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C-H Activation for Industrial Renewal

Project description

European training network on sustainable organic synthesis

Carbon–hydrogen (C–H) bond activation is one of the most rapidly developing fields in organic chemistry, but its application for industrial purposes remains limited. This is mainly due to the lack of cooperation between academia and industry and a limited number of young experts in the field. The EU-funded CHAIR project is a unique European Research Network aiming to address these issues. The network brings together nine renowned academic research institutions and six industrial partners, strongly motivated to establish a profound basis that will enable industrial C–H activation to find wider use. Fifteen early-stage and fifteen senior researchers will be engaged in fundamental research projects to showcase the potential of C–H bond activation.


C-H activation is one of the most rapidly expanding areas of molecular chemistry and has emerged as an increasingly viable tool. Despite clear benefits offered by the C-H activation for sustainable and eco-responsible synthesis, its industrial applications are scarce. The lack of its widespread implementation in the industrial sector is due to multiple factors, amongst which the major reasons are a) the limited interactions between academia and industrial practitioners, and b) a limited number of young scientists with a strong expertise in the domain. CHAIR is aimed to specifically address these issues. CHAIR represents a unique European Research Network, combining nine renowned academic research groups and six industrial partners, strongly motivated to settle a solid basement for profound embedment of the C-H activation in an industrial environment. To achieve this ambitious goal 15 ESRs and 15 advanced scientists will be mobilized to implement direct C-H functionalization in industry, including both lead development and process chemistry. Fundamental research projects will be conducted to showcase the potential of the C-H activation to 1) speed up lead-to-hit optimization in pharmaceutical industries; 2) rapidly access molecular diversity; 3) assemble advanced materials; 4) convert raw materials into valuable building blocks; 5) bring new techniques to easily implement C-H activation based protocols for large-scale production. Development of these projects, combined with the scientific training and close collaborations within the CHAIR consortiums through specific secondments will provide 15 ESRs with unique competences in this edge-cutting field. Trainings on personal development, career development and societal/business aspects will complement their unique education, providing them with far-reaching and complementary competences to become future key actors of chemical industries in charge of the modernization of chemical and pharmaceutical industries.


Net EU contribution
€ 824 406,12
75794 Paris

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Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Total cost
€ 824 406,12

Participants (13)