Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation

Informazioni relative al progetto

CANCERPREV

ID dell’accordo di sovvenzione: 859860

DOI

10.3030/859860

Progetto chiuso

Data della firma CE 21 Agosto 2019

Data di avvio 1 Novembre 2019

Data di completamento 29 Febbraio 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 096 014,48

Contributo UE

€ 4 096 014,48

Coordinato da

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Project website
Doctoral degrees award

Other (2)

Annual summer course and workshop - Year 2

Annual summer course and workshop – Year 2

Annual summer course and workshop - Year 3

Annual summer course and workshop – Year 3

Open Research Data Pilot (1)

Data Management Plan

Pubblicazioni

Peer reviewed articles (26)

An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia

Autori: Hao Xie, Christoph Heier, Xia Meng, Latifa Bakiri, Isabella Pototschnig, Zhiyuan Tang, Silvia Schauer, Vanessa J. Baumgartner, Gernot F. Grabner, Gernot Schabbauer, Heimo Wolinski, Graham R. Robertson, Gerald Hoefler, Wenwen Zeng, Erwin F. Wagner, Martina Schweiger, Rudolf Zechner
Pubblicato in: Proc Natl Acad Sci U S A, Numero Mar 1; 119(9), 2022, Pagina/e e2112840119, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2112840119

Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples

Autori: Eirini Chrysanthou, Emir Sehovic, Paola Ostano, and Giovanna Chiorino
Pubblicato in: Cells, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11071099

Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

Autori: Carlos Ronchi Cathrin Brisken
Pubblicato in: Clinical Cancer Research, 2023, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-3374

Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer

Autori: Bode HF, Heikkinen A, Lundgren S, Kaprio J, Ollikainen M.
Pubblicato in: Twin Research and Human Genetics, Numero October 2022, 2022, Pagina/e 171-179, ISSN 1839-2628
Editore: Cambridge University Press
DOI: 10.1017/thg.2022.32

The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

Autori: Philipp Novoszel , Barbara Drobits , Martin Holcmann , Cristiano De Sa Fernandes , Roland Tschismarov , Sophia Derdak, Thomas Decker , Erwin F Wagner , Maria Sibilia
Pubblicato in: Cell Death & Differentiation, Numero Aug;28(8), 2021, Pagina/e 2404-2420, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-021-00765-4

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

Autori: Patrick Aouad; Yueyun Zhang; Fabio De Martino; Céline Stibolt; simak Ali; Giovanna Ambrosini; Sendurai A. Mani; Kelly Maggs; Hazel M. Quinn; George Sflomos & Cathrin Brisken
Pubblicato in: Nature Communications, Numero 20411723, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-32523-6

Meta-analysis of diagnostic cell-free circulating microRNAs for breast cancer detection

Autori: Emir Sehovic, Sara Urru, Giovanna Chiorino, Philipp Doebler
Pubblicato in: BMC Cancer, Numero 2022 Jun 9;22(1):634, 2022, Pagina/e 634, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/s12885-022-09698-8

ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.

Autori: Luigi Mazzeo, Soumitra Ghosh, Emery Di Cicco, Jovan Isma, Daniele Tavernari, Anastasia Samarkina, Paola Ostano, Markus K. Youssef, Christian Simon, Gian-Paolo Dotto
Pubblicato in: Nature Communications, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-45308-w

Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model

Autori: Nuria Gago‐López, Carmen Lagunas Arnal, Juan J. Perez, Erwin F. Wagner
Pubblicato in: Experimental Dermatology, Numero Nov;30(11), 2021, Pagina/e 1662-1674, ISSN 0906-6705
Editore: Blackwell Publishing Inc.
DOI: 10.1111/exd.14390

Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells

Autori: Novoszel P, Holcmann M, Stulnig G, De Sa Fernandes C, Zyulina V, Borek I, Linder M, Bogusch A, Drobits B, Bauer T, Tam-Amersdorfer C, Brunner PM, Stary G, Bakiri L, Wagner EF, Strobl H, Sibilia M.
Pubblicato in: EMBO Molecular Medicine, 2021, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202012409

Androgen receptor is a determinant of melanoma targeted drug resistance

Autori: Anastasia Samarkina; Markus Kirolos Youssef; Paola Ostano; Soumitra Ghosh; Min Ma; Beatrice Tassone; Tatiana Proust; Giovanna Chiorino; Mitchell P. Levesque; Sandro Goruppi; Gian Paolo Dotto
Pubblicato in: Nature Communications, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-42239-w

Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.

