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What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation

Project description

Teasing out differences in tangled chromatin may reveal a pathogen's recipe for success

Most pathogens are single-celled organisms, or in the case of viruses, small parasitic particles consisting of nucleic acid and outer protein shells. Once they have successfully invaded our bodies, some within the same community are more successful at establishing infection than others. Extensive research has revealed global mechanisms for pathogen adaptation and survival. However, little is known about local variations or cell-to-cell heterogeneity within the same microbial population. Cell2Cell is studying that heterogeneity at the level of chromatin, the DNA and histone proteins its wound around that make up chromosomes. Ground-breaking studies will help elucidate how chromatin is organised in pathogens and how chromatin heterogeneity might favour successful colonisation by certain cells, providing ammunition in the war against often-deadly invaders.

Call for proposal

H2020-MSCA-ITN-2019
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Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Address
Geschwister Scholl Platz 1
80539 Muenchen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 011 153,60

Participants (10)

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 505 576,80
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
INSTITUT CURIE
France
EU contribution
€ 274 802,04
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 281 982,96
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT
Switzerland
EU contribution
€ 281 276,64
Address
Socinstrasse 57
CH-4002 Basel
Activity type
Research Organisations
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 263 500,92
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Portugal
EU contribution
€ 237 720,24
Address
Avenida Prof Egas Moniz
1649 028 Lisboa
Activity type
Research Organisations
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 303 172,56
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
STICHTING RADBOUD UNIVERSITEIT
Netherlands
EU contribution
€ 265 619,88
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS
Turkey
EU contribution
€ 235 248,12
Address
Teknopark Istanbul, Sanayi Mh. Teknopark Blv. No: 1/4A Kulucka Merkezi, Pendik
34906 Istanbul
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CELLSORTER MUSZAKI KUTATO ES FEJLESZTO KFT
Hungary
EU contribution
€ 229 715,28
Address
Erdoalja Ut 174
1037 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)