Lipid droplet hypertrophy : the link between adipocyte dysfunction and cardiometabolic diseases

Información del proyecto

SPHERES

Identificador del acuerdo de subvención: 856404

DOI

10.3030/856404

Fecha de la firma de la CE 18 Marzo 2020

Fecha de inicio 1 Septiembre 2020

Fecha de finalización 31 Agosto 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 9 741 774,25

Aportación de la UE

€ 9 741 774,00

Coordinado por

UNIVERSITE DE TOULOUSE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (36)

Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting

Autores: Dávid Kovács, Anne-Sophie Gay, Delphine Debayle, Sophie Abélanet, Amanda Patel, Bruno Mesmin, Frédéric Luton, Bruno Antonny
Publicado en: Journal of Cell Biology, Edición 223, 2023, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202307051

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

Autores: Joanne X. Shen, Morgane Couchet, Jérémy Dufau, Thais de Castro Barbosa, Marie-Adeline Marques, Niklas Mejhert, Volker M. Lauschke
Publicado en: Advanced Science, Edición Vol. 8 Edición 16, 2021, ISSN 2198-3844
Editor: John Wiley & Sons, Ltd
DOI: 10.1002/advs.202100106

Metabolic and cardiovascular adaptations to an 8-wk lifestyle weight loss intervention in younger and older obese men

Autores: Julie Vion, Veronika Sramkova, Emilie Montastier, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Thibaut Duparc, Laurent O Martinez , Virginie Bourlier, Isabelle Harant, Dominique Larrouy, Nabila Moussaoui, Sophie Bonnel, Cécile Vindis, Cédric Dray, Philippe Valet, Jean-Sébastien Saulnier-Blache, Joost P Schanstra, Claire Thalamas, Nathalie Viguerie, Cedric Moro, Dominique Lan
Publicado en: American journal of physiology. Endocrinology and metabolism., Edición 2021 Sep 1, 2021, ISSN 0193-1849
Editor: American Physiological Society
DOI: 10.1152/ajpendo.00109.2021

Baseline gene expression in subcutaneous adipose tissue predicts diet-induced weight loss in individuals with obesity

Autores: Oghabian, A., van der Kolk, B. W., Marttinen, P., Valsesia, A., Saris, W. H., Astrup, A., Blaak, E. E. & Pietilainen, K. H.
Publicado en: PeerJ - Life and Environment, 2023, ISSN 2167-8359
Editor: PeerJ
DOI: 10.7717/peerj.15100

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

Autores: Omer Keinan, Joseph M. Valentine, Haopeng Xiao, Sushil K. Mahata, Shannon M. Reilly, Mohammad Abu-Odeh, Julia H. Deluca, Benyamin Dadpey, Leslie Cho, Austin Pan, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Aldons J. Lusis, Markku Laakso, Edward T. Chouchani, Mikael Rydén, Alan R. Saltiel
Publicado en: Nature, Edición 599, 2022, Página(s) 296-301, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-04019-8

Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes

Autores: Etienne Mouisel, Anaïs Bodon, Christophe Noll, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Remy Flores-Flores, Elodie Riant, Camille Bergoglio, Pierre Vezin, Sylvie Caspar-Bauguil, Camille Fournes-Fraresso, Geneviève Tavernier, Khalil Acheikh Ibn Oumar, Pierre Gourdy, Denis P. Blondin, Pierre-Damien Denechaud, André C. Carpentier, Dominique Langin
Publicado en: Cell Metabolism, Edición 37, 2025, Página(s) 429-440.e5, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2024.10.018

Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation

Autores: Gianluca Renzi, Ivan Vlassakev, Mattias Hansen, Romane Higos, Simon Lecoutre, Merve Elmastas, Ondrej Hodek, Thomas Moritz, Lynn M. Alaeddine, Scott Frendo–Cumbo, Ingrid Dahlman, Alastair Kerr, Salwan Maqdasy, Niklas Mejhert, Mikael Rydén
Publicado en: Molecular Metabolism, Edición 92, 2025, Página(s) 102082, ISSN 2212-8778
Editor: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.102082

