Using cell-cell interactions to unlock new cancer treatments: Forcing neural crest tumors back onto the developmental path

Información del proyecto

KILL-OR-DIFFERENTIAT

Identificador del acuerdo de subvención: 856529

DOI

10.3030/856529

Fecha de la firma de la CE 27 Mayo 2020

Fecha de inicio 1 Octubre 2020

Fecha de finalización 30 Septiembre 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 9 377 151,00

Aportación de la UE

€ 9 377 151,00

Coordinado por

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (19)

Evolutionary switch in expression of key markers between mouse and human leads to mis-assignment of cell types in developing adrenal medulla.

Autores: Kameneva P, V Artemov A, Kastriti, Sundström E, Kharchenko PV, Adameyko I.
Publicado en: Cancer Cell, 2021, ISSN 1535-6108
Editor: Cell Press

scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data

Autores: Louis Faure, Ruslan Soldatov, Peter V Kharchenko, Igor Adameyko
Publicado en: Bioinformatics, 2023, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btac746

Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma

Autores: Lourdes Sainero-Alcolado, Muhammad Mushtaq, Judit Liaño-Pons, Aida Rodriguez-Garcia, Ye Yuan, Tong Liu, María Victoria Ruiz-Pérez, Susanne Schlisio, Oscar Bedoya-Reina, Marie Arsenian-Henriksson
Publicado en: Journal of Experimental & Clinical Cancer Research, Edición 41, 2023, ISSN 1756-9966
Editor: Nature Publishing House
DOI: 10.1186/s13046-022-02399-x

Boosting multiplexing capabilities for error-robust spatial transcriptomic methods using a set exchange approach

Autores: Johan Boström, Michaɫ Zapaɫa, Igor Adameyko
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adr4026

Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.

Autores: Shi Y, Yuan J, Rraklli V, Maxymovitz E, Cipullo M, Liu M, Li S, Westerlund I, Bedoya-Reina, Bullova P, Rorbach J, Juhlin CC, Stenman A, Larsson C, Kogner P, O'Sullivan MJ, Schlisio S, Holmberg J.
Publicado en: Nucleic Acids Research, 2022, ISSN 1362-4962
Editor: Oxford Academic

Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

Autores: Cécile Thirant, Agathe Peltier, Simon Durand, Amira Kramdi, Caroline Louis-Brennetot, Cécile Pierre-Eugène, Margot Gautier, Ana Costa, Amandine Grelier, Sakina Zaïdi, Nadège Gruel, Irène Jimenez, Eve Lapouble, Gaëlle Pierron, Déborah Sitbon, Hervé J. Brisse, Arnaud Gauthier, Paul Fréneaux, Sandrine Grossetête, Laura G. Baudrin, Virginie Raynal, Sylvain Baulande, Angela Bellini, Jaydutt
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38239-5

A pan-tissue survey of mosaic chromosomal alterations in 948 individuals

Autores: Teng Gao, Maria Eleni Kastriti, Viktor Ljungström, Andreas Heinzel, Arthur S. Tischler, Rainer Oberbauer, Po-Ru Loh, Igor Adameyko, Peter J. Park & Peter V. Kharchenko
Publicado en: Nature Genetics, 2023, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-023-01537-1

Schwann cell precursors represent a neural crest-like state with biased multipotency

Autores: Maria Eleni Kastriti Louis Faure Dorothea Von Ahsen Thibault Gerald Bouderlique Johan Boström Tatiana Solovieva Cameron Jackson Marianne Bronner Dies Meijer Saida Hadjab Francois Lallemend Alek Erickson Marketa Kaucka Viacheslav Dyachuk Thomas Perlmann Laura Lahti Jan Krivanek Jean-Francois Brunet Kaj Fried Igor Adameyko
Publicado en: EMBO Journal, Edición 02614189, 2022, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2021108780

Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

Autores: Bedoya-Reina, Schlisio S.
Publicado en: Cancer Cell, 2021, ISSN 1535-6108
Editor: Cell Press

Serotonin limits generation of chromaffin cells during adrenal organ development

Autores: Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund,
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30438-w

Theory of branching morphogenesis by local interactions and global guidance

Autores: Uçar MC, Kamenev D, Sunadome K, Fachet D, Lallemend F, Adameyko, Hadjab S, Hannezo E.
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group

The transcriptional portraits of the neural crest at the individual cell level.

