Multidisciplinary Institute of Ageing - Portugal | MIA-Portugal | Proyecto | Resultados | H2020 | CORDIS

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Events - M36

Report of scientific, translational, innovation and societal events (M36).

Elaboration and approval (by UC Rector) of internal regulations and bylaws

Elaboration and approval (by UC Rector) of internal regulations and bylaws.

Initial teams in place: Installation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board

Initial teams in place; Instalation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board.

MIA-Portugal research groups in place (8 in total)
Events - M60

Report of scientific, translational, innovation and societal events (M60).

Report on web site development and performance
Report on co-supervision of Master's and PhD students

Report on co-supervision of Master’s and PhD students

Presentation of PhD programs supported by MIA-Portugal
Report on translational / clinics research for MIA- Portugal

Report on translational clinics research for MIAPortugal

MIA-Portugal Communication, Exploitation and Dissemination Plan, and Dissemination Booklet

MIAPortugal Communication Exploitation and Dissemination Plan and Dissemination Booklet

Subscription of internal regulations by the ERA Chair team
Events - M48

Report of scientific, translational, innovation and societal events (M48).

Events - M12

Report of scientific, translational, innovation and societal events (M12).

Report on high impact media communications

Report on highimpact media communications

Report on Common Advanced Teaching Synergies with Teaming Partners
MIA-Portugal management team in place

MIAPortugal management team in place

Events - M24

Report of scientific translational innovation and societal events M24

Recruitment of 7 MIA-Portugal research groups (excluding the ERA Chair)

Recruitment of 7 MIAPortugal research groups excluding the ERA Chair

Recruitment of MIA-Portugal Scientific Director

Recruitment of MIAPortugal Scientific Director

MIA-Portugal flyer

Publicaciones

Lymphatic-immune interactions in the musculoskeletal system

Autores: Hanyu Liu, Lu Liu, Yuheng Zhang, Qi Tian, Zhangfan Ding, Junyu Chen, Anjali P. Kusumbe
Publicado en: Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1578847

Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons

Autores: Ivan L. Salazar, Michele Curcio, Miranda Mele, Rossela Vetrone, Simone Frisari, Rui O. Costa, Margarida V. Caldeira, Darci J Trader, Carlos B. Duarte
Publicado en: Apoptosis, 2025, ISSN 1573-675X
Editor: Springer Netherlands
DOI: 10.1101/2024.05.15.594129

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

Autores: Marisa Ferreira-Marques, Sara Carmo-Silva, Joana Pereira, Mariana Botelho, Clévio Nóbrega, Carlos López‐Otín, Luís Pereira de Almeida, Célia A. Aveleira, Cláudia Cavadas
Publicado en: GeroScience, 2025, ISSN 2509-2723
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s11357-025-01574-0

Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics

Autores: Satomi Miwa, Edward P. Fielder, Abbas Ishaq, Evon Low, Joseph A. Laws, Aisha Calista, Jemma Castle, Thomas von Zglinicki
Publicado en: Aging Biology, Edición 1, 2024, Página(s) 20240022, ISSN 2994-2578
Editor: Aging Biology LLC
DOI: 10.59368/agingbio.20240022

Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy

Autores: Gonçalo Ferreira, Pedro Vieira, André Alves, Sara Nunes, Inês Preguiça, Tânia Martins-Marques, Tânia Ribeiro, Henrique Girão, Artur Figueirinha, Lígia Salgueiro, Manuela Pintado, Pedro Gomes, Sofia Viana, Flávio Reis
Publicado en: Nutrients, Edición 16, 2025, Página(s) 513, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16040513

Guidelines for minimal information on cellular senescence experimentation in vivo

Autores: Mikolaj Ogrodnik, Juan Carlos Acosta, Peter D. Adams, Fabrizio d’Adda di Fagagna, Darren J. Baker, Cleo L. Bishop, Tamir Chandra, Manuel Collado, Jesus Gil, Vassilis Gorgoulis, Florian Gruber, Eiji Hara, Pidder Jansen-Dürr, Diana Jurk, Sundeep Khosla, James L. Kirkland, Valery Krizhanovsky, Tohru Minamino, Laura J. Niedernhofer, João F. Passos, Nadja A.R. Ring, Heinz Redl, Paul D. Robbins, Fra
Publicado en: Cell, Edición 187, 2024, Página(s) 4150-4175, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2024.05.059

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Autores: Tania Martins-Marques, Katja Witschas, Ilda Ribeiro, Mónica Zuzarte, Steve Catarino, Teresa Ribeiro-Rodrigues, Francisco Caramelo, Trond Aasen, Isabel Marques Carreira, Lino Goncalves, Luc Leybaert, Henrique Girao
Publicado en: Open Biology, Edición 13, 2024, ISSN 2046-2441
Editor: Royal Society Publishing
DOI: 10.1098/rsob.230258

