Multidisciplinary Institute of Ageing - Portugal | MIA-Portugal | Projet | Résultats | H2020 | CORDIS

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Events - M36

Report of scientific, translational, innovation and societal events (M36).

Elaboration and approval (by UC Rector) of internal regulations and bylaws

Elaboration and approval (by UC Rector) of internal regulations and bylaws.

Initial teams in place: Installation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board

Initial teams in place; Instalation Committee, Science and Business Council, International Advisory Board, Advocacy Committee, Ethics Advisory Board.

MIA-Portugal research groups in place (8 in total)
Report on web site development and performance
Report on translational / clinics research for MIA- Portugal

Report on translational clinics research for MIAPortugal

MIA-Portugal Communication, Exploitation and Dissemination Plan, and Dissemination Booklet

MIAPortugal Communication Exploitation and Dissemination Plan and Dissemination Booklet

Subscription of internal regulations by the ERA Chair team
Events - M48

Report of scientific, translational, innovation and societal events (M48).

Events - M12

Report of scientific, translational, innovation and societal events (M12).

Report on Common Advanced Teaching Synergies with Teaming Partners
MIA-Portugal management team in place

MIAPortugal management team in place

Events - M24

Report of scientific translational innovation and societal events M24

Recruitment of 7 MIA-Portugal research groups (excluding the ERA Chair)

Recruitment of 7 MIAPortugal research groups excluding the ERA Chair

Recruitment of MIA-Portugal Scientific Director

Recruitment of MIAPortugal Scientific Director

MIA-Portugal flyer

Publications

Lymphatic-immune interactions in the musculoskeletal system

Auteurs: Hanyu Liu, Lu Liu, Yuheng Zhang, Qi Tian, Zhangfan Ding, Junyu Chen, Anjali P. Kusumbe
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1578847

Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons

Auteurs: Ivan L. Salazar, Michele Curcio, Miranda Mele, Rossela Vetrone, Simone Frisari, Rui O. Costa, Margarida V. Caldeira, Darci J Trader, Carlos B. Duarte
Publié dans: Apoptosis, 2025, ISSN 1573-675X
Éditeur: Springer Netherlands
DOI: 10.1101/2024.05.15.594129

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

Auteurs: Marisa Ferreira-Marques, Sara Carmo-Silva, Joana Pereira, Mariana Botelho, Clévio Nóbrega, Carlos López‐Otín, Luís Pereira de Almeida, Célia A. Aveleira, Cláudia Cavadas
Publié dans: GeroScience, 2025, ISSN 2509-2723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s11357-025-01574-0

Mild Uncoupling of Mitochondria Synergistically Enhances Senolytic Specificity and Sensitivity of BH3 Mimetics

Auteurs: Satomi Miwa, Edward P. Fielder, Abbas Ishaq, Evon Low, Joseph A. Laws, Aisha Calista, Jemma Castle, Thomas von Zglinicki
Publié dans: Aging Biology, Numéro 1, 2024, Page(s) 20240022, ISSN 2994-2578
Éditeur: Aging Biology LLC
DOI: 10.59368/agingbio.20240022

Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy

Auteurs: Gonçalo Ferreira, Pedro Vieira, André Alves, Sara Nunes, Inês Preguiça, Tânia Martins-Marques, Tânia Ribeiro, Henrique Girão, Artur Figueirinha, Lígia Salgueiro, Manuela Pintado, Pedro Gomes, Sofia Viana, Flávio Reis
Publié dans: Nutrients, Numéro 16, 2025, Page(s) 513, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16040513

Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(6) sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism

Auteurs: Amorim R, Magalhães CC, Benfeito S, Cagide F, Tavares LC, Santos K, Sardão VA, Datta S, Cortopassi GA, Baldeiras I, Jones JG, Borges F, Oliveira PJ, Teixeira J.
Publié dans: Biochemical Pharmacology, 2023, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2023.115953

Guidelines for minimal information on cellular senescence experimentation in vivo

Auteurs: Mikolaj Ogrodnik, Juan Carlos Acosta, Peter D. Adams, Fabrizio d’Adda di Fagagna, Darren J. Baker, Cleo L. Bishop, Tamir Chandra, Manuel Collado, Jesus Gil, Vassilis Gorgoulis, Florian Gruber, Eiji Hara, Pidder Jansen-Dürr, Diana Jurk, Sundeep Khosla, James L. Kirkland, Valery Krizhanovsky, Tohru Minamino, Laura J. Niedernhofer, João F. Passos, Nadja A.R. Ring, Heinz Redl, Paul D. Robbins, Fra
Publié dans: Cell, Numéro 187, 2024, Page(s) 4150-4175, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2024.05.059