Autori: Latifa Bakiri, Sebastian C Hasenfuss, Ana Guío-Carrión, Martin K Thomsen, Peter Hasselblatt, Erwin F Wagner.
Pubblicato in: Proc Natl Acad Sci U S A, Numero Apr 30;121(18) - Epub, 2024, Pagina/e e2404188121 (Epub), ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2404188121

DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study

Autori: Emir Sehovic, Stephanie M. Zellers, Markus K. Youssef, Aino Heikkinen, Jaakko Kaprio, Miina Ollikainen
Pubblicato in: Clinical Epigenetics, Numero 2023, volume 15, 2023, Pagina/e Article number: 181, ISSN 1868-7083
Editore: Springer Nature
DOI: 10.1186/s13148-023-01594-7

TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages

Autori: Louise Blair, Michael J. Pattison, Probir Chakravarty, Stamatia Papoutsopoulou, Latifa Bakiri, Erwin F. Wagner, Stephen Smale, Steven C. Ley
Pubblicato in: J Immunol, Numero Feb 15; 208 (4), 2022, Pagina/e 941–954, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.2100213

Tumor dormancy: EMT beyond invasion and metastasis

Autori: Patrick Aouad, Hazel M. Quinn, Adeline Berger, Cathrin Brisken
Pubblicato in: Genesis, 2023, ISSN 1526-954X
Editore: John Wiley & Sons Inc.
DOI: 10.1002/dvg.23552

Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia

Autori: Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Pubblicato in: Journal of Cachexia, Sarcopenia and Muscle, 2022, ISSN 2190-5991
Editore: Springer Verlag
DOI: 10.1002/jcsm.13109

GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma

Autori: Scatolini, M., Patel, A., Grosso, E., Mello-Grand, M., Ostano, P., Coppo, R., Vitiello, M., Venesio, T., Zaccagna, A., Pisacane, A., Sarotto, I., Taverna, D., Poliseno, L., Bergamaschi, D., & Chiorino, G
Pubblicato in: The British journal of dermatology 2021, 2021, ISSN 0007-0963
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjd.20629

Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease

Autori: Liliana F Mellor; Nuria Gago-Lopez; Latifa Bakiri; Felix N Schmidt; Björn Busse; Simon Rauber; Maria Jimenez; Diego Megías; Sergio Oterino-Sogo; Ricardo Sanchez-Prieto; Sergei Grivennikov; Xinzhu Pu; Julia Oxford; Andreas Ramming; Georg Schett; Erwin F Wagner
Pubblicato in: Ann Rheum Dis, Numero 00034967, 2022, Pagina/e 1400-1408, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222229

Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia

Autori: Michele Petruzzelli, Miriam Ferrer, Martijn J. Schuijs, Sam O. Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J. Lukey, Duncan I. Jodrell, Christian Frezza, Erwin F. Wagner, Ashok R. Venkitaraman, Timotheus Y. F. Halim,Tobias Janowitz
Pubblicato in: Cancers (Basel), Numero Feb 15;14(4), 2022, Pagina/e 963, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040963

A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization

Autori: Almet AA, Yuan H, Annusver K, Ramos R, Liu Y, Wiedemann J, Sorkin DH, Landén NX, Sonkoly E, Haniffa M, Nie Q, Lichtenberger BM, Luecken MD, Andersen B, Tsoi LC, Watt FM, Gudjonsson JE, Plikus MV, Kasper M.
Pubblicato in: J Invest Dermatol., Numero Sep;143(9), 2023, Pagina/e 1667-1677, ISSN 0022-202X
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2023.03.1679

