Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation.

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

NeutroCure newsletter No.3
Set-up of NeutroCure web page/ design of consortium's Logo

Design of consortium’s Logo; set-up of NeutroCure web page that should include consortium’s Logo

NeutroCure newsletter No.2
NeutroCure newsletter No.1

A symposium with participation of the supervisory board

A symposium with participation of the supervisory board (Prof. Dr. C. Hackenberger, Leibniz Research Institute for Molecular Pharmacology and Prof. Dr. R. Voll, University Medical Center Freiburg): report with agenda, list of participants, and executive summary of the meeting.

Setup of in vitro assays to assess ROS production, NET formation and killing of cancerous cells mediated by neutrophils

Publicaciones

The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients.

Autores: Andrii Rabets; Galyna Bila; Roman Grytsko; Markian Samborskyy; Yuriy Rebets; Sandor G. Vari; Quentin Pagneux; Alexandre Barras; Rabah Boukherroub; Sabine Szunerits; Rostyslav Bilyy
Publicado en: Springer Nature, Edición 2, 2021, ISSN 1661-4917
Editor: Springer
DOI: 10.1007/s00005-021-00607-8

3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo

Autores: Insa Klemt, Oleg Varzatskii, Roman Selin, Serhii Vakarov, Vladyslava Kovalska, Galyna Bila, Rostyslav Bilyy, Yan Voloshin, Itziar Cossío Cuartero, Andrés Hidalgo, Benjamin Frey, Ina Becker, Bernhard Friedrich, Rainer Tietze, Ralf P. Friedrich, Christoph Alexiou, Elena-Laura Ursu, Alexandru Rotaru, Iris Solymosi, M. Eugenia Pérez-Ojeda, and Andriy Mokhir
Publicado en: Journal of the American Chemical Society, Edición 2, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c08827

Targeted opening of the blood–brain barrier facilitates doxorubicin/anti-PD-1-based chemoimmunotherapy of glioblastoma

Autores: Jonathan G. Pol, Manuela Lizarralde-Guerrero, Andrea Checcoli, Guido Kroemer
Publicado en: OncoImmunology, Edición 13, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2024.2385124

Neutrophils as Main Players of Immune Response towards Nondegradable Nanoparticles

Autores: Rostyslav Bilyy, Galyna Bila, Oleg Vishchur, Volodymyr Vovk, Martin Herrmann
Publicado en: Nanomaterials, Edición 10/7, 2020, Página(s) 1273, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano10071273

Potent immune-dependent anticancer effects of the non-cardiotoxic anthracycline aclarubicin

Autores: Giulia Cerrato, Allan Sauvat, Mahmoud Abdellatif, Guido Kroemer
Publicado en: OncoImmunology, Edición 14, 2025, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2025.2515176

Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue

Autores: Liwei Zhao, Peng Liu, Oliver Kepp, Guido Kroemer
Publicado en: OncoImmunology, Edición 14, 2025, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2025.2512109

Neutrophil Depletion Changes the N-Glycosylation Pattern of IgG in Experimental Murine Sepsis

Autores: Kursat O. Yaykasli, Karin A. van Schie, René E. M. Toes, Manfred Wuhrer, Carolien A. M. Koeleman, Galyna Bila, Nazar Negrych, Georg Schett, Jasmin Knopf, Martin Herrmann, Rostyslav Bilyy
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 6478, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25126478

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers

Autores: Hong-Gui Xu; Viktor Reshetnikov; Marit Wondrak; Lisa Eckhardt; Leoni A. Kunz-Schughart; Christina Janko; Rainer Tietze; Christoph Alexiou; Hannes Borchardt; Achim Aigner; Wenjie Gong; Michael Schmitt; Leopold Sellner; Steffen Daum; Hülya Gizem Özkan; Andriy Mokhir
Publicado en: Cancers, Edición 1, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010208

Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death

Autores: Karla Alvarez-Valadez, Jonathan G. Pol, Guido Kroemer, Mojgan Djavaheri-Mergny
Publicado en: OncoImmunology, Edición 14, 2025, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2025.2531113

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Autores: Hülya Gizem Özkan; Vanrajsinh Thakor; Hong‐Gui Xu; Galyna Bila; Rostyslav Bilyy; Daria Bida; Martin Böttcher; Dimitrios Mougiakakos; Rainer Tietze; Andriy Mokhir
Publicado en: Chemistry, Eur. J., Edición 3, 2022, ISSN 1521-3765
Editor: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/chem.202104420