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Auteurs: Tania Martins-Marques, Katja Witschas, Ilda Ribeiro, Mónica Zuzarte, Steve Catarino, Teresa Ribeiro-Rodrigues, Francisco Caramelo, Trond Aasen, Isabel Marques Carreira, Lino Goncalves, Luc Leybaert, Henrique Girao
Publié dans: Open Biology, Numéro 13, 2024, ISSN 2046-2441
Éditeur: Royal Society Publishing
DOI: 10.1098/rsob.230258

Role of lipids in interorganelle communication

Auteurs: Neuza Domingues, Joana Pires, Ira Milosevic, Nuno Raimundo
Publié dans: Trends in Cell Biology, Numéro 35, 2025, Page(s) 46-58, ISSN 0962-8924
Éditeur: Elsevier BV
DOI: 10.1016/j.tcb.2024.04.008

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator

Auteurs: Bessa, C; Loureiro, JB; Barros, M; Isca, VMS; Sardao, VA; Oliveira, PJ; Bernardino, RL; Herman-de-Sousa, C; Costa, MA; Correia-de-Sa, P; Alves, MG; Rijo, P; Saraiva, L
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1661-6596
Éditeur: MDPI
DOI: 10.3390/ijms24065710

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Auteurs: João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira
Publié dans: Aging Cell, Numéro 23, 2024, ISSN 1474-9718
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acel.14270

Age-Dependent Alterations in Semen Parameters and Human Sperm MicroRNA Profile

Auteurs: Santiago J, Silva JV, Santos MAS, Fardilha M.
Publié dans: Biomedicines, 2023, ISSN 2227-9059
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biomedicines11112923

In vivo modeling recapitulates radiotherapy delivery and late-effect profile for childhood medulloblastoma

Auteurs: Jemma Castle, Gary Shaw, Dominic Weller, Edward Fielder, Teklu Egnuni, Mankaran Singh, Roderick Skinner, Thomas von Zglinicki, Steven C Clifford, Susan C Short, Satomi Miwa, Debbie Hicks
Publié dans: Neuro-Oncology Advances, Numéro 6, 2024, ISSN 2632-2498
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/noajnl/vdae091

A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification

Auteurs: Miguel M. Lopes, Jacques Paysan, José Rino, Sara M. Lopes, Luís Pereira de Almeida, Luísa Cortes, Rui Jorge Nobre
Publié dans: Gene Therapy, Numéro 29, 2022, Page(s) 665-679, ISSN 0969-7128
Éditeur: Nature Publishing Group
DOI: 10.1038/s41434-022-00372-z

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Auteurs: Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S.
Publié dans: https://www.sciencedirect.com/science/article/pii/S0896627322001465, 2022, ISSN 0896-6273
Éditeur: Cell Press
DOI: 10.1016/j.neuron.2022.02.008

Skin senescence: mechanisms and impact on whole-body aging

Auteurs: Ana Catarina Franco, Célia Aveleira, Cláudia Cavadas
Publié dans: Trends in Molecular Medicine, Numéro 28, 2023, Page(s) 97-109, ISSN 1471-4914
Éditeur: Elsevier BV
DOI: 10.1016/j.molmed.2021.12.003

A Proteogenomic Pipeline for the Analysis of Protein Biosynthesis Errors in the Human Pathogen Candida albicans

Auteurs: Inês Correia, Carla Oliveira, Andreia Reis, Ana Rita Guimarães, Susana Aveiro, Pedro Domingues, Ana Rita Bezerra, Rui Vitorino, Gabriela Moura, Manuel A.S. Santos
Publié dans: Molecular & Cellular Proteomics, Numéro 23, 2024, Page(s) 100818, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2024.100818

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

Auteurs: Beatriz M, Rodrigues RJ, Vilaça R, Egas C, Pinheiro PS, Daley GQ, Schlaeger TM, Raimundo N, Rego AC, Lopes C.
Publié dans: Theranostics, 2023, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.81981

Senescent Dermal Fibroblasts Decrease Stemness in Basal Keratinocytes in a Bioengineered Model of Human Full-Thickness Skin

Auteurs: Evon Low, Lucy A. Smith, Satomi Miwa, Edward Fielder, Stefan Przyborski, Thomas von Zglinicki
Publié dans: Journal of Investigative Dermatology, Numéro 145, 2025, Page(s) 208-211.e8, ISSN 0022-202X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2024.07.004

