Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation

Información del proyecto

CANCERPREV

Identificador del acuerdo de subvención: 859860

DOI

10.3030/859860

Proyecto cerrado

Fecha de la firma de la CE 21 Agosto 2019

Fecha de inicio 1 Noviembre 2019

Fecha de finalización 29 Febrero 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 096 014,48

Aportación de la UE

€ 4 096 014,48

Coordinado por

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (2)

Project website
Doctoral degrees award

Other (2)

Annual summer course and workshop - Year 2

Annual summer course and workshop – Year 2

Annual summer course and workshop - Year 3

Annual summer course and workshop – Year 3

Open Research Data Pilot (1)

Data Management Plan

Publicaciones

Peer reviewed articles (26)

An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia

Autores: Hao Xie, Christoph Heier, Xia Meng, Latifa Bakiri, Isabella Pototschnig, Zhiyuan Tang, Silvia Schauer, Vanessa J. Baumgartner, Gernot F. Grabner, Gernot Schabbauer, Heimo Wolinski, Graham R. Robertson, Gerald Hoefler, Wenwen Zeng, Erwin F. Wagner, Martina Schweiger, Rudolf Zechner
Publicado en: Proc Natl Acad Sci U S A, Edición Mar 1; 119(9), 2022, Página(s) e2112840119, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2112840119

Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples

Autores: Eirini Chrysanthou, Emir Sehovic, Paola Ostano, and Giovanna Chiorino
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11071099

Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

Autores: Carlos Ronchi Cathrin Brisken
Publicado en: Clinical Cancer Research, 2023, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-3374

Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer

Autores: Bode HF, Heikkinen A, Lundgren S, Kaprio J, Ollikainen M.
Publicado en: Twin Research and Human Genetics, Edición October 2022, 2022, Página(s) 171-179, ISSN 1839-2628
Editor: Cambridge University Press
DOI: 10.1017/thg.2022.32

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Autores: Philipp Novoszel , Barbara Drobits , Martin Holcmann , Cristiano De Sa Fernandes , Roland Tschismarov , Sophia Derdak, Thomas Decker , Erwin F Wagner , Maria Sibilia
Publicado en: Cell Death & Differentiation, Edición Aug;28(8), 2021, Página(s) 2404-2420, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-021-00765-4

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

Autores: Patrick Aouad; Yueyun Zhang; Fabio De Martino; Céline Stibolt; simak Ali; Giovanna Ambrosini; Sendurai A. Mani; Kelly Maggs; Hazel M. Quinn; George Sflomos & Cathrin Brisken
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-32523-6

Meta-analysis of diagnostic cell-free circulating microRNAs for breast cancer detection

Autores: Emir Sehovic, Sara Urru, Giovanna Chiorino, Philipp Doebler
Publicado en: BMC Cancer, Edición 2022 Jun 9;22(1):634, 2022, Página(s) 634, ISSN 1471-2407
Editor: BioMed Central
DOI: 10.1186/s12885-022-09698-8

ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.

Autores: Luigi Mazzeo, Soumitra Ghosh, Emery Di Cicco, Jovan Isma, Daniele Tavernari, Anastasia Samarkina, Paola Ostano, Markus K. Youssef, Christian Simon, Gian-Paolo Dotto
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-45308-w

Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model

Autores: Nuria Gago‐López, Carmen Lagunas Arnal, Juan J. Perez, Erwin F. Wagner
Publicado en: Experimental Dermatology, Edición Nov;30(11), 2021, Página(s) 1662-1674, ISSN 0906-6705
Editor: Blackwell Publishing Inc.
DOI: 10.1111/exd.14390

Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells

Autores: Novoszel P, Holcmann M, Stulnig G, De Sa Fernandes C, Zyulina V, Borek I, Linder M, Bogusch A, Drobits B, Bauer T, Tam-Amersdorfer C, Brunner PM, Stary G, Bakiri L, Wagner EF, Strobl H, Sibilia M.
Publicado en: EMBO Molecular Medicine, 2021, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012409

Androgen receptor is a determinant of melanoma targeted drug resistance

Autores: Anastasia Samarkina; Markus Kirolos Youssef; Paola Ostano; Soumitra Ghosh; Min Ma; Beatrice Tassone; Tatiana Proust; Giovanna Chiorino; Mitchell P. Levesque; Sandro Goruppi; Gian Paolo Dotto
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-42239-w

Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.

