Tuning Tubulin Dynamics and Interactions to Face Neurotoxicity: a Multidisciplinary Approach for Training and Research

Informazioni relative al progetto

TubInTrain

ID dell’accordo di sovvenzione: 860070

DOI

10.3030/860070

Progetto chiuso

Data della firma CE 4 Settembre 2019

Data di avvio 1 Ottobre 2019

Data di completamento 30 Settembre 2023

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 409 972,92

Contributo UE

€ 3 409 972,92

Coordinato da

UNIVERSITA DEGLI STUDI DI MILANO
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (5)

Training School

Organization of the Training School 3 days Live Cell Imaging providing stateoftheart of advanced imaging application in living cells The training school will be followed by a Seminar Presentations about the new achieved research results 1 day

Workshop 2

Workshop 6 (1 day): “Ethics and Research” providing the main ethic issues

Training School 2

Training School 2 (3 days): “Industrial Property Management” providing the indispensable and fundamental know-how of Industrial Property issues

Workshop 1

Workshop 3 1 day keynotes lecture on Protein aggregation in neuronal diseases with invitation of external scientists

Final Conference

Organization of the Final Conference

Documents, reports (3)

Paper Publication 1

Publication of 23 papers acknowledging the project published

Recruitment advertising publication

Recruitment advertising publication has to be avilable and published on the website The advertisement has to be just published also on the social media and on the pages of the specialistic journals

Paper Publication 2

At least 6 papers acknowledging the project published

Websites, patent fillings, videos etc. (2)

Flyer

the flyer with the description of the project has to be available

Web Site

Web site has to be online and updated with all the relevant information

Pubblicazioni

Peer reviewed articles (26)

Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function

Autori: Ángela Oliva, Carlota Tosat-Bitrián, Lucía Barrado-Gil, Francesca Bonato, Inmaculada Galindo, Urtzi Garaigorta, Beatriz Álvarez-Bernad, Rebeca París-Ogáyar, Daniel Lucena-Agell, Juan Francisco Giménez-Abián, Isabel García-Dorival, Jesús Urquiza, Pablo Gastaminza, José Fernando Díaz, Valle Palomo and Covadonga Alonso
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073448

Design, Synthesis, and In Vitro Evaluation of Tubulin-targeting Dibenzothiazines with Antiproliferative Activity as Novel Heterocycle Building Block

Autori: Guerra, W.D.; Lucena-Agell, D.; Hortigüela, R.; Rossi, R.A.; Díaz, J.F.; Padrón, J.M. and Barolo, S.M.
Pubblicato in: ChemMedChem, 2021, ISSN 1860-7179
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202100383

α-Synuclein: An All-Inclusive Trip Around its Structure, Influencing Factors and Applied Techniques

Autori: Nicolò Bisi, Lucia Feni, Kaliroi Peqini, Helena Pérez-Peña, Sandrine Ongeri, Stefano Pieraccini, Sara Pellegrino
Pubblicato in: Frontiers in Chemistry, Numero 9, 2021, ISSN 2296-2646
Editore: Frontiers
DOI: 10.3389/fchem.2021.666585

Structural basis of noscapine activation for tubulin binding

Autori: Oliva, M.A.; Prota, A.E.; Rodríguez-Salarichs, J.; Gu, W.; Bennani, Y.L.; Jiménez-Barbero, J.; Bargsten, K.; Canales, A.; Steinmetz, M.O.; Díaz, J.F.
Pubblicato in: Journal of medicinal chemistry, 2020, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00855

Breaking down and building up alpha-synuclein: an insight on its N-terminal domain

Autori: Kaliroi Peqini, Simone Attanasio, L. Feni, Graziella Cappelletti, Sara Pellegrino
Pubblicato in: Journal of peptide science, 2023, ISSN 1099-1387
Editore: wiley
DOI: 10.1002/psc.3556

1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure

Autori: Cassandra Yong, Shane M. Devine, Anne-Catherine Abel, Stefan D. Tomlins, Divya Muthiah, Xuexin Gao, Richard Callaghan, Michel O. Steinmetz, Andrea E. Prota, Ben Capuano, and Peter J. Scammells
Pubblicato in: ChemMedChem, 2021, ISSN 1860-7187
Editore: ChemMedChem
DOI: 10.1002/cmdc.202100363

On the Importance of the Thiazole Nitrogen in Epothilones: Semisynthesis and Microtubule-Binding Affinity of Deaza-Epothilone C

Autori: Edenharter, A.; Ryckewaert, L.; Cintulová, D., Estévez-Gallego, J.; Díaz, J.F.; Altmann, K.H.
Pubblicato in: Chemistry, 2020, ISSN 2624-8549
Editore: MDPI
DOI: 10.3390/chemistry2020030

Microtubule-modulating Agents in the Fight Against Neurodegeneration: Will it ever Work?