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Auteurs: Carolina Ferreira, Pedro Vieira, Helena Sá, João Malva, Miguel Castelo-Branco, Flávio Reis, Sofia Viana
Publié dans: Frontiers in Immunology, Numéro 15, 2024, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1360065

ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers

Auteurs: Reinaldo B. Oriá, Raul S. Freitas, Cássia R. Roque, José Carlos R. Nascimento, Ana Paula Silva, João O. Malva, Richard L. Guerrant, Michael P. Vitek
Publié dans: Pharmaceutics, Numéro 15, 2023, Page(s) 1086, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041086

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age

Auteurs: David Villarroel-Campos, Elena R. Rhymes, Andrew P. Tosolini, Bilal Malik, Alessio Vagnoni, Giampietro Schiavo, James N. Sleigh
Publié dans: Neurobiology of Aging, Numéro 153, 2025, Page(s) 1-9, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2025.05.002

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

Auteurs: Tyler H. Ogunmowo, Christian Hoffmann, Chintan Patel, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Johanna Idel, Annie Ho, Sumana Raychaudhuri, Brady J. Maher, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe
Publié dans: Nature Neuroscience, 2025, ISSN 1097-6256
Éditeur: Nature Publishing Group
DOI: 10.1038/s41593-025-02002-4

Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection

Auteurs: Beatriz Cristovao, Lisa Rodrigues, Steve Catarino, Monica Abreu, Teresa Gonçalves, Neuza Domingues, Henrique Girao
Publié dans: Microbiology Spectrum, Numéro 11, 2023, ISSN 2165-0497
Éditeur: American Society for Microbiology
DOI: 10.1128/spectrum.01238-23

Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism

Auteurs: Adriana Marques‐Carvalho, Beatriz Silva, Francisco B. Pereira, Ha‐Neui Kim, Maria Almeida, Vilma A. Sardão
Publié dans: European Journal of Clinical Investigation, Numéro 54, 2024, ISSN 0014-2972
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/eci.14195

miRNA-642a-3p protects β cells from glucolipotoxicity

Auteurs: Sandra Sofia Pinhanços, João Teixeira de Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J.J. de Winter, Sofia Viana, Flávio Reis, Jorge Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferreira, Martin Gotthardt, John Jones, Hugo Fernandes
Publié dans: Molecular Therapy Nucleic Acids, Numéro 36, 2025, Page(s) 102498, ISSN 2162-2531
Éditeur: Nature Publishing Group
DOI: 10.1016/j.omtn.2025.102498

Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases.

Auteurs: Ira Milosevic; Ira Milosevic; Michael A. Cousin
Publié dans: reponame:Repositório Científico de Acesso Aberto de Portugal, Numéro 1, 2021, ISSN 0021-9525
Éditeur: Rockefeller University Press
DOI: 10.1083/jcb.202111056

Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment

Auteurs: Lu Liu, Yuheng Zhang, Hanyu Liu, Jian Yang, Qi Tian, Nareekarn Chueakula, Saravana Ramasamy, Navin Kumar Verma, Christine Cheung, Anjali P. Kusumbe
Publié dans: Cancer Research, Numéro 85, 2025, Page(s) 2152-2164, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-4744

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential

Auteurs: Rita Costa, Carolina Ferreira, André Alves, Sara Nunes, Flávio Reis, João Malva, Sofia Viana
Publié dans: Frontiers in Pharmacology, Numéro 16, 2025, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2025.1541871

Modeling senescence in ARPE19 cells to investigate the role of small extracellular vesicles in age‐related macular degeneration

Auteurs: Rosa Fernandes, Diana Correia, Beatriz Martins, João Malva, Henrique Girão
Publié dans: Acta Ophthalmologica, Numéro 103, 2025, ISSN 1755-375X
Éditeur: Wiley-Blackwell
DOI: 10.1111/aos.17344

Advanced biomaterial strategies for overcoming age-associated wound healing impairments

Auteurs: Rodrigo Dores, Telma A. Rodrigues, Daniel Carvalho, Eva Batista, Myroslava Kozak, Cristina Blanco-Elices, Hugo Fernandes, Luis M. Bimbo
Publié dans: APL Bioengineering, Numéro 9, 2025, ISSN 2473-2877
Éditeur: AIP Publishing
DOI: 10.1063/5.0251889

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Auteurs: Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Publié dans: Advanced Science, Numéro 11, 2025, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202309211

