Multidisciplinary Institute of Ageing - Portugal | MIA-Portugal | Progetto | Risultati | H2020 | CORDIS

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Events - M36

Report of scientific, translational, innovation and societal events (M36).

Elaboration and approval (by UC Rector) of internal regulations and bylaws

Elaboration and approval (by UC Rector) of internal regulations and bylaws.

Initial teams in place: Installation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board

Initial teams in place; Instalation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board.

MIA-Portugal research groups in place (8 in total)
Report on web site development and performance
Report on translational / clinics research for MIA- Portugal

Report on translational clinics research for MIAPortugal

MIA-Portugal Communication, Exploitation and Dissemination Plan, and Dissemination Booklet

MIAPortugal Communication Exploitation and Dissemination Plan and Dissemination Booklet

Subscription of internal regulations by the ERA Chair team
Events - M48

Report of scientific, translational, innovation and societal events (M48).

Events - M12

Report of scientific, translational, innovation and societal events (M12).

Report on Common Advanced Teaching Synergies with Teaming Partners
MIA-Portugal management team in place

MIAPortugal management team in place

Events - M24

Report of scientific translational innovation and societal events M24

Recruitment of 7 MIA-Portugal research groups (excluding the ERA Chair)

Recruitment of 7 MIAPortugal research groups excluding the ERA Chair

Recruitment of MIA-Portugal Scientific Director

Recruitment of MIAPortugal Scientific Director

MIA-Portugal flyer

Pubblicazioni

Lymphatic-immune interactions in the musculoskeletal system

Autori: Hanyu Liu, Lu Liu, Yuheng Zhang, Qi Tian, Zhangfan Ding, Junyu Chen, Anjali P. Kusumbe
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1578847

Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons

Autori: Ivan L. Salazar, Michele Curcio, Miranda Mele, Rossela Vetrone, Simone Frisari, Rui O. Costa, Margarida V. Caldeira, Darci J Trader, Carlos B. Duarte
Pubblicato in: Apoptosis, 2025, ISSN 1573-675X
Editore: Springer Netherlands
DOI: 10.1101/2024.05.15.594129

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

Autori: Marisa Ferreira-Marques, Sara Carmo-Silva, Joana Pereira, Mariana Botelho, Clévio Nóbrega, Carlos López‐Otín, Luís Pereira de Almeida, Célia A. Aveleira, Cláudia Cavadas
Pubblicato in: GeroScience, 2025, ISSN 2509-2723
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11357-025-01574-0

Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics

Autori: Satomi Miwa, Edward P. Fielder, Abbas Ishaq, Evon Low, Joseph A. Laws, Aisha Calista, Jemma Castle, Thomas von Zglinicki
Pubblicato in: Aging Biology, Numero 1, 2024, Pagina/e 20240022, ISSN 2994-2578
Editore: Aging Biology LLC
DOI: 10.59368/agingbio.20240022

Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy

Autori: Gonçalo Ferreira, Pedro Vieira, André Alves, Sara Nunes, Inês Preguiça, Tânia Martins-Marques, Tânia Ribeiro, Henrique Girão, Artur Figueirinha, Lígia Salgueiro, Manuela Pintado, Pedro Gomes, Sofia Viana, Flávio Reis
Pubblicato in: Nutrients, Numero 16, 2025, Pagina/e 513, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16040513

Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(6) sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism

Autori: Amorim R, Magalhães CC, Benfeito S, Cagide F, Tavares LC, Santos K, Sardão VA, Datta S, Cortopassi GA, Baldeiras I, Jones JG, Borges F, Oliveira PJ, Teixeira J.
Pubblicato in: Biochemical Pharmacology, 2023, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2023.115953

Guidelines for minimal information on cellular senescence experimentation in vivo

Autori: Mikolaj Ogrodnik, Juan Carlos Acosta, Peter D. Adams, Fabrizio d’Adda di Fagagna, Darren J. Baker, Cleo L. Bishop, Tamir Chandra, Manuel Collado, Jesus Gil, Vassilis Gorgoulis, Florian Gruber, Eiji Hara, Pidder Jansen-Dürr, Diana Jurk, Sundeep Khosla, James L. Kirkland, Valery Krizhanovsky, Tohru Minamino, Laura J. Niedernhofer, João F. Passos, Nadja A.R. Ring, Heinz Redl, Paul D. Robbins, Fra
Pubblicato in: Cell, Numero 187, 2024, Pagina/e 4150-4175, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2024.05.059

