Multidisciplinary Institute of Ageing - Portugal

Project Information

MIA-Portugal

Grant agreement ID: 857524

DOI

10.3030/857524

EC signature date 8 July 2019

Start date 1 January 2020

End date 31 December 2027

Funded under

• Teaming of excellent research institutions and low performing RDI regions

Total cost

€ 15 043 051,25

EU contribution

€ 15 000 000,00

Coordinated by

COMISSAO DE COORDENACAO E DESENVOLVIMENTO REGIONAL DO CENTRO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (14)

Events - M36

Report of scientific, translational, innovation and societal events (M36).

Elaboration and approval (by UC Rector) of internal regulations and bylaws

Elaboration and approval (by UC Rector) of internal regulations and bylaws.

Initial teams in place: Installation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board

Initial teams in place; Instalation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board.

MIA-Portugal research groups in place (8 in total)
Report on web site development and performance
Report on translational / clinics research for MIA- Portugal

Report on translational clinics research for MIAPortugal

MIA-Portugal Communication, Exploitation and Dissemination Plan, and Dissemination Booklet

MIAPortugal Communication Exploitation and Dissemination Plan and Dissemination Booklet

Subscription of internal regulations by the ERA Chair team
Events - M48

Report of scientific, translational, innovation and societal events (M48).

Events - M12

Report of scientific, translational, innovation and societal events (M12).

Report on Common Advanced Teaching Synergies with Teaming Partners
MIA-Portugal management team in place

MIAPortugal management team in place

Events - M24

Report of scientific translational innovation and societal events M24

Recruitment of 7 MIA-Portugal research groups (excluding the ERA Chair)

Recruitment of 7 MIAPortugal research groups excluding the ERA Chair

Websites, patent fillings, videos etc. (2)

Recruitment of MIA-Portugal Scientific Director

Recruitment of MIAPortugal Scientific Director

MIA-Portugal flyer

Publications

Peer reviewed articles (46)

Lymphatic-immune interactions in the musculoskeletal system

Author(s): Hanyu Liu, Lu Liu, Yuheng Zhang, Qi Tian, Zhangfan Ding, Junyu Chen, Anjali P. Kusumbe
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1578847

Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons

Author(s): Ivan L. Salazar, Michele Curcio, Miranda Mele, Rossela Vetrone, Simone Frisari, Rui O. Costa, Margarida V. Caldeira, Darci J Trader, Carlos B. Duarte
Published in: Apoptosis, 2025, ISSN 1573-675X
Publisher: Springer Netherlands
DOI: 10.1101/2024.05.15.594129

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

Author(s): Marisa Ferreira-Marques, Sara Carmo-Silva, Joana Pereira, Mariana Botelho, Clévio Nóbrega, Carlos López‐Otín, Luís Pereira de Almeida, Célia A. Aveleira, Cláudia Cavadas
Published in: GeroScience, 2025, ISSN 2509-2723
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11357-025-01574-0

Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics

Author(s): Satomi Miwa, Edward P. Fielder, Abbas Ishaq, Evon Low, Joseph A. Laws, Aisha Calista, Jemma Castle, Thomas von Zglinicki
Published in: Aging Biology, Issue 1, 2024, Page(s) 20240022, ISSN 2994-2578
Publisher: Aging Biology LLC
DOI: 10.59368/agingbio.20240022

Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy

Author(s): Gonçalo Ferreira, Pedro Vieira, André Alves, Sara Nunes, Inês Preguiça, Tânia Martins-Marques, Tânia Ribeiro, Henrique Girão, Artur Figueirinha, Lígia Salgueiro, Manuela Pintado, Pedro Gomes, Sofia Viana, Flávio Reis
Published in: Nutrients, Issue 16, 2025, Page(s) 513, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16040513

Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(6) sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism

Author(s): Amorim R, Magalhães CC, Benfeito S, Cagide F, Tavares LC, Santos K, Sardão VA, Datta S, Cortopassi GA, Baldeiras I, Jones JG, Borges F, Oliveira PJ, Teixeira J.
Published in: Biochemical Pharmacology, 2023, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2023.115953

Guidelines for minimal information on cellular senescence experimentation in vivo

