Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Informations projet

EDUC8

N° de convention de subvention: 859974

DOI

10.3030/859974

Projet clôturé

Date de signature de la CE 17 Decembre 2019

Date de début 1 Avril 2020

Date de fin 30 Septembre 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 2 100 701,91

Contribution de l’UE

€ 2 100 701,91

Coordonné par

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (22)

Second SSC activities

Organization of Second Second Short Scientific Course SSC

Dissemination report

Rreport on dissemination activities

Third SSC activities

Organisation of Second Short Scientific Course (SSC)

Participation to ECTH meeting 2023
Third SCT activities

Organisation of Third Short Course of Transferable training (SCT).

Network meetings

Report on organization Network Annual Meetings

First SSC activities

Organisation of First Short Scientific Course SSC

Participation to EAHAD meeting 2023
PhD Thesis

PhD thesis submission

Supervisory Board of the Network

Supervisory Board of the Network names of representatives

First SCT activities

Organisation of First Short Course of Transferable training (SCT) Report on activities done (M11, M18, M42)

Industrial, academic and virtual outreach: first report

Industrial, academic and virtual outreach: report

Potential inputs for policy feedback
Local training: first report

First year report on Local training

Second SCT activities

Organisation of Second Short Course of Transferable training SCT

Website
Participation to EAHAD meeting 2022
Recruitment

Report on the recruitment process including publication of call CV evaluation interview outcome final decision on the fellows

Local training: second report

Second year report on local training

Local training: third report

Third year report on Local training

Participation to EAHAD meeting 2021
Participation to ECTH meeting 2021

Open Research Data Pilot (1)

DMP

Data management Plan DMP

Publications

Peer reviewed articles (16)

Predicting inhibitor development using a random peptide phage-display library approach in the SIPPET cohort

Auteurs: Shermarke Hassan, Guido Baselli, Luca Mollica, Riccardo L. Rossi, Himani Chand, Amal El-Beshlawy, Mohsen Elalfy, Vijay Ramanan, Peyman Eshghi, Mehran Karimi, Roberta Palla, Frits R. Rosendaal, Flora Peyvandi
Publié dans: Blood Advances, Numéro 8, 2024, Page(s) 2880-2889, ISSN 2473-9529
Éditeur: Elsevier Inc.
DOI: 10.1182/bloodadvances.2023011388

Transplacental delivery of therapeutic proteins by engineered immunoglobulin G: a step toward perinatal replacement therapy

Auteurs: Angelina Mimoun, Melissa Bou-Jaoudeh, Sandrine Delignat, Victoria Daventure, Alejandra Reyes Ruiz, Maxime Lecerf, Aurélien Azam, Remi Noe, Ivan Peyron, Olivier D. Christophe, Peter J. Lenting, Valérie Proulle, Jenny McIntosh, Amit C. Nathwani, Jordan D. Dimitrov, Cécile V. Denis, Sébastien Lacroix-Desmazes
Publié dans: Journal of Thrombosis and Haemostasis, Numéro 21, 2024, Page(s) 2405-2417, ISSN 1538-7836
Éditeur: Elsevier
DOI: 10.1016/j.jtha.2023.05.021

The tissue glycome as regulator of immune activation and tolerance mediated by C-type lectins and Siglecs

Auteurs: Eleonora Nardini, Ernesto Rodriguez, Yvette van Kooyk
Publié dans: Seminars in Immunology, Numéro 76, 2025, Page(s) 101913, ISSN 1044-5323
Éditeur: Academic Press
DOI: 10.1016/j.smim.2024.101913

FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4

Auteurs: Mariarosaria Miranda, Bjarke Endel Hansen, Batoul Wehbi, Valeria Porcheddu, Floris P.J. Van Alphen, Paul Kaijen, Karin Fijnvandraat, Sebastien Lacroix-Desmazes, Maartje Van den Biggelaar, Bernard Maillere, Jan Voorberg, EDUC Consortium
Publié dans: Haematologica, 2024, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.286204

Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension

Auteurs: Alejandra Reyes-Ruiz, Sandrine Delignat, Aishwarya Sudam Bhale, Victoria Daventure, Robin V. Lacombe, Leslie Dourthe, Olivier Christophe, Sune Justesen, Krishnan Venkataraman, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes
Publié dans: Haematologica, Numéro Online ahead of print, 2024, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.286536

Microbial symphony orchestrated by mucosal IgA

Auteurs: Reyes-Ruiz A, Dimitrov JD
Publié dans: Cell Mol Immunol, Numéro 19(4), 2022, Page(s) 456-457
Éditeur: -
DOI: 10.1038/s41423-021-00819-0

Sialic acid–modified der p 2 allergen exerts immunomodulatory effects on human PBMCs

Auteurs: Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Hakan Kalay, Serge A. Versteeg, Joyce Lübbers, Gaby van Barneveld, Eveline R.J. Li, Sandra J. van Vliet, Ronald van Ree, Esther C. de Jong, Yvette van Kooyk
Publié dans: Journal of Allergy and Clinical Immunology: Global, Numéro 3, 2024, Page(s) 100193, ISSN 2772-8293
Éditeur: Elsevier
DOI: 10.1016/j.jacig.2023.100193

