Ubiquitin Chains in Viral Infections

Informazioni relative al progetto

CHUbVi

ID dell’accordo di sovvenzione: 856581

DOI 10.3030/856581

Data della firma CE 9 Dicembre 2019

Data di avvio 1 Marzo 2020

Data di completamento 28 Febbraio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 7 649 848,00

Contributo UE € 7 649 848,00

Coordinato da

FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland

Pubblicazioni

Peer reviewed articles (10)

Site-Specific Protein Ubiquitylation Using an Engineered, Chimeric E1 Activating Enzyme and E2 SUMO Conjugating Enzyme Ubc9

Autori: Akimoto, G.; Fernandes, A. P.; Bode, J. W
Pubblicato in: ACS central science, 2022, Pagina/e 275–281, ISSN 2374-7951
Editore: ACS Publications
DOI: 10.1021/acscentsci.1c01490

Chemoproteomik-basierende Zielprotein-Dekonvolution und Erstellung der Selektivitätsprofile von Histone Deacetylase Inhibitoren

Autori: Lechner, Severin
Pubblicato in: Nature Communications, Numero 3, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-39151-8

Atomic Tailoring of Ubiquitin Side Chains Influences E2-Mediated Ubiquitin Chain Formation

Autori: Haewon Song; Toshiki Mikami; Sohei Majima; Jeffrey Bode
Pubblicato in: Crossref, Numero 5, 2024, ISSN 0018-019X
Editore: Verlag Helvetica Chimica Acta
DOI: 10.26434/chemrxiv-2023-26rl0

Liquid Biomolecular Condensates and Viral Lifecycles: Review and Perspectives

Autori: Etibor TA, Yamauchi Y, Amorim MJ
Pubblicato in: Viruses, 2021, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030366

How Influenza Virus Uses Host Cell Pathways during Uncoating

Autori: Etori Aguiar Moreira, Yohei Yamauchi, Patrick Matthias
Pubblicato in: Cells, Numero 10/7, 2021, Pagina/e 1722, ISSN 2073-4409
Editore: Cells
DOI: 10.3390/cells10071722

The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses

Autori: Maria Giulia Bigotti; Katja Klein; Esther S. Gan; Maria Anastasina; Simon Andersson; Olli Vapalahti; Pekka Katajisto; Maximilian Erdmann; Andrew D. Davidson; Sarah J. Butcher; Ian Collinson; Eng Eong Ooi; Giuseppe Balistreri; Andrea Brancaccio; Yohei Yamauchi
Pubblicato in: Bigotti , M G , Klein , K , Gan , E S , Anastasina , M , Andersson , S , Vapalahti , O , Katajisto , P , Erdmann , M , Davidson , A D , Butcher , S J , Collinson , I , Ooi , E E , Balistreri , G , Brancaccio , A & Yamauchi , Y 2024 , ' The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses ' , Antiviral Research , vol. 224 , 105837 . https://doi, Numero 2, 2024, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1101/2023.11.06.565781

Neuropilin-1 is a host factor for SARS-CoV-2 infection.

Autori: James L. Daly; Boris Simonetti; Katja Klein; Kai-En Chen; Maia Kavanagh Williamson; Carlos Antón-Plágaro; Deborah K. Shoemark; Lorena Simón-Gracia; Michael Bauer; Reka Hollandi; Urs F. Greber; Peter Horvath; Peter Horvath; Richard B. Sessions; Ari Helenius; Julian A. Hiscox; Julian A. Hiscox; Tambet Teesalu; David A. Matthews; Andrew D. Davidson; Brett M. Collins; Peter J. Cullen; Yohei Yamauch
Pubblicato in: Science, Numero 2, 2020, Pagina/e 861-865, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abd3072

A widespread viral entry mechanism: The C-end Rule motif–neuropilin receptor interaction

Autori: Balistreri G, Yamauchi Y, Teesalu T. A widespread viral entry mechanism: The C-end Rule motif-neuropilin receptor interaction.
Pubblicato in: Proceedings of the National Academy of Sciences (PNAS), 2021, ISSN 1091-6490
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2112457118

ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

Autori: Simonetti B, Daly JL, Simón-Gracia L, Klein K, Weeratunga S, Antón-Plágaro C, Tobi A, Hodgson L, Lewis P, Heesom KJ, Shoemark DK, Davidson AD, Collins BM, Teesalu T, Yamauchi Y, Cullen PJ
Pubblicato in: Proceedings of the National Academy of Sciences (PNAS), 2022, ISSN 1091-6490
Editore: National Academy of Sciences
DOI: 10.1101/2022.01.20.477115

Biocompatible lysine protecting groups for the chemoenzymatic synthesis of K48/K63 heterotypic and branched ubiquitin chains

Autori: Toshiki Mikami; Sohei Majima; Haewon Song; Jeffrey W. Bode
Pubblicato in: ACS Central Science, Vol 9, Iss 8, Pp 1633-1641 (2023), Numero 3, 2023, ISSN 2374-7943
Editore: ACS Publication
DOI: 10.26434/chemrxiv-2023-hlk3f

Other (1)

Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways

Autori: Wang L, Moreira EA, Kempf G, Miyake Y, Oliveira Esteves BI, Fahmi A, Schaefer JV, Dreier B, Yamauchi Y, Alves MP, Plückthun A and Matthias P
Pubblicato in: 2022, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2022.110736