Role of lipids in interorganelle communication

Autores: Neuza Domingues, Joana Pires, Ira Milosevic, Nuno Raimundo
Publicado en: Trends in Cell Biology, Edición 35, 2025, Página(s) 46-58, ISSN 0962-8924
Editor: Elsevier BV
DOI: 10.1016/j.tcb.2024.04.008

Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile

Autores: Santiago J, Silva JV, Santos MAS, Fardilha M.
Publicado en: Biomedicines, 2023, ISSN 2227-9059
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines11112923

In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma

Autores: Jemma Castle, Gary Shaw, Dominic Weller, Edward Fielder, Teklu Egnuni, Mankaran Singh, Roderick Skinner, Thomas von Zglinicki, Steven C Clifford, Susan C Short, Satomi Miwa, Debbie Hicks
Publicado en: Neuro-Oncology Advances, Edición 6, 2024, ISSN 2632-2498
Editor: Oxford University Press (OUP)
DOI: 10.1093/noajnl/vdae091

The impact of insomnia on frailty and the hallmarks of aging

Autores: Catarina Carvalhas-Almeida, Cláudia Cavadas & Ana Rita Álvaro
Publicado en: Aging Clinical and Experimental Research, 2023, ISSN 1594-0667
Editor: Springer Verlag
DOI: 10.1007/s40520-022-02310-w

A Proteogenomic Pipeline for the Analysis of Protein Biosynthesis Errors in the Human Pathogen Candida albicans

Autores: Inês Correia, Carla Oliveira, Andreia Reis, Ana Rita Guimarães, Susana Aveiro, Pedro Domingues, Ana Rita Bezerra, Rui Vitorino, Gabriela Moura, Manuel A.S. Santos
Publicado en: Molecular & Cellular Proteomics, Edición 23, 2024, Página(s) 100818, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2024.100818

Senescent Dermal Fibroblasts Decrease Stemness in Basal Keratinocytes in a Bioengineered Model of Human Full-Thickness Skin

Autores: Evon Low, Lucy A. Smith, Satomi Miwa, Edward Fielder, Stefan Przyborski, Thomas von Zglinicki
Publicado en: Journal of Investigative Dermatology, Edición 145, 2025, Página(s) 208-211.e8, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.07.004

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Autores: Carolina Ferreira, Pedro Vieira, Helena Sá, João Malva, Miguel Castelo-Branco, Flávio Reis, Sofia Viana
Publicado en: Frontiers in Immunology, Edición 15, 2024, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1360065

ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers

Autores: Reinaldo B. Oriá, Raul S. Freitas, Cássia R. Roque, José Carlos R. Nascimento, Ana Paula Silva, João O. Malva, Richard L. Guerrant, Michael P. Vitek
Publicado en: Pharmaceutics, Edición 15, 2023, Página(s) 1086, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041086

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age

Autores: David Villarroel-Campos, Elena R. Rhymes, Andrew P. Tosolini, Bilal Malik, Alessio Vagnoni, Giampietro Schiavo, James N. Sleigh
Publicado en: Neurobiology of Aging, Edición 153, 2025, Página(s) 1-9, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2025.05.002

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

Autores: Tyler H. Ogunmowo, Christian Hoffmann, Chintan Patel, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Johanna Idel, Annie Ho, Sumana Raychaudhuri, Brady J. Maher, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe
Publicado en: Nature Neuroscience, 2025, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-025-02002-4

Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection

Autores: Beatriz Cristovao, Lisa Rodrigues, Steve Catarino, Monica Abreu, Teresa Gonçalves, Neuza Domingues, Henrique Girao
Publicado en: Microbiology Spectrum, Edición 11, 2023, ISSN 2165-0497
Editor: American Society for Microbiology
DOI: 10.1128/spectrum.01238-23

Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism

Autores: Adriana Marques‐Carvalho, Beatriz Silva, Francisco B. Pereira, Ha‐Neui Kim, Maria Almeida, Vilma A. Sardão
Publicado en: European Journal of Clinical Investigation, Edición 54, 2024, ISSN 0014-2972
Editor: Blackwell Publishing Inc.
DOI: 10.1111/eci.14195

miRNA-642a-3p protects β cells from glucolipotoxicity

Autores: Sandra Sofia Pinhanços, João Teixeira de Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J.J. de Winter, Sofia Viana, Flávio Reis, Jorge Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferreira, Martin Gotthardt, John Jones, Hugo Fernandes
Publicado en: Molecular Therapy Nucleic Acids, Edición 36, 2025, Página(s) 102498, ISSN 2162-2531
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2025.102498

Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases.