A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity

Autores: Sebastian J. Hofer, Ioanna Daskalaki, Mahmoud Abdellatif, Ulrich Stelzl, Simon Sedej, Nektarios Tavernarakis, Guido Kroemer, Frank Madeo
Publicado en: Autophagy, Edición 20, 2024, Página(s) 2824-2826, ISSN 1554-8627
Editor: Landes Bioscience
DOI: 10.1080/15548627.2024.2396793

Neutrophil extracellular traps characterize caseating granulomas

Autores: Leticija Zlatar, Jasmin Knopf, Jeeshan Singh, Han Wang, Marco Muñoz-Becerra, Irmgard Herrmann, Rebecca C. Chukwuanukwu, Markus Eckstein, Philip Eichhorn, Ralf J. Rieker, Elisabeth Naschberger, Andreas Burkovski, Veit Krenn, Rostyslav Bilyy, Tetiana Butova, Iryna Liskina, Ihor Kalabukha, Oleg Khmel, Michael Boettcher, Georg Schett, Dmytro Butov, Anton Tkachenko, Martin Herrmann
Publicado en: Cell Death & Disease, Edición 15, 2024, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-024-06892-3

An endoplasmic reticulum – specific pro‐amplifier of reactive oxygen species in cancer cells

Autores: Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Publicado en: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100054

Transcriptional Insights of Oxidative Stress and Extracellular Traps in Lung Tissues of Fatal COVID-19 Cases

Autores: Hans-Uwe Simon; Timothée Fettrelet; Aref Hosseini; Darko Stojkov; Shida Yousefi; Rostyslav Bilyy
Publicado en: International journal of molecular sciences, Edición 2, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032646

Vesicular Messages from Dental Biofilms for Neutrophils

Autores: Ljubomir Vitkov, Jelena Krunić, Johanna Dudek, Madhusudhan Reddy Bobbili, Johannes Grillari, Bernhard Hausegger, Irena Mladenović, Nikola Stojanović, Wolf Dietrich Krautgartner, Hannah Oberthaler, Christine Schauer, Martin Herrmann, Jeeshan Singh, Bernd Minnich, Matthias Hannig
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 3314, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25063314

Periodontitis-Derived Dark-NETs in Severe Covid-19

Autores: Ljubomir Vitkov, Jasmin Knopf, Jelena Krunić, Christine Schauer, Janina Schoen, Bernd Minnich, Matthias Hannig, Martin Herrmann
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.872695

Neutralization of acyl CoA binding protein (ACBP) for the experimental treatment of osteoarthritis

Autores: Uxía Nogueira-Recalde, Flavia Lambertucci, Léa Montégut, Omar Motiño, Hui Chen, Sylvie Lachkar, Gerasimos Anagnostopoulos, Gautier Stoll, Sijing Li, Vincent Carbonier, Ester Saavedra Díaz, Francisco J. Blanco, Geert van Tetering, Mark de Boer, Maria Chiara Maiuri, Beatriz Caramés, Isabelle Martins, Guido Kroemer
Publicado en: Cell Death & Differentiation, Edición 32, 2025, Página(s) 1484-1498, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-025-01474-y

Two decades of advances in clinical oncology — lessons learned and future directions

Autores: Susana Banerjee, Christopher M. Booth, Eduardo Bruera, Markus W. Büchler, Alexander Drilon, Terry J. Fry, Irene M. Ghobrial, Luca Gianni, Rakesh K. Jain, Guido Kroemer, Josep M. Llovet, Georgina V. Long, Klaus Pantel, Kathy Pritchard-Jones, Howard I. Scher, Josep Tabernero, Ralph R. Weichselbaum, Michael Weller, Yi-Long Wu
Publicado en: Nature Reviews Clinical Oncology, Edición 21, 2024, Página(s) 771-780, ISSN 1759-4774
Editor: Nature Publishing Group
DOI: 10.1038/s41571-024-00945-4

Reaction of N‐Ferrocenylcarbamates with Nitric Oxide: An Application for Detection of Inflammatory Sites In Vivo

Autores: Roman Selin, Hülya Gizem Özkan, Galyna Bila, Rostyslav Bilyy, Andriy Mokhir
Publicado en: ChemMedChem, Edición 20, 2025, ISSN 1860-7179
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/cmdc.202500356

Immunogenic oncolysis by tigilanol tiglate

Autores: Jonathan G. Pol, Manuela Lizarralde-Guerrero, Guido Kroemer
Publicado en: OncoImmunology, Edición 13, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2024.2360230