1,8-Cineole reduces pulmonary vascular remodelling in pulmonary arterial hypertension by restoring intercellular communication and inhibiting angiogenesis

Auteurs: Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Teresa Rodrigues, Júlia Barbeitos, Rui Caetano, Rui Baptista, Lígia Salgueiro, Henrique Girão
Publié dans: Phytomedicine, Numéro 137, 2025, Page(s) 156334, ISSN 0944-7113
Éditeur: Elsevier BV
DOI: 10.1016/j.phymed.2024.156334

Lack of peroxisomal catalase affects heat shock response in<i>Caenorhabditis elegans</i>

Auteurs: Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko
Publié dans: Crossref, Numéro 9, 2022, ISSN 2575-1077
Éditeur: Life Science Alliance
DOI: 10.26508/lsa.202201737

Ghrelin delays premature aging in <scp>Hutchinson‐Gilford</scp> progeria syndrome

Auteurs: Marisa Ferreira‐Marques; André Carvalho; Ana Catarina Franco; Ana Leal; Mariana Botelho; Sara Carmo‐Silva; Rodolfo Águas; Luísa Cortes; Vasco Lucas; Ana Carolina Real; Carlos López‐Otín; Xavier Nissan; Luís Pereira de Almeida; Cláudia Cavadas; Célia A. Aveleira
Publié dans: Aging Cell, Numéro 13, 2023, ISSN 1474-9718
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acel.13983

Oxidative stress and cell senescence as drivers of ageing: Chicken and egg

Auteurs: Thomas von Zglinicki
Publié dans: Ageing Research Reviews, Numéro 102, 2024, Page(s) 102558, ISSN 1568-1637
Éditeur: Elsevier BV
DOI: 10.1016/j.arr.2024.102558

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

Auteurs: Neuza Domingues, Steve Catarino, Beatriz Cristóvão, Lisa Rodrigues, Filomena A Carvalho, Maria João Sarmento, Mónica Zuzarte, Jani Almeida, Teresa Ribeiro-Rodrigues, Ânia Correia-Rodrigues, Fábio Fernandes, Paulo Rodrigues-Santos, Trond Aasen, Nuno C Santos, Viktor I Korolchuk, Teresa Gonçalves, Ira Milosevic, Nuno Raimundo, Henrique Girão
Publié dans: The EMBO Journal, Numéro 43, 2024, Page(s) 3627-3649, ISSN 1460-2075
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s44318-024-00177-3

Promoting advanced medical services in the framework of 3PM—a proof-of-concept by the “Centro” Region of Portugal

Auteurs: Fernando J. Regateiro, Henriqueta Silva, Manuel C. Lemos, Gabriela Moura, Pedro Torres, André Dias Pereira, Luís Dias, Pedro L. Ferreira, Sara Amaral, Manuel A. S. Santos
Publié dans: EPMA Journal, Numéro 15, 2024, Page(s) 135-148, ISSN 1878-5085
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s13167-024-00353-9

SIRT1 activation and its circadian clock control: a promising approach against (frailty in) neurodegenerative disorders

Auteurs: Rodrigo F. N. Ribeiro, Dina Pereira, Luis Pereira de Almeida, Maria Manuel C. Silva, Cláudia Cavadas
Publié dans: Aging Clinical and Experimental Research, Numéro 34, 2022, Page(s) 2963-2976, ISSN 1720-8319
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s40520-022-02257-y

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.

Auteurs: Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José A. Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; Fernanda Borges; Nuno Raimundo; Paulo J. Oliveira
Publié dans: Redox Biology, Vol 45, Iss , Pp 102037- (2021), Numéro 18, 2021, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2021.102037

Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell Death in a Liver Cell Model of Lipid Toxicity

Auteurs: José P. Castelão-Baptista, Sara A. Valente, Sara Canário, David Oppolzer, Ana Barros, Carlos Venâncio, Tânia Martins, Luís Antunes,Vilma A. Sardão, Eduardo Rosa, and Paulo J. Oliveira
Publié dans: Nutrients, 2023, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15040924

Age‐specific and compartment‐dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

Auteurs: James N. Sleigh, Francesca Mattedi, Sandy Richter, Emily Annuario, Kristal Ng, I. Emilie Steinmark, Iveta Ivanova, István L. Darabán, Parth P. Joshi, Elena R. Rhymes, Shirwa Awale, Gokhan Yahioglu, Jacqueline C. Mitchell, Klaus Suhling, Giampietro Schiavo, Alessio Vagnoni
Publié dans: Aging Cell, Numéro 23, 2024, ISSN 1474-9718
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acel.14250

