Strategies to strengthen scientific excellence and innoVation capacIty for early diagnoSIs of gastrOintestinal caNcers

Informazioni relative al progetto

VISION

ID dell’accordo di sovvenzione: 857381

DOI

10.3030/857381

Progetto chiuso

Data della firma CE 9 Luglio 2019

Data di avvio 1 Ottobre 2019

Data di completamento 30 Giugno 2023

Finanziato da

• Twinning of research institutions

Costo totale

€ 787 465,00

Contributo UE

€ 787 465,00

Coordinato da

BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED, VEREJNA VYSKUMNA INSTITUCIA
Slovakia

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (20)

Courses for early stage researchers

Courses (up to 5 days) will be realized with the aim to acquire new technical skills, and to increase the innovation capacity of early stage researchers in different fields.

Upgrading multidisciplinary clinical expertise update

Follow multidisciplinary meetings weekly presentation and review of high input clinical papers seminars on oncology topics by the experts

Co-supervision of PhD thesis

Experts from partners` organisations will act as co-supervisors of PhD theses.

Scientific workshop - oncology

BMC SAS in close cooperation with SCRF will continue in organising Scientific Workshops Oncology Young Oncologist and Open house targeted at students of secondary schools

Co-supervision of PhD thesis update

Experts from partners organisations will act as cosupervisors of PhD theses

Short-term staff exchanges of senior scientists

The short-term staff exchanges of senior scientists (up to 5 days) will be realized to discuss particular problems and to develop strategies to solve particular topics.

Joint summer school

BMC SAS will organise in close cooperation with VISION partners a JSS and open school targeted at undergraduate students

Active participation at international and national clinically oriented conference update

Achievements of VISION project will be presented at the international and national meetings and conferences with clinically oriented topics

Upgrading multidisciplinary clinical expertise

Follow multidisciplinary meetings weekly presentation and review of high input clinical papers seminars on oncology topics by the experts

Training activities update

Training up to 2 months 18 shortterm staff exchanges of early stage scientists up to 14 days will be realized with the aim to discuss particular problems and develop strategies to solve these problems

Short-term staff exchanges of senior scientists update

The shortterm staff exchanges of senior scientists up to 5 days will be realized to discuss particular problems and to develop strategies to solve particular topics

Active participation at international and national clinically oriented conference

Achievements of VISION project will be presented at the international and national meetings and conferences with clinically oriented topics.

Training activities

Training (up to 2 months) - 18 short-term staff exchanges of early stage scientists (up to 14 days) will be realized with the aim to discuss particular problems and develop strategies to solve these problems.

BMC SAV Lab Open House

BMC SAS in close cooperation with SCRF will continue in organising Scientific Workshops Oncology Young Oncologist and Open house targeted at students of secondary schools

Invited lectures on specific topics

Reputed clinicians will be invited to scientific meetings organized by BMC SAS to give keynote lectures on particular topics.

Invited lectures on specific topics update

Reputed clinicians will be invited to scientific meetings organized by BMC SAS to give keynote lectures on particular topics

Courses for early stage researchers update

Courses up to 5 days will be realized with the aim to acquire new technical skills and to increase the innovation capacity of early stage researchers in different fields

Young Oncologist Workshop

BMC SAS in close cooperation with SCRF will continue in organising Scientific Workshops Oncology Young Oncologist and Open house targeted at students of secondary schools

Open school

A cycle of lectures dedicated to uptodate knowledge in the field of molecular biology genetics liquid biopsy in oncology immunooncology nanobiology and nanomedicine eith the use of new communication channels

Joint International Scientific Conference VISION and International Network of Young Scientists Conference

International Network of Young Scientists INYS conference will be organized with expected participation of 50 young scientists

Websites, patent fillings, videos etc. (3)

Project leaflet

The leaflet with information on the project will be produced at the beginning of the project.

VISION website

Website will be regularly updated, at least annually in M12, M24.

Visual identity

The visual identity of the project will be created at the beginning of the project.

Open Research Data Pilot (1)

Manuscript preparation of joint research publications

Joint research publications will be submitted to peerreviewed journals The report on these publications will be updated in M24 and M45

Pubblicazioni

Peer reviewed articles (32)

The Metastatic Process through the Eyes of Epigenetic Regulation: A Promising Horizon for Cancer Therapy

Autori: Bozena Smolkova; Julie Earl; Agapi Kataki
Pubblicato in: International Journal of Molecular Sciences, Numero 23(24), 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415446

Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro—In Vivo Correlation

Autori: Tibor Dubaj; Katarina Kozics; Monika Sramkova; Alena Manova; Neus G. Bastús; Oscar H. Moriones; Yvonne Kohl; Maria Dusinska; Elise Runden-Pran; Victor Puntes; Andrew Nelson; Alena Gabelova; Peter Simon
Pubblicato in: Nanomaterials, Numero 12(3), 2022, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano12030511

Pharmacokinetics, Biodistribution, and Biosafety of PEGylated Gold Nanoparticles In Vivo.