Transcriptional determinants of lipid mobilization in human adipocytes

Autores: Alison C. Ludzki, Mattias Hansen, Danae Zareifi, Jutta Jalkanen, Zhiqiang Huang, Muhmmad Omar-Hmeadi, Gianluca Renzi, Felix Klingelhuber, Sebastian Boland, Yohannes A. Ambaw, Na Wang, Anastasios Damdimopoulos, Jianping Liu, Tomas Jernberg, Paul Petrus, Peter Arner, Natalie Krahmer, Rongrong Fan, Eckardt Treuter, Hui Gao, Mikael Rydén, Niklas Mejhert
Publicado en: Science Advances, Edición 10, 2024, ISSN 2375-2548
Editor: American Association for the Advancement of Science's
DOI: 10.1126/sciadv.adi2689

In vitro and ex vivo models of adipocytes

Autores: Jérémy Dufau, Joanne X. Shen, Morgane Couchet, Thais De Castro Barbosa, Niklas Mejhert, Lucas Massier, Elena Griseti, Etienne Mouisel, Ez-Zoubir Amri, Volker M. Lauschke, Mikael Rydén, and Dominique Langin
Publicado en: Cell Physiology, Edición Vol. 320 Edición 5, 2021, ISSN 0363-6143
Editor: American Physiological Society
DOI: 10.1152/ajpcell.00519.2020

Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function

Autores: Harayama, T.
Publicado en: Cold Spring Harbor Perspectives in Biology, 2023, ISSN 1943-0264
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/cshperspect.a041409

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin

Autores: Jesper Bäckdahl, Lovisa Franzén, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Rydén, Patrik L. Ståhl, Niklas Mejhert
Publicado en: Cell Metabolism, Edición Volume 33, Edición 9, 2021, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2021.07.018

ChREBPβ is dispensable for the control of glucose homeostasis and energy balance

Autores: Emeline Recazens, Geneviève Tavernier, Jérémy Dufau, Camille Bergoglio, Fadila Benhamed, Stéphanie Cassant-Sourdy, Marie-Adeline Marques, Sylvie Caspar-Bauguil, Alice Brion, Laurent Monbrun, Renaud Dentin, Clara Ferrier, Mélanie Leroux, Pierre-Damien Denechaud, Cedric Moro, Jean-Paul Concordet, Catherine Postic, Etienne Mouisel, Dominique Langin
Publicado en: JCI Insight, Edición Vol. 7, Edición 4, 2022, ISSN 2379-3708
Editor: The American Society for Clinical Investigation
DOI: 10.1172/jci.insight.153431

Adipocyte heterogeneity revealed by spatial transcriptomics of human adipose tissue: Painting and more

Autores: Dominique Langin
Publicado en: Cell Metabolism, Edición Vol 33 Edición 9, 2021, Página(s) 1869-1882, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2021.08.011

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Autores: Hui Gao, Peter Arner, Gallic Beauchef, Christelle Guéré, Katell Vie, Ingrid Dahlman, Niklas Mejhert, Mikael Rydén
Publicado en: Cell Metabolism, Edición 32, 2022, Página(s) 1-3, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.06.007

New insights into the OSBP‒VAP cycle

Autores: Subra M., Mesmin, B.
Publicado en: Current Opinion in Cell Biology, 2023, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2023.102172

Adipogenic characterization of immortalized CD55 ⁺ progenitor cells from human white adipose tissue

Autores: Morgane Couchet, Hui Gao, Felix Klingelhuber, Jutta Jalkanen, Thais De Castro Barbosa, Muhmmad Omar-Hmeadi, Lucas Massier, Natalie Krahmer, Niklas Mejhert, Mikael Rydén
Publicado en: Adipocyte, 2024, ISSN 2162-3945
Editor: Taylor & Francis Online
DOI: 10.1080/21623945.2023.2283213

