Multidisciplinary Institute of Ageing - Portugal

Información del proyecto

MIA-Portugal

Identificador del acuerdo de subvención: 857524

DOI 10.3030/857524

Fecha de la firma de la CE 8 Julio 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2027

Financiado con arreglo a

• Teaming of excellent research institutions and low performing RDI regions

Coste total € 15 043 051,25

Aportación de la UE € 15 000 000,00

Coordinado por

COMISSAO DE COORDENACAO E DESENVOLVIMENTO REGIONAL DO CENTRO
Portugal

Resultado final

Documents, reports (14)

Events - M36

Report of scientific, translational, innovation and societal events (M36).

Elaboration and approval (by UC Rector) of internal regulations and bylaws

Elaboration and approval (by UC Rector) of internal regulations and bylaws.

Initial teams in place: Installation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board

Initial teams in place; Instalation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board.

MIA-Portugal research groups in place (8 in total)
Report on web site development and performance
Report on translational / clinics research for MIA- Portugal

Report on translational clinics research for MIAPortugal

MIA-Portugal Communication, Exploitation and Dissemination Plan, and Dissemination Booklet

MIAPortugal Communication Exploitation and Dissemination Plan and Dissemination Booklet

Subscription of internal regulations by the ERA Chair team
Events - M48

Report of scientific, translational, innovation and societal events (M48).

Events - M12

Report of scientific, translational, innovation and societal events (M12).

Report on Common Advanced Teaching Synergies with Teaming Partners
MIA-Portugal management team in place

MIAPortugal management team in place

Events - M24

Report of scientific translational innovation and societal events M24

Recruitment of 7 MIA-Portugal research groups (excluding the ERA Chair)

Recruitment of 7 MIAPortugal research groups excluding the ERA Chair

Websites, patent fillings, videos etc. (2)

Recruitment of MIA-Portugal Scientific Director

Recruitment of MIAPortugal Scientific Director

MIA-Portugal flyer

Publicaciones

Peer reviewed articles (10)

Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(6) sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism

Autores: Amorim R, Magalhães CC, Benfeito S, Cagide F, Tavares LC, Santos K, Sardão VA, Datta S, Cortopassi GA, Baldeiras I, Jones JG, Borges F, Oliveira PJ, Teixeira J.
Publicado en: Biochemical Pharmacology, 2023, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2023.115953

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator

Autores: Bessa, C; Loureiro, JB; Barros, M; Isca, VMS; Sardao, VA; Oliveira, PJ; Bernardino, RL; Herman-de-Sousa, C; Costa, MA; Correia-de-Sa, P; Alves, MG; Rijo, P; Saraiva, L
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1661-6596
Editor: MDPI
DOI: 10.3390/ijms24065710

Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile

Autores: Santiago J, Silva JV, Santos MAS, Fardilha M.
Publicado en: Biomedicines, 2023, ISSN 2227-9059
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines11112923

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Autores: Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S.
Publicado en: https://www.sciencedirect.com/science/article/pii/S0896627322001465, 2022, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2022.02.008

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Autores: Beatriz M, Rodrigues RJ, Vilaça R, Egas C, Pinheiro PS, Daley GQ, Schlaeger TM, Raimundo N, Rego AC, Lopes C.
Publicado en: Theranostics, 2023, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.81981

Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases.

Autores: Ira Milosevic; Ira Milosevic; Michael A. Cousin
Publicado en: reponame:Repositório Científico de Acesso Aberto de Portugal, Edición 1, 2021, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202111056

Lack of peroxisomal catalase affects heat shock response in<i>Caenorhabditis elegans</i>

Autores: Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko
Publicado en: Crossref, Edición 9, 2022, ISSN 2575-1077
Editor: Life Science Alliance
DOI: 10.26508/lsa.202201737

Ghrelin delays premature aging in <scp>Hutchinson‐Gilford</scp> progeria syndrome

Autores: Marisa Ferreira‐Marques; André Carvalho; Ana Catarina Franco; Ana Leal; Mariana Botelho; Sara Carmo‐Silva; Rodolfo Águas; Luísa Cortes; Vasco Lucas; Ana Carolina Real; Carlos López‐Otín; Xavier Nissan; Luís Pereira de Almeida; Cláudia Cavadas; Célia A. Aveleira
Publicado en: Aging Cell, Edición 13, 2023, ISSN 1474-9718
Editor: Blackwell Publishing Inc.
DOI: 10.1111/acel.13983

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.

