Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

Informacje na temat projektu

SPHERES

Identyfikator umowy o grant: 856404

DOI

10.3030/856404

Data podpisania przez KE 18 Marca 2020

Data rozpoczęcia 1 Września 2020

Data zakończenia 31 Sierpnia 2027

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 9 741 774,25

Wkład UE

€ 9 741 774,00

Koordynowany przez

UNIVERSITE DE TOULOUSE
France

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (36)

Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting

Autorzy: Dávid Kovács, Anne-Sophie Gay, Delphine Debayle, Sophie Abélanet, Amanda Patel, Bruno Mesmin, Frédéric Luton, Bruno Antonny
Opublikowane w: Journal of Cell Biology, Numer 223, 2023, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.202307051

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

Autorzy: Joanne X. Shen, Morgane Couchet, Jérémy Dufau, Thais de Castro Barbosa, Marie-Adeline Marques, Niklas Mejhert, Volker M. Lauschke
Opublikowane w: Advanced Science, Numer Vol. 8 Numer 16, 2021, ISSN 2198-3844
Wydawca: John Wiley & Sons, Ltd
DOI: 10.1002/advs.202100106

Metabolic and cardiovascular adaptations to an 8-wk lifestyle weight loss intervention in younger and older obese men

Autorzy: Julie Vion, Veronika Sramkova, Emilie Montastier, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Thibaut Duparc, Laurent O Martinez , Virginie Bourlier, Isabelle Harant, Dominique Larrouy, Nabila Moussaoui, Sophie Bonnel, Cécile Vindis, Cédric Dray, Philippe Valet, Jean-Sébastien Saulnier-Blache, Joost P Schanstra, Claire Thalamas, Nathalie Viguerie, Cedric Moro, Dominique Lan
Opublikowane w: American journal of physiology. Endocrinology and metabolism., Numer 2021 Sep 1, 2021, ISSN 0193-1849
Wydawca: American Physiological Society
DOI: 10.1152/ajpendo.00109.2021

Baseline gene expression in subcutaneous adipose tissue predicts diet-induced weight loss in individuals with obesity

Autorzy: Oghabian, A., van der Kolk, B. W., Marttinen, P., Valsesia, A., Saris, W. H., Astrup, A., Blaak, E. E. & Pietilainen, K. H.
Opublikowane w: PeerJ - Life and Environment, 2023, ISSN 2167-8359
Wydawca: PeerJ
DOI: 10.7717/peerj.15100

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

Autorzy: Omer Keinan, Joseph M. Valentine, Haopeng Xiao, Sushil K. Mahata, Shannon M. Reilly, Mohammad Abu-Odeh, Julia H. Deluca, Benyamin Dadpey, Leslie Cho, Austin Pan, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Aldons J. Lusis, Markku Laakso, Edward T. Chouchani, Mikael Rydén, Alan R. Saltiel
Opublikowane w: Nature, Numer 599, 2022, Strona(/y) 296-301, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-021-04019-8

Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes

Autorzy: Etienne Mouisel, Anaïs Bodon, Christophe Noll, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Remy Flores-Flores, Elodie Riant, Camille Bergoglio, Pierre Vezin, Sylvie Caspar-Bauguil, Camille Fournes-Fraresso, Geneviève Tavernier, Khalil Acheikh Ibn Oumar, Pierre Gourdy, Denis P. Blondin, Pierre-Damien Denechaud, André C. Carpentier, Dominique Langin
Opublikowane w: Cell Metabolism, Numer 37, 2025, Strona(/y) 429-440.e5, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2024.10.018

Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation

Autorzy: Gianluca Renzi, Ivan Vlassakev, Mattias Hansen, Romane Higos, Simon Lecoutre, Merve Elmastas, Ondrej Hodek, Thomas Moritz, Lynn M. Alaeddine, Scott Frendo–Cumbo, Ingrid Dahlman, Alastair Kerr, Salwan Maqdasy, Niklas Mejhert, Mikael Rydén
Opublikowane w: Molecular Metabolism, Numer 92, 2025, Strona(/y) 102082, ISSN 2212-8778
Wydawca: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.102082