Author(s): Mikolaj Ogrodnik, Juan Carlos Acosta, Peter D. Adams, Fabrizio d’Adda di Fagagna, Darren J. Baker, Cleo L. Bishop, Tamir Chandra, Manuel Collado, Jesus Gil, Vassilis Gorgoulis, Florian Gruber, Eiji Hara, Pidder Jansen-Dürr, Diana Jurk, Sundeep Khosla, James L. Kirkland, Valery Krizhanovsky, Tohru Minamino, Laura J. Niedernhofer, João F. Passos, Nadja A.R. Ring, Heinz Redl, Paul D. Robbins, Fra
Published in: Cell, Issue 187, 2024, Page(s) 4150-4175, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.05.059

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Author(s): Tania Martins-Marques, Katja Witschas, Ilda Ribeiro, Mónica Zuzarte, Steve Catarino, Teresa Ribeiro-Rodrigues, Francisco Caramelo, Trond Aasen, Isabel Marques Carreira, Lino Goncalves, Luc Leybaert, Henrique Girao
Published in: Open Biology, Issue 13, 2024, ISSN 2046-2441
Publisher: Royal Society Publishing
DOI: 10.1098/rsob.230258

Role of lipids in interorganelle communication

Author(s): Neuza Domingues, Joana Pires, Ira Milosevic, Nuno Raimundo
Published in: Trends in Cell Biology, Issue 35, 2025, Page(s) 46-58, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2024.04.008

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator

Author(s): Bessa, C; Loureiro, JB; Barros, M; Isca, VMS; Sardao, VA; Oliveira, PJ; Bernardino, RL; Herman-de-Sousa, C; Costa, MA; Correia-de-Sa, P; Alves, MG; Rijo, P; Saraiva, L
Published in: International Journal of Molecular Sciences, 2023, ISSN 1661-6596
Publisher: MDPI
DOI: 10.3390/ijms24065710

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Author(s): João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira
Published in: Aging Cell, Issue 23, 2024, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.14270

Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile

Author(s): Santiago J, Silva JV, Santos MAS, Fardilha M.
Published in: Biomedicines, 2023, ISSN 2227-9059
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines11112923

In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma

Author(s): Jemma Castle, Gary Shaw, Dominic Weller, Edward Fielder, Teklu Egnuni, Mankaran Singh, Roderick Skinner, Thomas von Zglinicki, Steven C Clifford, Susan C Short, Satomi Miwa, Debbie Hicks
Published in: Neuro-Oncology Advances, Issue 6, 2024, ISSN 2632-2498
Publisher: Oxford University Press (OUP)
DOI: 10.1093/noajnl/vdae091

A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification

Author(s): Miguel M. Lopes, Jacques Paysan, José Rino, Sara M. Lopes, Luís Pereira de Almeida, Luísa Cortes, Rui Jorge Nobre
Published in: Gene Therapy, Issue 29, 2022, Page(s) 665-679, ISSN 0969-7128
Publisher: Nature Publishing Group
DOI: 10.1038/s41434-022-00372-z

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Author(s): Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S.
Published in: https://www.sciencedirect.com/science/article/pii/S0896627322001465, 2022, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.02.008

Skin senescence: mechanisms and impact on whole-body aging

Author(s): Ana Catarina Franco, Célia Aveleira, Cláudia Cavadas
Published in: Trends in Molecular Medicine, Issue 28, 2023, Page(s) 97-109, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2021.12.003

A Proteogenomic Pipeline for the Analysis of Protein Biosynthesis Errors in the Human Pathogen Candida albicans

Author(s): Inês Correia, Carla Oliveira, Andreia Reis, Ana Rita Guimarães, Susana Aveiro, Pedro Domingues, Ana Rita Bezerra, Rui Vitorino, Gabriela Moura, Manuel A.S. Santos
Published in: Molecular & Cellular Proteomics, Issue 23, 2024, Page(s) 100818, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2024.100818

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Author(s): Beatriz M, Rodrigues RJ, Vilaça R, Egas C, Pinheiro PS, Daley GQ, Schlaeger TM, Raimundo N, Rego AC, Lopes C.
Published in: Theranostics, 2023, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.81981

