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Multidisciplinary Institute of Ageing - Portugal

Deliverables

Events - M36

Report of scientific, translational, innovation and societal events (M36).

Elaboration and approval (by UC Rector) of internal regulations and bylaws

Elaboration and approval (by UC Rector) of internal regulations and bylaws.

Initial teams in place: Installation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board

Initial teams in place; Instalation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board.

MIA-Portugal research groups in place (8 in total)
Report on web site development and performance
Report on translational / clinics research for MIA- Portugal

Report on translational clinics research for MIAPortugal

MIA-Portugal Communication, Exploitation and Dissemination Plan, and Dissemination Booklet

MIAPortugal Communication Exploitation and Dissemination Plan and Dissemination Booklet

Subscription of internal regulations by the ERA Chair team
Events - M48

Report of scientific, translational, innovation and societal events (M48).

Events - M12

Report of scientific, translational, innovation and societal events (M12).

Report on Common Advanced Teaching Synergies with Teaming Partners
MIA-Portugal management team in place

MIAPortugal management team in place

Events - M24

Report of scientific translational innovation and societal events M24

Recruitment of 7 MIA-Portugal research groups (excluding the ERA Chair)

Recruitment of 7 MIAPortugal research groups excluding the ERA Chair

Publications

Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(6) sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism

Author(s): Amorim R, Magalhães CC, Benfeito S, Cagide F, Tavares LC, Santos K, Sardão VA, Datta S, Cortopassi GA, Baldeiras I, Jones JG, Borges F, Oliveira PJ, Teixeira J.
Published in: Biochemical Pharmacology, 2023, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2023.115953

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator

Author(s): Bessa, C; Loureiro, JB; Barros, M; Isca, VMS; Sardao, VA; Oliveira, PJ; Bernardino, RL; Herman-de-Sousa, C; Costa, MA; Correia-de-Sa, P; Alves, MG; Rijo, P; Saraiva, L
Published in: International Journal of Molecular Sciences, 2023, ISSN 1661-6596
Publisher: MDPI
DOI: 10.3390/ijms24065710

Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile

Author(s): Santiago J, Silva JV, Santos MAS, Fardilha M.
Published in: Biomedicines, 2023, ISSN 2227-9059
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines11112923

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Author(s): Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S.
Published in: https://www.sciencedirect.com/science/article/pii/S0896627322001465, 2022, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.02.008

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Author(s): Beatriz M, Rodrigues RJ, Vilaça R, Egas C, Pinheiro PS, Daley GQ, Schlaeger TM, Raimundo N, Rego AC, Lopes C.
Published in: Theranostics, 2023, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.81981

Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases.

Author(s): Ira Milosevic; Ira Milosevic; Michael A. Cousin
Published in: reponame:Repositório Científico de Acesso Aberto de Portugal, Issue 1, 2021, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202111056

Lack of peroxisomal catalase affects heat shock response in<i>Caenorhabditis elegans</i>

Author(s): Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko
Published in: Crossref, Issue 9, 2022, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.202201737

Ghrelin delays premature aging in <scp>Hutchinson‐Gilford</scp> progeria syndrome

Author(s): Marisa Ferreira‐Marques; André Carvalho; Ana Catarina Franco; Ana Leal; Mariana Botelho; Sara Carmo‐Silva; Rodolfo Águas; Luísa Cortes; Vasco Lucas; Ana Carolina Real; Carlos López‐Otín; Xavier Nissan; Luís Pereira de Almeida; Cláudia Cavadas; Célia A. Aveleira
Published in: Aging Cell, Issue 13, 2023, ISSN 1474-9718
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acel.13983

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.

Author(s): Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José A. Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; Fernanda Borges; Nuno Raimundo; Paulo J. Oliveira
Published in: Redox Biology, Vol 45, Iss , Pp 102037- (2021), Issue 18, 2021, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2021.102037

Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity

Author(s): José P. Castelão-Baptista, Sara A. Valente, Sara Canário, David Oppolzer, Ana Barros, Carlos Venâncio, Tânia Martins, Luís Antunes,Vilma A. Sardão, Eduardo Rosa, and Paulo J. Oliveira
Published in: Nutrients, 2023, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15040924

Exocytotic SNARE complex assembly, disassembly, and regulation

Author(s): Milosevic, I., & Knight, J. D.
Published in: 2022
Publisher: IOP Science
DOI: 10.1088/978-0-7503-3771-7ch3

