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CORDIS - Risultati della ricerca dell’UE
CORDIS

Targeted Anti-Cancer Therapies

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

invitation to the exhibition opening in Strasbourg (si apre in una nuova finestra)

Official invitation to the opening of TACT exhibition. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

completion of the network-wide meetings' schedules (si apre in una nuova finestra)

Schedules of all network-wide meetings will be issued every 8 months, starting at month 7. As network-wide meetings will be conducted at various locations, there will be several lead beneficiaries, namely WU, UCL, QUB, AD, UNISTRA and HDPR.

bimonthly newsletter launched (si apre in una nuova finestra)

A newsletter detailling the most representative achievements of the consortium and giving news about the progress of the project. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

annual scientific publications portfolio (si apre in una nuova finestra)

A portfolio of all scientific publications that will have been made during the past year in the frame of the TACT project. Three portfolios will thus be made, at month 18, 30 and 42. All beneficiaries should be lead beneficiaries for this deliverable.

meetings reports (si apre in una nuova finestra)

Report of all essential aspects discussed during the network-wide meetings, whether they be scientific or not. Sensitive results will not be disclosed as this report will be made public. Reports will be made every 8 months, until month 40.

kick-off press release (si apre in una nuova finestra)

A document sent to the press that officially announces the beginning of the project. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

translated and adapted versions of exhibition contents (si apre in una nuova finestra)

As the final exhibition aims at being as accessible to an international audience as possible, each text, figure, etc. will have to be translated to all languages spoken in the TACT consortium. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

public press releases portfolio (si apre in una nuova finestra)

A portfolio regrouping all press communications and releases concerning TACT's work, including the publication of all collated short graphic novels. As mutual lead beneficiaries of WP7 both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

YouTube tutorials channel launched (si apre in una nuova finestra)

A YouTube channel dedicated to tutorials in the diverse fields the ESRs will conduct their research projects in. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

production of three short scientific animations (si apre in una nuova finestra)

Three short scientific animations (e.g. “what is cancer?”, “how does a traditional chemotherapy work?” and “what are targeted therapies?”) will be created by a professional studio (such as Ella Maru's http://www.scientific-illustrations.com/). Those three animations will then be narrated by ESRs who will have participated in the elaboration of the script. The videos will then be posted on different platforms (TACT’s website, Twitter and Facebook accounts). All beneficiaries should be lead beneficiaries for this deliverable.

online publication of all exhibition contents (si apre in una nuova finestra)

All exhibition materials will be made available to the widest audience under a CC BY-NC-SA 4.0 license to be further exploited by other institutions. As mutual lead beneficiaries of WP7, both AD and UNISTRA are the actual lead beneficiaries of this deliverable.

creation of a test online chat group on Esperity (si apre in una nuova finestra)

A collaboration with the international cancer patients’ community Esperity (https://www.esperity.com/en) will be set up, where ESRs and their supervisors will create online chat groups dedicated to a particular cancer-related topic of their choice (e.g. ADCs, immunotherapies, pancreatic cancer). They will be the chat groups’ moderators and will answer patients’ questions regularly. The experience will first be conducted over a few weeks and extended or repeated if it were to prove fruitful. All beneficiaries should be lead beneficiaries for this deliverable.

online website and social media accounts (si apre in una nuova finestra)

Website of the TACT project and all social media accounts connected to it

completion of the PM recruitment (si apre in una nuova finestra)

Recruitment of a Project Manager.

TACT's yearly participation in at least one public event (si apre in una nuova finestra)

TACT ESRs will participate in at least one big public event every year, such as a charity (Movember, Breast Cancer Awareness Month, etc.) or science festivals, open days, etc. The due dates are succeptible to change, depending on the date of the corresponding event. All beneficiaries should be lead beneficiaries for this deliverable.

completion of the ESRs recruitment (si apre in una nuova finestra)

All ESRs recruited and ready to start their PhD projects. All beneficiaries should be lead beneficiaries for this deliverable.