Senescent Dermal Fibroblasts Decrease Stemness in Basal Keratinocytes in a Bioengineered Model of Human Full-Thickness Skin

Author(s): Evon Low, Lucy A. Smith, Satomi Miwa, Edward Fielder, Stefan Przyborski, Thomas von Zglinicki
Published in: Journal of Investigative Dermatology, Issue 145, 2025, Page(s) 208-211.e8, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.07.004

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Author(s): Carolina Ferreira, Pedro Vieira, Helena Sá, João Malva, Miguel Castelo-Branco, Flávio Reis, Sofia Viana
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1360065

ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers

Author(s): Reinaldo B. Oriá, Raul S. Freitas, Cássia R. Roque, José Carlos R. Nascimento, Ana Paula Silva, João O. Malva, Richard L. Guerrant, Michael P. Vitek
Published in: Pharmaceutics, Issue 15, 2023, Page(s) 1086, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041086

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age

Author(s): David Villarroel-Campos, Elena R. Rhymes, Andrew P. Tosolini, Bilal Malik, Alessio Vagnoni, Giampietro Schiavo, James N. Sleigh
Published in: Neurobiology of Aging, Issue 153, 2025, Page(s) 1-9, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2025.05.002

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

Author(s): Tyler H. Ogunmowo, Christian Hoffmann, Chintan Patel, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Johanna Idel, Annie Ho, Sumana Raychaudhuri, Brady J. Maher, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe
Published in: Nature Neuroscience, 2025, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-025-02002-4

Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection

Author(s): Beatriz Cristovao, Lisa Rodrigues, Steve Catarino, Monica Abreu, Teresa Gonçalves, Neuza Domingues, Henrique Girao
Published in: Microbiology Spectrum, Issue 11, 2023, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.01238-23

Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism

Author(s): Adriana Marques‐Carvalho, Beatriz Silva, Francisco B. Pereira, Ha‐Neui Kim, Maria Almeida, Vilma A. Sardão
Published in: European Journal of Clinical Investigation, Issue 54, 2024, ISSN 0014-2972
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/eci.14195

miRNA-642a-3p protects β cells from glucolipotoxicity

Author(s): Sandra Sofia Pinhanços, João Teixeira de Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J.J. de Winter, Sofia Viana, Flávio Reis, Jorge Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferreira, Martin Gotthardt, John Jones, Hugo Fernandes
Published in: Molecular Therapy Nucleic Acids, Issue 36, 2025, Page(s) 102498, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2025.102498

Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases.

Author(s): Ira Milosevic; Ira Milosevic; Michael A. Cousin
Published in: reponame:Repositório Científico de Acesso Aberto de Portugal, Issue 1, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202111056

Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment

Author(s): Lu Liu, Yuheng Zhang, Hanyu Liu, Jian Yang, Qi Tian, Nareekarn Chueakula, Saravana Ramasamy, Navin Kumar Verma, Christine Cheung, Anjali P. Kusumbe
Published in: Cancer Research, Issue 85, 2025, Page(s) 2152-2164, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-4744

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential

Author(s): Rita Costa, Carolina Ferreira, André Alves, Sara Nunes, Flávio Reis, João Malva, Sofia Viana
Published in: Frontiers in Pharmacology, Issue 16, 2025, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2025.1541871

Modeling senescence in ARPE19 cells to investigate the role of small extracellular vesicles in age‐related macular degeneration

Author(s): Rosa Fernandes, Diana Correia, Beatriz Martins, João Malva, Henrique Girão
Published in: Acta Ophthalmologica, Issue 103, 2025, ISSN 1755-375X
Publisher: Wiley-Blackwell
DOI: 10.1111/aos.17344

Advanced biomaterial strategies for overcoming age-associated wound healing impairments

Author(s): Rodrigo Dores, Telma A. Rodrigues, Daniel Carvalho, Eva Batista, Myroslava Kozak, Cristina Blanco-Elices, Hugo Fernandes, Luis M. Bimbo
Published in: APL Bioengineering, Issue 9, 2025, ISSN 2473-2877
Publisher: AIP Publishing
DOI: 10.1063/5.0251889