Autori: Ahmed Soliman, Lidia Bakota, Roland Brandt
Pubblicato in: Current Neuropharmacology, 2022, ISSN 1875-6190
Editore: Bentham Science Publisher
DOI: 10.2174/1570159x19666211201101020

Method for the Stereoselective Construction of the Hemiaminal Center in Zampanolides

Autori: Brütsch, T.M.; Berardozzi, S.; Rothe, M.L.; Redondo-Horcajo, M;. Díaz, J.F.; Altmann, K.H. A.
Pubblicato in: organic letters, 2020, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.0c02974

Super-resolution imaging and quantitative analysis of microtubule arrays in model neurons show that epothilone D increases the density but decreases the length and straightness of microtubules in axon-like processes

Autori: Christian Conze, Nataliya I Trushina, Michael Holtmannspötter, Marina Rierola, Simone Attanasio, Lidia Bakota, Jacob Piehler, Roland Brandt
Pubblicato in: Brain Research Bulletin, 2022, ISSN 1873-2747
Editore: Elsevier BV
DOI: 10.1016/j.brainresbull.2022.10.008

Structural insight into the stabilization 1 of microtubules by taxanes

Autori: Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Pubblicato in: Structural Biology and Molecular Biophysics, 2023, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.84791

Synthesis of Morpholine-Based Analogs of (-)-Zampanolide and Their Biological Activity

Autori: Bold, C. P.; Gut, M.; Schürmann, J.; Lucena-Agell, D.; Gertsch, J.; Díaz; J.F.; Altmann, K.H.
Pubblicato in: Chemistry a european journal, 2021, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003996

Studies toward the Synthesis of an Oxazole-Based Analog of (-)-Zampanolide

Autori: Bold, C.; Klaus, C.; Pfeiffer, B.; Schürmann, J.; Lombardi, R.; Lucena-Agell, D.; Díaz, J.F.; Altmann, K.-H
Pubblicato in: organic letters, 2021, ISSN 1523-7060
Editore: American Chemical Society
DOI: 10.1021/acs.orglett.1c00378

N‑alkylisatin‑based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity

Autori: Keenan, B., Finol‑Urdaneta, R.K.; Hope, A.; Bremner, J.B.; Kavallaris, M., Lucena‑Agell, D.; Oliva, M.A.; Díaz, J.F.; Vine, K.L
Pubblicato in: Cancer cell international, 2020, ISSN 1475-2867
Editore: BioMed Central
DOI: 10.1186/s12935-020-01251-6

The Positive Side of the Alzheimer’s Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1

Autori: Lidia Ciccone , Chenghui Shi, Davide di Lorenzo, Anne-Cécile Van Baelen and Nicolo Tonali
Pubblicato in: Molecules, 2020, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25102439

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

Autori: Peronne, L; Denarier, E.; Rai, A.; Prudent, R.; Vernet, A.; Suzanne, P.; Ramirez-Rios, S.; Michallet, S.; Guidetti, M.; Vollaire, J.; Lucena-Agell, D.; Ribba, A.S.; Josserand, V.; Coll, J.L.; Dallemagne, P.; Díaz, J.F.; Oliva, M.A.; Sadoul, K.; Akhmanova, A.; Andrieux, A.; Lafanechère, L.
Pubblicato in: Cancers, 2020, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082196

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Autori: Matthew, S.; Chen, Q.Y.; Ratnayake, R.; Fermaintt, C.S.; Lucena-Agell, D.; Bonato, F.; Prota, A.E.; Lim, S.T.; Wang, X.; Díaz, J.F.; Risinger, A.L.; Paul, V.J.; Oliva, M.A., Luesch, H.
Pubblicato in: Proceedings of the National academy of sciences (PNAS), 2021, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2021847118

Computational Approaches to the Rational Design of Tubulin-Targeting Agents

Autori: Helena Pérez-Peña , Anne-Catherine Abel, Maxim Shevelev , Andrea E Prota , Stefano Pieraccini , Dragos Horvath
Pubblicato in: Biomolecules, 2023, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom13020285

