Multidisciplinary Institute of Ageing - Portugal | MIA-Portugal | Project | Results | H2020 | CORDIS

Leistungen

Report of scientific, translational, innovation and societal events (M36).

Elaboration and approval (by UC Rector) of internal regulations and bylaws

Elaboration and approval (by UC Rector) of internal regulations and bylaws.

Initial teams in place: Installation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board

Initial teams in place; Instalation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board.

MIA-Portugal research groups in place (8 in total)
Report on web site development and performance
Report on translational / clinics research for MIA- Portugal

Report on translational clinics research for MIAPortugal

MIA-Portugal Communication, Exploitation and Dissemination Plan, and Dissemination Booklet

MIAPortugal Communication Exploitation and Dissemination Plan and Dissemination Booklet

Subscription of internal regulations by the ERA Chair team
Events - M48

Report of scientific, translational, innovation and societal events (M48).

Events - M12

Report of scientific, translational, innovation and societal events (M12).

Report on Common Advanced Teaching Synergies with Teaming Partners
MIA-Portugal management team in place

MIAPortugal management team in place

Events - M24

Report of scientific translational innovation and societal events M24

Recruitment of 7 MIA-Portugal research groups (excluding the ERA Chair)

Recruitment of 7 MIAPortugal research groups excluding the ERA Chair

Recruitment of MIA-Portugal Scientific Director

Recruitment of MIAPortugal Scientific Director

MIA-Portugal flyer

Veröffentlichungen

Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(6) sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism

Autoren: Amorim R, Magalhães CC, Benfeito S, Cagide F, Tavares LC, Santos K, Sardão VA, Datta S, Cortopassi GA, Baldeiras I, Jones JG, Borges F, Oliveira PJ, Teixeira J.
Veröffentlicht in: Biochemical Pharmacology, 2023, ISSN 0006-2952
Herausgeber: Elsevier BV
DOI: 10.1016/j.bcp.2023.115953

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator

Autoren: Bessa, C; Loureiro, JB; Barros, M; Isca, VMS; Sardao, VA; Oliveira, PJ; Bernardino, RL; Herman-de-Sousa, C; Costa, MA; Correia-de-Sa, P; Alves, MG; Rijo, P; Saraiva, L
Veröffentlicht in: International Journal of Molecular Sciences, 2023, ISSN 1661-6596
Herausgeber: MDPI
DOI: 10.3390/ijms24065710

Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile

Autoren: Santiago J, Silva JV, Santos MAS, Fardilha M.
Veröffentlicht in: Biomedicines, 2023, ISSN 2227-9059
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines11112923

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Autoren: Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S.
Veröffentlicht in: https://www.sciencedirect.com/science/article/pii/S0896627322001465, 2022, ISSN 0896-6273
Herausgeber: Cell Press
DOI: 10.1016/j.neuron.2022.02.008

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Autoren: Beatriz M, Rodrigues RJ, Vilaça R, Egas C, Pinheiro PS, Daley GQ, Schlaeger TM, Raimundo N, Rego AC, Lopes C.
Veröffentlicht in: Theranostics, 2023, ISSN 1838-7640
Herausgeber: Ivyspring International Publisher
DOI: 10.7150/thno.81981

Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases.

Autoren: Ira Milosevic; Ira Milosevic; Michael A. Cousin
Veröffentlicht in: reponame:Repositório Científico de Acesso Aberto de Portugal, Ausgabe 1, 2021, ISSN 0021-9525
Herausgeber: Rockefeller University Press
DOI: 10.1083/jcb.202111056

Lack of peroxisomal catalase affects heat shock response in<i>Caenorhabditis elegans</i>

Autoren: Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko
Veröffentlicht in: Crossref, Ausgabe 9, 2022, ISSN 2575-1077
Herausgeber: Life Science Alliance
DOI: 10.26508/lsa.202201737

Ghrelin delays premature aging in <scp>Hutchinson‐Gilford</scp> progeria syndrome

Autoren: Marisa Ferreira‐Marques; André Carvalho; Ana Catarina Franco; Ana Leal; Mariana Botelho; Sara Carmo‐Silva; Rodolfo Águas; Luísa Cortes; Vasco Lucas; Ana Carolina Real; Carlos López‐Otín; Xavier Nissan; Luís Pereira de Almeida; Cláudia Cavadas; Célia A. Aveleira
Veröffentlicht in: Aging Cell, Ausgabe 13, 2023, ISSN 1474-9718
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1111/acel.13983

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.