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Autores: Valerio Azzimato, Ping Chen, Emelie Barreby, Cecilia Morgantini, Laura Levi, Ana Vankova, Jennifer Jager, André Sulen, Marina Diotallevi, Joanne X. Shen, Anne Miller, Ewa Ellis, Mikael Rydén, Erik Näslund, Anders Thorell, Volker M. Lauschke, Keith M. Channon, Mark J. Crabtree, Arvand Haschemi, Siobhan M. Craige, Mattia Mori, Francesco Spallotta, and Myriam Aouadi
Publicado en: Gastroenterology, Edición Volume 161, Edición 6, 2021, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.08.030

Separation of polar and neutral lipids from mammalian cell lines by high-performance thin-layer chromatography

Autores: Ana Rita Dias Araújo, Océane Buvry, Bruno Antonny, Delphine Debayle
Publicado en: Journal of Chromatography A, Edición 1741, 2025, Página(s) 465610, ISSN 0021-9673
Editor: Elsevier BV
DOI: 10.1016/j.chroma.2024.465610

Surface tension-driven sorting of human perilipins on lipid droplets

Autores: Ana Rita Dias Araujo, Abdoul Akim Bello, Joëlle Bigay, Céline Franckhauser, Romain Gautier, Julie Cazareth, David Kovacs, Frédéric Brau, Nicolas Fuggetta, Alenka Copic, Bruno Antonny
Publicado en: bioRxiv, 2024, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1101/2024.02.12.579497

Molecular mechanisms of perilipin protein function in lipid droplet metabolism

Autores: Elena Griseti, Abdoul Akim Bello, Eric Bieth, Bayane Sabbagh, Jason S. Iacovoni, Joëlle Bigay, Henrik Laurell, Alenka Čopič
Publicado en: FEBS Letters, Edición 598, 2024, Página(s) 1170-1198, ISSN 0014-5793
Editor: Elsevier BV
DOI: 10.1002/1873-3468.14792

The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase

Autores: Kerr, A. G., Wang, Z., Wang, N., Kwok, K. H. M., Jalkanen, J., Ludzki, A., Lecoutre, S., Bergo, M. O., Dahlman, I., Mim, C., Arner, P. & Gao, H.
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30620-0

Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State

Autores: Enrichetta Mileti, Kelvin H.M. Kwok, Daniel P. Andersson, Anthony Mathelier, Amitha Raman, Jesper Bäckdahl, Jutta Jalkanen, Lucas Massier, Anders Thorell, Hui Gao, Peter Arner, Niklas Mejhert, Carsten O. Daub, Mikael Ryden
Publicado en: diabetes, 2021, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db21-0001

Surface tension–driven sorting of human perilipins on lipid droplets

Autores: Ana Rita Dias Araújo, Abdoul Akim Bello, Joëlle Bigay, Céline Franckhauser, Romain Gautier, Julie Cazareth, Dávid Kovács, Frédéric Brau, Nicolas Fuggetta, Alenka Čopič, Bruno Antonny
Publicado en: Journal of Cell Biology, Edición 223, 2024, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202403064

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Autores: """Fougerat, A., Schoiswohl, G., Polizzi, A., Regnier, M., Wagner, C., Smati, S., Fougeray, T., Lippi, Y., Lasserre, F., Raho, I., Melin, V., Tramunt, B., Metivier, R., Sommer, C., Benhamed, F., Alkhoury, C., Greulich, F., Jouffe, C., Emile, A., Schupp, M., Gourdy, P., Dubot, P., Levade, T., Meynard, D., Ellero-Simatos, S., Gamet-Payrastre, L., Panasyuk, G., Uhlenhaut, H., Amri, E. Z., Cruciani-Gugl"
Publicado en: Cell Reports, Edición 22111247, 2022, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.110910

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Autores: Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O Bergo, Robin P Choudhury, Myriam Aouadi, Juleen R Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén
Publicado en: Nature metabolism, Edición Vol. 4 February 2022, 2022, ISSN 2522-5812
Editor: Springer Nature
DOI: 10.1038/s42255-022-00525-9

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

Autores: Subra M., Dezi M., Bigay J., Lacas-Gervais S., Di Cicco A., Araújo A.R.D., Abélanet S., Fleuriot L., Debayle D., Gautier R., Patel A., Roussi F., Lévy D., Mesmin B.
Publicado en: Developmental Cell, 2023, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2022.12.010

