What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation

Project description

Teasing out differences in tangled chromatin may reveal a pathogen's recipe for success

Most pathogens are single-celled organisms, or in the case of viruses, small parasitic particles consisting of nucleic acid and outer protein shells. Once they have successfully invaded our bodies, some within the same community are more successful at establishing infection than others. Extensive research has revealed global mechanisms for pathogen adaptation and survival. However, little is known about local variations or cell-to-cell heterogeneity within the same microbial population. Cell2Cell is studying that heterogeneity at the level of chromatin, the DNA and histone proteins its wound around that make up chromosomes. Ground-breaking studies will help elucidate how chromatin is organised in pathogens and how chromatin heterogeneity might favour successful colonisation by certain cells, providing ammunition in the war against often-deadly invaders.

Fields of science

• natural sciences › biological sciences › genetics and heredity › genome
• medical and health sciences › health sciences › public and environmental health › epidemics prevention › immunisation
• natural sciences › biological sciences › genetics and heredity › dna
• natural sciences › biological sciences › genetics and heredity › epigenetics

Programme(s)

• H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers

Topic(s)

• MSCA-ITN-2019 - Innovative Training Networks

Call for proposal

H2020-MSCA-ITN-2019
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Address

Geschwister Scholl Platz 1
80539 Muenchen
Germany

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 011 153,60

Participants (10)

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU contribution

€ 505 576,80

Address

Ingolstadter Landstrasse 1
85764 Neuherberg

Activity type

Research Organisations

INSTITUT CURIE

France

EU contribution

€ 274 802,04

Address

Rue D'ulm 26
75231 Paris

Activity type

Research Organisations

KAROLINSKA INSTITUTET

Sweden

EU contribution

€ 281 982,96

Address

Nobels Vag 5
17177 Stockholm

Activity type

Higher or Secondary Education Establishments

SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT

Switzerland

EU contribution

€ 281 276,64

Address

Socinstrasse 57
CH-4002 Basel

Activity type

Research Organisations

WEIZMANN INSTITUTE OF SCIENCE

Israel

EU contribution

€ 263 500,92

Address

Herzl Street 234
7610001 Rehovot

Activity type

Higher or Secondary Education Establishments

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES

Portugal

EU contribution

€ 237 720,24

Address

Avenida Prof Egas Moniz
1649 028 Lisboa

Activity type

Research Organisations

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU contribution

€ 303 172,56

Address

Wellington Square University Offices
OX1 2JD Oxford

Activity type

Higher or Secondary Education Establishments

STICHTING RADBOUD UNIVERSITEIT

Netherlands

EU contribution

€ 265 619,88

Address

Houtlaan 4
6525 XZ Nijmegen

Activity type

Higher or Secondary Education Establishments

EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS

Turkey

EU contribution

€ 235 248,12

Address

Teknopark Istanbul, Sanayi Mh. Teknopark Blv. No: 1/4A Kulucka Merkezi, Pendik
34906 Istanbul

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

CELLSORTER MUSZAKI KUTATO ES FEJLESZTO KFT

Hungary

EU contribution

€ 229 715,28

Address

Erdoalja Ut 174
1037 Budapest

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)