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Autori: Tania Martins-Marques, Katja Witschas, Ilda Ribeiro, Mónica Zuzarte, Steve Catarino, Teresa Ribeiro-Rodrigues, Francisco Caramelo, Trond Aasen, Isabel Marques Carreira, Lino Goncalves, Luc Leybaert, Henrique Girao
Pubblicato in: Open Biology, Numero 13, 2024, ISSN 2046-2441
Editore: Royal Society Publishing
DOI: 10.1098/rsob.230258

Role of lipids in interorganelle communication

Autori: Neuza Domingues, Joana Pires, Ira Milosevic, Nuno Raimundo
Pubblicato in: Trends in Cell Biology, Numero 35, 2025, Pagina/e 46-58, ISSN 0962-8924
Editore: Elsevier BV
DOI: 10.1016/j.tcb.2024.04.008

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator

Autori: Bessa, C; Loureiro, JB; Barros, M; Isca, VMS; Sardao, VA; Oliveira, PJ; Bernardino, RL; Herman-de-Sousa, C; Costa, MA; Correia-de-Sa, P; Alves, MG; Rijo, P; Saraiva, L
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1661-6596
Editore: MDPI
DOI: 10.3390/ijms24065710

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Autori: João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira
Pubblicato in: Aging Cell, Numero 23, 2024, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.14270

Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile

Autori: Santiago J, Silva JV, Santos MAS, Fardilha M.
Pubblicato in: Biomedicines, 2023, ISSN 2227-9059
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines11112923

In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma

Autori: Jemma Castle, Gary Shaw, Dominic Weller, Edward Fielder, Teklu Egnuni, Mankaran Singh, Roderick Skinner, Thomas von Zglinicki, Steven C Clifford, Susan C Short, Satomi Miwa, Debbie Hicks
Pubblicato in: Neuro-Oncology Advances, Numero 6, 2024, ISSN 2632-2498
Editore: Oxford University Press (OUP)
DOI: 10.1093/noajnl/vdae091

A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification

Autori: Miguel M. Lopes, Jacques Paysan, José Rino, Sara M. Lopes, Luís Pereira de Almeida, Luísa Cortes, Rui Jorge Nobre
Pubblicato in: Gene Therapy, Numero 29, 2022, Pagina/e 665-679, ISSN 0969-7128
Editore: Nature Publishing Group
DOI: 10.1038/s41434-022-00372-z

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Autori: Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S.
Pubblicato in: https://www.sciencedirect.com/science/article/pii/S0896627322001465, 2022, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2022.02.008

Skin senescence: mechanisms and impact on whole-body aging

Autori: Ana Catarina Franco, Célia Aveleira, Cláudia Cavadas
Pubblicato in: Trends in Molecular Medicine, Numero 28, 2023, Pagina/e 97-109, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2021.12.003

A Proteogenomic Pipeline for the Analysis of Protein Biosynthesis Errors in the Human Pathogen Candida albicans

Autori: Inês Correia, Carla Oliveira, Andreia Reis, Ana Rita Guimarães, Susana Aveiro, Pedro Domingues, Ana Rita Bezerra, Rui Vitorino, Gabriela Moura, Manuel A.S. Santos
Pubblicato in: Molecular & Cellular Proteomics, Numero 23, 2024, Pagina/e 100818, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2024.100818

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Autori: Beatriz M, Rodrigues RJ, Vilaça R, Egas C, Pinheiro PS, Daley GQ, Schlaeger TM, Raimundo N, Rego AC, Lopes C.
Pubblicato in: Theranostics, 2023, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.81981

Senescent Dermal Fibroblasts Decrease Stemness in Basal Keratinocytes in a Bioengineered Model of Human Full-Thickness Skin

Autori: Evon Low, Lucy A. Smith, Satomi Miwa, Edward Fielder, Stefan Przyborski, Thomas von Zglinicki
Pubblicato in: Journal of Investigative Dermatology, Numero 145, 2025, Pagina/e 208-211.e8, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.07.004

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Autori: Carolina Ferreira, Pedro Vieira, Helena Sá, João Malva, Miguel Castelo-Branco, Flávio Reis, Sofia Viana
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1360065

ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers

Autori: Reinaldo B. Oriá, Raul S. Freitas, Cássia R. Roque, José Carlos R. Nascimento, Ana Paula Silva, João O. Malva, Richard L. Guerrant, Michael P. Vitek
Pubblicato in: Pharmaceutics, Numero 15, 2023, Pagina/e 1086, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041086

