Systems biology of the individual stochastic timer of aging

Project Information

AgingTimer

Grant agreement ID: 856487

DOI 10.3030/856487

EC signature date 16 January 2020

Start date 1 February 2020

End date 31 January 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 8 687 500,00

EU contribution € 8 687 500,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publications

Peer reviewed articles (13)

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks

Author(s): Omer Karin, Moriya Raz, Avichai Tendler, Alon Bar, Yael Korem Kohanim, Tomer Milo, Uri Alon
Published in: Molecular Systems Biology, Issue 16/7, 2020, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20209510

An opponent process for alcohol addiction based on changes in endocrine gland mass

Author(s): Omer Karin, Moriya Raz, Uri Alon
Published in: iScience, Issue 24/3, 2021, Page(s) 102127, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2021.102127

Timescales of Human Hair Cortisol Dynamics

Author(s): Lior Maimon, Tomer Milo, Rina S. Moyal, Avi Mayo, Tamar Danon, Anat Bren, Uri Alon
Published in: iScience, Issue 23/9, 2020, Page(s) 101501, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2020.101501

Rules for body fat interventions based on an operating point mechanism

Author(s): Alon Bar, Omer Karin , Avi Mayo , Danny Ben-Zvi , Uri Alon
Published in: iScience, 2023, ISSN 2589-0042
Publisher: CellPress
DOI: 10.1016/j.isci.2023.106047

Senescent cells and the incidence of age‐related diseases

Author(s): Itay Katzir, Miri Adler, Omer Karin, Netta Mendelsohn‐Cohen, Avi Mayo, Uri Alon
Published in: Aging Cell, Issue 20/3, 2021, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13314

Senescent cell accumulation mechanisms inferred from parabiosis

Author(s): Omer Karin, Uri Alon
Published in: GeroScience, Issue 43/1, 2021, Page(s) 329-341, ISSN 2509-2715
Publisher: Springer
DOI: 10.1007/s11357-020-00286-x

Alone, in the dark: The extraordinary neuroethology of the solitary blind mole rat

Author(s): Yael Kashash, Grace Smarsh, Noga Zilkha, Yossi Yovel, Tali Kimchi
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.78295

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Author(s): Noga Zilkha, Yizhak Sofer, Yael Kashash, Tali Kimchi
Published in: Current Opinion in Neurobiology, Issue 68, 2021, Page(s) 137-151, ISSN 0959-4388
Publisher: Elsevier BV
DOI: 10.1016/j.conb.2021.03.005

p21 facilitates chronic lung inflammation via epithelial and endothelial cells

Author(s): Naama Levi, , Nurit Papismadov, Julia Majewska , Lior Roitman, Noa Wigoda , Raya Eilam, Michael Tsoory , Ron Rotkopf , Yossi Ovadya , Hagay Akiva , Ofer Regev , Valery Krizhanovsky
Published in: Aging, 2023, ISSN 1945-4589
Publisher: Albany
DOI: 10.18632/aging.204622

Temporal fluctuations in chemotaxis gain implement a simulated-tempering strategy for efficient navigation in complex environments

Author(s): Omer Karin, Uri Alon
Published in: iScience, Issue 24/7, 2021, Page(s) 102796, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2021.102796

Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance

Author(s): Tomer Milo, Yael Korem Kohanim, Yoel Toledano, Uri Alon
Published in: Trends in Immunology, 2023, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2023.03.007

Sex-dependent control of pheromones on social organization within groups of wild house mice

Author(s): Noga Zilkha , Silvia Gabriela Chuartzman , Yizhak Sofer , Yefim Pen , Meghan Cum, Avi Mayo , Uri Alon , Tali Kimchi
Published in: Current Biology, 2023, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2023.02.039

Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

Author(s): Dror Kolodkin-Gal, Lior Roitman, Yossi Ovadya, Narmen Azazmeh, Benjamin Assouline, Yehuda Schlesinger, Rachel Kalifa, Shaul Horwitz, Yonatan Khalatnik, Anna Hochner-Ger, Ashraf Imam, Jonathan Abraham Demma, Eitan Winter, Hadar Benyamini, Sharona Elgavish, Areej AS Khatib, Karen Meir, Karine Atlan, Eli Pikarsky, Oren Parnas, Yuval Dor, Gideon Zamir, Ittai Ben-Porath, Valery Krizhanovsky
Published in: Gut, 2021, Page(s) gutjnl-2020-321112, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-321112

Non-peer reviewed articles (3)

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Author(s): Raffaella Di Micco, Valery Krizhanovsky, Darren Baker & Fabrizio d’Adda di Fagagna
Published in: Nature Reviews Molecular Cell Biology, 2021, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-020-00314-w

The intricate nature of senescence in development and cell plasticity

Author(s): Hilah Gal , Julia Majewska , Valery Krizhanovsky
Published in: Seminars in cancer Biology, 2022, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2021.01.004

Senescent cells in the brain and where to find them

Author(s): Noa Rachmian, Valery Krizhanovsky
Published in: The FEBS Journal, 2023, ISSN 1742-4658
Publisher: Wiley
DOI: 10.1111/febs.16649