Autori: Katarína Kozics; Monika Sramkova; Kristina Kopecka; Patricia Begerova; Alena Manova; Zora Krivošíková; Zuzana Ševčíková; Aurelia Liskova; Eva Rollerova; Tibor Dubaj; Víctor F. Puntes; Ladislava Wsolova; Peter Šimon; Jana Tulinska; Alena Gábelová
Pubblicato in: Nanomaterials, Numero 11(7), 2021, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano11071702

Liquid Biopsy in Gastrointestinal Cancers: How Close Are We to Reaching the Clinic?

Autori: Julie Earl; Agapi Kataki; Bozena Smolkova
Pubblicato in: Cancers, Numero 15(10), 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15102831

Molecular features and gene expression signature of metastatic colorectal cancer (Review).

Autori: Martina Poturnajova; Tatiana Furielova; Sona Balintova; Silvia Schmidtova; Lucia Kucerova; Miroslava Matuskova
Pubblicato in: Oncology Reports, Numero 11, 2021, ISSN 1021-335X
Editore: Demetrios A. Spandidos Ed. & Pub.
DOI: 10.3892/or.2021.7961

Personalized medicine: Stem cells in colorectal cancer treatment

Autori: Athanasios Patsalias; Zuzana Kozovska
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 141, 2021, ISSN 0753-3322
Editore: Elsevier Masson
DOI: 10.1016/j.biopha.2021.111821

Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms

Autori: Bozena Smolkova; Agapi Kataki; Julie Earl; Ignacio Ruz-Caracuel; Marina Cihova; Maria Urbanova; Verona Buocikova; Sandra Tamargo; Vita Rovite; Helvijs Niedra; Joerg Schrader; Yvonne Kohl
Pubblicato in: Critical Reviews in Oncology/Hematology, Numero 180, 2022, ISSN 1040-8428
Editore: Elsevier BV
DOI: 10.1016/j.critrevonc.2022.103865

Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer

Autori: M. Poturnajova; Z. Kozovska; M. Matuskova
Pubblicato in: Cellular Signalling, Numero 87, 2021, ISSN 0898-6568
Editore: Elsevier BV
DOI: 10.1016/j.cellsig.2021.110120

Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Autori: Jesús Frutos Díaz-Alejo; Simon April-Monn; Marina Cihova; Verona Buocikova; Jorge Villalón López; Maria Urbanova; Carmen G. Lechuga; Miroslav Tomas; Peter Dubovan; Bárbara Luna Sánchez; Sonia Camaño Páez; Alfonso Sanjuanbenito; Eduardo Lobo; Estefanía Romio de la Heras; Carmen Guerra; Carolina de la Pinta; Emma Barreto Melian; Mercedes Rodríguez Garrote; Alfredo Carrato; Laura Ruiz-Caña
Pubblicato in: Journal of visualized experiments, Numero 195, 2023, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/65229

Teoretický prehľad epigenetických zmien a ich možné využitie pri liečbe duktálneho adenokarcinómu pankreasu

Autori: Bc. Mária Urbanová; MUDr. Peter Dubovan; MUDr. Miroslav Tomáš, PhD.; Mgr. Marína Cihová, PhD.; RNDr. Soňa Čierniková, PhD.; Mgr. Božena Smolková, PhD.
Pubblicato in: Onkológia, Numero 15(5), 2020, Pagina/e 324-328, ISSN 1336-8176
Editore: Solen s.r.o.
DOI: 10.5281/zenodo.4498218

The evaluation of the efficacy and potential genotoxic hazard of combined SAHA and 5-FU treatment in the chemoresistant colorectal cancer cell lines

Autori: Lucia Balintova; Miroslava Matuskova; Alena Gabelova
Pubblicato in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Numero 874-875, 2022, ISSN 1383-5718
Editore: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503445

Membranous CD44v6 is upregulated as an early event in colorectal cancer: Downregulation is Associated with circulating tumor cells and poor prognosis

Autori: Agapi Kataki Vassilis G. Giannakoulis Anastasia Derventzi Konstantinos Papiris Eythimios Koniaris Manousos Konstadoulakis
Pubblicato in: Oncology Letters, Numero 22(6), 2021, ISSN 1792-1074
Editore: Spandidos Publications
DOI: 10.3892/ol.2021.13081

Genotoxic effects of occupational exposure to glass fibres - A human biomonitoring study