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age

Autori: David Villarroel-Campos, Elena R. Rhymes, Andrew P. Tosolini, Bilal Malik, Alessio Vagnoni, Giampietro Schiavo, James N. Sleigh
Pubblicato in: Neurobiology of Aging, Numero 153, 2025, Pagina/e 1-9, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2025.05.002

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

Autori: Tyler H. Ogunmowo, Christian Hoffmann, Chintan Patel, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Johanna Idel, Annie Ho, Sumana Raychaudhuri, Brady J. Maher, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe
Pubblicato in: Nature Neuroscience, 2025, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-025-02002-4

Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection

Autori: Beatriz Cristovao, Lisa Rodrigues, Steve Catarino, Monica Abreu, Teresa Gonçalves, Neuza Domingues, Henrique Girao
Pubblicato in: Microbiology Spectrum, Numero 11, 2023, ISSN 2165-0497
Editore: American Society for Microbiology
DOI: 10.1128/spectrum.01238-23

Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism

Autori: Adriana Marques‐Carvalho, Beatriz Silva, Francisco B. Pereira, Ha‐Neui Kim, Maria Almeida, Vilma A. Sardão
Pubblicato in: European Journal of Clinical Investigation, Numero 54, 2024, ISSN 0014-2972
Editore: Blackwell Publishing Inc.
DOI: 10.1111/eci.14195

miRNA-642a-3p protects β cells from glucolipotoxicity

Autori: Sandra Sofia Pinhanços, João Teixeira de Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J.J. de Winter, Sofia Viana, Flávio Reis, Jorge Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferreira, Martin Gotthardt, John Jones, Hugo Fernandes
Pubblicato in: Molecular Therapy Nucleic Acids, Numero 36, 2025, Pagina/e 102498, ISSN 2162-2531
Editore: Nature Publishing Group
DOI: 10.1016/j.omtn.2025.102498

Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases.

Autori: Ira Milosevic; Ira Milosevic; Michael A. Cousin
Pubblicato in: reponame:Repositório Científico de Acesso Aberto de Portugal, Numero 1, 2021, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202111056

Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment

Autori: Lu Liu, Yuheng Zhang, Hanyu Liu, Jian Yang, Qi Tian, Nareekarn Chueakula, Saravana Ramasamy, Navin Kumar Verma, Christine Cheung, Anjali P. Kusumbe
Pubblicato in: Cancer Research, Numero 85, 2025, Pagina/e 2152-2164, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-4744

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential

Autori: Rita Costa, Carolina Ferreira, André Alves, Sara Nunes, Flávio Reis, João Malva, Sofia Viana
Pubblicato in: Frontiers in Pharmacology, Numero 16, 2025, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2025.1541871

Modeling senescence in ARPE19 cells to investigate the role of small extracellular vesicles in age‐related macular degeneration

Autori: Rosa Fernandes, Diana Correia, Beatriz Martins, João Malva, Henrique Girão
Pubblicato in: Acta Ophthalmologica, Numero 103, 2025, ISSN 1755-375X
Editore: Wiley-Blackwell
DOI: 10.1111/aos.17344

Advanced biomaterial strategies for overcoming age-associated wound healing impairments

Autori: Rodrigo Dores, Telma A. Rodrigues, Daniel Carvalho, Eva Batista, Myroslava Kozak, Cristina Blanco-Elices, Hugo Fernandes, Luis M. Bimbo
Pubblicato in: APL Bioengineering, Numero 9, 2025, ISSN 2473-2877
Editore: AIP Publishing
DOI: 10.1063/5.0251889

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Autori: Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Pubblicato in: Advanced Science, Numero 11, 2025, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202309211

1,8-Cineole reduces pulmonary vascular remodelling in pulmonary arterial hypertension by restoring intercellular communication and inhibiting angiogenesis

Autori: Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Teresa Rodrigues, Júlia Barbeitos, Rui Caetano, Rui Baptista, Lígia Salgueiro, Henrique Girão
Pubblicato in: Phytomedicine, Numero 137, 2025, Pagina/e 156334, ISSN 0944-7113
Editore: Elsevier BV
DOI: 10.1016/j.phymed.2024.156334

Lack of peroxisomal catalase affects heat shock response in<i>Caenorhabditis elegans</i>

Autori: Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko
Pubblicato in: Crossref, Numero 9, 2022, ISSN 2575-1077
Editore: Life Science Alliance
DOI: 10.26508/lsa.202201737

Ghrelin delays premature aging in <scp>Hutchinson‐Gilford</scp> progeria syndrome

