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What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation

Project description

Teasing out differences in tangled chromatin may reveal a pathogen's recipe for success

Most pathogens are single-celled organisms, or in the case of viruses, small parasitic particles consisting of nucleic acid and outer protein shells. Once they have successfully invaded our bodies, some within the same community are more successful at establishing infection than others. Extensive research has revealed global mechanisms for pathogen adaptation and survival. However, little is known about local variations or cell-to-cell heterogeneity within the same microbial population. Cell2Cell is studying that heterogeneity at the level of chromatin, the DNA and histone proteins its wound around that make up chromosomes. Ground-breaking studies will help elucidate how chromatin is organised in pathogens and how chromatin heterogeneity might favour successful colonisation by certain cells, providing ammunition in the war against often-deadly invaders.

Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Net EU contribution
€ 754 854,25
Address
Geschwister Scholl Platz 1
80539 Muenchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (11)

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
Net EU contribution
€ 505 576,80
Address
Ingolstadter Landstrasse 1
85764 Neuherberg

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Region
Bayern Oberbayern München, Landkreis
Activity type
Research Organisations
Other funding
€ 0,00
INSTITUT CURIE
France
Net EU contribution
€ 274 802,04
Address
Rue D Ulm 26
75231 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 281 982,96
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Switzerland
Net EU contribution
€ 281 276,64
Address
Kreuzstrasse 2
4123 Allschwil

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Landschaft
Activity type
Research Organisations
Other funding
€ 0,00
WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 263 500,92
Address
Herzl Street 234
7610001 Rehovot

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal
Net EU contribution
€ 237 720,24
Address
Avenida Prof Egas Moniz
1649 028 Lisboa

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Other funding
€ 0,00
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 303 172,56
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
STICHTING RADBOUD UNIVERSITEIT
Netherlands
Net EU contribution
€ 265 619,88
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS
Türkiye
Net EU contribution
€ 235 248,12
Address
Teknopark Istanbul, Sanayi Mh. Teknopark Blv. No: 1/4a Kulucka Merkezi, Pendik
34906 Istanbul

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
İstanbul İstanbul İstanbul
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CELLSORTER MUSZAKI KUTATO ES FEJLESZTO KFT
Hungary
Net EU contribution
€ 229 715,28
Address
Erdoalja Ut 174
1037 Budapest

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Közép-Magyarország Budapest Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
Germany
Net EU contribution
€ 256 299,35
Address
Ludwigstrasse 23
35390 Giessen

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Region
Gießen Gießen, Landkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00