Chemical modulation of microtubule structure through the laulimalide/peloruside site

Autori: JuanEstévez-Gallego, Beatriz Álvarez-Bernad, Benet Pera, Christoph Wullschleger, Olivier Raes, Dirk Menche, Juan Carlos Martínez, Daniel Lucena-Agell, Andrea E.Prota, Francesca Bonato, Katja Bargsten, Jelle Cornelus, Juan Francisco Giménez-Abián, Peter Northcote, Michel O.Steinmetz, Shinji Kamimura, Karl-Heinz Altmann, Ian Paterson, Federico Gago, Johan Van der Eycke, J Fernando Díaz, Marí
Pubblicato in: Structure, 2023, ISSN 1878-4186
Editore: Elsevier BV
DOI: 10.1016/j.str.2022.11.006

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders

Autori: Paola Marzullo, Zlata Boiarska, Helena Pérez‐Peña, Anne‐Catherine Abel, Beatriz Álvarez‐Bernad, Daniel Lucena‐Agell, Francesca Vasile, Maurizio Sironi, Karl‐Heinz Altmann, Andrea E. Prota, J. Fernando Díaz, Stefano Pieraccini, Daniele Passarella
Pubblicato in: Chemistry – A European Journal, 2021, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103520

Microtubule-targeting agents and neurodegeneration

Autori: Zlata Boiarska, Daniele Passarella
Pubblicato in: Drug Discovery Today, Numero 26/2, 2021, Pagina/e 604-615, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2020.11.033

Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: further chemical modifications and potential therapeutic effects against lymphomas

Autori: Marilia Barreca; Virginia Spanò; Roberta Rocca; Roberta Bivacqua; Anne-Catherine Abel; Annalisa Maruca; Alessandra Montalbano; Maria Valeria Raimondi; Chiara Tarantelli; Eugenio Gaudio; Luciano Cascione; Andrea Rinaldi; Ruoli Bai; Michel O. Steinmetz; Andrea E. Prota; Stefano Alcaro; Ernest Hamel; Francesco Bertoni; Paola Barraja
Pubblicato in: European Journal of Medicinal Chemistry, 2022, ISSN 0223-5234
Editore: Elsevier BV
DOI: 10.1016/j.ejmech.2022.114744

Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics

Autori: Zlata Boiarska, Helena Pérez-Peña, Anne-Catherine Abel, Paola Marzullo, Beatriz Álvarez-Bernad, Francesca Bonato, Benedetta Santini, Dragos Horvath, Daniel Lucena-Agell, Francesca Vasile, Maurizio Sironi, J. Fernando Díaz, Andrea E. Prota, Stefano Pieraccini, Daniele Passarella
Pubblicato in: Chemistry-A European Journal, 2022, ISSN 1521-3765
Editore: Wiley-VCH GmbH
DOI: 10.1002/chem.202203431

CLIP-170S is a novel microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement

Autori: Thakkar, P.V.; Kita, K.; del Castillo, U.; Galletti, G.; Madhukar; N.; Vila-Navarro, E.; Barasoain, I.; Goodson, H.V.; Sackett, D.; Díaz, J.F.; Lu, Y; RoyChoudhary, A.; Molina, H.; Elemento, O.; Shah, M.A.; Giannakakou, P.
Pubblicato in: Developmental Cell, 2021, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2021.09.023

Structural model for differential cap maturation at growing microtubule ends

Autori: Estévez-Gallego, J.; Josa-Prado, F.; Ku, S.; Buey, R.M.; Balaguer, F.A., Prota, A.E.; Lucena-Agell, D.; Kamma-Lorger,C.; Steinmetz, M.O.; Barasoain,I.; Chrétien, D.; Kamimura, S.; Díaz, J.F.; Oliva, M.A.
Pubblicato in: Structural Biology and Molecular Biophysics, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.50155

Pathological Pathways and Alpha-Synuclein in Parkinson’s Disease: A View from the Periphery

Autori: Milo Jarno Basellini,, Josine Marie Kothuis, Alessandro Comincini, Gianni Pezzoli, Graziella Cappelletti, Samanta Mazzetti Front. Biosci
Pubblicato in: Frontiers in Bioscience-Landmark, 2023, ISSN 2768-6698
Editore: IMR press
DOI: 10.31083/j.fbl2802033