Descripción del proyecto
Una nueva red de formación espera dilucidar nuevas estrategias para la prevención de los cánceres comunes
Dos factores importantes que repercuten en el riesgo de desarrollar cáncer son la inflamación crónica y los niveles de hormonas sexuales circulantes. Hace más de ciento cincuenta años, los científicos observaron que las células inflamatorias están dentro de los tumores y que estos aparecen en sitios de inflamación crónica, lo cual deriva en un supuesto vínculo entre ambos. Tras años de estudios epidemiológicos, ahora se cree que hasta una cuarta parte de los cánceres se deben a infecciones crónicas u otros tipos de inflamación crónica. Además, actualmente se ha establecido una fuerte correlación entre los niveles de hormonas circulantes y los cánceres reproductivos femeninos. El proyecto CANCERPREV está formando a jóvenes investigadores en técnicas matemáticas y experimentales de última generación con el fin de elaborar unas directrices para la prevención de cánceres relacionados con los órganos reproductores y no reproductores.
Objetivo
Incidence and prevalence of many cancer types are significantly increasing worldwide, with substantial differences between the sexes. Environmental influences in concert with genetic and epigenetic factors are still poorly understood.
Simultaneously, more sophisticated and expensive treatments cannot be afforded by society, increasing urgency of efforts in cancer prevention.
CANCERPREV is an innovative interdisciplinary research and training program gathering seven academic beneficiaries and nine partner organizations : (one leading pharmaceutical company, one leading technology company, a health insurance, an internationally known nursing school, three foundations and two universities) in nine European countries. CANCERPREV aims to establish new strategies in cancer prevention, with a focus on two key determinants of cancer risk: sex hormone signaling and chronic inflammation, in breast and skin as benchmarks of early steps of cancer development in organs with reproductive and non-reproductive functions, respectively.
Fifteen Early Stage Researchers (ESRs) will benefit from the complementary expertise of participating organizations and Principal Investigators in: basic cancer research, xenografts and genetic mouse models, bioinformatics and mathematical algorithms, epidemiology / human genetics, biomarkers, pharmacological approaches, behavioral / societal issues and outreach.
This network provides ESRs with unique future career opportunities in both academic and private sectors, through research training for PhD thesis projects with secondments and short and long visits to other participating research institutions, and yearly courses / formal lectures on various aspects of cancer prevention, including global health and occupational / behavioral issues. CANCERPREV will ensure that more knowledge and ideas are converted into products and services, and that a new generation of scientists is trained to contribute to the knowledge-based economy and society.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
1015 Lausanne
Suiza