Autores: Latifa Bakiri, Sebastian C Hasenfuss, Ana Guío-Carrión, Martin K Thomsen, Peter Hasselblatt, Erwin F Wagner.
Publicado en: Proc Natl Acad Sci U S A, Edición Apr 30;121(18) - Epub, 2024, Página(s) e2404188121 (Epub), ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2404188121

DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

Autores: Emir Sehovic, Stephanie M. Zellers, Markus K. Youssef, Aino Heikkinen, Jaakko Kaprio, Miina Ollikainen
Publicado en: Clinical Epigenetics, Edición 2023, volume 15, 2023, Página(s) Article number: 181, ISSN 1868-7083
Editor: Springer Nature
DOI: 10.1186/s13148-023-01594-7

TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

Autores: Louise Blair, Michael J. Pattison, Probir Chakravarty, Stamatia Papoutsopoulou, Latifa Bakiri, Erwin F. Wagner, Stephen Smale, Steven C. Ley
Publicado en: J Immunol, Edición Feb 15; 208 (4), 2022, Página(s) 941–954, ISSN 0022-1767
Editor: American Association of Immunologists
DOI: 10.4049/jimmunol.2100213

Tumor dormancy: EMT beyond invasion and metastasis

Autores: Patrick Aouad, Hazel M. Quinn, Adeline Berger, Cathrin Brisken
Publicado en: Genesis, 2023, ISSN 1526-954X
Editor: John Wiley & Sons Inc.
DOI: 10.1002/dvg.23552

Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia

Autores: Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, 2022, ISSN 2190-5991
Editor: Springer Verlag
DOI: 10.1002/jcsm.13109

GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma

Autores: Scatolini, M., Patel, A., Grosso, E., Mello-Grand, M., Ostano, P., Coppo, R., Vitiello, M., Venesio, T., Zaccagna, A., Pisacane, A., Sarotto, I., Taverna, D., Poliseno, L., Bergamaschi, D., & Chiorino, G
Publicado en: The British journal of dermatology 2021, 2021, ISSN 0007-0963
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjd.20629

Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease

Autores: Liliana F Mellor; Nuria Gago-Lopez; Latifa Bakiri; Felix N Schmidt; Björn Busse; Simon Rauber; Maria Jimenez; Diego Megías; Sergio Oterino-Sogo; Ricardo Sanchez-Prieto; Sergei Grivennikov; Xinzhu Pu; Julia Oxford; Andreas Ramming; Georg Schett; Erwin F Wagner
Publicado en: Ann Rheum Dis, Edición 00034967, 2022, Página(s) 1400-1408, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222229

Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia

Autores: Michele Petruzzelli, Miriam Ferrer, Martijn J. Schuijs, Sam O. Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J. Lukey, Duncan I. Jodrell, Christian Frezza, Erwin F. Wagner, Ashok R. Venkitaraman, Timotheus Y. F. Halim,Tobias Janowitz
Publicado en: Cancers (Basel), Edición Feb 15;14(4), 2022, Página(s) 963, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040963

A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization

Autores: Almet AA, Yuan H, Annusver K, Ramos R, Liu Y, Wiedemann J, Sorkin DH, Landén NX, Sonkoly E, Haniffa M, Nie Q, Lichtenberger BM, Luecken MD, Andersen B, Tsoi LC, Watt FM, Gudjonsson JE, Plikus MV, Kasper M.
Publicado en: J Invest Dermatol., Edición Sep;143(9), 2023, Página(s) 1667-1677, ISSN 0022-202X
Editor: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.03.1679