Transcriptional determinants of lipid mobilization in human adipocytes

Autorzy: Alison C. Ludzki, Mattias Hansen, Danae Zareifi, Jutta Jalkanen, Zhiqiang Huang, Muhmmad Omar-Hmeadi, Gianluca Renzi, Felix Klingelhuber, Sebastian Boland, Yohannes A. Ambaw, Na Wang, Anastasios Damdimopoulos, Jianping Liu, Tomas Jernberg, Paul Petrus, Peter Arner, Natalie Krahmer, Rongrong Fan, Eckardt Treuter, Hui Gao, Mikael Rydén, Niklas Mejhert
Opublikowane w: Science Advances, Numer 10, 2024, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science's
DOI: 10.1126/sciadv.adi2689

In vitro and ex vivo models of adipocytes

Autorzy: Jérémy Dufau, Joanne X. Shen, Morgane Couchet, Thais De Castro Barbosa, Niklas Mejhert, Lucas Massier, Elena Griseti, Etienne Mouisel, Ez-Zoubir Amri, Volker M. Lauschke, Mikael Rydén, and Dominique Langin
Opublikowane w: Cell Physiology, Numer Vol. 320 Numer 5, 2021, ISSN 0363-6143
Wydawca: American Physiological Society
DOI: 10.1152/ajpcell.00519.2020

Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function

Autorzy: Harayama, T.
Opublikowane w: Cold Spring Harbor Perspectives in Biology, 2023, ISSN 1943-0264
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041409

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Autorzy: Jesper Bäckdahl, Lovisa Franzén, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Rydén, Patrik L. Ståhl, Niklas Mejhert
Opublikowane w: Cell Metabolism, Numer Volume 33, Numer 9, 2021, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2021.07.018

ChREBPβ is dispensable for the control of glucose homeostasis and energy balance

Autorzy: Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, Dominique Langin
Opublikowane w: JCI Insight, Numer Vol. 7, Numer 4, 2022, ISSN 2379-3708
Wydawca: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.153431

Adipocyte heterogeneity revealed by spatial transcriptomics of human adipose tissue: Painting and more

Autorzy: Dominique Langin
Opublikowane w: Cell Metabolism, Numer Vol 33 Numer 9, 2021, Strona(/y) 1869-1882, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2021.08.011

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Autorzy: Hui Gao, Peter Arner, Gallic Beauchef, Christelle Guéré, Katell Vie, Ingrid Dahlman, Niklas Mejhert, Mikael Rydén
Opublikowane w: Cell Metabolism, Numer 32, 2022, Strona(/y) 1-3, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2020.06.007

New insights into the OSBP‒VAP cycle

Autorzy: Subra M., Mesmin, B.
Opublikowane w: Current Opinion in Cell Biology, 2023, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/j.ceb.2023.102172

Adipogenic characterization of immortalized CD55 ⁺ progenitor cells from human white adipose tissue

Autorzy: Morgane Couchet, Hui Gao, Felix Klingelhuber, Jutta Jalkanen, Thais De Castro Barbosa, Muhmmad Omar-Hmeadi, Lucas Massier, Natalie Krahmer, Niklas Mejhert, Mikael Rydén
Opublikowane w: Adipocyte, 2024, ISSN 2162-3945
Wydawca: Taylor & Francis Online
DOI: 10.1080/21623945.2023.2283213

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Autorzy: Valerio Azzimato, Ping Chen, Emelie Barreby, Cecilia Morgantini, Laura Levi, Ana Vankova, Jennifer Jager, André Sulen, Marina Diotallevi, Joanne X. Shen, Anne Miller, Ewa Ellis, Mikael Rydén, Erik Näslund, Anders Thorell, Volker M. Lauschke, Keith M. Channon, Mark J. Crabtree, Arvand Haschemi, Siobhan M. Craige, Mattia Mori, Francesco Spallotta, and Myriam Aouadi
Opublikowane w: Gastroenterology, Numer Volume 161, Numer 6, 2021, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.08.030

Separation of polar and neutral lipids from mammalian cell lines by high-performance thin-layer chromatography