Autori: Marisa Ferreira‐Marques; André Carvalho; Ana Catarina Franco; Ana Leal; Mariana Botelho; Sara Carmo‐Silva; Rodolfo Águas; Luísa Cortes; Vasco Lucas; Ana Carolina Real; Carlos López‐Otín; Xavier Nissan; Luís Pereira de Almeida; Cláudia Cavadas; Célia A. Aveleira
Pubblicato in: Aging Cell, Numero 13, 2023, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.13983

Oxidative stress and cell senescence as drivers of ageing: Chicken and egg

Autori: Thomas von Zglinicki
Pubblicato in: Ageing Research Reviews, Numero 102, 2024, Pagina/e 102558, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2024.102558

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Autori: Neuza Domingues, Steve Catarino, Beatriz Cristóvão, Lisa Rodrigues, Filomena A Carvalho, Maria João Sarmento, Mónica Zuzarte, Jani Almeida, Teresa Ribeiro-Rodrigues, Ânia Correia-Rodrigues, Fábio Fernandes, Paulo Rodrigues-Santos, Trond Aasen, Nuno C Santos, Viktor I Korolchuk, Teresa Gonçalves, Ira Milosevic, Nuno Raimundo, Henrique Girão
Pubblicato in: The EMBO Journal, Numero 43, 2024, Pagina/e 3627-3649, ISSN 1460-2075
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00177-3

Promoting advanced medical services in the framework of 3PM—a proof-of-concept by the “Centro” Region of Portugal

Autori: Fernando J. Regateiro, Henriqueta Silva, Manuel C. Lemos, Gabriela Moura, Pedro Torres, André Dias Pereira, Luís Dias, Pedro L. Ferreira, Sara Amaral, Manuel A. S. Santos
Pubblicato in: EPMA Journal, Numero 15, 2024, Pagina/e 135-148, ISSN 1878-5085
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s13167-024-00353-9

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Autori: Rodrigo F. N. Ribeiro, Dina Pereira, Luis Pereira de Almeida, Maria Manuel C. Silva, Cláudia Cavadas
Pubblicato in: Aging Clinical and Experimental Research, Numero 34, 2022, Pagina/e 2963-2976, ISSN 1720-8319
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s40520-022-02257-y

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.

Autori: Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José A. Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; Fernanda Borges; Nuno Raimundo; Paulo J. Oliveira
Pubblicato in: Redox Biology, Vol 45, Iss , Pp 102037- (2021), Numero 18, 2021, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2021.102037

Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity

Autori: José P. Castelão-Baptista, Sara A. Valente, Sara Canário, David Oppolzer, Ana Barros, Carlos Venâncio, Tânia Martins, Luís Antunes,Vilma A. Sardão, Eduardo Rosa, and Paulo J. Oliveira
Pubblicato in: Nutrients, 2023, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15040924

Age‐specific and compartment‐dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

Autori: James N. Sleigh, Francesca Mattedi, Sandy Richter, Emily Annuario, Kristal Ng, I. Emilie Steinmark, Iveta Ivanova, István L. Darabán, Parth P. Joshi, Elena R. Rhymes, Shirwa Awale, Gokhan Yahioglu, Jacqueline C. Mitchell, Klaus Suhling, Giampietro Schiavo, Alessio Vagnoni
Pubblicato in: Aging Cell, Numero 23, 2024, ISSN 1474-9718
Editore: Blackwell Publishing Inc.
DOI: 10.1111/acel.14250

Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters

Autori: Lucia Barazzuol, Tetiana Tykhonenko, Tia L. Griffiths, Alessio Vagnoni, Marisa Brini, Tito Calì
Pubblicato in: Cell Death & Disease, Numero 16, 2025, ISSN 2041-4889
Editore: Nature Publishing Group
DOI: 10.1038/s41419-025-07511-5

Impact of coffee intake on human aging: Epidemiology and cellular mechanisms

Autori: Cátia R. Lopes, Rodrigo A. Cunha
Pubblicato in: Ageing Research Reviews, Numero 102, 2024, Pagina/e 102581, ISSN 1568-1637
Editore: Elsevier BV
DOI: 10.1016/j.arr.2024.102581

Impact of Coffee Intake on Measures of Wellbeing in Mice

Autori: Nuno J. Machado, Ana Paula Ardais, Ana Nunes, Eszter C. Szabó, Vasco Silveirinha, Henrique B. Silva, Manuella P. Kaster, Rodrigo A. Cunha
Pubblicato in: Nutrients, Numero 16, 2025, Pagina/e 2920, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16172920

