Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation

An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia

Author(s): Hao Xie, Christoph Heier, Xia Meng, Latifa Bakiri, Isabella Pototschnig, Zhiyuan Tang, Silvia Schauer, Vanessa J. Baumgartner, Gernot F. Grabner, Gernot Schabbauer, Heimo Wolinski, Graham R. Robertson, Gerald Hoefler, Wenwen Zeng, Erwin F. Wagner, Martina Schweiger, Rudolf Zechner
Published in: Proc Natl Acad Sci U S A, Issue Mar 1; 119(9), 2022, Page(s) e2112840119, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2112840119

Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples

Author(s): Eirini Chrysanthou, Emir Sehovic, Paola Ostano, and Giovanna Chiorino
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11071099

Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

Author(s): Carlos Ronchi Cathrin Brisken
Published in: Clinical Cancer Research, 2023, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-3374

Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer

Author(s): Bode HF, Heikkinen A, Lundgren S, Kaprio J, Ollikainen M.
Published in: Twin Research and Human Genetics, Issue October 2022, 2022, Page(s) 171-179, ISSN 1839-2628
Publisher: Cambridge University Press
DOI: 10.1017/thg.2022.32

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Author(s): Philipp Novoszel , Barbara Drobits , Martin Holcmann , Cristiano De Sa Fernandes , Roland Tschismarov , Sophia Derdak, Thomas Decker , Erwin F Wagner , Maria Sibilia
Published in: Cell Death & Differentiation, Issue Aug;28(8), 2021, Page(s) 2404-2420, ISSN 1350-9047
Publisher: Nature Publishing Group
DOI: 10.1038/s41418-021-00765-4

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

Author(s): Patrick Aouad; Yueyun Zhang; Fabio De Martino; Céline Stibolt; simak Ali; Giovanna Ambrosini; Sendurai A. Mani; Kelly Maggs; Hazel M. Quinn; George Sflomos & Cathrin Brisken
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32523-6

Meta-analysis of diagnostic cell-free circulating microRNAs for breast cancer detection

Author(s): Emir Sehovic, Sara Urru, Giovanna Chiorino, Philipp Doebler
Published in: BMC Cancer, Issue 2022 Jun 9;22(1):634, 2022, Page(s) 634, ISSN 1471-2407
Publisher: BioMed Central
DOI: 10.1186/s12885-022-09698-8

ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.

Author(s): Luigi Mazzeo, Soumitra Ghosh, Emery Di Cicco, Jovan Isma, Daniele Tavernari, Anastasia Samarkina, Paola Ostano, Markus K. Youssef, Christian Simon, Gian-Paolo Dotto
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-45308-w

Identification of a minimum number of genes to predict triple-negative breast cancer subgroups from gene expression profiles

Author(s): Laila Akhouayri, Paola Ostano, Maurizia Mello-Grand, Ilaria Gregnanin, Francesca Crivelli, Sara Laurora, Daniele Liscia, Francesco Leone, Angela Santoro, Antonino Mulè, Donatella Guarino, Claudia Maggiore, Angela Carlino, Stefano Magno, Maria Scatolini, Alba Di Leone, Riccardo Masetti, Giovanna Chiorino
Published in: Human Genomics, 2022, ISSN 1479-7364
Publisher: Biomed Central Springer Nature
DOI: 10.1186/s40246-022-00436-6

Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model

Author(s): Nuria Gago‐López, Carmen Lagunas Arnal, Juan J. Perez, Erwin F. Wagner
Published in: Experimental Dermatology, Issue Nov;30(11), 2021, Page(s) 1662-1674, ISSN 0906-6705
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/exd.14390

Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells

Author(s): Novoszel P, Holcmann M, Stulnig G, De Sa Fernandes C, Zyulina V, Borek I, Linder M, Bogusch A, Drobits B, Bauer T, Tam-Amersdorfer C, Brunner PM, Stary G, Bakiri L, Wagner EF, Strobl H, Sibilia M.
Published in: EMBO Molecular Medicine, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012409

Androgen receptor is a determinant of melanoma targeted drug resistance

Author(s): Anastasia Samarkina; Markus Kirolos Youssef; Paola Ostano; Soumitra Ghosh; Min Ma; Beatrice Tassone; Tatiana Proust; Giovanna Chiorino; Mitchell P. Levesque; Sandro Goruppi; Gian Paolo Dotto
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42239-w

Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.