Autorzy: Ana Rita Dias Araújo, Océane Buvry, Bruno Antonny, Delphine Debayle
Opublikowane w: Journal of Chromatography A, Numer 1741, 2025, Strona(/y) 465610, ISSN 0021-9673
Wydawca: Elsevier BV
DOI: 10.1016/j.chroma.2024.465610

Surface tension-driven sorting of human perilipins on lipid droplets

Autorzy: Ana Rita Dias Araujo, Abdoul Akim Bello, Joëlle Bigay, Céline Franckhauser, Romain Gautier, Julie Cazareth, David Kovacs, Frédéric Brau, Nicolas Fuggetta, Alenka Copic, Bruno Antonny
Opublikowane w: bioRxiv, 2024, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1101/2024.02.12.579497

Molecular mechanisms of perilipin protein function in lipid droplet metabolism

Autorzy: Elena Griseti, Abdoul Akim Bello, Eric Bieth, Bayane Sabbagh, Jason S. Iacovoni, Joëlle Bigay, Henrik Laurell, Alenka Čopič
Opublikowane w: FEBS Letters, Numer 598, 2024, Strona(/y) 1170-1198, ISSN 0014-5793
Wydawca: Elsevier BV
DOI: 10.1002/1873-3468.14792

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

Autorzy: Kerr, A. G., Wang, Z., Wang, N., Kwok, K. H. M., Jalkanen, J., Ludzki, A., Lecoutre, S., Bergo, M. O., Dahlman, I., Mim, C., Arner, P. & Gao, H.
Opublikowane w: Nature Communications, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-30620-0

Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State

Autorzy: Enrichetta Mileti, Kelvin H.M. Kwok, Daniel P. Andersson, Anthony Mathelier, Amitha Raman, Jesper Bäckdahl, Jutta Jalkanen, Lucas Massier, Anders Thorell, Hui Gao, Peter Arner, Niklas Mejhert, Carsten O. Daub, Mikael Ryden
Opublikowane w: diabetes, 2021, ISSN 0012-1797
Wydawca: American Diabetes Association
DOI: 10.2337/db21-0001

Surface tension–driven sorting of human perilipins on lipid droplets

Autorzy: Ana Rita Dias Araújo, Abdoul Akim Bello, Joëlle Bigay, Céline Franckhauser, Romain Gautier, Julie Cazareth, Dávid Kovács, Frédéric Brau, Nicolas Fuggetta, Alenka Čopič, Bruno Antonny
Opublikowane w: Journal of Cell Biology, Numer 223, 2024, ISSN 0021-9525
Wydawca: Rockefeller University Press
DOI: 10.1083/jcb.202403064

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Autorzy: """Fougerat, A., Schoiswohl, G., Polizzi, A., Regnier, M., Wagner, C., Smati, S., Fougeray, T., Lippi, Y., Lasserre, F., Raho, I., Melin, V., Tramunt, B., Metivier, R., Sommer, C., Benhamed, F., Alkhoury, C., Greulich, F., Jouffe, C., Emile, A., Schupp, M., Gourdy, P., Dubot, P., Levade, T., Meynard, D., Ellero-Simatos, S., Gamet-Payrastre, L., Panasyuk, G., Uhlenhaut, H., Amri, E. Z., Cruciani-Gugl"
Opublikowane w: Cell Reports, Numer 22111247, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.110910

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Autorzy: Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O Bergo, Robin P Choudhury, Myriam Aouadi, Juleen R Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén
Opublikowane w: Nature metabolism, Numer Vol. 4 February 2022, 2022, ISSN 2522-5812
Wydawca: Springer Nature
DOI: 10.1038/s42255-022-00525-9

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

Autorzy: Subra M., Dezi M., Bigay J., Lacas-Gervais S., Di Cicco A., Araújo A.R.D., Abélanet S., Fleuriot L., Debayle D., Gautier R., Patel A., Roussi F., Lévy D., Mesmin B.
Opublikowane w: Developmental Cell, 2023, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2022.12.010