Autores: Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José A. Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; Fernanda Borges; Nuno Raimundo; Paulo J. Oliveira
Publicado en: Redox Biology, Vol 45, Iss , Pp 102037- (2021), Edición 18, 2021, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2021.102037

Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity

Autores: José P. Castelão-Baptista, Sara A. Valente, Sara Canário, David Oppolzer, Ana Barros, Carlos Venâncio, Tânia Martins, Luís Antunes,Vilma A. Sardão, Eduardo Rosa, and Paulo J. Oliveira
Publicado en: Nutrients, 2023, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15040924

Book chapters (2)

Exocytotic SNARE complex assembly, disassembly, and regulation

Autores: Milosevic, I., & Knight, J. D.
Publicado en: 2022
Editor: IOP Science
DOI: 10.1088/978-0-7503-3771-7ch3

Disrupted cellular quality control mechanisms in aging

Autores: Cristina Carvalho; Joana F. Pires; Paula I. Moreira; Nuno Raimundo
Publicado en: Crossref, Edición 5, 2022
Editor: Elsevier
DOI: 10.1016/b978-0-12-823761-8.00016-1

Other (13)

Cellular senescence: from mechanisms to current biomarkers and senotherapies

Autores: Vasco Lucas, Cláudia Cavadas and Célia Alexandra Aveleira
Publicado en: 2023
Editor: American Society for Pharmacology and Experimental Therapy
DOI: 10.1124/pharmrev.122.000622

Primary cilia shape hallmarks of health and aging

Autores: Silva, DF; Cavadas, C
Publicado en: 2023
Editor: Elsevier
DOI: 10.1016/j.molmed.2023.04.001

Modulation of signaling pathways by DJ-1: An updated overview

Autores: Neves, M; Graos, M; Anjo, SI; Manadas, B
Publicado en: 2022
Editor: Elsevier
DOI: 10.1016/j.redox.2022.102283

The impact of insomnia on frailty and the hallmarks of aging

Autores: Catarina Carvalhas-Almeida, Cláudia Cavadas & Ana Rita Álvaro
Publicado en: Aging Clinical and Experimental Research, 2023, ISSN 1594-0667
Editor: Springer Verlag
DOI: 10.1007/s40520-022-02310-w

How good is the evidence that cellular senescence causes skin ageing?

Autores: Low, E; Alimohammadiha, G; Smith, LA; Costello, LF; Przyborski, SA; Von Zglinicki, T; Miwa, S
Publicado en: 2021
Editor: Elsevier Ireland
DOI: 10.1016/j.arr.2021.101456

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

Autores: Deus CM, Teixeira J, Raimundo N, Tucci P, Borges F, Saso L, Oliveira PJ
Publicado en: Eur Journal of Clinical Investigation, 2022
Editor: Book in Press
DOI: 10.1111/eci.13820

Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics

Autores: Pinho, SA; Anjo, SI; Cunha-Oliveira, T
Publicado en: Antioxidants, 2023
Editor: MDPI
DOI: 10.3390/antiox12051072

Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease

Autores: Magaña, JC; Deus, CM; Giné-Garriga, M; Montané, J; Pereira, SP
Publicado en: 2022
Editor: MDPI
DOI: 10.3390/biomedicines10123228

Mitochondrial dysfunction in cell senescence and aging

Autores: Miwa, S; Kashyap, S; Chini, E; von Zglinicki, T
Publicado en: 2022
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci158447

The role of microRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging

Autores: Stephany Francisco, Vera Martinho, Margarida Ferreira, Andreia reis, Gabriela Moura, Ana Raquel Soares and Manuel A. S. Santos
Publicado en: Int. J. Mol.Sci, Edición PMID: 35328652 PMCID: PMC8955204, 2022
Editor: Int. J. Mol.Sci
DOI: 10.3390/ijms23063232

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Autores: Ribeiro, RFN; Pereira, D; De Almeida, LP; Silva, MMC; Cavadas, C
Publicado en: 2022
Editor: Springer Science and Business Media Deutschanld GMBH
DOI: 10.1007/s40520-022-02257-y

From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria

Autores: Ricardo Amorim, Carina C. Magalhães, Fernanda Borges, Paulo J. Oliveira, andJosé Teixeira
Publicado en: 2023
Editor: Biology (Basel)
DOI: 10.3390/biology12040595

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

Autores: Almeida SFF, Santos L, Sampaio-Ribeiro G, Ferreira HRS, Lima N, Caetano R, Abreu M, Zuzarte M, Ribeiro AS, Paiva A, Martins-Marques T, Teixeira P, Almeida R, Casanova JM, Girão H, Abrunhosa AJ, Gomes CM.
Publicado en: 2023
Editor: BioMed Central Ltd
DOI: 10.1186/s13046-023-02886-9

Non-peer reviewed articles (1)

The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism

Autores: Adriana Marques-Carvalho, Beatriz Silva, Francisco B. Pereira, Ha-Neui Kim, Maria Almeida, Vilma A. Sardão
Publicado en: bioRxiv, 2023, ISSN 2692-8205
Editor: bioRxiv
DOI: 10.1101/2023.03.30.534893