Systems biology of the individual stochastic timer of aging

Informacje na temat projektu

AgingTimer

Identyfikator umowy o grant: 856487

DOI 10.3030/856487

Data podpisania przez KE 16 Stycznia 2020

Data rozpoczęcia 1 Lutego 2020

Data zakończenia 31 Stycznia 2027

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity € 8 687 500,00

Wkład UE € 8 687 500,00

Koordynowany przez

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publikacje

Peer reviewed articles (13)

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks

Autorzy: Omer Karin, Moriya Raz, Avichai Tendler, Alon Bar, Yael Korem Kohanim, Tomer Milo, Uri Alon
Opublikowane w: Molecular Systems Biology, Numer 16/7, 2020, ISSN 1744-4292
Wydawca: Nature Publishing Group
DOI: 10.15252/msb.20209510

An opponent process for alcohol addiction based on changes in endocrine gland mass

Autorzy: Omer Karin, Moriya Raz, Uri Alon
Opublikowane w: iScience, Numer 24/3, 2021, Strona(/y) 102127, ISSN 2589-0042
Wydawca: Elsevier
DOI: 10.1016/j.isci.2021.102127

Timescales of Human Hair Cortisol Dynamics

Autorzy: Lior Maimon, Tomer Milo, Rina S. Moyal, Avi Mayo, Tamar Danon, Anat Bren, Uri Alon
Opublikowane w: iScience, Numer 23/9, 2020, Strona(/y) 101501, ISSN 2589-0042
Wydawca: Elsevier
DOI: 10.1016/j.isci.2020.101501

Rules for body fat interventions based on an operating point mechanism

Autorzy: Alon Bar, Omer Karin , Avi Mayo , Danny Ben-Zvi , Uri Alon
Opublikowane w: iScience, 2023, ISSN 2589-0042
Wydawca: CellPress
DOI: 10.1016/j.isci.2023.106047

Senescent cells and the incidence of age‐related diseases

Autorzy: Itay Katzir, Miri Adler, Omer Karin, Netta Mendelsohn‐Cohen, Avi Mayo, Uri Alon
Opublikowane w: Aging Cell, Numer 20/3, 2021, ISSN 1474-9718
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/acel.13314

Senescent cell accumulation mechanisms inferred from parabiosis

Autorzy: Omer Karin, Uri Alon
Opublikowane w: GeroScience, Numer 43/1, 2021, Strona(/y) 329-341, ISSN 2509-2715
Wydawca: Springer
DOI: 10.1007/s11357-020-00286-x

Alone, in the dark: The extraordinary neuroethology of the solitary blind mole rat

Autorzy: Yael Kashash, Grace Smarsh, Noga Zilkha, Yossi Yovel, Tali Kimchi
Opublikowane w: eLife, 2022, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.78295

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Autorzy: Noga Zilkha, Yizhak Sofer, Yael Kashash, Tali Kimchi
Opublikowane w: Current Opinion in Neurobiology, Numer 68, 2021, Strona(/y) 137-151, ISSN 0959-4388
Wydawca: Elsevier BV
DOI: 10.1016/j.conb.2021.03.005

p21 facilitates chronic lung inflammation via epithelial and endothelial cells

Autorzy: Naama Levi, , Nurit Papismadov, Julia Majewska , Lior Roitman, Noa Wigoda , Raya Eilam, Michael Tsoory , Ron Rotkopf , Yossi Ovadya , Hagay Akiva , Ofer Regev , Valery Krizhanovsky
Opublikowane w: Aging, 2023, ISSN 1945-4589
Wydawca: Albany
DOI: 10.18632/aging.204622

Temporal fluctuations in chemotaxis gain implement a simulated-tempering strategy for efficient navigation in complex environments

Autorzy: Omer Karin, Uri Alon
Opublikowane w: iScience, Numer 24/7, 2021, Strona(/y) 102796, ISSN 2589-0042
Wydawca: Elsevier
DOI: 10.1016/j.isci.2021.102796

Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance

Autorzy: Tomer Milo, Yael Korem Kohanim, Yoel Toledano, Uri Alon
Opublikowane w: Trends in Immunology, 2023, ISSN 1471-4906
Wydawca: Elsevier BV
DOI: 10.1016/j.it.2023.03.007

Sex-dependent control of pheromones on social organization within groups of wild house mice

Autorzy: Noga Zilkha , Silvia Gabriela Chuartzman , Yizhak Sofer , Yefim Pen , Meghan Cum, Avi Mayo , Uri Alon , Tali Kimchi
Opublikowane w: Current Biology, 2023, ISSN 0960-9822
Wydawca: Cell Press
DOI: 10.1016/j.cub.2023.02.039

Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

Autorzy: Dror Kolodkin-Gal, Lior Roitman, Yossi Ovadya, Narmen Azazmeh, Benjamin Assouline, Yehuda Schlesinger, Rachel Kalifa, Shaul Horwitz, Yonatan Khalatnik, Anna Hochner-Ger, Ashraf Imam, Jonathan Abraham Demma, Eitan Winter, Hadar Benyamini, Sharona Elgavish, Areej AS Khatib, Karen Meir, Karine Atlan, Eli Pikarsky, Oren Parnas, Yuval Dor, Gideon Zamir, Ittai Ben-Porath, Valery Krizhanovsky
Opublikowane w: Gut, 2021, Strona(/y) gutjnl-2020-321112, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-321112

Non-peer reviewed articles (3)

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Autorzy: Raffaella Di Micco, Valery Krizhanovsky, Darren Baker & Fabrizio d’Adda di Fagagna
Opublikowane w: Nature Reviews Molecular Cell Biology, 2021, ISSN 1471-0072
Wydawca: Nature Publishing Group
DOI: 10.1038/s41580-020-00314-w

The intricate nature of senescence in development and cell plasticity

Autorzy: Hilah Gal , Julia Majewska , Valery Krizhanovsky
Opublikowane w: Seminars in cancer Biology, 2022, ISSN 1044-579X
Wydawca: Academic Press
DOI: 10.1016/j.semcancer.2021.01.004

Senescent cells in the brain and where to find them

Autorzy: Noa Rachmian, Valery Krizhanovsky
Opublikowane w: The FEBS Journal, 2023, ISSN 1742-4658
Wydawca: Wiley
DOI: 10.1111/febs.16649