Autoren: Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José A. Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; Fernanda Borges; Nuno Raimundo; Paulo J. Oliveira
Veröffentlicht in: Redox Biology, Vol 45, Iss , Pp 102037- (2021), Ausgabe 18, 2021, ISSN 2213-2317
Herausgeber: Elsevier BV
DOI: 10.1016/j.redox.2021.102037

Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity

Autoren: José P. Castelão-Baptista, Sara A. Valente, Sara Canário, David Oppolzer, Ana Barros, Carlos Venâncio, Tânia Martins, Luís Antunes,Vilma A. Sardão, Eduardo Rosa, and Paulo J. Oliveira
Veröffentlicht in: Nutrients, 2023, ISSN 2072-6643
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15040924

Exocytotic SNARE complex assembly, disassembly, and regulation

Autoren: Milosevic, I., & Knight, J. D.
Veröffentlicht in: 2022
Herausgeber: IOP Science
DOI: 10.1088/978-0-7503-3771-7ch3

Disrupted cellular quality control mechanisms in aging

Autoren: Cristina Carvalho; Joana F. Pires; Paula I. Moreira; Nuno Raimundo
Veröffentlicht in: Crossref, Ausgabe 5, 2022
Herausgeber: Elsevier
DOI: 10.1016/b978-0-12-823761-8.00016-1

Cellular senescence: from mechanisms to current biomarkers and senotherapies

Autoren: Vasco Lucas, Cláudia Cavadas and Célia Alexandra Aveleira
Veröffentlicht in: 2023
Herausgeber: American Society for Pharmacology and Experimental Therapy
DOI: 10.1124/pharmrev.122.000622

Primary cilia shape hallmarks of health and aging

Autoren: Silva, DF; Cavadas, C
Veröffentlicht in: 2023
Herausgeber: Elsevier
DOI: 10.1016/j.molmed.2023.04.001

Modulation of signaling pathways by DJ-1: An updated overview

Autoren: Neves, M; Graos, M; Anjo, SI; Manadas, B
Veröffentlicht in: 2022
Herausgeber: Elsevier
DOI: 10.1016/j.redox.2022.102283

The impact of insomnia on frailty and the hallmarks of aging

Autoren: Catarina Carvalhas-Almeida, Cláudia Cavadas & Ana Rita Álvaro
Veröffentlicht in: Aging Clinical and Experimental Research, 2023, ISSN 1594-0667
Herausgeber: Springer Verlag
DOI: 10.1007/s40520-022-02310-w

How good is the evidence that cellular senescence causes skin ageing?

Autoren: Low, E; Alimohammadiha, G; Smith, LA; Costello, LF; Przyborski, SA; Von Zglinicki, T; Miwa, S
Veröffentlicht in: 2021
Herausgeber: Elsevier Ireland
DOI: 10.1016/j.arr.2021.101456

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

Autoren: Deus CM, Teixeira J, Raimundo N, Tucci P, Borges F, Saso L, Oliveira PJ
Veröffentlicht in: Eur Journal of Clinical Investigation, 2022
Herausgeber: Book in Press
DOI: 10.1111/eci.13820

Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics

Autoren: Pinho, SA; Anjo, SI; Cunha-Oliveira, T
Veröffentlicht in: Antioxidants, 2023
Herausgeber: MDPI
DOI: 10.3390/antiox12051072

Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease

Autoren: Magaña, JC; Deus, CM; Giné-Garriga, M; Montané, J; Pereira, SP
Veröffentlicht in: 2022
Herausgeber: MDPI
DOI: 10.3390/biomedicines10123228

Mitochondrial dysfunction in cell senescence and aging

Autoren: Miwa, S; Kashyap, S; Chini, E; von Zglinicki, T
Veröffentlicht in: 2022
Herausgeber: American Society for Clinical Investigation
DOI: 10.1172/jci158447

The role of microRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging

Autoren: Stephany Francisco, Vera Martinho, Margarida Ferreira, Andreia reis, Gabriela Moura, Ana Raquel Soares and Manuel A. S. Santos
Veröffentlicht in: Int. J. Mol.Sci, Ausgabe PMID: 35328652 PMCID: PMC8955204, 2022
Herausgeber: Int. J. Mol.Sci
DOI: 10.3390/ijms23063232

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Autoren: Ribeiro, RFN; Pereira, D; De Almeida, LP; Silva, MMC; Cavadas, C
Veröffentlicht in: 2022
Herausgeber: Springer Science and Business Media Deutschanld GMBH
DOI: 10.1007/s40520-022-02257-y

From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria

Autoren: Ricardo Amorim, Carina C. Magalhães, Fernanda Borges, Paulo J. Oliveira, andJosé Teixeira
Veröffentlicht in: 2023
Herausgeber: Biology (Basel)
DOI: 10.3390/biology12040595

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

Autoren: Almeida SFF, Santos L, Sampaio-Ribeiro G, Ferreira HRS, Lima N, Caetano R, Abreu M, Zuzarte M, Ribeiro AS, Paiva A, Martins-Marques T, Teixeira P, Almeida R, Casanova JM, Girão H, Abrunhosa AJ, Gomes CM.
Veröffentlicht in: 2023
Herausgeber: BioMed Central Ltd
DOI: 10.1186/s13046-023-02886-9

The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism

Autoren: Adriana Marques-Carvalho, Beatriz Silva, Francisco B. Pereira, Ha-Neui Kim, Maria Almeida, Vilma A. Sardão
Veröffentlicht in: bioRxiv, 2023, ISSN 2692-8205
Herausgeber: bioRxiv
DOI: 10.1101/2023.03.30.534893

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Multidisciplinary Institute of Ageing - Portugal

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