Systems biology of the individual stochastic timer of aging

Project Information

AgingTimer

Grant agreement ID: 856487

DOI

10.3030/856487

EC signature date 16 January 2020

Start date 1 February 2020

End date 31 January 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 8 687 500,00

EU contribution

€ 8 687 500,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (26)

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks

Author(s): Omer Karin, Moriya Raz, Avichai Tendler, Alon Bar, Yael Korem Kohanim, Tomer Milo, Uri Alon
Published in: Molecular Systems Biology, Issue 16/7, 2020, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20209510

p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

Author(s): Nurit Papismadov, Naama Levi, Lior Roitman, Amit Agrawal, Yossi Ovadya, Ulysse Cherqui, Reut Yosef, Hagay Akiva, Hilah Gal, Valery Krizhanovsky
Published in: The EMBO Journal, 2024, ISSN 1460-2075
Publisher: EMBO Press
DOI: 10.1038/s44318-024-00246-7

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Author(s): Julia Majewska, Amit Agrawal, Avi Mayo, Lior Roitman, Rishita Chatterjee, Jarmila Sekeresova Kralova, Tomer Landsberger, Yonatan Katzenelenbogen, Tomer Meir-Salame, Efrat Hagai, Ilanit Sopher, Juan-Felipe Perez-Correa, Wolfgang Wagner, Avi Maimon, Ido Amit, Uri Alon, Valery Krizhanovsky
Published in: Nature Cell Biology, Issue 26, 2024, Page(s) 1336-1345, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01465-0

Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice

Author(s): Yizhak Sofer, Noga Zilkha, Elena Gimpel, Shlomo Wagner, Silvia Gabriela Chuartzman, Tali Kimchi
Published in: Nature Neuroscience, Issue 27, 2024, Page(s) 1565-1573, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01685-5

An opponent process for alcohol addiction based on changes in endocrine gland mass

Author(s): Omer Karin, Moriya Raz, Uri Alon
Published in: iScience, Issue 24/3, 2021, Page(s) 102127, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2021.102127

Endocrine gland size is proportional to its target tissue size

Author(s): Moriya Raz, Tomer Milo, David S. Glass, Avi Mayo, Uri Alon
Published in: iScience, Issue 27, 2024, Page(s) 110625, ISSN 2589-0042
Publisher: Elseiver
DOI: 10.1016/j.isci.2024.110625

Timescales of Human Hair Cortisol Dynamics

Author(s): Lior Maimon, Tomer Milo, Rina S. Moyal, Avi Mayo, Tamar Danon, Anat Bren, Uri Alon
Published in: iScience, Issue 23/9, 2020, Page(s) 101501, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2020.101501

Rules for body fat interventions based on an operating point mechanism

Author(s): Alon Bar, Omer Karin , Avi Mayo , Danny Ben-Zvi , Uri Alon
Published in: iScience, 2023, ISSN 2589-0042
Publisher: CellPress
DOI: 10.1016/j.isci.2023.106047

Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain

Author(s): Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwartz
Published in: Nature Neuroscience, Issue 27, 2024, Page(s) 1116-1124, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-024-01620-8

Maternal high-fat or low-protein diets promote autism-related behavior and altered social behavior within groups in offspring male mice

Author(s): Noga Zilkha, Silvia Gabriela Chuartzman, Ruth Fishman, Shifra Ben-Dor, Tali Kimchi
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-70062-w

Major depressive disorder and bistability in an HPA-CNS toggle switch

Author(s): Ben Ron Mizrachi, Avichai Tendler, Omer Karin, Tomer Milo, Dafna Haran, Avi Mayo, Uri Alon
Published in: PLOS Computational Biology, Issue 19, 2023, Page(s) e1011645, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1011645

Senescent cells and the incidence of age‐related diseases

Author(s): Itay Katzir, Miri Adler, Omer Karin, Netta Mendelsohn‐Cohen, Avi Mayo, Uri Alon
Published in: Aging Cell, Issue 20/3, 2021, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13314

Senescent cell accumulation mechanisms inferred from parabiosis

Author(s): Omer Karin, Uri Alon
Published in: GeroScience, Issue 43/1, 2021, Page(s) 329-341, ISSN 2509-2715
Publisher: Springer
DOI: 10.1007/s11357-020-00286-x

Alone, in the dark: The extraordinary neuroethology of the solitary blind mole rat

Author(s): Yael Kashash, Grace Smarsh, Noga Zilkha, Yossi Yovel, Tali Kimchi
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.78295

