Franckhauser, Romain Gautier, Julie Cazareth, David Kovacs, Frédéric Brau, Nicolas Fuggetta, Alenka Copic, Bruno Antonny
Pubblicato in: bioRxiv, 2024, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1101/2024.02.12.579497

Molecular mechanisms of perilipin protein function in lipid droplet metabolism

Autori: Elena Griseti, Abdoul Akim Bello, Eric Bieth, Bayane Sabbagh, Jason S. Iacovoni, Joëlle Bigay, Henrik Laurell, Alenka Čopič
Pubblicato in: FEBS Letters, Numero 598, 2024, Pagina/e 1170-1198, ISSN 0014-5793
Editore: Elsevier BV
DOI: 10.1002/1873-3468.14792

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

Autori: Kerr, A. G., Wang, Z., Wang, N., Kwok, K. H. M., Jalkanen, J., Ludzki, A., Lecoutre, S., Bergo, M. O., Dahlman, I., Mim, C., Arner, P. & Gao, H.
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30620-0

Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State

Autori: Enrichetta Mileti, Kelvin H.M. Kwok, Daniel P. Andersson, Anthony Mathelier, Amitha Raman, Jesper Bäckdahl, Jutta Jalkanen, Lucas Massier, Anders Thorell, Hui Gao, Peter Arner, Niklas Mejhert, Carsten O. Daub, Mikael Ryden
Pubblicato in: diabetes, 2021, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db21-0001

Surface tension–driven sorting of human perilipins on lipid droplets

Autori: Ana Rita Dias Araújo, Abdoul Akim Bello, Joëlle Bigay, Céline Franckhauser, Romain Gautier, Julie Cazareth, Dávid Kovács, Frédéric Brau, Nicolas Fuggetta, Alenka Čopič, Bruno Antonny
Pubblicato in: Journal of Cell Biology, Numero 223, 2024, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202403064

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Autori: """Fougerat, A., Schoiswohl, G., Polizzi, A., Regnier, M., Wagner, C., Smati, S., Fougeray, T., Lippi, Y., Lasserre, F., Raho, I., Melin, V., Tramunt, B., Metivier, R., Sommer, C., Benhamed, F., Alkhoury, C., Greulich, F., Jouffe, C., Emile, A., Schupp, M., Gourdy, P., Dubot, P., Levade, T., Meynard, D., Ellero-Simatos, S., Gamet-Payrastre, L., Panasyuk, G., Uhlenhaut, H., Amri, E. Z., Cruciani-Gugl"
Pubblicato in: Cell Reports, Numero 22111247, 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.110910

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Autori: Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O Bergo, Robin P Choudhury, Myriam Aouadi, Juleen R Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén
Pubblicato in: Nature metabolism, Numero Vol. 4 February 2022, 2022, ISSN 2522-5812
Editore: Springer Nature
DOI: 10.1038/s42255-022-00525-9

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

Autori: Subra M., Dezi M., Bigay J., Lacas-Gervais S., Di Cicco A., Araújo A.R.D., Abélanet S., Fleuriot L., Debayle D., Gautier R., Patel A., Roussi F., Lévy D., Mesmin B.
Pubblicato in: Developmental Cell, 2023, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2022.12.010

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

Autori: Niklas Mejhert, Katlyn R.Gabriel, Scott Frendo-Cumbo, Natalie Krahmer, Jiunn Song, Leena Kuruvilla, Chandramohan Chitraju, Sebastian Boland, Dong-Keun Jang, Marcin von Grotthuss, Maria C.Costanzo, Mikael Ryden, James A.Olzmann, Jason Flannick, Noël P.Burtt, Robert V. Farese Jr.,Tobias C. Walther
Pubblicato in: Developmental Cell, 2022, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2022.01.003

Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Autori: Manuel Giménez-Andrés, Tadej Emeršič, Sandra Antoine-Bally, Juan Martin D'Ambrosio, Bruno Antonny, Jure Derganc, Alenka Čopič
Pubblicato in: eLife, Numero 10, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.61401

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Autori: Simon Lecoutre, Salwan Maqdasy, David Rizo-Roca, Gianluca Renzi, Ivan Vlassakev, Lynn M. Alaeddine, Romane Higos, Jutta Jalkanen, Jiawei Zhong, Danae S. Zareifi, Scott Frendo-Cumbo, Lucas Massier, Ondrej Hodek, Marta Juvany, Thomas Moritz, Thais de Castro Barbosa, Muhmmad Omar-Hmeadi, Marta López-Yus, Fatiha Merabtene, Jimon Boniface Abatan, Geneviève Marcelin, Elie-Julien El Hachem, Christine R
Pubblicato in: Nature Metabolism, Numero 6, 2024, Pagina/e 1329-1346, ISSN 2522-5812
Editore: Nature Publishing Group
DOI: 10.1038/s42255-024-01083-y

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

Autori: Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Pubblicato in: Nature reviews endocrinology, 2021, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-021-00471-8

Cellular senescence and its role in white adipose tissue

Autori: Ulf Smith, Qian Li, Mikael Rydén, Kirsty L. Spalding
Pubblicato in: International Journal of Obesity, 2021, ISSN 0307-0565
Editore: Nature Publishing Group
DOI: 10.1038/s41366-021-00757-x

Hormone-sensitive lipase: sixty years later

Autori: Emeline Recazens, Etienne Mouisel, Dominique Langin
Pubblicato in: Progress in Lipid Research, Numero 82, 2021, ISSN 0163-7827
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2020.101084

Effects of Fatty Acid Metabolites on Adipocytes Britening: Role of Thromboxane A2

Autori: Colson, C., Batrow, P. L., Dieckmann, S., Contu, L., Roux, C. H., Balas, L., Vigor, C., Fourmaux, B., Gautier, N., Rochet, N., Bernoud-Hubac, N., Durand, T., Klingenspor, M. & Amri, E. Z.
Pubblicato in: Cells, 2023, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12030446

An integrated single cell and spatial transcriptomic map of human white adipose tissue

Autori: Massier L, Jalkanen J, Elmastas M, Zhong J, Wang T, Nono Nankam PA, Frendo-Cumbo S, Bäckdahl J, Subramanian N, Sekine T, Kerr AG, Tseng BTP, Laurencikiene J, Buggert M, Lourda M, Kublickiene K, Bhalla N, Andersson A, Valsesia A, Astrup A, Blaak EE, Ståhl PL, Viguerie N, Wolfrum C, Blüher M, Mejhert N.
Pubblicato in: Nature Publishing Group, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-36983-2

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

Autori: Hui Gao, Ruth T. Yu, Christopher Liddle, Michael Downes, Jin Zhang, Aldons J. Lusis, Alan D. Attie, Ronald M. Evans, Mikael Rydén, and Alan R. Saltiel
Pubblicato in: JCI The Journal of Clinical Investigation, 2021, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci153357

Adipose tissue retains an epigenetic memory of obesity after weight loss

Autori: Laura C. Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn
Pubblicato in: Nature, Numero 636, 2024, Pagina/e 457-465, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-08165-7