Using cell-cell interactions to unlock new cancer treatments: Forcing neural crest tumors back onto the developmental path

Informazioni relative al progetto

KILL-OR-DIFFERENTIAT

ID dell’accordo di sovvenzione: 856529

DOI

10.3030/856529

Data della firma CE 27 Maggio 2020

Data di avvio 1 Ottobre 2020

Data di completamento 30 Settembre 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 9 377 151,00

Contributo UE

€ 9 377 151,00

Coordinato da

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (19)

Evolutionary switch in expression of key markers between mouse and human leads to mis-assignment of cell types in developing adrenal medulla.

Autori: Kameneva P, V Artemov A, Kastriti, Sundström E, Kharchenko PV, Adameyko I.
Pubblicato in: Cancer Cell, 2021, ISSN 1535-6108
Editore: Cell Press

scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data

Autori: Louis Faure, Ruslan Soldatov, Peter V Kharchenko, Igor Adameyko
Pubblicato in: Bioinformatics, 2023, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btac746

Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma

Autori: Lourdes Sainero-Alcolado, Muhammad Mushtaq, Judit Liaño-Pons, Aida Rodriguez-Garcia, Ye Yuan, Tong Liu, María Victoria Ruiz-Pérez, Susanne Schlisio, Oscar Bedoya-Reina, Marie Arsenian-Henriksson
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 41, 2023, ISSN 1756-9966
Editore: Nature Publishing House
DOI: 10.1186/s13046-022-02399-x

Boosting multiplexing capabilities for error-robust spatial transcriptomic methods using a set exchange approach

Autori: Johan Boström, Michaɫ Zapaɫa, Igor Adameyko
Pubblicato in: Science Advances, Numero 11, 2025, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adr4026

Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.

Autori: Shi Y, Yuan J, Rraklli V, Maxymovitz E, Cipullo M, Liu M, Li S, Westerlund I, Bedoya-Reina, Bullova P, Rorbach J, Juhlin CC, Stenman A, Larsson C, Kogner P, O'Sullivan MJ, Schlisio S, Holmberg J.
Pubblicato in: Nucleic Acids Research, 2022, ISSN 1362-4962
Editore: Oxford Academic

Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma

Autori: Cécile Thirant, Agathe Peltier, Simon Durand, Amira Kramdi, Caroline Louis-Brennetot, Cécile Pierre-Eugène, Margot Gautier, Ana Costa, Amandine Grelier, Sakina Zaïdi, Nadège Gruel, Irène Jimenez, Eve Lapouble, Gaëlle Pierron, Déborah Sitbon, Hervé J. Brisse, Arnaud Gauthier, Paul Fréneaux, Sandrine Grossetête, Laura G. Baudrin, Virginie Raynal, Sylvain Baulande, Angela Bellini, Jaydutt
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38239-5

A pan-tissue survey of mosaic chromosomal alterations in 948 individuals

Autori: Teng Gao, Maria Eleni Kastriti, Viktor Ljungström, Andreas Heinzel, Arthur S. Tischler, Rainer Oberbauer, Po-Ru Loh, Igor Adameyko, Peter J. Park & Peter V. Kharchenko
Pubblicato in: Nature Genetics, 2023, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-023-01537-1

Schwann cell precursors represent a neural crest-like state with biased multipotency

Autori: Maria Eleni Kastriti Louis Faure Dorothea Von Ahsen Thibault Gerald Bouderlique Johan Boström Tatiana Solovieva Cameron Jackson Marianne Bronner Dies Meijer Saida Hadjab Francois Lallemend Alek Erickson Marketa Kaucka Viacheslav Dyachuk Thomas Perlmann Laura Lahti Jan Krivanek Jean-Francois Brunet Kaj Fried Igor Adameyko
Pubblicato in: EMBO Journal, Numero 02614189, 2022, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.2021108780

Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

Autori: Bedoya-Reina, Schlisio S.
Pubblicato in: Cancer Cell, 2021, ISSN 1535-6108
Editore: Cell Press

Serotonin limits generation of chromaffin cells during adrenal organ development

Autori: Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund,
Pubblicato in: Nature Communications, Numero 20411723, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30438-w

Theory of branching morphogenesis by local interactions and global guidance

Autori: Uçar MC, Kamenev D, Sunadome K, Fachet D, Lallemend F, Adameyko, Hadjab S, Hannezo E.
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group

The transcriptional portraits of the neural crest at the individual cell level.