The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A

Auteurs: Ilja Oomen, Marieke Verhagen, Mariarosaria Miranda, Peter Allacher, Erik A. M. Beckers, Nicole M. A. Blijlevens, Johanna G. van der Bom, Michiel Coppens, Mariëtte Driessens, Jeroen C. J. Eikenboom, Karin Fijnvandraat, Shermarke Hassan, Waander L. van Heerde, H. Louise Hooimeijer, Joop H. Jansen, Paul Kaijen, Frank W. G. Leebeek, Daniëlle Meijer, Helmut Paul, Sanna R. Rijpma, Frits R. Rosendaal,
Publié dans: Frontiers in Immunology, Numéro 15, 2024, ISSN 1664-3224
Éditeur: the International Union of Immunological Societies (IUIS).
DOI: 10.3389/fimmu.2024.1355813

Temperature sensitivity of bat antibodies links metabolic state of bats with antigen-recognition diversity

Auteurs: Nia Toshkova, Violeta Zhelyzkova, Alejandra Reyes-Ruiz, Eline Haerens, Marina de Castro Deus, Robin V. Lacombe, Maxime Lecerf, Gaelle Gonzalez, Nolwenn Jouvenet, Cyril Planchais, Jordan D. Dimitrov
Publié dans: Nature Communications, Numéro 15, 2024, Page(s) 5878, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-50316-x

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of <scp>SARS‐CoV</scp>‐2

Auteurs: Cyril Planchais, Alejandra Reyes‐Ruiz, Robin Lacombe, Alessandra Zarantonello, Maxime Lecerf, Margot Revel, Lubka T. Roumenina, Boris P. Atanasov, Hugo Mouquet, Jordan D. Dimitrov
Publié dans: Protein Science, Numéro 31, 2023, Page(s) e4447, ISSN 0961-8368
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4447

How can polyreactive antibodies conquer rapidly evolving viruses?

Auteurs: Alejandra Reyes-Ruiz, Jordan Dimitrov
Publié dans: Trends Immunol, Numéro 42(8), 2021, Page(s) 654-657
Éditeur: -
DOI: 10.1016/j.it.2021.06.008

The self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes

Auteurs: Valeria Porcheddu, Gautier Lhomme, Rémi Giraudet, Evelyne Correia, Bernard Maillère
Publié dans: Frontiers in Immunology, Numéro 15, 2024, Page(s) 1345195, ISSN 1664-3224
Éditeur: the International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2024.1345195

Efanesoctocog alfa: the renaissance of Factor VIII replacement therapy

Auteurs: Yesim Dargaud, Alexandre Leuci, Alejandra Reyes Ruiz, Sebastien Lacroix-Desmazes
Publié dans: Haematologica, Numéro 109(8), 2024, Page(s) 2436-2444, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2023.284498

Exploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A

Auteurs: Mariarosaria Miranda, Eelke Brandsma, Lotte Robben, Helena Van Dender, Floris P.J. van Alphen, Karin Fijnvandraat, Maartje van den Biggelaar, Sebastien Lacroix-Desmazes, Robin van Bruggen, Jan Voorberg
Publié dans: Journal of Thrombosis and Haemostasis, 2025, ISSN 1538-7836
Éditeur: Elsevier
DOI: 10.1016/j.jtha.2024.11.012

α2-3 Sialic acids-decorated allergens exert a tolerogenic effect on CD4 T cells from Der p 2 – allergic patients

Auteurs: Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Evert E. Peterse, Hakan Kalay, Serge A. Versteeg, Ronald Van Ree, Esther E.C. de Jong, Yvette Van Kooyk
Publié dans: International Archives of Allergy and Immunology, 2024, Page(s) 1-19, ISSN 1018-2438
Éditeur: S. Karger AG
DOI: 10.1159/000543157

Binding Promiscuity of Therapeutic Factor VIII

Auteurs: Alejandra Reyes Ruiz, Aishwarya S. Bhale, Krishnan Venkataraman, Jordan D. Dimitrov, Sébastien Lacroix-Desmazes
Publié dans: Thrombosis and Haemostasis, 2024, Page(s) Online ahead of print, ISSN 0340-6245
Éditeur: Schattauer
DOI: 10.1055/a-2358-0853

Conference proceedings (1)

Induction of neonatal tolerance to therapeutic FVIII in hemophilia A

Auteurs: A Ruiz Reyes, S Delignant, V Daventure, A Mimoun, D J Dimitrov, S Lacroix-Desmazes
Publié dans: Hämostaseologie, GTH Congress 2023 – 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research – The patient as a benchmark, Numéro 43(S 01), 2023, Page(s) S37-S38
Éditeur: Georg Thieme Verlag
DOI: 10.1055/s-0042-1760514