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

Autorzy: Niklas Mejhert, Katlyn R.Gabriel, Scott Frendo-Cumbo, Natalie Krahmer, Jiunn Song, Leena Kuruvilla, Chandramohan Chitraju, Sebastian Boland, Dong-Keun Jang, Marcin von Grotthuss, Maria C.Costanzo, Mikael Ryden, James A.Olzmann, Jason Flannick, Noël P.Burtt, Robert V. Farese Jr.,Tobias C. Walther
Opublikowane w: Developmental Cell, 2022, ISSN 1534-5807
Wydawca: Cell Press
DOI: 10.1016/j.devcel.2022.01.003

Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Autorzy: Manuel Giménez-Andrés, Tadej Emeršič, Sandra Antoine-Bally, Juan Martin D'Ambrosio, Bruno Antonny, Jure Derganc, Alenka Čopič
Opublikowane w: eLife, Numer 10, 2021, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.61401

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Autorzy: Simon Lecoutre, Salwan Maqdasy, David Rizo-Roca, Gianluca Renzi, Ivan Vlassakev, Lynn M. Alaeddine, Romane Higos, Jutta Jalkanen, Jiawei Zhong, Danae S. Zareifi, Scott Frendo-Cumbo, Lucas Massier, Ondrej Hodek, Marta Juvany, Thomas Moritz, Thais de Castro Barbosa, Muhmmad Omar-Hmeadi, Marta López-Yus, Fatiha Merabtene, Jimon Boniface Abatan, Geneviève Marcelin, Elie-Julien El Hachem, Christine R
Opublikowane w: Nature Metabolism, Numer 6, 2024, Strona(/y) 1329-1346, ISSN 2522-5812
Wydawca: Nature Publishing Group
DOI: 10.1038/s42255-024-01083-y

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

Autorzy: Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Opublikowane w: Nature reviews endocrinology, 2021, ISSN 1759-5029
Wydawca: Nature Publishing Group
DOI: 10.1038/s41574-021-00471-8

Cellular senescence and its role in white adipose tissue

Autorzy: Ulf Smith, Qian Li, Mikael Rydén, Kirsty L. Spalding
Opublikowane w: International Journal of Obesity, 2021, ISSN 0307-0565
Wydawca: Nature Publishing Group
DOI: 10.1038/s41366-021-00757-x

Hormone-sensitive lipase: sixty years later

Autorzy: Emeline Recazens, Etienne Mouisel, Dominique Langin
Opublikowane w: Progress in Lipid Research, Numer 82, 2021, ISSN 0163-7827
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2020.101084

Effects of Fatty Acid Metabolites on Adipocytes Britening: Role of Thromboxane A2

Autorzy: Colson, C., Batrow, P. L., Dieckmann, S., Contu, L., Roux, C. H., Balas, L., Vigor, C., Fourmaux, B., Gautier, N., Rochet, N., Bernoud-Hubac, N., Durand, T., Klingenspor, M. & Amri, E. Z.
Opublikowane w: Cells, 2023, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells12030446

An integrated single cell and spatial transcriptomic map of human white adipose tissue

Autorzy: Massier L, Jalkanen J, Elmastas M, Zhong J, Wang T, Nono Nankam PA, Frendo-Cumbo S, Bäckdahl J, Subramanian N, Sekine T, Kerr AG, Tseng BTP, Laurencikiene J, Buggert M, Lourda M, Kublickiene K, Bhalla N, Andersson A, Valsesia A, Astrup A, Blaak EE, Ståhl PL, Viguerie N, Wolfrum C, Blüher M, Mejhert N.
Opublikowane w: Nature Publishing Group, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-36983-2

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

Autorzy: Hui Gao, Ruth T. Yu, Christopher Liddle, Michael Downes, Jin Zhang, Aldons J. Lusis, Alan D. Attie, Ronald M. Evans, Mikael Rydén, and Alan R. Saltiel
Opublikowane w: JCI The Journal of Clinical Investigation, 2021, ISSN 0021-9738
Wydawca: American Society for Clinical Investigation
DOI: 10.1172/jci153357

Adipose tissue retains an epigenetic memory of obesity after weight loss

Autorzy: Laura C. Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn
Opublikowane w: Nature, Numer 636, 2024, Strona(/y) 457-465, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-024-08165-7