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Author(s): Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Published in: Advanced Science, Issue 11, 2025, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202309211

1,8-Cineole reduces pulmonary vascular remodelling in pulmonary arterial hypertension by restoring intercellular communication and inhibiting angiogenesis

Author(s): Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Teresa Rodrigues, Júlia Barbeitos, Rui Caetano, Rui Baptista, Lígia Salgueiro, Henrique Girão
Published in: Phytomedicine, Issue 137, 2025, Page(s) 156334, ISSN 0944-7113
Publisher: Elsevier BV
DOI: 10.1016/j.phymed.2024.156334

Lack of peroxisomal catalase affects heat shock response in<i>Caenorhabditis elegans</i>

Author(s): Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko
Published in: Crossref, Issue 9, 2022, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.202201737

Ghrelin delays premature aging in <scp>Hutchinson‐Gilford</scp> progeria syndrome

Author(s): Marisa Ferreira‐Marques; André Carvalho; Ana Catarina Franco; Ana Leal; Mariana Botelho; Sara Carmo‐Silva; Rodolfo Águas; Luísa Cortes; Vasco Lucas; Ana Carolina Real; Carlos López‐Otín; Xavier Nissan; Luís Pereira de Almeida; Cláudia Cavadas; Célia A. Aveleira
Published in: Aging Cell, Issue 13, 2023, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13983

Oxidative stress and cell senescence as drivers of ageing: Chicken and egg

Author(s): Thomas von Zglinicki
Published in: Ageing Research Reviews, Issue 102, 2024, Page(s) 102558, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2024.102558

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Author(s): Neuza Domingues, Steve Catarino, Beatriz Cristóvão, Lisa Rodrigues, Filomena A Carvalho, Maria João Sarmento, Mónica Zuzarte, Jani Almeida, Teresa Ribeiro-Rodrigues, Ânia Correia-Rodrigues, Fábio Fernandes, Paulo Rodrigues-Santos, Trond Aasen, Nuno C Santos, Viktor I Korolchuk, Teresa Gonçalves, Ira Milosevic, Nuno Raimundo, Henrique Girão
Published in: The EMBO Journal, Issue 43, 2024, Page(s) 3627-3649, ISSN 1460-2075
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00177-3

Promoting advanced medical services in the framework of 3PM—a proof-of-concept by the “Centro” Region of Portugal

Author(s): Fernando J. Regateiro, Henriqueta Silva, Manuel C. Lemos, Gabriela Moura, Pedro Torres, André Dias Pereira, Luís Dias, Pedro L. Ferreira, Sara Amaral, Manuel A. S. Santos
Published in: EPMA Journal, Issue 15, 2024, Page(s) 135-148, ISSN 1878-5085
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s13167-024-00353-9

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Author(s): Rodrigo F. N. Ribeiro, Dina Pereira, Luis Pereira de Almeida, Maria Manuel C. Silva, Cláudia Cavadas
Published in: Aging Clinical and Experimental Research, Issue 34, 2022, Page(s) 2963-2976, ISSN 1720-8319
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s40520-022-02257-y

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.

Author(s): Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José A. Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; Fernanda Borges; Nuno Raimundo; Paulo J. Oliveira
Published in: Redox Biology, Vol 45, Iss , Pp 102037- (2021), Issue 18, 2021, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2021.102037

Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity

Author(s): José P. Castelão-Baptista, Sara A. Valente, Sara Canário, David Oppolzer, Ana Barros, Carlos Venâncio, Tânia Martins, Luís Antunes,Vilma A. Sardão, Eduardo Rosa, and Paulo J. Oliveira
Published in: Nutrients, 2023, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15040924

Age‐specific and compartment‐dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

Author(s): James N. Sleigh, Francesca Mattedi, Sandy Richter, Emily Annuario, Kristal Ng, I. Emilie Steinmark, Iveta Ivanova, István L. Darabán, Parth P. Joshi, Elena R. Rhymes, Shirwa Awale, Gokhan Yahioglu, Jacqueline C. Mitchell, Klaus Suhling, Giampietro Schiavo, Alessio Vagnoni
Published in: Aging Cell, Issue 23, 2024, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.14250

Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters

Author(s): Lucia Barazzuol, Tetiana Tykhonenko, Tia L. Griffiths, Alessio Vagnoni, Marisa Brini, Tito Calì
Published in: Cell Death &amp; Disease, Issue 16, 2025, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-025-07511-5

Impact of coffee intake on human aging: Epidemiology and cellular mechanisms

Author(s): Cátia R. Lopes, Rodrigo A. Cunha
Published in: Ageing Research Reviews, Issue 102, 2024, Page(s) 102581, ISSN 1568-1637
Publisher: Elsevier BV
DOI: 10.1016/j.arr.2024.102581

Impact of Coffee Intake on Measures of Wellbeing in Mice

Author(s): Nuno J. Machado, Ana Paula Ardais, Ana Nunes, Eszter C. Szabó, Vasco Silveirinha, Henrique B. Silva, Manuella P. Kaster, Rodrigo A. Cunha
Published in: Nutrients, Issue 16, 2025, Page(s) 2920, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16172920

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype

Author(s): Inés Muela-Zarzuela, Juan Miguel Suarez-Rivero, Andrea Gallardo-Orihuela, Chun Wang, Kumi Izawa, Marta de Gregorio-Procopio, Isabelle Couillin, Bernhard Ryffel, Jiro Kitaura, Alberto Sanz, Thomas von Zglinicki, Gabriel Mbalaviele, Mario D. Cordero
Published in: Inflammation Research, Issue 73, 2024, Page(s) 1253-1266, ISSN 1023-3830
Publisher: Birkhauser Verlag
DOI: 10.1007/s00011-024-01892-7

Other (17)

Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment

Author(s): Tyler Ogunmowo, Christian Hoffmann, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Annie Ho, Sumana Raychaudhuri, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe
Published in: 2023
Publisher: bioRxiv
DOI: 10.1101/2023.08.22.554276

Cellular senescence: from mechanisms to current biomarkers and senotherapies

Author(s): Vasco Lucas, Cláudia Cavadas and Célia Alexandra Aveleira
Published in: 2023
Publisher: American Society for Pharmacology and Experimental Therapy
DOI: 10.1124/pharmrev.122.000622

Primary cilia shape hallmarks of health and aging

Author(s): Silva, DF; Cavadas, C
Published in: 2023
Publisher: Elsevier
DOI: 10.1016/j.molmed.2023.04.001

Modulation of signaling pathways by DJ-1: An updated overview

Author(s): Neves, M; Graos, M; Anjo, SI; Manadas, B
Published in: 2022
Publisher: Elsevier
DOI: 10.1016/j.redox.2022.102283

The impact of insomnia on frailty and the hallmarks of aging

Author(s): Catarina Carvalhas-Almeida, Cláudia Cavadas & Ana Rita Álvaro
Published in: Aging Clinical and Experimental Research, 2023, ISSN 1594-0667
Publisher: Springer Verlag
DOI: 10.1007/s40520-022-02310-w

How good is the evidence that cellular senescence causes skin ageing?

Author(s): Low, E; Alimohammadiha, G; Smith, LA; Costello, LF; Przyborski, SA; Von Zglinicki, T; Miwa, S
Published in: 2021
Publisher: Elsevier Ireland
DOI: 10.1016/j.arr.2021.101456

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

Author(s): Deus CM, Teixeira J, Raimundo N, Tucci P, Borges F, Saso L, Oliveira PJ
Published in: Eur Journal of Clinical Investigation, 2022
Publisher: Book in Press
DOI: 10.1111/eci.13820

Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics

Author(s): Pinho, SA; Anjo, SI; Cunha-Oliveira, T
Published in: Antioxidants, 2023
Publisher: MDPI
DOI: 10.3390/antiox12051072

Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease

Author(s): Magaña, JC; Deus, CM; Giné-Garriga, M; Montané, J; Pereira, SP
Published in: 2022
Publisher: MDPI
DOI: 10.3390/biomedicines10123228

Mitochondrial dysfunction in cell senescence and aging

Author(s): Miwa, S; Kashyap, S; Chini, E; von Zglinicki, T
Published in: 2022
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci158447