Autori: Marcello Ceppi; Bozena Smolkova; Marta Staruchova; Alena Kazimirova; Magdalena Barancokova; Katarina Volkovova; Andrew Collins; Anton Kocan; Zuzana Dzupinkova; Alexandra Horska; Verona Buocikova; Jana Tulinska; Aurelia Liskova; Miroslava Lehotska Mikusova; Zora Krivosikova; Ladislava Wsolova; Daniel Kuba; Elise Runden-Pran; Naouale El Yamani; Eleonora Martha Longhin; Erika Halasova; Soterios Kyrto
Pubblicato in: Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Numero 885, 2022, ISSN 1383-5718
Editore: Elsevier BV
DOI: 10.1016/j.mrgentox.2022.503572

Rapid identification of in vitro cell toxicity using an electrochemical membrane screening platform

Autori: Yvonne Kohl; Nicola William; Elisabeth Elje; Nadine Backes; Mario Rothbauer; Annamaria Srancikova; Elise Rundén-Pran; Naouale El Yamani; Rafi Korenstein; Lea Madi; Alexander Barbul; Katarina Kozics; Monika Sramkova; Karen Steenson; Alena Gabelova; Peter Ertl; Maria Dusinska; Andrew Nelson
Pubblicato in: Bioelectrochemistry, Numero 153, 2023, ISSN 1567-5394
Editore: Elsevier BV
DOI: 10.1016/j.bioelechem.2023.108467

DNA Methylation Mediates EMT Gene Expression in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Autori: Maria Urbanova; Verona Buocikova; Lenka Trnkova; Sabina Strapcova; Viera Horvathova Kajabova; Emma Barreto Melian; Maria Novisedlakova; Miroslav Tomas; Peter Dubovan; Julie Earl; Jozef Bizik; Eliska Svastova; Sona Ciernikova; Bozena Smolkova
Pubblicato in: International Journal of Molecular Sciences, Numero 23(4), 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23042117

ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells

Autori: Erika Durinikova, Zuzana Kozovska, Martina Poturnajova, Jana Plava, Zuzana Cierna, Andrea Babelova, Roman Bohovic, Silvia Schmidtova, Miroslav Tomas, Lucia Kucerova, Miroslava Matuskova
Pubblicato in: BMC Cancer, Numero 18/1, 2018, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-018-4758-y

Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods

Autori: Monika Zarska, Michal Sramek, Filip Novotny, Filip Havel, Andrea Babelova, Blanka Mrazkova, Oldrich Benada, Milan Reinis, Ivan Stepanek, Kamil Musilek, Jiri Bartek, Monika Ursinyova, Ondrej Novak, Rastislav Dzijak, Kamil Kuca, Jan Proska, Zdenek Hodny
Pubblicato in: Biomaterials, Numero 154, 2018, Pagina/e 275-290, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.10.044

Surface-modified magnetite nanoparticles act as aneugen-like spindle poison

Autori: Barbora Buliaková, Monika Mesárošová, Andrea Bábelová, Michal Šelc, Veronika Némethová, Lívia Šebová, Filip Rázga, Monika Ursínyová, Ivan Chalupa, Alena Gábelová
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 13/1, 2017, Pagina/e 69-80, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/j.nano.2016.08.027

ALDH1A inhibition sensitizes colon cancer cells to chemotherapy

Autori: Z. Kozovska, A. Patsalias, V. Bajzik, E. Durinikova, L. Demkova, S. Jargasova, B. Smolkova, J. Plava, L. Kucerova, M. Matuskova
Pubblicato in: BMC Cancer, Numero 18/1, 2018, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-018-4572-6

Preparation, properties and anticancer effects of mixed As4S4/ZnS nanoparticles capped by Poloxamer 407

Autori: Z. Bujňáková, M. Baláž, M. Zdurienčíková, J. Sedlák, M. Čaplovičová, Ľ. Čaplovič, E. Dutková, A. Zorkovská, E. Turianicová, P. Baláž, O. Shpotyuk, S. Andrejko
Pubblicato in: Materials Science and Engineering: C, Numero 71, 2017, Pagina/e 541-551, ISSN 0928-4931
Editore: Elsevier BV
DOI: 10.1016/j.msec.2016.10.041

Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

Autori: Barbora Svitkova, Vlasta Zavisova, Veronika Nemethova, Martina Koneracka, Miroslava Kretova, Filip Razga, Monika Ursinyova and Alena Gabelova
Pubblicato in: Beilstein Journal of Nanotechnology, Numero 12, 2021, ISSN 2190-4286
Editore: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bjnano.12.22

Genome-wide DNA methylome and transcriptome changes induced by inorganic nanoparticles in human kidney cells after chronic exposure

Autori: Andrea Soltysova; Patricia Begerova; Kristina Jakic; Katarina Kozics; Monika Sramkova; Eckart Meese; Bozena Smolkova; Alena Gabelova
Pubblicato in: Cell Biology and Toxicology, Numero 17, 2022, ISSN 0742-2091
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10565-021-09680-3

Overexpression of TNFα induces senescence, autophagy and mitochondrial dysfunctions in melanoma cells.

