Targeted Anti-Cancer Therapies

Información del proyecto

TACT

Identificador del acuerdo de subvención: 859458

DOI

10.3030/859458

Proyecto cerrado

Fecha de la firma de la CE 5 Febrero 2020

Fecha de inicio 1 Abril 2020

Fecha de finalización 31 Marzo 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 089 569,68

Aportación de la UE

€ 3 089 569,68

Coordinado por

UNIVERSITE DE STRASBOURG
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (8)

invitation to the exhibition opening in Strasbourg

Official invitation to the opening of TACT exhibition. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

completion of the network-wide meetings' schedules

Schedules of all network-wide meetings will be issued every 8 months, starting at month 7. As network-wide meetings will be conducted at various locations, there will be several lead beneficiaries, namely WU, UCL, QUB, AD, UNISTRA and HDPR.

bimonthly newsletter launched

A newsletter detailling the most representative achievements of the consortium and giving news about the progress of the project. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

annual scientific publications portfolio

A portfolio of all scientific publications that will have been made during the past year in the frame of the TACT project. Three portfolios will thus be made, at month 18, 30 and 42. All beneficiaries should be lead beneficiaries for this deliverable.

meetings reports

Report of all essential aspects discussed during the network-wide meetings, whether they be scientific or not. Sensitive results will not be disclosed as this report will be made public. Reports will be made every 8 months, until month 40.

kick-off press release

A document sent to the press that officially announces the beginning of the project. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

translated and adapted versions of exhibition contents

As the final exhibition aims at being as accessible to an international audience as possible, each text, figure, etc. will have to be translated to all languages spoken in the TACT consortium. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

public press releases portfolio

A portfolio regrouping all press communications and releases concerning TACT's work, including the publication of all collated short graphic novels. As mutual lead beneficiaries of WP7 both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

Websites, patent fillings, videos etc. (5)

YouTube tutorials channel launched

A YouTube channel dedicated to tutorials in the diverse fields the ESRs will conduct their research projects in. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

production of three short scientific animations

Three short scientific animations (e.g. “what is cancer?”, “how does a traditional chemotherapy work?” and “what are targeted therapies?”) will be created by a professional studio (such as Ella Maru's http://www.scientific-illustrations.com/). Those three animations will then be narrated by ESRs who will have participated in the elaboration of the script. The videos will then be posted on different platforms (TACT’s website, Twitter and Facebook accounts). All beneficiaries should be lead beneficiaries for this deliverable.

online publication of all exhibition contents

All exhibition materials will be made available to the widest audience under a CC BY-NC-SA 4.0 license to be further exploited by other institutions. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

creation of a test online chat group on Esperity

A collaboration with the international cancer patients’ community Esperity (https://www.esperity.com/en) will be set up, where ESRs and their supervisors will create online chat groups dedicated to a particular cancer-related topic of their choice (e.g. ADCs, immunotherapies, pancreatic cancer). They will be the chat groups’ moderators and will answer patients’ questions regularly. The experience will first be conducted over a few weeks and extended or repeated if it were to prove fruitful. All beneficiaries should be lead beneficiaries for this deliverable.

online website and social media accounts

Website of the TACT project and all social media accounts connected to it

Other (3)

completion of the PM recruitment

Recruitment of a Project Manager.

TACT's yearly participation in at least one public event

TACT ESRs will participate in at least one big public event every year, such as a charity (Movember, Breast Cancer Awareness Month, etc.) or science festivals, open days, etc. The due dates are succeptible to change, depending on the date of the corresponding event. All beneficiaries should be lead beneficiaries for this deliverable.

completion of the ESRs recruitment

All ESRs recruited and ready to start their PhD projects. All beneficiaries should be lead beneficiaries for this deliverable.