Tracking spatiotemporal distribution of organelle contacts in vivo with SPLICS reporters

Auteurs: Lucia Barazzuol, Tetiana Tykhonenko, Tia L. Griffiths, Alessio Vagnoni, Marisa Brini, Tito Calì
Publié dans: Cell Death & Disease, Numéro 16, 2025, ISSN 2041-4889
Éditeur: Nature Publishing Group
DOI: 10.1038/s41419-025-07511-5

Impact of coffee intake on human aging: Epidemiology and cellular mechanisms

Auteurs: Cátia R. Lopes, Rodrigo A. Cunha
Publié dans: Ageing Research Reviews, Numéro 102, 2024, Page(s) 102581, ISSN 1568-1637
Éditeur: Elsevier BV
DOI: 10.1016/j.arr.2024.102581

Impact of Coffee Intake on Measures of Wellbeing in Mice

Auteurs: Nuno J. Machado, Ana Paula Ardais, Ana Nunes, Eszter C. Szabó, Vasco Silveirinha, Henrique B. Silva, Manuella P. Kaster, Rodrigo A. Cunha
Publié dans: Nutrients, Numéro 16, 2025, Page(s) 2920, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16172920

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype

Auteurs: Inés Muela-Zarzuela, Juan Miguel Suarez-Rivero, Andrea Gallardo-Orihuela, Chun Wang, Kumi Izawa, Marta de Gregorio-Procopio, Isabelle Couillin, Bernhard Ryffel, Jiro Kitaura, Alberto Sanz, Thomas von Zglinicki, Gabriel Mbalaviele, Mario D. Cordero
Publié dans: Inflammation Research, Numéro 73, 2024, Page(s) 1253-1266, ISSN 1023-3830
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00011-024-01892-7

Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment

Auteurs: Tyler Ogunmowo, Christian Hoffmann, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Annie Ho, Sumana Raychaudhuri, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe
Publié dans: 2023
Éditeur: bioRxiv
DOI: 10.1101/2023.08.22.554276

Cellular senescence: from mechanisms to current biomarkers and senotherapies

Auteurs: Vasco Lucas, Cláudia Cavadas and Célia Alexandra Aveleira
Publié dans: 2023
Éditeur: American Society for Pharmacology and Experimental Therapy
DOI: 10.1124/pharmrev.122.000622

Primary cilia shape hallmarks of health and aging

Auteurs: Silva, DF; Cavadas, C
Publié dans: 2023
Éditeur: Elsevier
DOI: 10.1016/j.molmed.2023.04.001

Modulation of signaling pathways by DJ-1: An updated overview

Auteurs: Neves, M; Graos, M; Anjo, SI; Manadas, B
Publié dans: 2022
Éditeur: Elsevier
DOI: 10.1016/j.redox.2022.102283

The impact of insomnia on frailty and the hallmarks of aging

Auteurs: Catarina Carvalhas-Almeida, Cláudia Cavadas & Ana Rita Álvaro
Publié dans: Aging Clinical and Experimental Research, 2023, ISSN 1594-0667
Éditeur: Springer Verlag
DOI: 10.1007/s40520-022-02310-w

How good is the evidence that cellular senescence causes skin ageing?

Auteurs: Low, E; Alimohammadiha, G; Smith, LA; Costello, LF; Przyborski, SA; Von Zglinicki, T; Miwa, S
Publié dans: 2021
Éditeur: Elsevier Ireland
DOI: 10.1016/j.arr.2021.101456

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

Auteurs: Deus CM, Teixeira J, Raimundo N, Tucci P, Borges F, Saso L, Oliveira PJ
Publié dans: Eur Journal of Clinical Investigation, 2022
Éditeur: Book in Press
DOI: 10.1111/eci.13820

Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics

Auteurs: Pinho, SA; Anjo, SI; Cunha-Oliveira, T
Publié dans: Antioxidants, 2023
Éditeur: MDPI
DOI: 10.3390/antiox12051072

Exercise-Boosted Mitochondrial Remodeling in Parkinson’s Disease

Auteurs: Magaña, JC; Deus, CM; Giné-Garriga, M; Montané, J; Pereira, SP
Publié dans: 2022
Éditeur: MDPI
DOI: 10.3390/biomedicines10123228

Mitochondrial dysfunction in cell senescence and aging

Auteurs: Miwa, S; Kashyap, S; Chini, E; von Zglinicki, T
Publié dans: 2022
Éditeur: American Society for Clinical Investigation
DOI: 10.1172/jci158447