Autores: Ira Milosevic; Ira Milosevic; Michael A. Cousin
Publicado en: reponame:Repositório Científico de Acesso Aberto de Portugal, Edición 1, 2021, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202111056

Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment

Autores: Lu Liu, Yuheng Zhang, Hanyu Liu, Jian Yang, Qi Tian, Nareekarn Chueakula, Saravana Ramasamy, Navin Kumar Verma, Christine Cheung, Anjali P. Kusumbe
Publicado en: Cancer Research, Edición 85, 2025, Página(s) 2152-2164, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-4744

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential

Autores: Rita Costa, Carolina Ferreira, André Alves, Sara Nunes, Flávio Reis, João Malva, Sofia Viana
Publicado en: Frontiers in Pharmacology, Edición 16, 2025, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2025.1541871

Advanced biomaterial strategies for overcoming age-associated wound healing impairments

Autores: Rodrigo Dores, Telma A. Rodrigues, Daniel Carvalho, Eva Batista, Myroslava Kozak, Cristina Blanco-Elices, Hugo Fernandes, Luis M. Bimbo
Publicado en: APL Bioengineering, Edición 9, 2025, ISSN 2473-2877
Editor: AIP Publishing
DOI: 10.1063/5.0251889

1,8-Cineole reduces pulmonary vascular remodelling in pulmonary arterial hypertension by restoring intercellular communication and inhibiting angiogenesis

Autores: Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Teresa Rodrigues, Júlia Barbeitos, Rui Caetano, Rui Baptista, Lígia Salgueiro, Henrique Girão
Publicado en: Phytomedicine, Edición 137, 2025, Página(s) 156334, ISSN 0944-7113
Editor: Elsevier BV
DOI: 10.1016/j.phymed.2024.156334

Ghrelin delays premature aging in <scp>Hutchinson‐Gilford</scp> progeria syndrome

Autores: Marisa Ferreira‐Marques, André Carvalho, Ana Catarina Franco, Ana Leal, Mariana Botelho, Sara Carmo‐Silva, Rodolfo Águas, Luísa Cortes, Vasco Lucas, Ana Carolina Real, Carlos López‐Otín, Xavier Nissan, Luís Pereira de Almeida, Cláudia Cavadas, Célia A. Aveleira
Publicado en: Aging Cell, Edición 22, 2024, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13983

Lack of peroxisomal catalase affects heat shock response in<i>Caenorhabditis elegans</i>

Autores: Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko
Publicado en: Crossref, Edición 9, 2022, ISSN 2575-1077
Editor: Life Science Alliance
DOI: 10.26508/lsa.202201737

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Autores: Neuza Domingues, Steve Catarino, Beatriz Cristóvão, Lisa Rodrigues, Filomena A Carvalho, Maria João Sarmento, Mónica Zuzarte, Jani Almeida, Teresa Ribeiro-Rodrigues, Ânia Correia-Rodrigues, Fábio Fernandes, Paulo Rodrigues-Santos, Trond Aasen, Nuno C Santos, Viktor I Korolchuk, Teresa Gonçalves, Ira Milosevic, Nuno Raimundo, Henrique Girão
Publicado en: The EMBO Journal, Edición 43, 2024, Página(s) 3627-3649, ISSN 1460-2075
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00177-3

Promoting advanced medical services in the framework of 3PM—a proof-of-concept by the “Centro” Region of Portugal

Autores: Fernando J. Regateiro, Henriqueta Silva, Manuel C. Lemos, Gabriela Moura, Pedro Torres, André Dias Pereira, Luís Dias, Pedro L. Ferreira, Sara Amaral, Manuel A. S. Santos
Publicado en: EPMA Journal, Edición 15, 2024, Página(s) 135-148, ISSN 1878-5085
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s13167-024-00353-9

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.

Autores: Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José A. Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; Fernanda Borges; Nuno Raimundo; Paulo J. Oliveira
Publicado en: Redox Biology, Vol 45, Iss , Pp 102037- (2021), Edición 18, 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.102037

Age‐specific and compartment‐dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

Autores: James N. Sleigh, Francesca Mattedi, Sandy Richter, Emily Annuario, Kristal Ng, I. Emilie Steinmark, Iveta Ivanova, István L. Darabán, Parth P. Joshi, Elena R. Rhymes, Shirwa Awale, Gokhan Yahioglu, Jacqueline C. Mitchell, Klaus Suhling, Giampietro Schiavo, Alessio Vagnoni
Publicado en: Aging Cell, Edición 23, 2024, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.14250

Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters

Autores: Lucia Barazzuol, Tetiana Tykhonenko, Tia L. Griffiths, Alessio Vagnoni, Marisa Brini, Tito Calì
Publicado en: Cell Death & Disease, Edición 16, 2025, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-025-07511-5