Moonlighting chromatin: when DNA escapes nuclear control

Autores: Jeeshan Singh, Michael Boettcher, Maximilian Dölling, Annika Heuer, Bettina Hohberger, Moritz Leppkes, Elisabeth Naschberger, Mirco Schapher, Christine Schauer, Janina Schoen, Michael Stürzl, Ljubomir Vitkov, Han Wang, Leticija Zlatar, Georg A. Schett, David S. Pisetsky, Ming-Lin Liu, Martin Herrmann, Jasmin Knopf
Publicado en: Cell Death & Differentiation, Edición 30, 2023, Página(s) 861-875, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-023-01124-1

A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Autores: Jeeshan Singh; Irmgard Herrmann; Aparna Mahajan; Christine Schauer; Xiaomei Shan; Arndt Hartmann; Ralf J. Rieker; Katja Evert; Christina Falkeis; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Georg Schett; Martin Herrmann; Jasmin Knopf
Publicado en: International Journal of Molecular Sciences; Volume 23; Edición 23; Pages: 15126, Edición 2, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232315126

Fatty Acid Metabolism Provides an Essential Survival Signal in OxPhos and BCR DLBCL Cells

Autores: Aurélie Montagne, Konstantina Kotta, Karoline Kielbassa-Elkadi, Isabelle Martins, José Ángel Martinez-Climent, Guido Kroemer, Catherine Thieblemont, Véronique Baud
Publicado en: Biomedicines, Edición 13, 2025, Página(s) 707, ISSN 2227-9059
Editor: MDPI AG
DOI: 10.3390/biomedicines13030707

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex

Autores: Simon Lind, Claes Dahlgren, Rikard Holmdahl, Peter Olofsson, Huamei Forsman
Publicado en: Journal of Leukocyte Biology, 2020, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1002/jlb.2hi0520-317r

Neutrophil extracellular traps: from physiology to pathology.

Autores: Andrés Hidalgo; Peter Libby; Oliver Soehnlein; Oliver Soehnlein; Iker Valle Aramburu; Venizelos Papayannopoulos; Carlos Silvestre-Roig
Publicado en: Cardiovasc Res, Edición 1, 2022, ISSN 1755-3245
Editor: Cardiovascular Research
DOI: 10.1093/cvr/cvab329

Metabolic Heterogeneity in Diffuse Large B-Cell Lymphoma Cells Reveals an Innovative Antimetabolic Combination Strategy

Autores: Leonardo Lordello, Stéphanie Nuan-Aliman, Karoline Kielbassa-Elkadi, Aurélie Montagne, Konstantina Kotta, Isabelle Martins, Eva Pinto Jurado, Cédric Caradeuc, Jacqueline Lehmann-Che, José Ángel Martínez-Climent, Véronique Meignin, Nicolas Giraud, Guido Kroemer, Gildas Bertho, Catherine Thieblemont, Véronique Baud
Publicado en: Cancers, Edición 17, 2025, Página(s) 394, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers17030394

A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism

Autores: Khushboo Borah, Olivia J. Rickman, Nikol Voutsina, Isaac Ampong, Dan Gao, Emma L. Baple, Irundika HK. Dias, Andrew H. Crosby, Helen R. Griffiths
Publicado en: Redox Biology, Edición 36, 2020, Página(s) 101595, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2020.101595

Immunogenic cell death and bystander killing: expanding the therapeutic potential of modern antibody-drug conjugates

Autores: Oliver Kepp, Guido Kroemer
Publicado en: OncoImmunology, Edición 14, 2025, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2025.2533488

Neutrophil swarm control: what goes up must come down

Autores: Uderhardt, Stefan; Knopf, Jasmin; Herrmann, Martin
Publicado en: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021), Edición 1, 2021, ISSN 2059-3635
Editor: Springer Nature
DOI: 10.1038/s41392-021-00836-5

AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity

Autores: Giulia Cerrato, Peng Liu, Liwei Zhao, Adriana Petrazzuolo, Juliette Humeau, Sophie Theresa Schmid, Mahmoud Abdellatif, Allan Sauvat, Guido Kroemer
Publicado en: Molecular Cancer, Edición 23, 2024, ISSN 1476-4598
Editor: BioMed Central
DOI: 10.1186/s12943-024-02189-3

Obesity accelerates cardiovascular ageing

Autores: Celia Ruperez, Frank Madeo, Rafael de Cabo, Guido Kroemer, Mahmoud Abdellatif
Publicado en: European Heart Journal, Edición 46, 2025, Página(s) 2161-2185, ISSN 0195-668X
Editor: Oxford University Press
DOI: 10.1093/eurheartj/ehaf216

Patients with COVID-19: in the dark-NETs of neutrophils

Autores: Maximilian Ackermann, Hans-Joachim Anders, Rostyslav Bilyy, Gary L. Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andrés Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J. Kaplan, Jason S. Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A. Manfredi, Christian Maueröder, Norma Maugeri, Ioannis Mitr
Publicado en: Nature, 2021, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds.