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

Autores: Niklas Mejhert, Katlyn R.Gabriel, Scott Frendo-Cumbo, Natalie Krahmer, Jiunn Song, Leena Kuruvilla, Chandramohan Chitraju, Sebastian Boland, Dong-Keun Jang, Marcin von Grotthuss, Maria C.Costanzo, Mikael Ryden, James A.Olzmann, Jason Flannick, Noël P.Burtt, Robert V. Farese Jr.,Tobias C. Walther
Publicado en: Developmental Cell, 2022, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2022.01.003

Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Autores: Manuel Giménez-Andrés, Tadej Emeršič, Sandra Antoine-Bally, Juan Martin D'Ambrosio, Bruno Antonny, Jure Derganc, Alenka Čopič
Publicado en: eLife, Edición 10, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.61401

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Autores: Simon Lecoutre, Salwan Maqdasy, David Rizo-Roca, Gianluca Renzi, Ivan Vlassakev, Lynn M. Alaeddine, Romane Higos, Jutta Jalkanen, Jiawei Zhong, Danae S. Zareifi, Scott Frendo-Cumbo, Lucas Massier, Ondrej Hodek, Marta Juvany, Thomas Moritz, Thais de Castro Barbosa, Muhmmad Omar-Hmeadi, Marta López-Yus, Fatiha Merabtene, Jimon Boniface Abatan, Geneviève Marcelin, Elie-Julien El Hachem, Christine R
Publicado en: Nature Metabolism, Edición 6, 2024, Página(s) 1329-1346, ISSN 2522-5812
Editor: Nature Publishing Group
DOI: 10.1038/s42255-024-01083-y

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

Autores: Pauline Morigny, Jeremie Boucher, Peter Arner, Dominique Langin
Publicado en: Nature reviews endocrinology, 2021, ISSN 1759-5029
Editor: Nature Publishing Group
DOI: 10.1038/s41574-021-00471-8

Cellular senescence and its role in white adipose tissue

Autores: Ulf Smith, Qian Li, Mikael Rydén, Kirsty L. Spalding
Publicado en: International Journal of Obesity, 2021, ISSN 0307-0565
Editor: Nature Publishing Group
DOI: 10.1038/s41366-021-00757-x

Hormone-sensitive lipase: sixty years later

Autores: Emeline Recazens, Etienne Mouisel, Dominique Langin
Publicado en: Progress in Lipid Research, Edición 82, 2021, ISSN 0163-7827
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.plipres.2020.101084

Effects of Fatty Acid Metabolites on Adipocytes Britening: Role of Thromboxane A2

Autores: Colson, C., Batrow, P. L., Dieckmann, S., Contu, L., Roux, C. H., Balas, L., Vigor, C., Fourmaux, B., Gautier, N., Rochet, N., Bernoud-Hubac, N., Durand, T., Klingenspor, M. & Amri, E. Z.
Publicado en: Cells, 2023, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells12030446

An integrated single cell and spatial transcriptomic map of human white adipose tissue

Autores: Massier L, Jalkanen J, Elmastas M, Zhong J, Wang T, Nono Nankam PA, Frendo-Cumbo S, Bäckdahl J, Subramanian N, Sekine T, Kerr AG, Tseng BTP, Laurencikiene J, Buggert M, Lourda M, Kublickiene K, Bhalla N, Andersson A, Valsesia A, Astrup A, Blaak EE, Ståhl PL, Viguerie N, Wolfrum C, Blüher M, Mejhert N.
Publicado en: Nature Publishing Group, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-36983-2

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

Autores: Hui Gao, Ruth T. Yu, Christopher Liddle, Michael Downes, Jin Zhang, Aldons J. Lusis, Alan D. Attie, Ronald M. Evans, Mikael Rydén, and Alan R. Saltiel
Publicado en: JCI The Journal of Clinical Investigation, 2021, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci153357

Adipose tissue retains an epigenetic memory of obesity after weight loss

Autores: Laura C. Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn
Publicado en: Nature, Edición 636, 2024, Página(s) 457-465, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-024-08165-7