The role of microRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging

Author(s): Stephany Francisco, Vera Martinho, Margarida Ferreira, Andreia reis, Gabriela Moura, Ana Raquel Soares and Manuel A. S. Santos
Published in: Int. J. Mol.Sci, Issue PMID: 35328652 PMCID: PMC8955204, 2022
Publisher: Int. J. Mol.Sci
DOI: 10.3390/ijms23063232

Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling

Author(s): Neuza Domingues, Alessia Calcagni’, Joana Pires, Sofia Roque Freire, Niculin Joachim Herz, Tuong Huynh, Katarzyna Wieciorek, Maria João Moreno, Tiago Fleming Outeiro, Henrique Girão, Ira Milosevic, Andrea Ballabio, Nuno Raimundo
Published in: 2024
Publisher: bioRxiv
DOI: 10.1101/2024.05.31.596474

Nuclear aging in polyglutamine-induced neurodegeneration

Author(s): Dina Pereira, Janete Cunha-Santos, Ana Vasconcelos-Ferreira, Joana Duarte-Neves, Isabel Onofre, Vítor Carmona, Célia A Aveleira, Sara M Lopes, Diana D Lobo, Inês M Martins, Nélio Gonçalves, Cláudia Cavadas, Luís Pereira de Almeida
Published in: 2023
Publisher: BioRxiv
DOI: 10.1101/2023.06.09.544056

The Impact of Moderate-to-High-Intensity Exercise Protocols on Glycated Hemoglobin Levels in Type 2 Diabetes Patients

Author(s): Ana Pedrosa,Guilherme Furtado, Marcelo Paes de Barros, André Luís Lacerda Bachi, José Pedro Ferreira,Vilma A. Sardão,Luís Rama and Ana Teixeira
Published in: 2023
Publisher: MDPI
DOI: 10.3390/diabetology4010002

From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria

Author(s): Ricardo Amorim, Carina C. Magalhães, Fernanda Borges, Paulo J. Oliveira, andJosé Teixeira
Published in: 2023
Publisher: Biology (Basel)
DOI: 10.3390/biology12040595

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

Author(s): Almeida SFF, Santos L, Sampaio-Ribeiro G, Ferreira HRS, Lima N, Caetano R, Abreu M, Zuzarte M, Ribeiro AS, Paiva A, Martins-Marques T, Teixeira P, Almeida R, Casanova JM, Girão H, Abrunhosa AJ, Gomes CM.
Published in: 2023
Publisher: BioMed Central Ltd
DOI: 10.1186/s13046-023-02886-9

Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity Substances

Author(s): Satomi Miwa, Olena Kucheryavenko, Kristin Herrmann, Christopher Saunter, Adelaide Raimundo, David Weinkove, Lars Niemann, Thomas von Zglinicki
Published in: 2025
Publisher: bioRxiv
DOI: 10.1101/2025.01.30.635304

Book chapters (3)

Exocytotic SNARE complex assembly, disassembly, and regulation

Author(s): Ira Milosevic, Jefferson D Knight
Published in: Exocytosis: From Molecules to Cells, 2025, Page(s) 3-1-3-32
Publisher: IOP Publishing
DOI: 10.1088/978-0-7503-3771-7ch3

Disrupted cellular quality control mechanisms in aging

Author(s): Cristina Carvalho; Joana F. Pires; Paula I. Moreira; Nuno Raimundo
Published in: Crossref, Issue 5, 2022
Publisher: Elsevier
DOI: 10.1016/b978-0-12-823761-8.00016-1

Understanding Mitochondrial and Lysosomal Dynamics by Fluorescent Microscopy

Author(s): Pedro A. Dionísio, Vilma A. Sardão, Nuno Raimundo
Published in: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2025, Page(s) 211-221
Publisher: Springer US
DOI: 10.1007/978-1-0716-4264-1_11

Non-peer reviewed articles (1)

The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism

Author(s): Adriana Marques-Carvalho, Beatriz Silva, Francisco B. Pereira, Ha-Neui Kim, Maria Almeida, Vilma A. Sardão
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2023.03.30.534893