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Author(s): Noga Zilkha, Yizhak Sofer, Yael Kashash, Tali Kimchi
Published in: Current Opinion in Neurobiology, Issue 68, 2021, Page(s) 137-151, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2021.03.005

p21 facilitates chronic lung inflammation via epithelial and endothelial cells

Author(s): Naama Levi, , Nurit Papismadov, Julia Majewska , Lior Roitman, Noa Wigoda , Raya Eilam, Michael Tsoory , Ron Rotkopf , Yossi Ovadya , Hagay Akiva , Ofer Regev , Valery Krizhanovsky
Published in: Aging, 2023, ISSN 1945-4589
Publisher: Albany
DOI: 10.18632/aging.204622

Temporal fluctuations in chemotaxis gain implement a simulated-tempering strategy for efficient navigation in complex environments

Author(s): Omer Karin, Uri Alon
Published in: iScience, Issue 24/7, 2021, Page(s) 102796, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2021.102796

Longitudinal hair cortisol in bipolar disorder and a mechanism based on HPA dynamics

Author(s): Tomer Milo, Lior Maimon, Ben Cohen, Dafna Haran, Dror Segman, Tamar Danon, Anat Bren, Avi Mayo , Gadi Cohen Rappaport , Melvin McInnis , Uri Alon
Published in: iScience, 2024, ISSN 2589-0042
Publisher: Elsiever
DOI: 10.1016/j.isci.2024.109234

Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism

Author(s): Tomer Landsberger, Ido Amit, Uri Alon
Published in: GeroScience, 2023, ISSN 2509-2723
Publisher: Springer
DOI: 10.1007/s11357-023-00915-1

Damage dynamics and the role of chance in the timing of E. coli cell death

Author(s): Yifan Yang ,Omer Karin, Avi Mayo , Xiaohu Song ,Peipei Chen , Ana L. Santos, Ariel B. Lindner, Uri Alon
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37930-x

Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance

Author(s): Tomer Milo, Yael Korem Kohanim, Yoel Toledano, Uri Alon
Published in: Trends in Immunology, 2023, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2023.03.007

A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover

Author(s): David S. Glass, Anat Bren, Elizabeth Vaisbourd, Avi Mayo, Uri alon
Published in: Cell, 2024, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.01.024

Sex-dependent control of pheromones on social organization within groups of wild house mice

Author(s): Noga Zilkha , Silvia Gabriela Chuartzman , Yizhak Sofer , Yefim Pen , Meghan Cum, Avi Mayo , Uri Alon , Tali Kimchi
Published in: Current Biology, 2023, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2023.02.039

Tradeoffs in bacterial physiology determine the efficiency of antibiotic killing

Author(s): Anat Bren, David S. Glass, Yael Koem Kohanim, Avi Mayo, Uri Alon
Published in: PNAS, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2312651120

Excitable dynamics of flares and relapses in autoimmune diseases

Author(s): Yael Lebel, Tomer Milo, Alon Bar, Avi Mayo, Uri Alon
Published in: iScience, 2023, ISSN 2589-0042
Publisher: Elseiver
DOI: 10.1016/j.isci.2023.108084

Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

Author(s): Dror Kolodkin-Gal, Lior Roitman, Yossi Ovadya, Narmen Azazmeh, Benjamin Assouline, Yehuda Schlesinger, Rachel Kalifa, Shaul Horwitz, Yonatan Khalatnik, Anna Hochner-Ger, Ashraf Imam, Jonathan Abraham Demma, Eitan Winter, Hadar Benyamini, Sharona Elgavish, Areej AS Khatib, Karen Meir, Karine Atlan, Eli Pikarsky, Oren Parnas, Yuval Dor, Gideon Zamir, Ittai Ben-Porath, Valery Krizhanovsky
Published in: Gut, 2021, Page(s) gutjnl-2020-321112, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-321112

Non-peer reviewed articles (3)

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Author(s): Raffaella Di Micco, Valery Krizhanovsky, Darren Baker & Fabrizio d’Adda di Fagagna
Published in: Nature Reviews Molecular Cell Biology, 2021, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-00314-w

The intricate nature of senescence in development and cell plasticity

Author(s): Hilah Gal , Julia Majewska , Valery Krizhanovsky
Published in: Seminars in cancer Biology, 2022, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2021.01.004

Senescent cells in the brain and where to find them

Author(s): Noa Rachmian, Valery Krizhanovsky
Published in: The FEBS Journal, 2023, ISSN 1742-4658
Publisher: Wiley
DOI: 10.1111/febs.16649