The role of microRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging

Auteurs: Stephany Francisco, Vera Martinho, Margarida Ferreira, Andreia reis, Gabriela Moura, Ana Raquel Soares and Manuel A. S. Santos
Publié dans: Int. J. Mol.Sci, Numéro PMID: 35328652 PMCID: PMC8955204, 2022
Éditeur: Int. J. Mol.Sci
DOI: 10.3390/ijms23063232

Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling

Auteurs: Neuza Domingues, Alessia Calcagni’, Joana Pires, Sofia Roque Freire, Niculin Joachim Herz, Tuong Huynh, Katarzyna Wieciorek, Maria João Moreno, Tiago Fleming Outeiro, Henrique Girão, Ira Milosevic, Andrea Ballabio, Nuno Raimundo
Publié dans: 2024
Éditeur: bioRxiv
DOI: 10.1101/2024.05.31.596474

Nuclear aging in polyglutamine-induced neurodegeneration

Auteurs: Dina Pereira, Janete Cunha-Santos, Ana Vasconcelos-Ferreira, Joana Duarte-Neves, Isabel Onofre, Vítor Carmona, Célia A Aveleira, Sara M Lopes, Diana D Lobo, Inês M Martins, Nélio Gonçalves, Cláudia Cavadas, Luís Pereira de Almeida
Publié dans: 2023
Éditeur: BioRxiv
DOI: 10.1101/2023.06.09.544056

The Impact of Moderate-to-High-Intensity Exercise Protocols on Glycated Hemoglobin Levels in Type 2 Diabetes Patients

Auteurs: Ana Pedrosa,Guilherme Furtado, Marcelo Paes de Barros, André Luís Lacerda Bachi, José Pedro Ferreira,Vilma A. Sardão,Luís Rama and Ana Teixeira
Publié dans: 2023
Éditeur: MDPI
DOI: 10.3390/diabetology4010002

From Non-Alcoholic Fatty Liver to Hepatocellular Carcinoma: A Story of (Mal)Adapted Mitochondria

Auteurs: Ricardo Amorim, Carina C. Magalhães, Fernanda Borges, Paulo J. Oliveira, andJosé Teixeira
Publié dans: 2023
Éditeur: Biology (Basel)
DOI: 10.3390/biology12040595

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

Auteurs: Almeida SFF, Santos L, Sampaio-Ribeiro G, Ferreira HRS, Lima N, Caetano R, Abreu M, Zuzarte M, Ribeiro AS, Paiva A, Martins-Marques T, Teixeira P, Almeida R, Casanova JM, Girão H, Abrunhosa AJ, Gomes CM.
Publié dans: 2023
Éditeur: BioMed Central Ltd
DOI: 10.1186/s13046-023-02886-9

Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity Substances

Auteurs: Satomi Miwa, Olena Kucheryavenko, Kristin Herrmann, Christopher Saunter, Adelaide Raimundo, David Weinkove, Lars Niemann, Thomas von Zglinicki
Publié dans: 2025
Éditeur: bioRxiv
DOI: 10.1101/2025.01.30.635304

Exocytotic SNARE complex assembly, disassembly, and regulation

Auteurs: Ira Milosevic, Jefferson D Knight
Publié dans: Exocytosis: From Molecules to Cells, 2025, Page(s) 3-1-3-32
Éditeur: IOP Publishing
DOI: 10.1088/978-0-7503-3771-7ch3

Disrupted cellular quality control mechanisms in aging

Auteurs: Cristina Carvalho; Joana F. Pires; Paula I. Moreira; Nuno Raimundo
Publié dans: Crossref, Numéro 5, 2022
Éditeur: Elsevier
DOI: 10.1016/b978-0-12-823761-8.00016-1

Understanding Mitochondrial and Lysosomal Dynamics by Fluorescent Microscopy

Auteurs: Pedro A. Dionísio, Vilma A. Sardão, Nuno Raimundo
Publié dans: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2025, Page(s) 211-221
Éditeur: Springer US
DOI: 10.1007/978-1-0716-4264-1_11

The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism

Auteurs: Adriana Marques-Carvalho, Beatriz Silva, Francisco B. Pereira, Ha-Neui Kim, Maria Almeida, Vilma A. Sardão
Publié dans: bioRxiv, 2023, ISSN 2692-8205
Éditeur: bioRxiv
DOI: 10.1101/2023.03.30.534893

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