Project description
Teasing out differences in tangled chromatin may reveal a pathogen's recipe for success
Most pathogens are single-celled organisms, or in the case of viruses, small parasitic particles consisting of nucleic acid and outer protein shells. Once they have successfully invaded our bodies, some within the same community are more successful at establishing infection than others. Extensive research has revealed global mechanisms for pathogen adaptation and survival. However, little is known about local variations or cell-to-cell heterogeneity within the same microbial population. Cell2Cell is studying that heterogeneity at the level of chromatin, the DNA and histone proteins its wound around that make up chromosomes. Ground-breaking studies will help elucidate how chromatin is organised in pathogens and how chromatin heterogeneity might favour successful colonisation by certain cells, providing ammunition in the war against often-deadly invaders.
Fields of science
Programme(s)
Coordinator
80539 Muenchen
Germany
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Participants (11)
85764 Neuherberg
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75231 Paris
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17177 Stockholm
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4123 Allschwil
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7610001 Rehovot
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1649 028 Lisboa
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OX1 2JD Oxford
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6525 XZ Nijmegen
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34906 Istanbul
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1037 Budapest
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
35390 Giessen
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