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CORDIS

Training towards Personalized Antibiotic Treatment

Descrizione del progetto

Un gruppo di giovani ricercatori prende sul personale la resistenza agli antibiotici

Storicamente, i farmaci per le infezioni e le malattie sono stati sviluppati a partire da test effettuati su grandi popolazioni di pazienti simili. I progressi scientifici, soprattutto in materia di genetica, hanno dato inizio a una nuova era di medicina personalizzata in cui geni, proteine e persino parti di proteine possono essere utilizzati per creare terapie mirate. La terapia antibiotica personalizzata è un’area in cui tali metodi possono essere utilizzati per migliorare l’efficacia della terapia antibiotica, combattendo nel contempo il pericoloso aumento di ceppi di batteri resistenti agli antibiotici. TIPAT sta formando dei giovani ricercatori nelle tecniche necessarie per valutare strategicamente le interazioni farmaco-patogeno-ospite per un'efficace terapia antibiotica personalizzata. Un approccio nuovo a quello che sta diventando un problema comune potrebbe essere proprio la «medicina giusta».

Obiettivo

Antimicrobial resistance (AMR) is an increasing threat to effectively treat serious bacterial infections. To this end, tailoring antibiotic treatments to individual patients is urgently needed to maximize efficacy while minimizing the risk of promoting further resistance. To enable development of innovative personalized antibiotic treatment strategies, quantitative understanding of the interplay between drug, pathogen and host is crucial. The Training towards Innovative Personalized Antibiotic Therapy (TIPAT) network will train inter-disciplinary specialists optimally equipped with a skill set to address this challenge.
TIPAT offers a cutting-edge training-by-research programme for 15 Early Stage Researchers (ESRs) who will investigate translation and integration of biological and pharmacological data related to drug-pathogen-host interactions towards personalized therapies. Central to the TIPAT research and training program is the combination of state-of-the art quantitative modelling with approaches in clinical pharmacology, immunology and microbiology, which enables development of innovative methodology to personalized antibiotic therapies.
The consortium unites a cross-disciplinary team of leading academic experts and inter-sectoral partners including SMEs, pharmaceutical companies and hospitals. Secondments complementary to ESR research projects will promote inter-professional and cross-disciplinary research and communication. The TIPAT integrated program is enriched with transferable, regulatory and entrepreneurial skills training delivered through themed Summer and Winter schools.
The TIPAT network will deliver inter-disciplinary specialists in personalized antibiotic treatment strategies. The TIPAT training will strongly expand career perspectives of ESRs in academia, hospitals, industry or regulatory agencies, and develop scientific innovations to enable optimal therapy for individual patients to address current and future challenges of AMR-infections.

Coordinatore

UNIVERSITEIT LEIDEN
Contribution nette de l'UE
€ 796 859,64
Indirizzo
RAPENBURG 70
2311 EZ Leiden
Paesi Bassi

Mostra sulla mappa

Regione
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 796 859,64

Partecipanti (6)