Targeted Anti-Cancer Therapies

Livrables

completion of the network-wide meetings' schedules

Schedules of all networkwide meetings will be issued every 8 months starting at month 7 As networkwide meetings will be conducted at various locations there will be several lead beneficiaries namely WU UCL QUB AD UNISTRA and HDPR

bimonthly newsletter launched

A newsletter detailling the most representative achievements of the consortium and giving news about the progress of the project As mutual lead beneficiaries of WP7 both AD and UNISTRA are the actual lead beneficiaries of this deliverable

meetings reports

Report of all essential aspects discussed during the networkwide meetings whether they be scientific or not Sensitive results will not be disclosed as this report will be made public Reports will be made every 8 months until month 40

kick-off press release

A document sent to the press that officially announces the beginning of the project. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

completion of the PM recruitment

Recruitment of a Project Manager.

completion of the ESRs recruitment

All ESRs recruited and ready to start their PhD projects. All beneficiaries should be lead beneficiaries for this deliverable.

TACT's yearly participation in at least one public event

TACT ESRs will participate in at least one big public event every year such as a charity Movember Breast Cancer Awareness Month etc or science festivals open days etc The due dates are succeptible to change depending on the date of the corresponding event All beneficiaries should be lead beneficiaries for this deliverable

online website and social media accounts

Website of the TACT project and all social media accounts connected to it

Publications

Hydrogel crosslinking via thiol-reactive pyridazinediones

Auteurs: Calise Bahou; Richard Spears; Angela Ramirez Rosales; Lea Rochet; Lydia Barber; Vijay Chudasama; Christopher Spicer
Publié dans: Biomacromolecules, Numéro 10, 2023, Page(s) 4646-4652, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.3c00290

A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold

Auteurs: R.J. Spears; Clíona McMahon; Monika Shamsabadi; Calise Bahou; Ioanna A. Thanasi; Léa N. C. Rochet; Nafsika Forte; Fabien Thoreau; James R. Baker; Vijay Chudasama
Publié dans: Chemical Communications, 2022, Page(s) Chem. Commun., 2022, 58, 645-648, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1cc03802h

Macrocyclic Dual‐Locked “Turn‐On” Drug for Selective and Traceless Release in Cancer Cells

Auteurs: Dominik Schauenburg; Bingjie Gao; Léa N. C. Rochet; Darijan Schüler; Jaime A. S. Coelho; David Y. W. Ng; Vijay Chudasama; Seah Ling Kuan; Tanja Weil
Publié dans: Crossref, Numéro 3, 2024, Page(s) e202314143, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202314143

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

Auteurs: Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Publié dans: Nature Communications, 2022, Page(s) 1-5, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-33827-3

A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity

Auteurs: Tony Rady; Lorenzo Turelli; Marc Nothisen; Elisabetta Tobaldi; Stéphane Erb; Fabien Thoreau; Oscar Hernandez-Alba; Sarah Cianferani; François Daubeuf; Alain Wagner; Guilhem Chaubet
Publié dans: Bioconjugate Chemistry, Numéro 33, 2022, Page(s) 1860-1866, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00314

Site‐Selective Protein Conjugation by a Multicomponent Ugi Reaction

Auteurs: Ilias Koutsopetras; Valentine Vaur; Rania Benazza; Hélène Diemer; Charlotte Sornay; Yağmur Ersoy; Léa Rochet; Carmen Longo; Oscar Hernandez‐Alba; Stéphane Erb; Alexandre Detappe; Arne Skerra; Alain Wagner; Sarah Cianferani; Guilhem Chaubet
Publié dans: Chemistry - A European Journal, Numéro 10, 2023, Page(s) e202303242, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202303242

Rapid Access to Potent Bispecific T Cell Engagers Using Biogenic Tyrosine Click Chemistry

Auteurs: Irene Shajan; Léa N. C. Rochet; Shannon R. Tracey; Bianka Jackowska; Rania Benazza; Oscar Hernandez-Alba; Sarah Cianférani; Christopher J. Scott; Floris L. van Delft; Vijay Chudasama; Bauke Albada
Publié dans: Bioconjugate Chemistry (2023) (In press)., Numéro 8, 2023, Page(s) 2215-2220, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.3c00357

Modular chemical construction of IgG-like mono- and bispecific synthetic antibodies (SynAbs)

Auteurs: Fabien Thoreau; Peter A. Szijj; Michelle K. Greene; Léa N. C. Rochet; Ioanna A. Thanasi; Jaine K. Blayney; Antoine Maruani; James R. Baker; Christopher J. Scott; Vijay Chudasama
Publié dans: ACS Central Science, Numéro 9, 2023, Page(s) 476-487, ISSN 2374-7943
Éditeur: ACS
DOI: 10.1021/acscentsci.2c01437

Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp3-rich chemical space

Auteurs: Loïc Herter, Ilias Koutsopetras, Lorenzo Turelli, Thomas Fessard*, Christophe Salomé*
Publié dans: Organic & Biomolecular Chemistry, 2022, Page(s) 9108-9111, ISSN 1477-0520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2ob01669a

Cysteine‐Cysteine Cross‐Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine‐Electrophilic Reagent

Auteurs: Koutsopetras, Ilias; Mishra, Abhaya Kumar; Benazza, Rania; Hernandez‐Alba, Oscar; Cianférani, Sarah; Chaubet, Guilhem; Nicolai, Stefano; Waser, Jérôme
Publié dans: Chemistry A European Journal, Numéro 10, 2023, Page(s) e202302689, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202302689

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

Auteurs: Fabien Thoreau; Léa N. C. Rochet; James R. Baker; Vijay Chudasama
Publié dans: Chemical Science (14) (2023), Numéro 10, 2023, Page(s) 3752-3762, ISSN 2041-6520
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d2sc06318b

Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting

Auteurs: Adam Creamer; Alessandra Lo Fiego; Alice Agliano; Lino Prados‐Martin; Håkon Høgset; Adrian Najer; Daniel A. Richards; Jonathan P. Wojciechowski; James E. J. Foote; Nayoung Kim; Amy Monahan; Jiaqing Tang; André Shamsabadi; Léa N. C. Rochet; Ioanna A. Thanasi; Laura R. de la Ballina; Charlotte L. Rapley; Stephen Turnock; Elizabeth A. Love; Laurence Bugeon; Margaret J. Dallman; Martin Heeney; G
Publié dans: Advanced Materials, Numéro 9, 2023, Page(s) 2300413, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300413

Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer

Auteurs: Renyu Guo, Yu-Che Chang, Loic Herter, Christophe Salome, Sarah E. Braley, Thomas C. Fessard, and M. Kevin Brown
Publié dans: Journal of the American Chemical Society, 2022, Page(s) J. Am. Chem. Soc. 2022, 144, 18, 7988–7994, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.2c02976

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