Autores: Rostyslav Bilyy; Quentin Pagneux; Nathan François; Galyna Bila; Roman Grytsko; Yuri Lebedin; Alexandre Barras; Jean Dubuisson; Sandrine Belouzard; Karin Séron; Rabah Boukherroub; Sabine Szunerits
Publicado en: https://hal.archives-ouvertes.fr/hal-03348197, Edición 1, 2021, ISSN 2076-0817
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070861

Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction

Autores: Maximilian Dölling, Markus Eckstein, Jeeshan Singh, Christine Schauer, Janina Schoen, Xiaomei Shan, Aline Bozec, Jasmin Knopf, Georg Schett, Luis E Muñoz, Martin Herrmann
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.726153

Matrix-producing neutrophils populate and shield the skin

Autores: Tommaso Vicanolo, Alaz Özcan, Jackson LiangYao Li, Carla Huerta-López, Iván Ballesteros, Andrea Rubio-Ponce, Andra C. Dumitru, Jose Ángel Nicolás-Ávila, Miguel Molina-Moreno, Pablo Reyes-Gutierrez, Andrew D. Johnston, Catherine Martone, Eric Greto, Antonio Quílez-Alvarez, Enrique Calvo, Elena Bonzon-Kulichenko, Rebeca Álvarez-Velez, Ming Yao Chooi, Immanuel Kwok, Blanca González-Bermúdez
Publicado en: Nature, Edición 641, 2025, Página(s) 740-748, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-025-08741-5

Atlas of expression of acyl CoA binding protein/diazepam binding inhibitor (ACBP/DBI) in human and mouse

Autores: Sijing Li, Silvia Mingoia, Léa Montégut, Flavia Lambertucci, Hui Chen, Yanbing Dong, Fatima Domenica Elisa De Palma, Sarah Adriana Scuderi, Yan Rong, Vincent Carbonnier, Isabelle Martins, Maria Chiara Maiuri, Guido Kroemer
Publicado en: Cell Death & Disease, Edición 16, 2025, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-025-07447-w

Datasets of whole cell and mitochondrial oxysterols derived from THP-1, SH-SY5Y and human peripheral blood mononuclear cells using targeted metabolomics

Autores: Khushboo Borah; Olivia J. Rickman; Nikol Voutsina; Emma L. Baple; Irundika H.K. Dias; Andrew H. Crosby; Helen R. Griffiths
Publicado en: Data in Brief, Edición 2, 2020, ISSN 2352-3409
Editor: Elsevier BV
DOI: 10.1016/j.dib.2020.106382

FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner

Autores: Fei He; Apple H.M. Tay; Ahmed Calandigary; Enana Malki; Sayaka Suzuki; Tianjie Liu; Qi Wang; Carlos Fernández-Moro; Marina Kaisso; Peter Olofsson-Sahl; Marit Melssen; Siu Kwan Sze; Mikael Björnstedt; Matthias J. Löhr; Mikael C.I. Karlsson; Rainer Heuchel; Dhifaf Sarhan
Publicado en: Cancer Research, Edición 1, 2023, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-2932

Neutrophils as drivers of vascular injury in sickle cell disease

Autores: Lidiane S Torres, Andrés Hidalgo
Publicado en: Immunological Reviews, 2022, ISSN 0105-2896
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imr.13146

ACBP/DBI neutralization for the experimental treatment of fatty liver disease

Autores: Omar Motiño, Flavia Lambertucci, Adrien Joseph, Sylvère Durand, Gerasimos Anagnostopoulos, Sijing Li, Vincent Carbonnier, Uxía Nogueira-Recalde, Léa Montégut, Hui Chen, Fanny Aprahamian, Nitharsshini Nirmalathasan, Maria Chiara Maiuri, Federico Pietrocola, Dominique Valla, Cédric Laouénan, Jean-François Gautier, Laurent Castera, null null, Laurent Castera, Anaïs Vallet-Pichard, Tiphaine V
Publicado en: Cell Death & Differentiation, Edición 32, 2025, Página(s) 434-446, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-024-01410-6

Neutrophil Extracellular Traps Drive Dacryolithiasis

Autores: Leticija Zlatar, Thomas Timm, Günter Lochnit, Rostyslav Bilyy, Tobias Bäuerle, Marco Munoz-Becerra, Georg Schett, Jasmin Knopf, Jens Heichel, Mohammad Javed Ali, Mirco Schapher, Friedrich Paulsen, Martin Herrmann
Publicado en: Cells, Edición 12, 2025, Página(s) 1857, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells12141857