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

Autores: Talwelkar,S., Mäyränpää, M., Søraas, L., Potdar, S., Bao, J,, Hemmes,A., Linnavirta, N., Lømo, J, Räsänen,J,, Knuuttila, A, Wennerberg,K. Verschuren, EW
Publicado en: Cell Reports Medicine, 2021, ISSN 2666-3791
Editor: Elsevier Inc.
DOI: 10.1016/j.xcrm.2021.100373

Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

Autores: Kazuhiko Matsuoka, Latifa Bakiri, Martin Bilban, Stefan Toegel, Arvand Haschemi, Hao Yuan, Maria Kasper, Reinhard Windhager, Erwin F Wagner
Publicado en: Ann Rheum Dis, Edición Jun 21, 2023, Página(s) ard-2023-224002, ISSN 0003-4967
Editor: BMJ Publishing Group
DOI: 10.1136/ard-2023-224002

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

Autores: Valentina Scabia, Ayyakkannu Ayyanan, Fabio De Martino, Andrea Agnoletto, Laura Battista, Csaba Laszlo, Assia Treboux, Khalil Zaman, Athina Stravodimou, Didier Jallut, Maryse Fiche, Philip Bucher, Giovanna Ambrosini, George Sflomos & Cathrin Brisken
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30898-0

Functions of the RIP kinase family members in the skin

Autores: Corinne Urwyler-Rösselet, Giel Tanghe, Michael Devos, Paco Hulpiau, Yvan Saeys and Wim Declercq
Publicado en: Cell Mol Life Sci, Edición 2023 Sep 9;80(10):285, 2023, ISSN 1420-682X
Editor: Birkhauser Verlag
DOI: 10.1007/s00018-023-04917-2

Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma

Autores: Sflomos G, Schaumann N, Christgen M, Christgen H, Bartels S, Kreipe H, Battista L, Brisken C.
Publicado en: Cancers, 2023, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15133299

Plasma microRNA ratios associated with breast cancer detection in a nested case–control study from a mammography screening cohort

Autores: Giovanna Chiorino, Elisabetta Petracci, Emir Sehovic, Ilaria Gregnanin, Elisa Camussi, Maurizia Mello-Grand, Paola Ostano, Emilia Riggi, Viviana Vergini, Alessia Russo, Enrico Berrino, Andrea Ortale, Francesca Garena, Tiziana Venesio, Federica Gallo, Elisabetta Favettini, Alfonso Frigerio, Giuseppe Matullo, Nereo Segnan, Livia Giordano
Publicado en: Scientific Reports, Edición Edición 1, Vol 13, page 12040, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-38886-0

Non-peer reviewed articles (2)

How does inflammation spread through the body?

Autores: Latifa Bakiri, Erwin F Wagner
Publicado en: EU Research, Edición Spring issue, vol. (34), 2023, Página(s) 17 - 19, ISSN 2752-4736
Editor: Blazon Publishing & Media Limited
DOI: 10.56181/fhju5543

Open Thy Lattice Osteoclast, Resorb me!

Autores: Latifa Bakiri
Publicado en: J Cell Biol, Edición Volume 222, Edición 4,, 2023, Página(s) e202302033, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.202302033

Other (2)

Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk

Autores: Hannes Frederik Bode, Liang He, Jacob Hjelmborg, Jaakko Kaprio, Miina Ollikainen
Publicado en: medrxiv, 2023
Editor: Medrxiv
DOI: 10.1101/2023.08.15.23293985

Mechanism of chronic inflammation in psoriasis-like skin and joint disease

Autores: Latifa Bakiri, Georg Schett , Erwin F Wagner
Publicado en: SPECTRUM Dermatologie, Edición SD 04|2022, Nov 24, 2022
Editor: Karger Publishers