Publicaciones

Peer reviewed articles (18)

Preparation of 3,5-Methanobenzo[b]azepines: An sp3-Rich Quinolone Isostere

Autores: L Herter, T Perrin, T Fessard, C Salomé
Publicado en: Org. Lett., 2023, Página(s) 6161–6166, ISSN 1523-7060
Editor: American Chemical Society
DOI: 10.1021/acs.orglett.3c02250

Hydrogel crosslinking via thiol-reactive pyridazinediones

Autores: Calise Bahou; Richard Spears; Angela Ramirez Rosales; Lea Rochet; Lydia Barber; Vijay Chudasama; Christopher Spicer
Publicado en: Biomacromolecules, Edición 10, 2023, Página(s) 4646-4652, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.3c00290

Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase

Autores: Maurice Sebastiani, Christina Behrens, Stefanie Dörr, Hans-Dieter Gerber, Rania Benazza, Oscar Hernandez-Alba, Sarah Cianférani, Gerhard Klebe, Andreas Heine, Klaus Reuter
Publicado en: ACS Chem. Biol., 2022, Página(s) 2229–2247, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.2c00368

A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold

Autores: R.J. Spears; Clíona McMahon; Monika Shamsabadi; Calise Bahou; Ioanna A. Thanasi; Léa N. C. Rochet; Nafsika Forte; Fabien Thoreau; James R. Baker; Vijay Chudasama
Publicado en: Chemical Communications, 2022, Página(s) Chem. Commun., 2022, 58, 645-648, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cc03802h

Macrocyclic Dual‐Locked “Turn‐On” Drug for Selective and Traceless Release in Cancer Cells

Autores: Dominik Schauenburg; Bingjie Gao; Léa N. C. Rochet; Darijan Schüler; Jaime A. S. Coelho; David Y. W. Ng; Vijay Chudasama; Seah Ling Kuan; Tanja Weil
Publicado en: Crossref, Edición 3, 2024, Página(s) e202314143, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202314143

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

Autores: Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Publicado en: Nature Communications, 2022, Página(s) 1-5, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-33827-3

Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction

Autores: Valentine Vaur, Ilias Koutsopetras, Stéphane Erb, Bianka Jackowska, Rania Benazza, Héloïse Cahuzac, Alexandre Detappe, Oscar Hernandez-Alba, Sarah Cianférani, Christopher J. Scott, Guilhem Chaubet
Publicado en: ChemBioChem, 2024, Página(s) e202400170, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400170

A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity

Autores: Tony Rady; Lorenzo Turelli; Marc Nothisen; Elisabetta Tobaldi; Stéphane Erb; Fabien Thoreau; Oscar Hernandez-Alba; Sarah Cianferani; François Daubeuf; Alain Wagner; Guilhem Chaubet
Publicado en: Bioconjugate Chemistry, Edición 33, 2022, Página(s) 1860-1866, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00314

Site‐Selective Protein Conjugation by a Multicomponent Ugi Reaction

Autores: Ilias Koutsopetras; Valentine Vaur; Rania Benazza; Hélène Diemer; Charlotte Sornay; Yağmur Ersoy; Léa Rochet; Carmen Longo; Oscar Hernandez‐Alba; Stéphane Erb; Alexandre Detappe; Arne Skerra; Alain Wagner; Sarah Cianferani; Guilhem Chaubet
Publicado en: Chemistry - A European Journal, Edición 10, 2023, Página(s) e202303242, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202303242

Rapid Access to Potent Bispecific T Cell Engagers Using Biogenic Tyrosine Click Chemistry

Autores: Irene Shajan; Léa N. C. Rochet; Shannon R. Tracey; Bianka Jackowska; Rania Benazza; Oscar Hernandez-Alba; Sarah Cianférani; Christopher J. Scott; Floris L. van Delft; Vijay Chudasama; Bauke Albada
Publicado en: Bioconjugate Chemistry (2023) (In press)., Edición 8, 2023, Página(s) 2215-2220, ISSN 1043-1802
Editor: American Chemical Society
DOI: 10.1021/acs.bioconjchem.3c00357

Modular chemical construction of IgG-like mono- and bispecific synthetic antibodies (SynAbs)

Autores: Fabien Thoreau; Peter A. Szijj; Michelle K. Greene; Léa N. C. Rochet; Ioanna A. Thanasi; Jaine K. Blayney; Antoine Maruani; James R. Baker; Christopher J. Scott; Vijay Chudasama
Publicado en: ACS Central Science, Edición 9, 2023, Página(s) 476-487, ISSN 2374-7943
Editor: ACS
DOI: 10.1021/acscentsci.2c01437

Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp3-rich chemical space

Autores: Loïc Herter, Ilias Koutsopetras, Lorenzo Turelli, Thomas Fessard*, Christophe Salomé*
Publicado en: Organic & Biomolecular Chemistry, 2022, Página(s) 9108-9111, ISSN 1477-0520
Editor: Royal Society of Chemistry
DOI: 10.1039/d2ob01669a

Cysteine‐Cysteine Cross‐Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine‐Electrophilic Reagent

Autores: Koutsopetras, Ilias; Mishra, Abhaya Kumar; Benazza, Rania; Hernandez‐Alba, Oscar; Cianférani, Sarah; Chaubet, Guilhem; Nicolai, Stefano; Waser, Jérôme
Publicado en: Chemistry A European Journal, Edición 10, 2023, Página(s) e202302689, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202302689

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

Autores: Fabien Thoreau; Léa N. C. Rochet; James R. Baker; Vijay Chudasama
Publicado en: Chemical Science (14) (2023), Edición 10, 2023, Página(s) 3752-3762, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sc06318b

SEC-MS in denaturing conditions (dSEC-MS) for in-depth analysis of rebridged monoclonal antibody-based formats

Autores: Rania Benazza (1) , Ilias Koutsopetras (2) , Valentine Vaur (2) , Guilhem Chaubet (2) , Oscar Hernandez Alba (1) , Sarah Cianferani (1)
Publicado en: Talanta, 2024, Página(s) 125727, ISSN 0039-9140
Editor: Elsevier BV
DOI: 10.1016/j.talanta.2024.125727

Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting

Autores: Adam Creamer; Alessandra Lo Fiego; Alice Agliano; Lino Prados‐Martin; Håkon Høgset; Adrian Najer; Daniel A. Richards; Jonathan P. Wojciechowski; James E. J. Foote; Nayoung Kim; Amy Monahan; Jiaqing Tang; André Shamsabadi; Léa N. C. Rochet; Ioanna A. Thanasi; Laura R. de la Ballina; Charlotte L. Rapley; Stephen Turnock; Elizabeth A. Love; Laurence Bugeon; Margaret J. Dallman; Martin Heeney; G
Publicado en: Advanced Materials, Edición 9, 2023, Página(s) 2300413, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300413

Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels

Autores: Léa N. C. Rochet, Calise Bahou, Jonathan P. Wojciechowski, Ilias Koutsopetras, Phyllida Britton, Richard J. Spears, Ioanna A. Thanasi, Baihao Shao, Lisha Zhong, Dejan-Kresimir Bucar, Abil E. Aliev, Michael J. Porter, Molly M. Stevens, James R. Baker and Vijay Chudasama
Publicado en: Chemical Science, 2023, Página(s) 13743-13754, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d3sc04976k

Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer

Autores: Renyu Guo, Yu-Che Chang, Loic Herter, Christophe Salome, Sarah E. Braley, Thomas C. Fessard, and M. Kevin Brown
Publicado en: Journal of the American Chemical Society, 2022, Página(s) J. Am. Chem. Soc. 2022, 144, 18, 7988–7994, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.2c02976

Other (2)

Development of fine-tuned top-down mass spectrometry strategies in the chromatographic time scale (LC-TD-MS) for the complete characterization of an anti EGFR single domain antibody-drug conjugate (sdADC)

Autores: Rania Benazza ,Greg Papadakos ,Jen Thom ,Hélène Diemer ,Graham Cotton ,Sarah Cianférani, Oscar Hernandez Alba
Publicado en: 2024
Editor: ChemRxiv
DOI: 10.26434/chemrxiv-2024-wnx5w

A Modular Semi-Synthetic Approach to Generate T cell-Dependent Bispecific Constructs from Recombinant IgG1 Antibodies

Autores: Irene Shajan, Lea Rochet, Shannon Tracey, Rania Benazza, Bianka Jackowska, Oscar Hernandez-Alba, Sarah Cianferani, Christopher Scott, Floris van Delft, Vijay Chudasama, Bauke Albada
Publicado en: 2024, ISSN 2573-2293
Editor: ChemRxiv
DOI: 10.26434/chemrxiv-2024-5hv9x