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Systems biology of the individual stochastic timer of aging

Publicaciones

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks

Autores: Omer Karin, Moriya Raz, Avichai Tendler, Alon Bar, Yael Korem Kohanim, Tomer Milo, Uri Alon
Publicado en: Molecular Systems Biology, Edición 16/7, 2020, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.15252/msb.20209510

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Autores: Julia Majewska, Amit Agrawal, Avi Mayo, Lior Roitman, Rishita Chatterjee, Jarmila Sekeresova Kralova, Tomer Landsberger, Yonatan Katzenelenbogen, Tomer Meir-Salame, Efrat Hagai, Ilanit Sopher, Juan-Felipe Perez-Correa, Wolfgang Wagner, Avi Maimon, Ido Amit, Uri Alon, Valery Krizhanovsky
Publicado en: Nature Cell Biology, Edición 26, 2024, Página(s) 1336-1345, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-024-01465-0

Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice

Autores: Yizhak Sofer, Noga Zilkha, Elena Gimpel, Shlomo Wagner, Silvia Gabriela Chuartzman, Tali Kimchi
Publicado en: Nature Neuroscience, Edición 27, 2024, Página(s) 1565-1573, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-024-01685-5

An opponent process for alcohol addiction based on changes in endocrine gland mass

Autores: Omer Karin, Moriya Raz, Uri Alon
Publicado en: iScience, Edición 24/3, 2021, Página(s) 102127, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2021.102127

Endocrine gland size is proportional to its target tissue size

Autores: Moriya Raz, Tomer Milo, David S. Glass, Avi Mayo, Uri Alon
Publicado en: iScience, Edición 27, 2024, Página(s) 110625, ISSN 2589-0042
Editor: Elseiver
DOI: 10.1016/j.isci.2024.110625

Timescales of Human Hair Cortisol Dynamics

Autores: Lior Maimon, Tomer Milo, Rina S. Moyal, Avi Mayo, Tamar Danon, Anat Bren, Uri Alon
Publicado en: iScience, Edición 23/9, 2020, Página(s) 101501, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2020.101501

Rules for body fat interventions based on an operating point mechanism

Autores: Alon Bar, Omer Karin , Avi Mayo , Danny Ben-Zvi , Uri Alon
Publicado en: iScience, 2023, ISSN 2589-0042
Editor: CellPress
DOI: 10.1016/j.isci.2023.106047

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain

Autores: Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwartz
Publicado en: Nature Neuroscience, Edición 27, 2024, Página(s) 1116-1124, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-024-01620-8

Maternal high-fat or low-protein diets promote autism-related behavior and altered social behavior within groups in offspring male mice

Autores: Noga Zilkha, Silvia Gabriela Chuartzman, Ruth Fishman, Shifra Ben-Dor, Tali Kimchi
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-70062-w

Major depressive disorder and bistability in an HPA-CNS toggle switch

Autores: Ben Ron Mizrachi, Avichai Tendler, Omer Karin, Tomer Milo, Dafna Haran, Avi Mayo, Uri Alon
Publicado en: PLOS Computational Biology, Edición 19, 2023, Página(s) e1011645, ISSN 1553-7358
Editor: PLOS
DOI: 10.1371/journal.pcbi.1011645

Senescent cells and the incidence of age‐related diseases

Autores: Itay Katzir, Miri Adler, Omer Karin, Netta Mendelsohn‐Cohen, Avi Mayo, Uri Alon
Publicado en: Aging Cell, Edición 20/3, 2021, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13314

Senescent cell accumulation mechanisms inferred from parabiosis

Autores: Omer Karin, Uri Alon
Publicado en: GeroScience, Edición 43/1, 2021, Página(s) 329-341, ISSN 2509-2715
Editor: Springer
DOI: 10.1007/s11357-020-00286-x

Alone, in the dark: The extraordinary neuroethology of the solitary blind mole rat

Autores: Yael Kashash, Grace Smarsh, Noga Zilkha, Yossi Yovel, Tali Kimchi
Publicado en: eLife, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.78295

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Autores: Noga Zilkha, Yizhak Sofer, Yael Kashash, Tali Kimchi
Publicado en: Current Opinion in Neurobiology, Edición 68, 2021, Página(s) 137-151, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.1016/j.conb.2021.03.005

p21 facilitates chronic lung inflammation via epithelial and endothelial cells

Autores: Naama Levi, , Nurit Papismadov, Julia Majewska , Lior Roitman, Noa Wigoda , Raya Eilam, Michael Tsoory , Ron Rotkopf , Yossi Ovadya , Hagay Akiva , Ofer Regev , Valery Krizhanovsky
Publicado en: Aging, 2023, ISSN 1945-4589
Editor: Albany
DOI: 10.18632/aging.204622

Temporal fluctuations in chemotaxis gain implement a simulated-tempering strategy for efficient navigation in complex environments

Autores: Omer Karin, Uri Alon
Publicado en: iScience, Edición 24/7, 2021, Página(s) 102796, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2021.102796

Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance

Autores: Tomer Milo, Yael Korem Kohanim, Yoel Toledano, Uri Alon
Publicado en: Trends in Immunology, 2023, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2023.03.007

Sex-dependent control of pheromones on social organization within groups of wild house mice

Autores: Noga Zilkha , Silvia Gabriela Chuartzman , Yizhak Sofer , Yefim Pen , Meghan Cum, Avi Mayo , Uri Alon , Tali Kimchi
Publicado en: Current Biology, 2023, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2023.02.039

Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

Autores: Dror Kolodkin-Gal, Lior Roitman, Yossi Ovadya, Narmen Azazmeh, Benjamin Assouline, Yehuda Schlesinger, Rachel Kalifa, Shaul Horwitz, Yonatan Khalatnik, Anna Hochner-Ger, Ashraf Imam, Jonathan Abraham Demma, Eitan Winter, Hadar Benyamini, Sharona Elgavish, Areej AS Khatib, Karen Meir, Karine Atlan, Eli Pikarsky, Oren Parnas, Yuval Dor, Gideon Zamir, Ittai Ben-Porath, Valery Krizhanovsky
Publicado en: Gut, 2021, Página(s) gutjnl-2020-321112, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-321112

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Autores: Raffaella Di Micco, Valery Krizhanovsky, Darren Baker & Fabrizio d’Adda di Fagagna
Publicado en: Nature Reviews Molecular Cell Biology, 2021, ISSN 1471-0072
Editor: Nature Publishing Group
DOI: 10.1038/s41580-020-00314-w

The intricate nature of senescence in development and cell plasticity

Autores: Hilah Gal , Julia Majewska , Valery Krizhanovsky
Publicado en: Seminars in cancer Biology, 2022, ISSN 1044-579X
Editor: Academic Press
DOI: 10.1016/j.semcancer.2021.01.004

Senescent cells in the brain and where to find them

Autores: Noa Rachmian, Valery Krizhanovsky
Publicado en: The FEBS Journal, 2023, ISSN 1742-4658
Editor: Wiley
DOI: 10.1111/febs.16649

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