Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Informacje na temat projektu

EDUC8

Identyfikator umowy o grant: 859974

DOI

10.3030/859974

Projekt został zamknięty

Data podpisania przez KE 17 Grudnia 2019

Data rozpoczęcia 1 Kwietnia 2020

Data zakończenia 30 Września 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 2 100 701,91

Wkład UE

€ 2 100 701,91

Koordynowany przez

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (22)

Second SSC activities

Organization of Second Second Short Scientific Course SSC

Dissemination report

Rreport on dissemination activities

Third SSC activities

Organisation of Second Short Scientific Course (SSC)

Participation to ECTH meeting 2023
Third SCT activities

Organisation of Third Short Course of Transferable training (SCT).

Network meetings

Report on organization Network Annual Meetings

First SSC activities

Organisation of First Short Scientific Course SSC

Participation to EAHAD meeting 2023
PhD Thesis

PhD thesis submission

Supervisory Board of the Network

Supervisory Board of the Network names of representatives

First SCT activities

Organisation of First Short Course of Transferable training (SCT) Report on activities done (M11, M18, M42)

Industrial, academic and virtual outreach: first report

Industrial, academic and virtual outreach: report

Potential inputs for policy feedback
Local training: first report

First year report on Local training

Second SCT activities

Organisation of Second Short Course of Transferable training SCT

Website
Participation to EAHAD meeting 2022
Recruitment

Report on the recruitment process including publication of call CV evaluation interview outcome final decision on the fellows

Local training: second report

Second year report on local training

Local training: third report

Third year report on Local training

Participation to EAHAD meeting 2021
Participation to ECTH meeting 2021

Open Research Data Pilot (1)

DMP

Data management Plan DMP

Publikacje

Peer reviewed articles (16)

Predicting inhibitor development using a random peptide phage-display library approach in the SIPPET cohort

Autorzy: Shermarke Hassan, Guido Baselli, Luca Mollica, Riccardo L. Rossi, Himani Chand, Amal El-Beshlawy, Mohsen Elalfy, Vijay Ramanan, Peyman Eshghi, Mehran Karimi, Roberta Palla, Frits R. Rosendaal, Flora Peyvandi
Opublikowane w: Blood Advances, Numer 8, 2024, Strona(/y) 2880-2889, ISSN 2473-9529
Wydawca: Elsevier Inc.
DOI: 10.1182/bloodadvances.2023011388

Transplacental delivery of therapeutic proteins by engineered immunoglobulin G: a step toward perinatal replacement therapy

Autorzy: Angelina Mimoun, Melissa Bou-Jaoudeh, Sandrine Delignat, Victoria Daventure, Alejandra Reyes Ruiz, Maxime Lecerf, Aurélien Azam, Remi Noe, Ivan Peyron, Olivier D. Christophe, Peter J. Lenting, Valérie Proulle, Jenny McIntosh, Amit C. Nathwani, Jordan D. Dimitrov, Cécile V. Denis, Sébastien Lacroix-Desmazes
Opublikowane w: Journal of Thrombosis and Haemostasis, Numer 21, 2024, Strona(/y) 2405-2417, ISSN 1538-7836
Wydawca: Elsevier
DOI: 10.1016/j.jtha.2023.05.021

The tissue glycome as regulator of immune activation and tolerance mediated by C-type lectins and Siglecs

Autorzy: Eleonora Nardini, Ernesto Rodriguez, Yvette van Kooyk
Opublikowane w: Seminars in Immunology, Numer 76, 2025, Strona(/y) 101913, ISSN 1044-5323
Wydawca: Academic Press
DOI: 10.1016/j.smim.2024.101913

FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4

Autorzy: Mariarosaria Miranda, Bjarke Endel Hansen, Batoul Wehbi, Valeria Porcheddu, Floris P.J. Van Alphen, Paul Kaijen, Karin Fijnvandraat, Sebastien Lacroix-Desmazes, Maartje Van den Biggelaar, Bernard Maillere, Jan Voorberg, EDUC Consortium
Opublikowane w: Haematologica, 2024, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.286204

Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension

Autorzy: Alejandra Reyes-Ruiz, Sandrine Delignat, Aishwarya Sudam Bhale, Victoria Daventure, Robin V. Lacombe, Leslie Dourthe, Olivier Christophe, Sune Justesen, Krishnan Venkataraman, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes
Opublikowane w: Haematologica, Numer Online ahead of print, 2024, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.286536

Microbial symphony orchestrated by mucosal IgA

Autorzy: Reyes-Ruiz A, Dimitrov JD
Opublikowane w: Cell Mol Immunol, Numer 19(4), 2022, Strona(/y) 456-457
Wydawca: -
DOI: 10.1038/s41423-021-00819-0

Sialic acid–modified der p 2 allergen exerts immunomodulatory effects on human PBMCs

Autorzy: Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Hakan Kalay, Serge A. Versteeg, Joyce Lübbers, Gaby van Barneveld, Eveline R.J. Li, Sandra J. van Vliet, Ronald van Ree, Esther C. de Jong, Yvette van Kooyk
Opublikowane w: Journal of Allergy and Clinical Immunology: Global, Numer 3, 2024, Strona(/y) 100193, ISSN 2772-8293
Wydawca: Elsevier
DOI: 10.1016/j.jacig.2023.100193

