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Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation

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Publications

IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

Author(s): Rasmus Siersbæk, Valentina Scabia, Sankari Nagarajan, Igor Chernukhin, Evangelia K. Papachristou, Rebecca Broome, Simon J. Johnston, Stacey E.P. Joosten, Andrew R. Green, Sanjeev Kumar, Julia Jones, Soleilmane Omarjee, Ruben Alvarez-Fernandez, Silvia Glont, Sarah J. Aitken, Kamal Kishore, Danya Cheeseman, Emad A. Rakha, Clive D'Santos, Wilbert Zwart, Alasdair Russell, Cathrin Brisken, Jason S. Ca
Published in: Cancer Cell, Issue 38/3, 2020, Page(s) 412-423.e9, ISSN 1535-6108
DOI: 10.1016/j.ccell.2020.06.007

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Author(s): Philipp Novoszel , Barbara Drobits , Martin Holcmann , Cristiano De Sa Fernandes , Roland Tschismarov , Sophia Derdak, Thomas Decker , Erwin F Wagner , Maria Sibilia
Published in: cell death & differentiation, 2021, ISSN 1350-9047
DOI: 10.1038/s41418-021-00765-4

Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation

Author(s): Agata Lichawska-Cieslar, Piotr Konieczny, Weronika Szukala, Wim Declercq, Mingui Fu, Jolanta Jura
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1868/1, 2021, Page(s) 118866, ISSN 0167-4889
DOI: 10.1016/j.bbamcr.2020.118866

Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model

Author(s): Nuria Gago‐López, Carmen Lagunas Arnal, Juan J. Perez, Erwin F. Wagner
Published in: Experimental Dermatology, Issue Nov;30(11), 2021, Page(s) 1662-1674, ISSN 0906-6705
DOI: 10.1111/exd.14390

Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells

Author(s): Novoszel P, Holcmann M, Stulnig G, De Sa Fernandes C, Zyulina V, Borek I, Linder M, Bogusch A, Drobits B, Bauer T, Tam-Amersdorfer C, Brunner PM, Stary G, Bakiri L, Wagner EF, Strobl H, Sibilia M.
Published in: EMBO Molecular Medicine, 2021, ISSN 1757-4676
DOI: 10.15252/emmm.202012409

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection

Author(s): Tania Løve Aaes, Hanne Verschuere, Agnieszka Kaczmarek, Liesbeth Heyndrickx, Bartosz Wiernicki, Iris Delrue, Bram De Craene, Joachim Taminau, Tinneke Delvaeye, Mathieu J. M. Bertrand, Wim Declercq, Geert Berx, Dmitri V. Krysko, Sandy Adjemian, Peter Vandenabeele
Published in: The Journal of Immunology, Issue 204/4, 2020, Page(s) 775-787, ISSN 0022-1767
DOI: 10.4049/jimmunol.1900072

Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium

Author(s): Laurine Gagniac, Mariam Rusidzé, Frederic Boudou, Stephanie Cagnet, Marine Adlanmerini, Pauline Jeannot, Nicolas Gaide, Frank Giton, Arnaud Besson, Ariane Weyl, Pierre Gourdy, Isabelle Raymond-Letron, Jean-Francois Arnal, Cathrin Brisken, Francoise Lenfant
Published in: Development, Issue 147/5, 2020, Page(s) dev182303, ISSN 0950-1991
DOI: 10.1242/dev.182303

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

Author(s): Claudia Koch, Andra Kuske, Simon A Joosse, Gökhan Yigit, George Sflomos, Sonja Thaler, Daniel J Smit, Stefan Werner, Kerstin Borgmann, Sebastian Gärtner, Parinaz Mossahebi Mohammadi, Laura Battista, Laure Cayrefourcq, Janine Altmüller, Gabriela Salinas‐Riester, Kaamini Raithatha, Arne Zibat, Yvonne Goy, Leonie Ott, Kai Bartkowiak, Tuan Zea Tan, Qing Zhou, Michael R Speicher, Volkmar Müller,
Published in: EMBO Molecular Medicine, Issue 12/9, 2020, ISSN 1757-4676
DOI: 10.15252/emmm.201911908

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

Author(s): Sofie Martens, Sam Hofmans, Wim Declercq, Koen Augustyns, Peter Vandenabeele
Published in: Trends in Pharmacological Sciences, Issue 41/3, 2020, Page(s) 209-224, ISSN 0165-6147
DOI: 10.1016/j.tips.2020.01.002

A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures

Author(s): Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André, Catarina Brito
Published in: Journal of Experimental & Clinical Cancer Research, Issue 39/1, 2020, ISSN 1756-9966
DOI: 10.1186/s13046-020-01653-4

GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma

Author(s): Scatolini, M., Patel, A., Grosso, E., Mello-Grand, M., Ostano, P., Coppo, R., Vitiello, M., Venesio, T., Zaccagna, A., Pisacane, A., Sarotto, I., Taverna, D., Poliseno, L., Bergamaschi, D., & Chiorino, G
Published in: The British journal of dermatology 2021, 2021, ISSN 0007-0963
DOI: 10.1111/bjd.20629

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

Author(s): Dalya Ataca, Patrick Aouad, Céline Constantin, Csaba Laszlo, Manfred Beleut, Marie Shamseddin, Renuga Devi Rajaram, Rachel Jeitziner, Timothy J. Mead, Marian Caikovski, Philipp Bucher, Giovanna Ambrosini, Suneel S. Apte, Cathrin Brisken
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-15357-y

NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

Author(s): Atul Katarkar, Giulia Bottoni, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Francesca Lazzaroni, Ilaria Gregnanin, Paola Ostano, Victor Neel, G. Paolo Dotto
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-18919-2

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

Author(s): Talwelkar,S., Mäyränpää, M., Søraas, L., Potdar, S., Bao, J,, Hemmes,A., Linnavirta, N., Lømo, J, Räsänen,J,, Knuuttila, A, Wennerberg,K. Verschuren, EW
Published in: Cell Reports Medicine, 2021, ISSN 2666-3791
DOI: 10.1016/j.xcrm.2021.100373

90 YEARS OF PROGESTERONE: Progesterone receptor signaling in the normal breast and its implications for cancer

Author(s): Cathrin Brisken, Valentina Scabia
Published in: Journal of Molecular Endocrinology, Issue 65/1, 2020, Page(s) T81-T94, ISSN 0952-5041
DOI: 10.1530/jme-20-0091

Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation

Author(s): Esther Hoste, Christian Maueröder, Lisette van Hove, Leen Catrysse, Hanna-Kaisa Vikkula, Mozes Sze, Bastiaan Maes, Dyah Karjosukarso, Liesbet Martens, Amanda Gonçalves, Eef Parthoens, Ria Roelandt, Wim Declercq, Ignacia Fuentes, Francis Palisson, Sergio Gonzalez, Julio C. Salas-Alanis, Louis Boon, Peter Huebener, Klaas Willem Mulder, Kodi Ravichandran, Yvan Saeys, Robert Felix Schwabe, Geert van
Published in: Cell Reports, Issue 29/9, 2019, Page(s) 2689-2701.e4, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.10.104

Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation

Author(s): Piotr Konieczny, Agata Lichawska-Cieslar, Patrycja Kwiecinska, Joanna Cichy, Roza Pietrzycka, Weronika Szukala, Wim Declercq, Michael Devos, Agnieszka Paziewska, Izabela Rumienczyk, Maria Kulecka, Michal Mikula, Mingui Fu, Julia Borowczyk, Luis F Santamaria-Babí, Jolanta Jura
Published in: Journal of Molecular Medicine, Issue 97/12, 2019, Page(s) 1669-1684, ISSN 0946-2716
DOI: 10.1007/s00109-019-01853-2

Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis

Author(s): Min Ma, Soumitra Ghosh, Daniele Tavernari, Atul Katarkar, Andrea Clocchiatti, Luigi Mazzeo, Anastasia Samarkina, Justine Epiney, Yi-Ru Yu, Ping-Chih Ho, Mitchell P. Levesque, Berna C. Özdemir, Giovanni Ciriello, Reinhard Dummer, G. Paolo Dotto
Published in: Journal of Experimental Medicine, Issue 218/2, 2021, ISSN 0022-1007
DOI: 10.1084/jem.20201137

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

Author(s): Nina Mars, Elisabeth Widén, Sini Kerminen, Tuomo Meretoja, Matti Pirinen, Pietro della Briotta Parolo, Priit Palta, Aarno Palotie, Jaakko Kaprio, Heikki Joensuu, Mark Daly, Samuli Ripatti
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-19966-5

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

Author(s): Michael Devos, Giel Tanghe, Barbara Gilbert, Evelien Dierick, Maud Verheirstraeten, Josephine Nemegeer, Richard de Reuver, Sylvie Lefebvre, Jolien De Munck, Jan Rehwinkel, Peter Vandenabeele, Wim Declercq, Jonathan Maelfait
Published in: Journal of Experimental Medicine, Issue 217/7, 2020, ISSN 0022-1007
DOI: 10.1084/jem.20191913

Wnt signaling and Loxl2 promote aggressive osteosarcoma

Author(s): Kazuhiko Matsuoka, Latifa Bakiri, Lena I. Wolff, Markus Linder, Amanda Mikels-Vigdal, Ana Patiño-García, Fernando Lecanda, Christine Hartmann, Maria Sibilia, Erwin F. Wagner
Published in: Cell Research, Issue 30/10, 2020, Page(s) 885-901, ISSN 1001-0602
DOI: 10.1038/s41422-020-0370-1