Autores: Erickson AG, Kameneva P, Adameyko
Publicado en: Seminars in Cell & Developmental Biology, 2022, ISSN 1084-9521
Editor: Academic Press

Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma

Autores: Thale K. Olsen, Jörg Otte, Shenglin Mei, Bethel Tesfai Embaie, Polina Kameneva, Huaitao Cheng, Teng Gao, Vasilios Zachariadis, Ioanna Tsea, Åsa Björklund, Emil Kryukov, Ziyi Hou, Anna Johansson, Erik Sundström, Tommy Martinsson, Susanne Fransson, Jakob Stenman, Shahrzad Shirazi Fard, John Inge Johnsen, Per Kogner, Igor Adameyko, Martin Enge, Peter V. Kharchenko, Ninib Baryawno
Publicado en: Molecular Cancer, Edición 23, 2024, ISSN 1476-4598
Editor: BioMed Central
DOI: 10.1186/s12943-024-02091-y

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.

Autores: Kameneva P, Artemov AV, Kastriti, Faure L, Olsen TK, Otte J, Erickson A, Semsch B, Andersson ER, Ratz M, Frisén J, Tischler AS, de Krijger RR, Bouderlique T, Akkuratova N, Vorontsova M, Gusev O, Fried K, Sundström E, Mei S, Kogner P, Baryawno N, Kharchenko PV, Adameyko I.
Publicado en: Nature Genetics, 2021, ISSN 1061-4036
Editor: Nature Publishing Group

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges.

Autores: Kaucka M, Szarowska B, Kavkova M, Kastriti, Kameneva P, Schmidt I, Peskova L, Joven Araus A, Simon A, Kaiser J, Adameyko I.
Publicado en: Cellular Molecular Life Sciences, 2021, ISSN 1420-682X
Editor: Birkhauser Verlag

Motor innervation directs the correct development of the mouse sympathetic nervous system

Autores: Alek G. Erickson, Alessia Motta, Maria Eleni Kastriti, Steven Edwards, Fanny Coulpier, Emy Théoulle, Aliia Murtazina, Irina Poverennaya, Daniel Wies, Jeremy Ganofsky, Giovanni Canu, Francois Lallemend, Piotr Topilko, Saida Hadjab, Kaj Fried, Christiana Ruhrberg, Quenten Schwarz, Valerie Castellani, Dario Bonanomi, Igor Adameyko
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-51290-0

Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes

Autores: Teng Gao, Ruslan Soldatov, Hirak Sarkar, Adam Kurkiewicz, Evan Biederstedt, Po-Ru Loh, Peter V Kharchenko
Publicado en: Nature Biotechnology, Edición 10870156, 2022, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-022-01468-y

Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue

Autores: Benjamin Jevans, Fay Cooper, Yuliia Fatieieva, Antigoni Gogolou, Yi-Ning Kang, Restuadi Restuadi, Dale Moulding, Pieter Vanden Berghe, Igor Adameyko, Nikhil Thapar, Peter W Andrews, Paolo De Coppi, Anestis Tsakiridis, Conor J McCann
Publicado en: Gut, Edición 73, 2024, Página(s) 1441-1453, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331532

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.

Autores: Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S.
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group

Non-peer reviewed articles (1)

Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma

Autores: Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Nadege Gruel, Eve Lapouble, Gaëlle Pierron, Deborah Sitbon, Hervé Brisse, Arnaud Gauthier, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Aurelien Marabelle, Birgit Geoer
Publicado en: J Immunother Cancer, Edición 20511426, 2022, ISSN 2051-1426
Editor: Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-004807