What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation

Project Information

Cell2Cell

Grant agreement ID: 860675

DOI 10.3030/860675

Project closed

EC signature date 11 September 2019

Start date 1 November 2019

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 832 859,30

EU contribution € 3 832 859,30

Coordinated by

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (6)

Potential inputs for Policy feedback

Consortium should include any relevant information, results, activities who could contribute to any policy development in their domain. This information could then be used for policy feedback purposes.

Summer school (Spetses)

Summer school with invited speakers held

Information flyer complete

Flyer information and design completed

Network logo designed

Cooperate image designed

Public Engagement progress review

Public Engagement progress review completed

Final conference / Career Day (Munich)

Final conference with invited speakers, modules in imaging (module 4: Microfluidics), NGS (ATAC-seq & ChIP-seq), Data Analysis (module 5: review of key aspects) and Career Day

Websites, patent fillings, videos etc. (1)

Website online

Cell2Cell network website design completed and online

Publications

Peer reviewed articles (9)

The molecular grammar of protein disorder guiding genome-binding locations

Author(s): Felix Jonas, Miri Carmi, Beniamin Krupkin, Joseph Steinberger, Sagie Brodsky, Tamar Jana, Naama Barkai
Published in: Nucleic Acids Research, Issue Vol. 51, Issue 10, 2023, Page(s) 4831-4844, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad184

Cell-to-Cell Heterogeneity in Trypanosomes

Author(s): Vanessa Luzak, Lara López-Escobar, T. Nicolai Siegel, Luisa M. Figueiredo
Published in: Annual Review of Microbiology, Issue 75/1, 2021, Page(s) 107-128, ISSN 0066-4227
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-micro-040821-012953

The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery

Author(s): Lucía Martín Caballero, Matías Capella, Ramón Ramos Barrales, Nikolay Dobrev, Thomas van Emden, Yasuhiro Hirano, Vishnu N. Suma Sreechakram, Sabine Fischer-Burkart, Yasuha Kinugasa, Alicia Nevers, Mathieu Rougemaille, Irmgard Sinning, Tamás Fischer, Yasushi Hiraoka & Sigurd Braun
Published in: Nature Structural & Molecular Biology, Issue Vol. 29, 2022, Page(s) 910-921, ISSN 1545-9993
Publisher: Nature Publishing Group
DOI: 10.1038/s41594-022-00831-6

The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites

Author(s): Eva Hitz, Natalie Wiedemar, Armin Passecker, Beatriz A. S. Graça, Christian Scheurer, Sergio Wittlin, Nicolas M. B. Brancucci, Ioannis Vakonakis, Pascal Mäser, Till S. Voss
Published in: PLoS Biology, Issue 19(12), 2021, ISSN 1545-7885
Publisher: Plos
DOI: 10.1371/journal.pbio.3001483

A genome-wide map of DNA replication at single-molecule resolution in the malaria parasite Plasmodium falciparum

Author(s): Francis Isidore Garcia Totañes, Jonas Gockel, Sarah E. Chapman, Richárd Bártfai, Michael A. Boemo, Catherine J. Merrick
Published in: Nucleic Acids Research, Issue Volume 51, Issue 6, 2023, Page(s) 2709-2724, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkad093

m6A landscape is more pervasive when Trypanosoma brucei exits the cell cycle

Author(s): Lúcia Serra, Sara Silva Pereira, Idálio J. Viegas, Henrique Machado, Lara López-Escobar, Luísa M. Figueiredo
Published in: Biomedical Journal, 2024, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1101/2024.02.23.581781

Continuous distribution of cancer cells in the cell cycle unveiled by AI-segmented imaging of 37,000 HeLa FUCCI cells

Author(s): Hamid Cheraghi, Kinga Dóra Kovács, Inna Székács, Robert Horvath, Bálint Szabó
Published in: Heliyon, Issue Volume 10, Issue 9, 2024, ISSN 2405-8440
Publisher: Londen: Elsevier Ltd.
DOI: 10.1016/j.heliyon.2024.e30239

The troubled puberty of malaria parasites

Author(s): Jonas Gockel, Till S. Voss, Richárd Bártfai
Published in: Trends in Parasitology, Issue Volume 39, Issue 3, 2023, Page(s) 155-157, ISSN 1097-4172
Publisher: Cell Press
DOI: 10.1016/j.pt.2023.01.006

Slow growing behavior in African trypanosomes during adipose tissue colonization

Author(s): Sandra Trindade, Mariana de Niz, Mariana Costa-Sequeira, Tiago Bizarra-Rebelo, Fábio Bento, Mario Dejung, Marta Valido Narciso, Lara López-Escobar, João Ferreira, Falk Butter, Frédéric Bringaud, Erida Gjini, Luisa M. Figueiredo
Published in: Nature Communications, Issue 13, Article number: 7548, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34622-w

Other (2)

A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation

Author(s): Abubakar Muhammad, Zsuzsa Sarkadi, Thomas van Emden, Agnisrota Mazumder, Matias Capella, Gergely Fekete, Vishnu N. Suma Sreechakram, Bassem Al-Sady, Balázs Papp, Ramón Ramos Barrales, Sigurd Braun
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.13.579970

High-resolution scRNA-seq reveals genomic determinants of antigen expression hierarchy in African Trypanosomes

Author(s): Kirsty R McWilliam, Zhibek Keneskhanova, Raul O Cosentino, Atai Dobrynin, Jaclyn E Smith, Ines Subota, Monica R Mugnier, Maria Colome-Tatche, T Nicolai Siegel
Published in: bioRxiv, 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.03.22.586247