Disrupted cellular quality control mechanisms in aging

Author(s): Cristina Carvalho; Joana F. Pires; Paula I. Moreira; Nuno Raimundo
Published in: Crossref, Issue 5, 2022
Publisher: Elsevier
DOI: 10.1016/b978-0-12-823761-8.00016-1

Cellular senescence: from mechanisms to current biomarkers and senotherapies

Author(s): Vasco Lucas, Cláudia Cavadas and Célia Alexandra Aveleira
Published in: 2023
Publisher: American Society for Pharmacology and Experimental Therapy
DOI: 10.1124/pharmrev.122.000622

Primary cilia shape hallmarks of health and aging

Author(s): Silva, DF; Cavadas, C
Published in: 2023
Publisher: Elsevier
DOI: 10.1016/j.molmed.2023.04.001

Modulation of signaling pathways by DJ-1: An updated overview

Author(s): Neves, M; Graos, M; Anjo, SI; Manadas, B
Published in: 2022
Publisher: Elsevier
DOI: 10.1016/j.redox.2022.102283

The impact of insomnia on frailty and the hallmarks of aging

Author(s): Catarina Carvalhas-Almeida, Cláudia Cavadas & Ana Rita Álvaro
Published in: Aging Clinical and Experimental Research, 2023, ISSN 1594-0667
Publisher: Springer Verlag
DOI: 10.1007/s40520-022-02310-w

How good is the evidence that cellular senescence causes skin ageing?

Author(s): Low, E; Alimohammadiha, G; Smith, LA; Costello, LF; Przyborski, SA; Von Zglinicki, T; Miwa, S
Published in: 2021
Publisher: Elsevier Ireland
DOI: 10.1016/j.arr.2021.101456

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

Author(s): Deus CM, Teixeira J, Raimundo N, Tucci P, Borges F, Saso L, Oliveira PJ
Published in: Eur Journal of Clinical Investigation, 2022
Publisher: Book in Press
DOI: 10.1111/eci.13820

Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics

Author(s): Pinho, SA; Anjo, SI; Cunha-Oliveira, T
Published in: Antioxidants, 2023
Publisher: MDPI
DOI: 10.3390/antiox12051072

Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease

Author(s): Magaña, JC; Deus, CM; Giné-Garriga, M; Montané, J; Pereira, SP
Published in: 2022
Publisher: MDPI
DOI: 10.3390/biomedicines10123228

Mitochondrial dysfunction in cell senescence and aging

Author(s): Miwa, S; Kashyap, S; Chini, E; von Zglinicki, T
Published in: 2022
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci158447

The role of microRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging

Author(s): Stephany Francisco, Vera Martinho, Margarida Ferreira, Andreia reis, Gabriela Moura, Ana Raquel Soares and Manuel A. S. Santos
Published in: Int. J. Mol.Sci, Issue PMID: 35328652 PMCID: PMC8955204, 2022
Publisher: Int. J. Mol.Sci
DOI: 10.3390/ijms23063232

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Author(s): Ribeiro, RFN; Pereira, D; De Almeida, LP; Silva, MMC; Cavadas, C
Published in: 2022
Publisher: Springer Science and Business Media Deutschanld GMBH
DOI: 10.1007/s40520-022-02257-y

From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria

Author(s): Ricardo Amorim, Carina C. Magalhães, Fernanda Borges, Paulo J. Oliveira, andJosé Teixeira
Published in: 2023
Publisher: Biology (Basel)
DOI: 10.3390/biology12040595

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

Author(s): Almeida SFF, Santos L, Sampaio-Ribeiro G, Ferreira HRS, Lima N, Caetano R, Abreu M, Zuzarte M, Ribeiro AS, Paiva A, Martins-Marques T, Teixeira P, Almeida R, Casanova JM, Girão H, Abrunhosa AJ, Gomes CM.
Published in: 2023
Publisher: BioMed Central Ltd
DOI: 10.1186/s13046-023-02886-9

The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism

Author(s): Adriana Marques-Carvalho, Beatriz Silva, Francisco B. Pereira, Ha-Neui Kim, Maria Almeida, Vilma A. Sardão
Published in: bioRxiv, 2023, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2023.03.30.534893

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