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype

Autori: Inés Muela-Zarzuela, Juan Miguel Suarez-Rivero, Andrea Gallardo-Orihuela, Chun Wang, Kumi Izawa, Marta de Gregorio-Procopio, Isabelle Couillin, Bernhard Ryffel, Jiro Kitaura, Alberto Sanz, Thomas von Zglinicki, Gabriel Mbalaviele, Mario D. Cordero
Pubblicato in: Inflammation Research, Numero 73, 2024, Pagina/e 1253-1266, ISSN 1023-3830
Editore: Birkhauser Verlag
DOI: 10.1007/s00011-024-01892-7

Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment

Autori: Tyler Ogunmowo, Christian Hoffmann, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Annie Ho, Sumana Raychaudhuri, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe
Pubblicato in: 2023
Editore: bioRxiv
DOI: 10.1101/2023.08.22.554276

Cellular senescence: from mechanisms to current biomarkers and senotherapies

Autori: Vasco Lucas, Cláudia Cavadas and Célia Alexandra Aveleira
Pubblicato in: 2023
Editore: American Society for Pharmacology and Experimental Therapy
DOI: 10.1124/pharmrev.122.000622

Primary cilia shape hallmarks of health and aging

Autori: Silva, DF; Cavadas, C
Pubblicato in: 2023
Editore: Elsevier
DOI: 10.1016/j.molmed.2023.04.001

Modulation of signaling pathways by DJ-1: An updated overview

Autori: Neves, M; Graos, M; Anjo, SI; Manadas, B
Pubblicato in: 2022
Editore: Elsevier
DOI: 10.1016/j.redox.2022.102283

The impact of insomnia on frailty and the hallmarks of aging

Autori: Catarina Carvalhas-Almeida, Cláudia Cavadas & Ana Rita Álvaro
Pubblicato in: Aging Clinical and Experimental Research, 2023, ISSN 1594-0667
Editore: Springer Verlag
DOI: 10.1007/s40520-022-02310-w

How good is the evidence that cellular senescence causes skin ageing?

Autori: Low, E; Alimohammadiha, G; Smith, LA; Costello, LF; Przyborski, SA; Von Zglinicki, T; Miwa, S
Pubblicato in: 2021
Editore: Elsevier Ireland
DOI: 10.1016/j.arr.2021.101456

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

Autori: Deus CM, Teixeira J, Raimundo N, Tucci P, Borges F, Saso L, Oliveira PJ
Pubblicato in: Eur Journal of Clinical Investigation, 2022
Editore: Book in Press
DOI: 10.1111/eci.13820

Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics

Autori: Pinho, SA; Anjo, SI; Cunha-Oliveira, T
Pubblicato in: Antioxidants, 2023
Editore: MDPI
DOI: 10.3390/antiox12051072

Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease

Autori: Magaña, JC; Deus, CM; Giné-Garriga, M; Montané, J; Pereira, SP
Pubblicato in: 2022
Editore: MDPI
DOI: 10.3390/biomedicines10123228

Mitochondrial dysfunction in cell senescence and aging

Autori: Miwa, S; Kashyap, S; Chini, E; von Zglinicki, T
Pubblicato in: 2022
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci158447

The role of microRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging

Autori: Stephany Francisco, Vera Martinho, Margarida Ferreira, Andreia reis, Gabriela Moura, Ana Raquel Soares and Manuel A. S. Santos
Pubblicato in: Int. J. Mol.Sci, Numero PMID: 35328652 PMCID: PMC8955204, 2022
Editore: Int. J. Mol.Sci
DOI: 10.3390/ijms23063232

Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling

Autori: Neuza Domingues, Alessia Calcagni’, Joana Pires, Sofia Roque Freire, Niculin Joachim Herz, Tuong Huynh, Katarzyna Wieciorek, Maria João Moreno, Tiago Fleming Outeiro, Henrique Girão, Ira Milosevic, Andrea Ballabio, Nuno Raimundo
Pubblicato in: 2024
Editore: bioRxiv
DOI: 10.1101/2024.05.31.596474

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Editore: BioRxiv
DOI: 10.1101/2023.06.09.544056

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Editore: MDPI
DOI: 10.3390/diabetology4010002

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Pubblicato in: 2023
Editore: Biology (Basel)
DOI: 10.3390/biology12040595

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

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Editore: BioMed Central Ltd
DOI: 10.1186/s13046-023-02886-9

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DOI: 10.1101/2025.01.30.635304

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DOI: 10.1088/978-0-7503-3771-7ch3

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DOI: 10.1101/2023.03.30.534893

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