Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Informazioni relative al progetto

EDUC8

ID dell’accordo di sovvenzione: 859974

DOI

10.3030/859974

Progetto chiuso

Data della firma CE 17 Dicembre 2019

Data di avvio 1 Aprile 2020

Data di completamento 30 Settembre 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 2 100 701,91

Contributo UE

€ 2 100 701,91

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (22)

Second SSC activities

Organization of Second Second Short Scientific Course SSC

Dissemination report

Rreport on dissemination activities

Third SSC activities

Organisation of Second Short Scientific Course (SSC)

Participation to ECTH meeting 2023
Third SCT activities

Organisation of Third Short Course of Transferable training (SCT).

Network meetings

Report on organization Network Annual Meetings

First SSC activities

Organisation of First Short Scientific Course SSC

Participation to EAHAD meeting 2023
PhD Thesis

PhD thesis submission

Supervisory Board of the Network

Supervisory Board of the Network names of representatives

First SCT activities

Organisation of First Short Course of Transferable training (SCT) Report on activities done (M11, M18, M42)

Industrial, academic and virtual outreach: first report

Industrial, academic and virtual outreach: report

Potential inputs for policy feedback
Local training: first report

First year report on Local training

Second SCT activities

Organisation of Second Short Course of Transferable training SCT

Website
Participation to EAHAD meeting 2022
Recruitment

Report on the recruitment process including publication of call CV evaluation interview outcome final decision on the fellows

Local training: second report

Second year report on local training

Local training: third report

Third year report on Local training

Participation to EAHAD meeting 2021
Participation to ECTH meeting 2021

Open Research Data Pilot (1)

DMP

Data management Plan DMP

Pubblicazioni

Peer reviewed articles (16)

Predicting inhibitor development using a random peptide phage-display library approach in the SIPPET cohort

Autori: Shermarke Hassan, Guido Baselli, Luca Mollica, Riccardo L. Rossi, Himani Chand, Amal El-Beshlawy, Mohsen Elalfy, Vijay Ramanan, Peyman Eshghi, Mehran Karimi, Roberta Palla, Frits R. Rosendaal, Flora Peyvandi
Pubblicato in: Blood Advances, Numero 8, 2024, Pagina/e 2880-2889, ISSN 2473-9529
Editore: Elsevier Inc.
DOI: 10.1182/bloodadvances.2023011388

Transplacental delivery of therapeutic proteins by engineered immunoglobulin G: a step toward perinatal replacement therapy

Autori: Angelina Mimoun, Melissa Bou-Jaoudeh, Sandrine Delignat, Victoria Daventure, Alejandra Reyes Ruiz, Maxime Lecerf, Aurélien Azam, Remi Noe, Ivan Peyron, Olivier D. Christophe, Peter J. Lenting, Valérie Proulle, Jenny McIntosh, Amit C. Nathwani, Jordan D. Dimitrov, Cécile V. Denis, Sébastien Lacroix-Desmazes
Pubblicato in: Journal of Thrombosis and Haemostasis, Numero 21, 2024, Pagina/e 2405-2417, ISSN 1538-7836
Editore: Elsevier
DOI: 10.1016/j.jtha.2023.05.021

The tissue glycome as regulator of immune activation and tolerance mediated by C-type lectins and Siglecs

Autori: Eleonora Nardini, Ernesto Rodriguez, Yvette van Kooyk
Pubblicato in: Seminars in Immunology, Numero 76, 2025, Pagina/e 101913, ISSN 1044-5323
Editore: Academic Press
DOI: 10.1016/j.smim.2024.101913

FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4

Autori: Mariarosaria Miranda, Bjarke Endel Hansen, Batoul Wehbi, Valeria Porcheddu, Floris P.J. Van Alphen, Paul Kaijen, Karin Fijnvandraat, Sebastien Lacroix-Desmazes, Maartje Van den Biggelaar, Bernard Maillere, Jan Voorberg, EDUC Consortium
Pubblicato in: Haematologica, 2024, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.286204

Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension

Autori: Alejandra Reyes-Ruiz, Sandrine Delignat, Aishwarya Sudam Bhale, Victoria Daventure, Robin V. Lacombe, Leslie Dourthe, Olivier Christophe, Sune Justesen, Krishnan Venkataraman, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes
Pubblicato in: Haematologica, Numero Online ahead of print, 2024, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.286536

Microbial symphony orchestrated by mucosal IgA

Autori: Reyes-Ruiz A, Dimitrov JD
Pubblicato in: Cell Mol Immunol, Numero 19(4), 2022, Pagina/e 456-457
Editore: -
DOI: 10.1038/s41423-021-00819-0

Sialic acid–modified der p 2 allergen exerts immunomodulatory effects on human PBMCs

