RNA in disease

Risultati finali

The organisation of the First RiboMed summer school will be reported

"""Science gallery in the street"" campaign"

The organisation of a science outreach event will bereported

International conference on RNA in disease

The organisation of an important international conference on RNA in disease will be reported

An initial set of communication material will be developed as to increase awareness of biomedical research in general, and iMM researchers in particular.

First Annual Project Meeting

The Consortium will together with the Scientific Advisory Board discuss the achievements and suggest alterations if necessary and this meeting will be reported

Widening KPI: Evolution of the publications in high impact journals in the RiboMed research field

Widening KPI: all the publications of iMM in high impact journals in the RiboMed research field published in 3 years prior to the start of RiboMed will be inserted in the GMS PP, and a 1-page statement report will be submitted.

Second Summer School

The organisation of the Second RiboMed Summer School will be reported

Pubblicazioni

Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblastos and safegards stem cell pluripotency

Autori: Bernardes de Jesus B, Matinho SP, Barros S, Sousa-Franco A, Alves-Vale C, Carvalho T, Carmo-Fonseca M
Pubblicato in: Nature Communications, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-017-01921-6

Short(16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes

Autori: Pires VB, Simões R, Mamchaoui K, Carvalho C, Carmo-Fonseca M.
Pubblicato in: PLOS ONE, 2017, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0181065

Deep intronic mutations and human disease.

Autori: Vaz-Drago R, Custódio N, Carmo-Fonseca M.
Pubblicato in: Human Genetics, Numero 136/9, 2017, ISSN 0340-6717
Editore: Springer Verlag
DOI: 10.1007/s00439-017-1809-4

Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis.

Autori: Francesco Roncato; Ofer Regev; Sara W. Feigelson; Sandeep Kumar Yadav; Lukasz Kaczmarczyk; Nehora Levi; Diana Drago-Garcia; Samuel Ovadia; Marina Kizner; Yoseph Addadi; João C. Sabino; Yossi Ovadya; Sérgio F. de Almeida; Ester Feldmesser; Gabi Gerlitz; Ronen Alon
Pubblicato in: Volume 13, Numero 3, 2021, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13102383

Design principles for pluripotent stem cell-derived organoid engineering

Autori: Silva TP, Cotovio JP, Bekman E, Carmo-Fonseca M, Cabral JMS, Fernandes TG
Pubblicato in: Stem Cells International, 2019, ISSN 1687-9678
Editore: Stem Cells International
DOI: 10.1155/2019/4508470

Pharmacological inhibition of the spliceosome subunit SF3b triggers EJC-independent NMD

Autori: Carvalho T, Martins S, Rino J, Marinho S, Carmo-Fonseca M.
Pubblicato in: Journal of Cell Science, Numero 130/9, 2017, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.202200

Transcription and splicing dynamics during early Drosophila development

Autori: Prudêncio P, Rebelo K, Savisaar R, Martinho RG, Carmo-Fonseca M
Pubblicato in: RNA, 2021, ISSN 1355-8382
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1261/rna.078933.121

RNA Splicing Defects in Hypertrophic Cardiomyopathy: Implications for Diagnosis and Therapy

Autori: Marta Ribeiro, Marta Furtado, Sandra Martins, Teresa Carvalho, Maria Carmo-Fonseca
Pubblicato in: International Journal of Molecular Sciences, Numero 21/4, 2020, Pagina/e 1329, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21041329

Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops

Autori: João C. Sabino, Madalena R. de Almeida, Patrícia L.Abreu, Ana M. Ferreira, Marco M Domingues, Nuno C Santos, Claus Azzalin, Ana Rita Grosso, Sérgio Fernandes de Almeida
Pubblicato in: Elife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.69476

POINT technology illuminates the processing of polymerase-associated intact nascent transcripts

Autori: Rui Sousa-Luís, Gwendal Dujardin, Inna Zukher, Hiroshi Kimura, Carika Weldon, Maria Carmo-Fonseca, Nick J. Proudfoot, Takayuki Nojima
Pubblicato in: Molecular Cell, 2021, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2021.02.034

Whole gene sequencing identifies deep-intronic variants with potential functional impact in patients with hypertrophic cardiomyopathy

Autori: Mendes de Almeida R, Tavares J, Martins S, Carvalho T, Enguita FJ, Brito D, Carmo-Fonseca M, Lopes LR.
Pubblicato in: Plos One, Numero 12/8, 2017, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0182946

RNA Polymerase II phosphorylated on CTD Serine 5 interacts with the spliceosome during co-transcriptional splicing

Autori: Nojima T, Rebelo K, Gomes T, Grosso AR, Proudfoot NJ, Carmo-Fonseca M
Pubblicato in: Molecular Cell, Numero 72/2, 2018, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2018.09.004

Distinctive patterns of transcription and RNA processing for human lincRNAs

Autori: Schlackow M, Nojima T, Gomes T, Dhir A, Carmo-Fonseca M, Proudfoot NJ
Pubblicato in: Molecular Cell, Numero 65/1, 2017, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2016.11.029

Live-Cell Imaging of Transcriptional Activity at DNA Double-Strand Breaks.

Autori: Madalena R. de Almeida; Eduardo Gameiro; Sérgio F. de Almeida; Robert M. Martin
Pubblicato in: reponame:Repositório Científico de Acesso Aberto de Portugal, Numero 1, 2021, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/62968

betAS: intuitive analysis and visualisation of differential alternative splicing using beta distributions (pre-print)

Autori: Mariana Ascensao-Ferreira, Nuno Saraiva-Agostinho, Nuno L Barbosa-Morais
Pubblicato in: 2022
Editore: biorxiv
DOI: 10.1101/2022.12.26.521935

voyAGEr: free web interface for the analysis of age-related gene expression alterations in human tissues (pre-print)

Autori: Arthur L Schneider, Nuno Saraiva-Agostinho, Nuno L Barbosa-Morais
Pubblicato in: 2022
Editore: Biorxiv
DOI: 10.1101/2022.12.22.521681

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

Autori: Silva B, Arora R, Bione S, Azzalin CM
Pubblicato in: Nature Communications, 2021
Editore: Nature Communications
DOI: 10.1101/2021.02.18.431840

Quantitative image analysis of single-molecule mRNA dynamics in living cells

Autori: Rino J, de Jesus AC, Carmo-Fonseca M
Pubblicato in: Light Microscopy - Methods and Protocols, Numero 1563, 2017
Editore: Methods in Molecular Biology
DOI: 10.1007/978-1-4939-6810-7_15

Diritti di proprietà intellettuale

METHODS OF TREATMENT OF CANCER ASSOCIATED WITH CENTROSOME AMPLIFICATION

Numero candidatura/pubblicazione: 20 19050045
Data: 2019-12-20

TREATMENT OF ALT CANCERS

Numero candidatura/pubblicazione: 20 20050021
Data: 2020-05-23