Pubblicazioni

Preparation of 3,5-Methanobenzo[b]azepines: An sp3-Rich Quinolone Isostere (si apre in una nuova finestra)

Autori: L Herter, T Perrin, T Fessard, C Salomé
Pubblicato in: Org. Lett., 2023, Pagina/e 6161–6166, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.3c02250

Hydrogel crosslinking via thiol-reactive pyridazinediones (si apre in una nuova finestra)

Autori: Calise Bahou; Richard Spears; Angela Ramirez Rosales; Lea Rochet; Lydia Barber; Vijay Chudasama; Christopher Spicer
Pubblicato in: Biomacromolecules, Numero 10, 2023, Pagina/e 4646-4652, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.3c00290

Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase (si apre in una nuova finestra)

Autori: Maurice Sebastiani, Christina Behrens, Stefanie Dörr, Hans-Dieter Gerber, Rania Benazza, Oscar Hernandez-Alba, Sarah Cianférani, Gerhard Klebe, Andreas Heine, Klaus Reuter
Pubblicato in: ACS Chem. Biol., 2022, Pagina/e 2229–2247, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.2c00368

A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold (si apre in una nuova finestra)

Autori: R.J. Spears; Clíona McMahon; Monika Shamsabadi; Calise Bahou; Ioanna A. Thanasi; Léa N. C. Rochet; Nafsika Forte; Fabien Thoreau; James R. Baker; Vijay Chudasama
Pubblicato in: Chemical Communications, 2022, Pagina/e Chem. Commun., 2022, 58, 645-648, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cc03802h

Macrocyclic Dual‐Locked “Turn‐On” Drug for Selective and Traceless Release in Cancer Cells (si apre in una nuova finestra)

Autori: Dominik Schauenburg; Bingjie Gao; Léa N. C. Rochet; Darijan Schüler; Jaime A. S. Coelho; David Y. W. Ng; Vijay Chudasama; Seah Ling Kuan; Tanja Weil
Pubblicato in: Crossref, Numero 3, 2024, Pagina/e e202314143, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202314143

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes (si apre in una nuova finestra)

Autori: Rachel C. Epplin, Shashwati Paul, Loïc Herter, Christophe Salome, Erin N. Hancock, Jay F. Larrow, Erich W. Baum, David R. Dunstan, Carol Ginsburg-Moraff, Thomas C. Fessard, M. Kevin Brown
Pubblicato in: Nature Communications, 2022, Pagina/e 1-5, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-33827-3

Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction (si apre in una nuova finestra)

Autori: Valentine Vaur, Ilias Koutsopetras, Stéphane Erb, Bianka Jackowska, Rania Benazza, Héloïse Cahuzac, Alexandre Detappe, Oscar Hernandez-Alba, Sarah Cianférani, Christopher J. Scott, Guilhem Chaubet
Pubblicato in: ChemBioChem, 2024, Pagina/e e202400170, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400170

A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity (si apre in una nuova finestra)

Autori: Tony Rady; Lorenzo Turelli; Marc Nothisen; Elisabetta Tobaldi; Stéphane Erb; Fabien Thoreau; Oscar Hernandez-Alba; Sarah Cianferani; François Daubeuf; Alain Wagner; Guilhem Chaubet
Pubblicato in: Bioconjugate Chemistry, Numero 33, 2022, Pagina/e 1860-1866, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.2c00314

Site‐Selective Protein Conjugation by a Multicomponent Ugi Reaction (si apre in una nuova finestra)

Autori: Ilias Koutsopetras; Valentine Vaur; Rania Benazza; Hélène Diemer; Charlotte Sornay; Yağmur Ersoy; Léa Rochet; Carmen Longo; Oscar Hernandez‐Alba; Stéphane Erb; Alexandre Detappe; Arne Skerra; Alain Wagner; Sarah Cianferani; Guilhem Chaubet
Pubblicato in: Chemistry - A European Journal, Numero 10, 2023, Pagina/e e202303242, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202303242

Rapid Access to Potent Bispecific T Cell Engagers Using Biogenic Tyrosine Click Chemistry (si apre in una nuova finestra)

Autori: Irene Shajan; Léa N. C. Rochet; Shannon R. Tracey; Bianka Jackowska; Rania Benazza; Oscar Hernandez-Alba; Sarah Cianférani; Christopher J. Scott; Floris L. van Delft; Vijay Chudasama; Bauke Albada
Pubblicato in: Bioconjugate Chemistry (2023) (In press)., Numero 8, 2023, Pagina/e 2215-2220, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.3c00357

Modular chemical construction of IgG-like mono- and bispecific synthetic antibodies (SynAbs) (si apre in una nuova finestra)

Autori: Fabien Thoreau; Peter A. Szijj; Michelle K. Greene; Léa N. C. Rochet; Ioanna A. Thanasi; Jaine K. Blayney; Antoine Maruani; James R. Baker; Christopher J. Scott; Vijay Chudasama
Pubblicato in: ACS Central Science, Numero 9, 2023, Pagina/e 476-487, ISSN 2374-7943
Editore: ACS
DOI: 10.1021/acscentsci.2c01437

Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp3-rich chemical space (si apre in una nuova finestra)