Autori: Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Hakan Kalay, Serge A. Versteeg, Joyce Lübbers, Gaby van Barneveld, Eveline R.J. Li, Sandra J. van Vliet, Ronald van Ree, Esther C. de Jong, Yvette van Kooyk
Pubblicato in: Journal of Allergy and Clinical Immunology: Global, Numero 3, 2024, Pagina/e 100193, ISSN 2772-8293
Editore: Elsevier
DOI: 10.1016/j.jacig.2023.100193

The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A

Autori: Ilja Oomen, Marieke Verhagen, Mariarosaria Miranda, Peter Allacher, Erik A. M. Beckers, Nicole M. A. Blijlevens, Johanna G. van der Bom, Michiel Coppens, Mariëtte Driessens, Jeroen C. J. Eikenboom, Karin Fijnvandraat, Shermarke Hassan, Waander L. van Heerde, H. Louise Hooimeijer, Joop H. Jansen, Paul Kaijen, Frank W. G. Leebeek, Daniëlle Meijer, Helmut Paul, Sanna R. Rijpma, Frits R. Rosendaal,
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: the International Union of Immunological Societies (IUIS).
DOI: 10.3389/fimmu.2024.1355813

Temperature sensitivity of bat antibodies links metabolic state of bats with antigen-recognition diversity

Autori: Nia Toshkova, Violeta Zhelyzkova, Alejandra Reyes-Ruiz, Eline Haerens, Marina de Castro Deus, Robin V. Lacombe, Maxime Lecerf, Gaelle Gonzalez, Nolwenn Jouvenet, Cyril Planchais, Jordan D. Dimitrov
Pubblicato in: Nature Communications, Numero 15, 2024, Pagina/e 5878, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-50316-x

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of <scp>SARS‐CoV</scp>‐2

Autori: Cyril Planchais, Alejandra Reyes‐Ruiz, Robin Lacombe, Alessandra Zarantonello, Maxime Lecerf, Margot Revel, Lubka T. Roumenina, Boris P. Atanasov, Hugo Mouquet, Jordan D. Dimitrov
Pubblicato in: Protein Science, Numero 31, 2023, Pagina/e e4447, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4447

How can polyreactive antibodies conquer rapidly evolving viruses?

Autori: Alejandra Reyes-Ruiz, Jordan Dimitrov
Pubblicato in: Trends Immunol, Numero 42(8), 2021, Pagina/e 654-657
Editore: -
DOI: 10.1016/j.it.2021.06.008

The self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes

Autori: Valeria Porcheddu, Gautier Lhomme, Rémi Giraudet, Evelyne Correia, Bernard Maillère
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, Pagina/e 1345195, ISSN 1664-3224
Editore: the International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2024.1345195

Efanesoctocog alfa: the renaissance of Factor VIII replacement therapy

Autori: Yesim Dargaud, Alexandre Leuci, Alejandra Reyes Ruiz, Sebastien Lacroix-Desmazes
Pubblicato in: Haematologica, Numero 109(8), 2024, Pagina/e 2436-2444, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2023.284498

Exploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A

Autori: Mariarosaria Miranda, Eelke Brandsma, Lotte Robben, Helena Van Dender, Floris P.J. van Alphen, Karin Fijnvandraat, Maartje van den Biggelaar, Sebastien Lacroix-Desmazes, Robin van Bruggen, Jan Voorberg
Pubblicato in: Journal of Thrombosis and Haemostasis, 2025, ISSN 1538-7836
Editore: Elsevier
DOI: 10.1016/j.jtha.2024.11.012

α2-3 Sialic acids-decorated allergens exert a tolerogenic effect on CD4 T cells from Der p 2 – allergic patients

Autori: Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Evert E. Peterse, Hakan Kalay, Serge A. Versteeg, Ronald Van Ree, Esther E.C. de Jong, Yvette Van Kooyk
Pubblicato in: International Archives of Allergy and Immunology, 2024, Pagina/e 1-19, ISSN 1018-2438
Editore: S. Karger AG
DOI: 10.1159/000543157

Binding Promiscuity of Therapeutic Factor VIII

Autori: Alejandra Reyes Ruiz, Aishwarya S. Bhale, Krishnan Venkataraman, Jordan D. Dimitrov, Sébastien Lacroix-Desmazes
Pubblicato in: Thrombosis and Haemostasis, 2024, Pagina/e Online ahead of print, ISSN 0340-6245
Editore: Schattauer
DOI: 10.1055/a-2358-0853

Conference proceedings (1)

Induction of neonatal tolerance to therapeutic FVIII in hemophilia A

Autori: A Ruiz Reyes, S Delignant, V Daventure, A Mimoun, D J Dimitrov, S Lacroix-Desmazes
Pubblicato in: Hämostaseologie, GTH Congress 2023 – 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research – The patient as a benchmark, Numero 43(S 01), 2023, Pagina/e S37-S38
Editore: Georg Thieme Verlag
DOI: 10.1055/s-0042-1760514