The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A

Autorzy: Ilja Oomen, Marieke Verhagen, Mariarosaria Miranda, Peter Allacher, Erik A. M. Beckers, Nicole M. A. Blijlevens, Johanna G. van der Bom, Michiel Coppens, Mariëtte Driessens, Jeroen C. J. Eikenboom, Karin Fijnvandraat, Shermarke Hassan, Waander L. van Heerde, H. Louise Hooimeijer, Joop H. Jansen, Paul Kaijen, Frank W. G. Leebeek, Daniëlle Meijer, Helmut Paul, Sanna R. Rijpma, Frits R. Rosendaal,
Opublikowane w: Frontiers in Immunology, Numer 15, 2024, ISSN 1664-3224
Wydawca: the International Union of Immunological Societies (IUIS).
DOI: 10.3389/fimmu.2024.1355813

Temperature sensitivity of bat antibodies links metabolic state of bats with antigen-recognition diversity

Autorzy: Nia Toshkova, Violeta Zhelyzkova, Alejandra Reyes-Ruiz, Eline Haerens, Marina de Castro Deus, Robin V. Lacombe, Maxime Lecerf, Gaelle Gonzalez, Nolwenn Jouvenet, Cyril Planchais, Jordan D. Dimitrov
Opublikowane w: Nature Communications, Numer 15, 2024, Strona(/y) 5878, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-50316-x

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of <scp>SARS‐CoV</scp>‐2

Autorzy: Cyril Planchais, Alejandra Reyes‐Ruiz, Robin Lacombe, Alessandra Zarantonello, Maxime Lecerf, Margot Revel, Lubka T. Roumenina, Boris P. Atanasov, Hugo Mouquet, Jordan D. Dimitrov
Opublikowane w: Protein Science, Numer 31, 2023, Strona(/y) e4447, ISSN 0961-8368
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4447

How can polyreactive antibodies conquer rapidly evolving viruses?

Autorzy: Alejandra Reyes-Ruiz, Jordan Dimitrov
Opublikowane w: Trends Immunol, Numer 42(8), 2021, Strona(/y) 654-657
Wydawca: -
DOI: 10.1016/j.it.2021.06.008

The self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes

Autorzy: Valeria Porcheddu, Gautier Lhomme, Rémi Giraudet, Evelyne Correia, Bernard Maillère
Opublikowane w: Frontiers in Immunology, Numer 15, 2024, Strona(/y) 1345195, ISSN 1664-3224
Wydawca: the International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2024.1345195

Efanesoctocog alfa: the renaissance of Factor VIII replacement therapy

Autorzy: Yesim Dargaud, Alexandre Leuci, Alejandra Reyes Ruiz, Sebastien Lacroix-Desmazes
Opublikowane w: Haematologica, Numer 109(8), 2024, Strona(/y) 2436-2444, ISSN 0390-6078
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2023.284498

Exploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A

Autorzy: Mariarosaria Miranda, Eelke Brandsma, Lotte Robben, Helena Van Dender, Floris P.J. van Alphen, Karin Fijnvandraat, Maartje van den Biggelaar, Sebastien Lacroix-Desmazes, Robin van Bruggen, Jan Voorberg
Opublikowane w: Journal of Thrombosis and Haemostasis, 2025, ISSN 1538-7836
Wydawca: Elsevier
DOI: 10.1016/j.jtha.2024.11.012

α2-3 Sialic acids-decorated allergens exert a tolerogenic effect on CD4 T cells from Der p 2 – allergic patients

Autorzy: Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Evert E. Peterse, Hakan Kalay, Serge A. Versteeg, Ronald Van Ree, Esther E.C. de Jong, Yvette Van Kooyk
Opublikowane w: International Archives of Allergy and Immunology, 2024, Strona(/y) 1-19, ISSN 1018-2438
Wydawca: S. Karger AG
DOI: 10.1159/000543157

Binding Promiscuity of Therapeutic Factor VIII

Autorzy: Alejandra Reyes Ruiz, Aishwarya S. Bhale, Krishnan Venkataraman, Jordan D. Dimitrov, Sébastien Lacroix-Desmazes
Opublikowane w: Thrombosis and Haemostasis, 2024, Strona(/y) Online ahead of print, ISSN 0340-6245
Wydawca: Schattauer
DOI: 10.1055/a-2358-0853

Conference proceedings (1)

Induction of neonatal tolerance to therapeutic FVIII in hemophilia A

Autorzy: A Ruiz Reyes, S Delignant, V Daventure, A Mimoun, D J Dimitrov, S Lacroix-Desmazes
Opublikowane w: Hämostaseologie, GTH Congress 2023 – 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research – The patient as a benchmark, Numer 43(S 01), 2023, Strona(/y) S37-S38
Wydawca: Georg Thieme Verlag
DOI: 10.1055/s-0042-1760514