Autori: Loïc Herter, Ilias Koutsopetras, Lorenzo Turelli, Thomas Fessard*, Christophe Salomé*
Pubblicato in: Organic & Biomolecular Chemistry, 2022, Pagina/e 9108-9111, ISSN 1477-0520
Editore: Royal Society of Chemistry
DOI: 10.1039/d2ob01669a

Cysteine‐Cysteine Cross‐Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine‐Electrophilic Reagent (si apre in una nuova finestra)

Autori: Koutsopetras, Ilias; Mishra, Abhaya Kumar; Benazza, Rania; Hernandez‐Alba, Oscar; Cianférani, Sarah; Chaubet, Guilhem; Nicolai, Stefano; Waser, Jérôme
Pubblicato in: Chemistry A European Journal, Numero 10, 2023, Pagina/e e202302689, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202302689

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs) (si apre in una nuova finestra)

Autori: Fabien Thoreau; Léa N. C. Rochet; James R. Baker; Vijay Chudasama
Pubblicato in: Chemical Science (14) (2023), Numero 10, 2023, Pagina/e 3752-3762, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d2sc06318b

SEC-MS in denaturing conditions (dSEC-MS) for in-depth analysis of rebridged monoclonal antibody-based formats (si apre in una nuova finestra)

Autori: Rania Benazza (1) , Ilias Koutsopetras (2) , Valentine Vaur (2) , Guilhem Chaubet (2) , Oscar Hernandez Alba (1) , Sarah Cianferani (1)
Pubblicato in: Talanta, 2024, Pagina/e 125727, ISSN 0039-9140
Editore: Elsevier BV
DOI: 10.1016/j.talanta.2024.125727

Modular Synthesis of Semiconducting Graft Copolymers to Achieve “Clickable” Fluorescent Nanoparticles with Long Circulation and Specific Cancer Targeting (si apre in una nuova finestra)

Autori: Adam Creamer; Alessandra Lo Fiego; Alice Agliano; Lino Prados‐Martin; Håkon Høgset; Adrian Najer; Daniel A. Richards; Jonathan P. Wojciechowski; James E. J. Foote; Nayoung Kim; Amy Monahan; Jiaqing Tang; André Shamsabadi; Léa N. C. Rochet; Ioanna A. Thanasi; Laura R. de la Ballina; Charlotte L. Rapley; Stephen Turnock; Elizabeth A. Love; Laurence Bugeon; Margaret J. Dallman; Martin Heeney; G
Pubblicato in: Advanced Materials, Numero 9, 2023, Pagina/e 2300413, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300413

Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels (si apre in una nuova finestra)

Autori: Léa N. C. Rochet, Calise Bahou, Jonathan P. Wojciechowski, Ilias Koutsopetras, Phyllida Britton, Richard J. Spears, Ioanna A. Thanasi, Baihao Shao, Lisha Zhong, Dejan-Kresimir Bucar, Abil E. Aliev, Michael J. Porter, Molly M. Stevens, James R. Baker and Vijay Chudasama
Pubblicato in: Chemical Science, 2023, Pagina/e 13743-13754, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d3sc04976k

Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer (si apre in una nuova finestra)

Autori: Renyu Guo, Yu-Che Chang, Loic Herter, Christophe Salome, Sarah E. Braley, Thomas C. Fessard, and M. Kevin Brown
Pubblicato in: Journal of the American Chemical Society, 2022, Pagina/e J. Am. Chem. Soc. 2022, 144, 18, 7988–7994, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.2c02976

Development of fine-tuned top-down mass spectrometry strategies in the chromatographic time scale (LC-TD-MS) for the complete characterization of an anti EGFR single domain antibody-drug conjugate (sdADC) (si apre in una nuova finestra)

Autori: Rania Benazza ,Greg Papadakos ,Jen Thom ,Hélène Diemer ,Graham Cotton ,Sarah Cianférani, Oscar Hernandez Alba
Pubblicato in: 2024
Editore: ChemRxiv
DOI: 10.26434/chemrxiv-2024-wnx5w

A Modular Semi-Synthetic Approach to Generate T cell-Dependent Bispecific Constructs from Recombinant IgG1 Antibodies (si apre in una nuova finestra)

Autori: Irene Shajan, Lea Rochet, Shannon Tracey, Rania Benazza, Bianka Jackowska, Oscar Hernandez-Alba, Sarah Cianferani, Christopher Scott, Floris van Delft, Vijay Chudasama, Bauke Albada
Pubblicato in: 2024, ISSN 2573-2293
Editore: ChemRxiv
DOI: 10.26434/chemrxiv-2024-5hv9x

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