Autori: Erickson AG, Kameneva P, Adameyko
Pubblicato in: Seminars in Cell & Developmental Biology, 2022, ISSN 1084-9521
Editore: Academic Press

Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma

Autori: Thale K. Olsen, Jörg Otte, Shenglin Mei, Bethel Tesfai Embaie, Polina Kameneva, Huaitao Cheng, Teng Gao, Vasilios Zachariadis, Ioanna Tsea, Åsa Björklund, Emil Kryukov, Ziyi Hou, Anna Johansson, Erik Sundström, Tommy Martinsson, Susanne Fransson, Jakob Stenman, Shahrzad Shirazi Fard, John Inge Johnsen, Per Kogner, Igor Adameyko, Martin Enge, Peter V. Kharchenko, Ninib Baryawno
Pubblicato in: Molecular Cancer, Numero 23, 2024, ISSN 1476-4598
Editore: BioMed Central
DOI: 10.1186/s12943-024-02091-y

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.

Autori: Kameneva P, Artemov AV, Kastriti, Faure L, Olsen TK, Otte J, Erickson A, Semsch B, Andersson ER, Ratz M, Frisén J, Tischler AS, de Krijger RR, Bouderlique T, Akkuratova N, Vorontsova M, Gusev O, Fried K, Sundström E, Mei S, Kogner P, Baryawno N, Kharchenko PV, Adameyko I.
Pubblicato in: Nature Genetics, 2021, ISSN 1061-4036
Editore: Nature Publishing Group

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges.

Autori: Kaucka M, Szarowska B, Kavkova M, Kastriti, Kameneva P, Schmidt I, Peskova L, Joven Araus A, Simon A, Kaiser J, Adameyko I.
Pubblicato in: Cellular Molecular Life Sciences, 2021, ISSN 1420-682X
Editore: Birkhauser Verlag

Motor innervation directs the correct development of the mouse sympathetic nervous system

Autori: Alek G. Erickson, Alessia Motta, Maria Eleni Kastriti, Steven Edwards, Fanny Coulpier, Emy Théoulle, Aliia Murtazina, Irina Poverennaya, Daniel Wies, Jeremy Ganofsky, Giovanni Canu, Francois Lallemend, Piotr Topilko, Saida Hadjab, Kaj Fried, Christiana Ruhrberg, Quenten Schwarz, Valerie Castellani, Dario Bonanomi, Igor Adameyko
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-51290-0

Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes

Autori: Teng Gao, Ruslan Soldatov, Hirak Sarkar, Adam Kurkiewicz, Evan Biederstedt, Po-Ru Loh, Peter V Kharchenko
Pubblicato in: Nature Biotechnology, Numero 10870156, 2022, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-022-01468-y

Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue

Autori: Benjamin Jevans, Fay Cooper, Yuliia Fatieieva, Antigoni Gogolou, Yi-Ning Kang, Restuadi Restuadi, Dale Moulding, Pieter Vanden Berghe, Igor Adameyko, Nikhil Thapar, Peter W Andrews, Paolo De Coppi, Anestis Tsakiridis, Conor J McCann
Pubblicato in: Gut, Numero 73, 2024, Pagina/e 1441-1453, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2023-331532

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.

Autori: Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S.
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group

Non-peer reviewed articles (1)

Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma

Autori: Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Nadege Gruel, Eve Lapouble, Gaëlle Pierron, Deborah Sitbon, Hervé Brisse, Arnaud Gauthier, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Aurelien Marabelle, Birgit Geoer
Pubblicato in: J Immunother Cancer, Numero 20511426, 2022, ISSN 2051-1426
Editore: Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-004807