Impact of coffee intake on human aging: Epidemiology and cellular mechanisms

Autores: Cátia R. Lopes, Rodrigo A. Cunha
Publicado en: Ageing Research Reviews, Edición 102, 2024, Página(s) 102581, ISSN 1568-1637
Editor: Elsevier BV
DOI: 10.1016/j.arr.2024.102581

Impact of Coffee Intake on Measures of Wellbeing in Mice

Autores: Nuno J. Machado, Ana Paula Ardais, Ana Nunes, Eszter C. Szabó, Vasco Silveirinha, Henrique B. Silva, Manuella P. Kaster, Rodrigo A. Cunha
Publicado en: Nutrients, Edición 16, 2025, Página(s) 2920, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16172920

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype

Autores: Inés Muela-Zarzuela, Juan Miguel Suarez-Rivero, Andrea Gallardo-Orihuela, Chun Wang, Kumi Izawa, Marta de Gregorio-Procopio, Isabelle Couillin, Bernhard Ryffel, Jiro Kitaura, Alberto Sanz, Thomas von Zglinicki, Gabriel Mbalaviele, Mario D. Cordero
Publicado en: Inflammation Research, Edición 73, 2024, Página(s) 1253-1266, ISSN 1023-3830
Editor: Birkhauser Verlag
DOI: 10.1007/s00011-024-01892-7

The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism

Autores: Adriana Marques-Carvalho, Beatriz Silva, Francisco B. Pereira, Ha-Neui Kim, Maria Almeida, Vilma A. Sardão
Publicado en: bioRxiv, 2023, ISSN 2692-8205
Editor: bioRxiv
DOI: 10.1101/2023.03.30.534893

Primary cilia shape hallmarks of health and aging

Autores: Silva, DF; Cavadas, C
Publicado en: 2023
Editor: Elsevier
DOI: 10.1016/j.molmed.2023.04.001

Modulation of signaling pathways by DJ-1: An updated overview

Autores: Neves, M; Graos, M; Anjo, SI; Manadas, B
Publicado en: 2022
Editor: Elsevier
DOI: 10.1016/j.redox.2022.102283

How good is the evidence that cellular senescence causes skin ageing?

Autores: Low, E; Alimohammadiha, G; Smith, LA; Costello, LF; Przyborski, SA; Von Zglinicki, T; Miwa, S
Publicado en: 2021
Editor: Elsevier Ireland
DOI: 10.1016/j.arr.2021.101456

Mitochondrial dysfunction in cell senescence and aging

Autores: Miwa, S; Kashyap, S; Chini, E; von Zglinicki, T
Publicado en: 2022
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci158447

The role of microRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging

Autores: Stephany Francisco, Vera Martinho, Margarida Ferreira, Andreia reis, Gabriela Moura, Ana Raquel Soares and Manuel A. S. Santos
Publicado en: Int. J. Mol.Sci, Edición PMID: 35328652 PMCID: PMC8955204, 2022
Editor: Int. J. Mol.Sci
DOI: 10.3390/ijms23063232

Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling

Autores: Neuza Domingues, Alessia Calcagni’, Joana Pires, Sofia Roque Freire, Niculin Joachim Herz, Tuong Huynh, Katarzyna Wieciorek, Maria João Moreno, Tiago Fleming Outeiro, Henrique Girão, Ira Milosevic, Andrea Ballabio, Nuno Raimundo
Publicado en: 2024
Editor: bioRxiv
DOI: 10.1101/2024.05.31.596474

Nuclear aging in polyglutamine-induced neurodegeneration

Autores: Dina Pereira, Janete Cunha-Santos, Ana Vasconcelos-Ferreira, Joana Duarte-Neves, Isabel Onofre, Vítor Carmona, Célia A Aveleira, Sara M Lopes, Diana D Lobo, Inês M Martins, Nélio Gonçalves, Cláudia Cavadas, Luís Pereira de Almeida
Publicado en: 2023
Editor: BioRxiv
DOI: 10.1101/2023.06.09.544056

Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity Substances

Autores: Satomi Miwa, Olena Kucheryavenko, Kristin Herrmann, Christopher Saunter, Adelaide Raimundo, David Weinkove, Lars Niemann, Thomas von Zglinicki
Publicado en: 2025
Editor: bioRxiv
DOI: 10.1101/2025.01.30.635304

Modeling senescence in ARPE19 cells to investigate the role of small extracellular vesicles in age‐related macular degeneration

Autores: Rosa Fernandes, Diana Correia, Beatriz Martins, João Malva, Henrique Girão
Publicado en: Acta Ophthalmologica, Edición 103, 2025, ISSN 1755-375X
Editor: Wiley-Blackwell
DOI: 10.1111/aos.17344

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Multidisciplinary Institute of Ageing - Portugal

Resultado final

Publicaciones

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