Using cell-cell interactions to unlock new cancer treatments: Forcing neural crest tumors back onto the developmental path

Project Information

KILL-OR-DIFFERENTIAT

Grant agreement ID: 856529

DOI 10.3030/856529

EC signature date 27 May 2020

Start date 1 October 2020

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 9 377 151,00

EU contribution € 9 377 151,00

Coordinated by

MEDIZINISCHE UNIVERSITAET WIEN
Austria

Publications

Peer reviewed articles (13)

Evolutionary switch in expression of key markers between mouse and human leads to mis-assignment of cell types in developing adrenal medulla.

Author(s): Kameneva P, V Artemov A, Kastriti, Sundström E, Kharchenko PV, Adameyko I.
Published in: Cancer Cell, 2021, ISSN 1535-6108
Publisher: Cell Press

scFates: a scalable python package for advanced pseudotime and bifurcation analysis from single-cell data

Author(s): Louis Faure, Ruslan Soldatov, Peter V Kharchenko, Igor Adameyko
Published in: Bioinformatics, 2023, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btac746

Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors.

Author(s): Shi Y, Yuan J, Rraklli V, Maxymovitz E, Cipullo M, Liu M, Li S, Westerlund I, Bedoya-Reina, Bullova P, Rorbach J, Juhlin CC, Stenman A, Larsson C, Kogner P, O'Sullivan MJ, Schlisio S, Holmberg J.
Published in: Nucleic Acids Research, 2022, ISSN 1362-4962
Publisher: Oxford Academic

A pan-tissue survey of mosaic chromosomal alterations in 948 individuals

Author(s): Teng Gao, Maria Eleni Kastriti, Viktor Ljungström, Andreas Heinzel, Arthur S. Tischler, Rainer Oberbauer, Po-Ru Loh, Igor Adameyko, Peter J. Park & Peter V. Kharchenko
Published in: Nature Genetics, 2023, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01537-1

Schwann cell precursors represent a neural crest-like state with biased multipotency

Author(s): Maria Eleni Kastriti Louis Faure Dorothea Von Ahsen Thibault Gerald Bouderlique Johan Boström Tatiana Solovieva Cameron Jackson Marianne Bronner Dies Meijer Saida Hadjab Francois Lallemend Alek Erickson Marketa Kaucka Viacheslav Dyachuk Thomas Perlmann Laura Lahti Jan Krivanek Jean-Francois Brunet Kaj Fried Igor Adameyko
Published in: EMBO Journal, Issue 02614189, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2021108780

Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

Author(s): Bedoya-Reina, Schlisio S.
Published in: Cancer Cell, 2021, ISSN 1535-6108
Publisher: Cell Press

Serotonin limits generation of chromaffin cells during adrenal organ development

Author(s): Polina Kameneva, Victoria I. Melnikova, Maria Eleni Kastriti, Anastasia Kurtova, Emil Kryukov, Aliia Murtazina, Louis Faure, Irina Poverennaya, Artem V. Artemov, Tatiana S. Kalinina, Nikita V. Kudryashov, Michael Bader, Jan Skoda, Petr Chlapek, Lucie Curylova, Lukas Sourada, Jakub Neradil, Marketa Tesarova, Massimo Pasqualetti, Patricia Gaspar, Vasily D. Yakushov, Boris I. Sheftel, Tomas Zikmund,
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30438-w

Theory of branching morphogenesis by local interactions and global guidance

Author(s): Uçar MC, Kamenev D, Sunadome K, Fachet D, Lallemend F, Adameyko, Hadjab S, Hannezo E.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group

The transcriptional portraits of the neural crest at the individual cell level.

Author(s): Erickson AG, Kameneva P, Adameyko
Published in: Seminars in Cell & Developmental Biology, 2022, ISSN 1084-9521
Publisher: Academic Press

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin.

Author(s): Kameneva P, Artemov AV, Kastriti, Faure L, Olsen TK, Otte J, Erickson A, Semsch B, Andersson ER, Ratz M, Frisén J, Tischler AS, de Krijger RR, Bouderlique T, Akkuratova N, Vorontsova M, Gusev O, Fried K, Sundström E, Mei S, Kogner P, Baryawno N, Kharchenko PV, Adameyko I.
Published in: Nature Genetics, 2021, ISSN 1061-4036
Publisher: Nature Publishing Group

Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges.

Author(s): Kaucka M, Szarowska B, Kavkova M, Kastriti, Kameneva P, Schmidt I, Peskova L, Joven Araus A, Simon A, Kaiser J, Adameyko I.
Published in: Cellular Molecular Life Sciences, 2021, ISSN 1420-682X
Publisher: Birkhauser Verlag

Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes

Author(s): Teng Gao, Ruslan Soldatov, Hirak Sarkar, Adam Kurkiewicz, Evan Biederstedt, Po-Ru Loh, Peter V Kharchenko
Published in: Nature Biotechnology, Issue 10870156, 2022, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01468-y

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.

Author(s): Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group

Non-peer reviewed articles (1)

Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma

Author(s): Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Nadege Gruel, Eve Lapouble, Gaëlle Pierron, Deborah Sitbon, Hervé Brisse, Arnaud Gauthier, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Aurelien Marabelle, Birgit Geoer
Published in: J Immunother Cancer, Issue 20511426, 2022, ISSN 2051-1426
Publisher: Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-004807