Author(s): Latifa Bakiri, Sebastian C Hasenfuss, Ana Guío-Carrión, Martin K Thomsen, Peter Hasselblatt, Erwin F Wagner.
Published in: Proc Natl Acad Sci U S A, Issue Apr 30;121(18) - Epub, 2024, Page(s) e2404188121 (Epub), ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2404188121

DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

Author(s): Emir Sehovic, Stephanie M. Zellers, Markus K. Youssef, Aino Heikkinen, Jaakko Kaprio, Miina Ollikainen
Published in: Clinical Epigenetics, Issue 2023, volume 15, 2023, Page(s) Article number: 181, ISSN 1868-7083
Publisher: Springer Nature
DOI: 10.1186/s13148-023-01594-7

NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

Author(s): Atul Katarkar, Giulia Bottoni, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Francesca Lazzaroni, Ilaria Gregnanin, Paola Ostano, Victor Neel, G. Paolo Dotto
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18919-2

TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

Author(s): Louise Blair, Michael J. Pattison, Probir Chakravarty, Stamatia Papoutsopoulou, Latifa Bakiri, Erwin F. Wagner, Stephen Smale, Steven C. Ley
Published in: J Immunol, Issue Feb 15; 208 (4), 2022, Page(s) 941–954, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.2100213

Tumor dormancy: EMT beyond invasion and metastasis

Author(s): Patrick Aouad, Hazel M. Quinn, Adeline Berger, Cathrin Brisken
Published in: Genesis, 2023, ISSN 1526-954X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dvg.23552

Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia

Author(s): Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Published in: Journal of Cachexia, Sarcopenia and Muscle, 2022, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.13109

GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma

Author(s): Scatolini, M., Patel, A., Grosso, E., Mello-Grand, M., Ostano, P., Coppo, R., Vitiello, M., Venesio, T., Zaccagna, A., Pisacane, A., Sarotto, I., Taverna, D., Poliseno, L., Bergamaschi, D., & Chiorino, G
Published in: The British journal of dermatology 2021, 2021, ISSN 0007-0963
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjd.20629

Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease

Author(s): Liliana F Mellor; Nuria Gago-Lopez; Latifa Bakiri; Felix N Schmidt; Björn Busse; Simon Rauber; Maria Jimenez; Diego Megías; Sergio Oterino-Sogo; Ricardo Sanchez-Prieto; Sergei Grivennikov; Xinzhu Pu; Julia Oxford; Andreas Ramming; Georg Schett; Erwin F Wagner
Published in: Ann Rheum Dis, Issue 00034967, 2022, Page(s) 1400-1408, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222229

Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia

Author(s): Michele Petruzzelli, Miriam Ferrer, Martijn J. Schuijs, Sam O. Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J. Lukey, Duncan I. Jodrell, Christian Frezza, Erwin F. Wagner, Ashok R. Venkitaraman, Timotheus Y. F. Halim,Tobias Janowitz
Published in: Cancers (Basel), Issue Feb 15;14(4), 2022, Page(s) 963, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040963

A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization

Author(s): Almet AA, Yuan H, Annusver K, Ramos R, Liu Y, Wiedemann J, Sorkin DH, Landén NX, Sonkoly E, Haniffa M, Nie Q, Lichtenberger BM, Luecken MD, Andersen B, Tsoi LC, Watt FM, Gudjonsson JE, Plikus MV, Kasper M.
Published in: J Invest Dermatol., Issue Sep;143(9), 2023, Page(s) 1667-1677, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.03.1679

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

Author(s): Talwelkar,S., Mäyränpää, M., Søraas, L., Potdar, S., Bao, J,, Hemmes,A., Linnavirta, N., Lømo, J, Räsänen,J,, Knuuttila, A, Wennerberg,K. Verschuren, EW
Published in: Cell Reports Medicine, 2021, ISSN 2666-3791
Publisher: Elsevier Inc.
DOI: 10.1016/j.xcrm.2021.100373

Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

Author(s): Kazuhiko Matsuoka, Latifa Bakiri, Martin Bilban, Stefan Toegel, Arvand Haschemi, Hao Yuan, Maria Kasper, Reinhard Windhager, Erwin F Wagner
Published in: Ann Rheum Dis, Issue Jun 21, 2023, Page(s) ard-2023-224002, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/ard-2023-224002

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

Author(s): Valentina Scabia, Ayyakkannu Ayyanan, Fabio De Martino, Andrea Agnoletto, Laura Battista, Csaba Laszlo, Assia Treboux, Khalil Zaman, Athina Stravodimou, Didier Jallut, Maryse Fiche, Philip Bucher, Giovanna Ambrosini, George Sflomos & Cathrin Brisken
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30898-0

Functions of the RIP kinase family members in the skin

Author(s): Corinne Urwyler-Rösselet, Giel Tanghe, Michael Devos, Paco Hulpiau, Yvan Saeys and Wim Declercq
Published in: Cell Mol Life Sci, Issue 2023 Sep 9;80(10):285, 2023, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-023-04917-2

Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis

Author(s): Min Ma; Soumitra Ghosh; Daniele Tavernari; Daniele Tavernari; Atul Katarkar; Andrea Clocchiatti; Luigi Mazzeo; Anastasia Samarkina; Justine Epiney; Yi-Ru Yu; Ping-Chih Ho; Mitchell P. Levesque; Berna C. Özdemir; Berna C. Özdemir; Giovanni Ciriello; Giovanni Ciriello; Reinhard Dummer; G. Paolo Dotto; G. Paolo Dotto; G. Paolo Dotto
Published in: The Journal of Experimental Medicine, Issue 21, 2021, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20201137

Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma

Author(s): Sflomos G, Schaumann N, Christgen M, Christgen H, Bartels S, Kreipe H, Battista L, Brisken C.
Published in: Cancers, 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15133299

Plasma microRNA ratios associated with breast cancer detection in a nested case–control study from a mammography screening cohort

Author(s): Giovanna Chiorino, Elisabetta Petracci, Emir Sehovic, Ilaria Gregnanin, Elisa Camussi, Maurizia Mello-Grand, Paola Ostano, Emilia Riggi, Viviana Vergini, Alessia Russo, Enrico Berrino, Andrea Ortale, Francesca Garena, Tiziana Venesio, Federica Gallo, Elisabetta Favettini, Alfonso Frigerio, Giuseppe Matullo, Nereo Segnan, Livia Giordano
Published in: Scientific Reports, Issue Issue 1, Vol 13, page 12040, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-38886-0

How does inflammation spread through the body?

Author(s): Latifa Bakiri, Erwin F Wagner
Published in: EU Research, Issue Spring issue, vol. (34), 2023, Page(s) 17 - 19, ISSN 2752-4736
Publisher: Blazon Publishing & Media Limited
DOI: 10.56181/fhju5543

Open Thy Lattice Osteoclast, Resorb me!

Author(s): Latifa Bakiri
Published in: J Cell Biol, Issue Volume 222, Issue 4,, 2023, Page(s) e202302033, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202302033

Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk

Author(s): Hannes Frederik Bode, Liang He, Jacob Hjelmborg, Jaakko Kaprio, Miina Ollikainen
Published in: medrxiv, 2023
Publisher: Medrxiv
DOI: 10.1101/2023.08.15.23293985

Mechanism of chronic inflammation in psoriasis-like skin and joint disease

Author(s): Latifa Bakiri, Georg Schett , Erwin F Wagner
Published in: SPECTRUM Dermatologie, Issue SD 04|2022, Nov 24, 2022
Publisher: Karger Publishers

Mechanism of chronic inflammation in psoriasis-like skin and joint disease

Author(s): Latifa Bakiri, Georg Schett , Erwin F Wagner
Published in: SPECTRUM Dermatologie, Issue SD 04|2022, Nov 24, 2022, Page(s) 94-95, ISSN 2223-0661
Publisher: MedMedia Verlag und Mediaservice GmbH, Vienna

Elucidating the molecular link between psoriasis and skin cancer

Author(s): Panagiota Tsokkou, Martin Holcmann, Kamil Mieczkowski, Latifa Bakiri, Maria Sibilia, Erwin F. Wagner.
Published in: Journal of Investigative Dermatology, Issue 143 (11), Supplement, 2023, Page(s) S350, ISSN 0022-202X
Publisher: Elsevier
DOI: 10.1016/j.jid.2023.09.111

Dissecting the progression of cardiac dysfunction in tumor-bearing mice(Abstract Book of: Frontiers in CardioVascular Biomedicine 2022 Budapest 29th April – 1st May Sixth Congress of the ESC Council on Basic Cardiovascular Science)

Author(s): Dostal, LP Szabo, C Aioanei, D Abraham, K Zins, Latifa Bakiri, E Wagner, BK Podesser, A Kiss
Published in: Cardiovascular Research, Issue Vol 118, Supplement 1, 2022, Page(s) cvac066.247, ISSN 1755-3245
Publisher: Oxford Academic
DOI: 10.1093/cvr/cvac066.247

Dissecting the progression of cardiac dysfunction in tumor-bearing mice(Abstract Book of: Österreichische Kardiologische Gesellschaft Jahrestagung 25.5-28.5.2022 Salzburg)

Author(s): C Dostal, LP Szabo, C Aioanei, D Abraham, K Zins, Latifa Bakiri, Erwin F Wagner, BK Podesser, Atilla Kiss.
Published in: The Wiener klinische Wochenschrift, Issue 134 (Suppl 2), 2022, Page(s) 77–210
Publisher: Springer-Verlag Wien
DOI: 10.1007/s00508-022-02035-w

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