Autori: Silvia Tyciakova; Valeria Valova; Valeria Valova; Barbora Svitkova; Miroslava Matuskova
Pubblicato in: BMC Cancer, Numero 6, 2021, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-021-08237-1

Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives

Autori: Verona Buocikova, Ivan Rios-Mondragon, Eleftherios Pilalis, Aristotelis Chatziioannou, Svetlana Miklikova, Michal Mego, Karlis Pajuste, Martins Rucins, Naouale El Yamani, Eleonora Marta Longhin, Arkadij Sobolev, Muriel Freixanet, Victor Puntes, Aiva Plotniece, Maria Dusinska, Mihaela Roxana Cimpan, Alena Gabelova, Bozena Smolkova
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3622, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123622

Nutraceuticals as Supportive Therapeutic Agents in Diabetes and Pancreatic Ductal Adenocarcinoma: A Systematic Review

Autori: Iveta Mikolaskova; Tatjana Crnogorac-Jurcevic; Bozena Smolkova; Luba Hunakova
Pubblicato in: Biology, Numero 12(2), 2023, ISSN 2079-7737
Editore: MDPI
DOI: 10.3390/biology12020158

Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review

Autori: Yvonne Kohl, Elise Rundén-Pran, Espen Mariussen, Michelle Hesler, Naouale El Yamani, Eleonora Marta Longhin, Maria Dusinska
Pubblicato in: Nanomaterials, Numero 10/10, 2020, Pagina/e 1911, ISSN 2079-4991
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nano10101911

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening.

Autori: Yvonne Kohl; Margit Biehl; Sarah Spring; Michelle Hesler; Vladimir Ogourtsov; Miomir Todorovic; Joshua Owen; Elisabeth Elje; Elisabeth Elje; Kristina Kopecka; Oscar H. Moriones; Oscar H. Moriones; Neus G. Bastús; Peter Šimon; Tibor Dubaj; Elise Rundén-Pran; Víctor F. Puntes; Víctor F. Puntes; Nicola William; Hagen von Briesen; Sylvia Wagner; Nikil Kapur; Espen Mariussen; Andrew Nelson; Alena
Pubblicato in: Small, Numero 17/15, 2021, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202006012

Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival

Autori: Maria Urbanova; Marina Cihova; Verona Buocikova; Jan Slopovsky; Peter Dubovan; Daniel Pindak; Miroslav Tomas; Laura García-Bermejo; Mercedes Rodríguez-Garrote; Julie Earl; Yvonne Kohl; Agapi Kataki; Maria Dusinska; Bruno Sainz Jr.; Bozena Smolkova; Alena Gabelova
Pubblicato in: Biomedicine & Pharmacotherapy, Numero 165, 2023, ISSN 0753-3322
Editore: Elsevier Masson
DOI: 10.1016/j.biopha.2023.115179

Epigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance?

Autori: Sona Ciernikova, Julie Earl, María Laura García Bermejo, Viola Stevurkova, Alfredo Carrato, Bozena Smolkova
Pubblicato in: International Journal of Molecular Sciences, Numero 21/11, 2020, Pagina/e 4091, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21114091

Somatic Mutation Profiling in the Liquid Biopsy and Clinical Analysis of Hereditary and Familial Pancreatic Cancer Cases Reveals KRAS Negativity and a Longer Overall Survival.

Autori: Julie Earl; Emma Barreto; María E. Castillo; Raquel Fuentes; Mercedes Rodríguez-Garrote; Reyes Ferreiro; Pablo Reguera; Gloria Muñoz; David García-Seisdedos; Jorge Villalón López; Bruno Sainz; Núria Malats; Alfredo Carrato
Pubblicato in: Cancers, Numero 13(7), 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071612

Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future Perspective

Autori: Vassilis G. Giannakoulis; Peter Dubovan; Eleni Papoutsi; Agapi Kataki; John Koskinas
Pubblicato in: Cancers, Numero 13(18), 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13184732

Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells

Autori: Michal Selc, Filip Razga, Veronika Nemethova, Petra Mazancova, Monika Ursinyova, Marta Novotova, Kristina Kopecka, Alena Gabelova, Andrea Babelova
Pubblicato in: RSC Advances, Numero 10/40, 2020, Pagina/e 23916-23929, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/d0ra03133j

Monographic books (1)

Genetic and Epigenetic Regulations of Tumor Progression and Metastasis

Autori: Bozena Smolkova; Julie Earl; Agapi Kataki
Pubblicato in: 2023, ISBN 978-3-0365-7185-0
Editore: MDPI
DOI: 10.3390/books978-3-0365-7184-3