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Advanced simulation, analysis and interpretation of network structures in biological data

Project description

Towards an understanding of biological networks’ behaviour

How can we understand the behaviour of networks? The relation between network structure and information processing capacity is essential. So far, a vast amount of data has been collected to understand the structure and functioning of networks. However, analysing these data can be challenging. The EU-funded SmartNets project aims to conduct research on networks and to use visualisation tools across three analysis dimensions: structure, activity and information processing. SmartNets will combine existing and novel techniques, from different types of research domains and across all three analysis dimensions. Ultimately, the project will provide new insights into the properties, behaviour and dynamic evolution of biological networks.

Objective

Think of the the murmuration of starlings, the schooling of fish, or even hypes on social media or the spreading of powerouts: the behaviour of a network is critically determined by its structure. This structure induces collective emergent behavior that can only be understood by analysing the whole network in relation to its constituent parts. Particularly in the brain, the architecture of the network is essential for its functioning: information transfer and processing within and between networks. The relation between network structure and information processing capacity is essential at every scale: from molecules and genes to large neural networks to populations of behaving agents, on every level nodes form complex networks underlying the most essential functions of the functioning of the brain, body and society. Only recently, with high-throughput techniques, have we begun to collect the vast amounts of data needed to study the structure and functioning of these networks. However, analysing these data is still a challenge and the nature of complex network processes are still poorly understood. In order to compare networks, simulated or physical ones, or healthy versus diseased, network analysis and visualization tools are needed across three analysis dimensions: structure, activity and information processing. Many quantitative tools exist for analysing networks, but they are mostly restricted to one application domain or network type and often only address one of these dimensions. The novelty of our contributions will lie in the combination of existing and new techniques, from different research domains, and across the three analysis dimensions. By transcending specific data sets or domains, we expect to open up new insights into the properties, behaviour and dynamic evolution of biological networks. We will train the data scientists of the future, that will be able to analyse biological networks across levels, domains and types.

Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-ITN-2019

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Coordinator

STICHTING RADBOUD UNIVERSITEIT
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 796 859,64
Address
HOUTLAAN 4
6525 XZ Nijmegen
Netherlands

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 796 859,64

Participants (5)

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