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

Autori: Talwelkar,S., Mäyränpää, M., Søraas, L., Potdar, S., Bao, J,, Hemmes,A., Linnavirta, N., Lømo, J, Räsänen,J,, Knuuttila, A, Wennerberg,K. Verschuren, EW
Pubblicato in: Cell Reports Medicine, 2021, ISSN 2666-3791
Editore: Elsevier Inc.
DOI: 10.1016/j.xcrm.2021.100373

Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis

Autori: Kazuhiko Matsuoka, Latifa Bakiri, Martin Bilban, Stefan Toegel, Arvand Haschemi, Hao Yuan, Maria Kasper, Reinhard Windhager, Erwin F Wagner
Pubblicato in: Ann Rheum Dis, Numero Jun 21, 2023, Pagina/e ard-2023-224002, ISSN 0003-4967
Editore: BMJ Publishing Group
DOI: 10.1136/ard-2023-224002

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

Autori: Valentina Scabia, Ayyakkannu Ayyanan, Fabio De Martino, Andrea Agnoletto, Laura Battista, Csaba Laszlo, Assia Treboux, Khalil Zaman, Athina Stravodimou, Didier Jallut, Maryse Fiche, Philip Bucher, Giovanna Ambrosini, George Sflomos & Cathrin Brisken
Pubblicato in: Nature Communications, Numero 20411723, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30898-0

Functions of the RIP kinase family members in the skin

Autori: Corinne Urwyler-Rösselet, Giel Tanghe, Michael Devos, Paco Hulpiau, Yvan Saeys and Wim Declercq
Pubblicato in: Cell Mol Life Sci, Numero 2023 Sep 9;80(10):285, 2023, ISSN 1420-682X
Editore: Birkhauser Verlag
DOI: 10.1007/s00018-023-04917-2

Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma

Autori: Sflomos G, Schaumann N, Christgen M, Christgen H, Bartels S, Kreipe H, Battista L, Brisken C.
Pubblicato in: Cancers, 2023, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15133299

Plasma microRNA ratios associated with breast cancer detection in a nested case–control study from a mammography screening cohort

Autori: Giovanna Chiorino, Elisabetta Petracci, Emir Sehovic, Ilaria Gregnanin, Elisa Camussi, Maurizia Mello-Grand, Paola Ostano, Emilia Riggi, Viviana Vergini, Alessia Russo, Enrico Berrino, Andrea Ortale, Francesca Garena, Tiziana Venesio, Federica Gallo, Elisabetta Favettini, Alfonso Frigerio, Giuseppe Matullo, Nereo Segnan, Livia Giordano
Pubblicato in: Scientific Reports, Numero Numero 1, Vol 13, page 12040, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-38886-0

Non-peer reviewed articles (2)

How does inflammation spread through the body?

Autori: Latifa Bakiri, Erwin F Wagner
Pubblicato in: EU Research, Numero Spring issue, vol. (34), 2023, Pagina/e 17 - 19, ISSN 2752-4736
Editore: Blazon Publishing & Media Limited
DOI: 10.56181/fhju5543

Open Thy Lattice Osteoclast, Resorb me!

Autori: Latifa Bakiri
Pubblicato in: J Cell Biol, Numero Volume 222, Numero 4,, 2023, Pagina/e e202302033, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202302033

Other (2)

Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk

Autori: Hannes Frederik Bode, Liang He, Jacob Hjelmborg, Jaakko Kaprio, Miina Ollikainen
Pubblicato in: medrxiv, 2023
Editore: Medrxiv
DOI: 10.1101/2023.08.15.23293985

Mechanism of chronic inflammation in psoriasis-like skin and joint disease

Autori: Latifa Bakiri, Georg Schett , Erwin F Wagner
Pubblicato in: SPECTRUM Dermatologie, Numero SD 04|2022, Nov 24, 2022
Editore: Karger Publishers