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex

Autores: Simon Lind; Rikard Holmdahl; Peter Olofsson; Claes Dahlgren; Huamei Forsman
Publicado en: Journal of Leukocyte Biology, Edición 4, 2020, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1101/2020.05.20.106310

Behavioural immune landscapes of inflammation

Autores: Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D Castillo, Heidi C E Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E Smithgall, Mauro Di Pila
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-04263-y

Targeting Lysosomal Thiols for Immunogenic Cancer Cell Death

Autores: Anton Arkhypov, Insa Klemt, Galyna Bila, Dina Attia, Svitlana Chernii, Rostyslav Bilyy, Andriy Mokhir
Publicado en: Angewandte Chemie, Edición 137, 2025, ISSN 0044-8249
Editor: Wiley
DOI: 10.1002/ange.202417509

Acyl CoA binding protein (ACBP): an autophagy checkpoint that can be targeted for improving cancer immunosurveillance

Autores: Léa Montégut, Isabelle Martins, Guido Kroemer
Publicado en: OncoImmunology, Edición 13, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2024.2413200

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

Autores: Michael Raucheisen, Dina Attia, Marlies Körber, Alejandra Aroca Crevillén, Andrés Hidalgo, Frank Beierlein, Petra Imhof, Andriy Mokhir
Publicado en: ChemCatChem, Edición 17, 2025, ISSN 1867-3880
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202500054

A consensus statement

Autores: Daniela F. Quail; Borko Amulic; Monowar Aziz; Betsy J. Barnes; Evgeniy Eruslanov; Zvi G. Fridlender; Helen S. Goodridge; Zvi Granot; Andrés Hidalgo; Anna Huttenlocher; Mariana J. Kaplan; Ilaria Malanchi; Taha Merghoub; Etienne Meylan; Vivek Mittal; Mikael J. Pittet; Andrea Rubio-Ponce; Irina A. Udalova; Timo K. van den Berg; Denisa D. Wagner; Ping Wang; Arturo Zychlinsky; Karin E. de Visser; Mika
Publicado en: Journal of Experimental Medicine, Edición 5, 2022, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220011

Suppression of neutrophils by sodium exacerbates oxidative stress and arthritis

Autores: Leticija Zlatar, Aparna Mahajan, Marco Muñoz-Becerra, Daniela Weidner, Galyna Bila, Rostyslav Bilyy, Jens Titze, Markus H. Hoffmann, Georg Schett, Martin Herrmann, Ulrike Steffen, Luis E. Muñoz, Jasmin Knopf
Publicado en: Frontiers in Immunology, Edición 14, 2023, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1174537

Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity

Autores: Stephane Isnard, Tsoarello Mabanga, Léna Royston, Carolina A. Berini, Simeng Bu, Orthy Aiyana, Hansen Feng, Bertrand Lebouché, Cecilia T. Costiniuk, Joseph Cox, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, null null
Publicado en: Frontiers in Immunology, Edición 15, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1505752

Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA

Autores: Han Wang; Antonia Margarethe Stehr; Jeeshan Singh; Leticija Zlatar; Arndt Hartmann; Katja Evert; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Jasmin Knopf; Michael Stürzl; Martin Herrmann
Publicado en: International Journal of Molecular Sciences, Edición 2, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24044101

Neutrophils Orchestrate the Periodontal Pocket

Autores: Ljubomir Vitkov, Luis E Muñoz, Janina Schoen, Jasmin Knopf, Christine Schauer, Bernd Minnich, Martin Herrmann, Matthias Hannig
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2021.788766

Synthesis of a lysosome-targeting aminoferrocene-based prodrug NCure2

Autores: Maximilian Dill, Attia Dina, Mokhir Andriy
Publicado en: Arkivoc, Edición 2025, 2025, ISSN 1551-7012
Editor: ARKAT USA, Inc.
DOI: 10.24820/ark.5550190.p012.322

Neutrophil Activity and Extracellular Matrix Degradation: Drivers of Lung Tissue Destruction in Fatal COVID-19 Cases and Implications for Long COVID

Autores: Teluguakula Narasaraju, Indira Neeli, Sheila L. Criswell, Amita Krishnappa, Wenzhao Meng, Vasuki Silva, Galyna Bila, Volodymyr Vovk, Zolotukhin Serhiy, Gary L. Bowlin, Nuala Meyer, Eline T. Luning Prak, Marko Radic, Rostyslav Bilyy
Publicado en: Biomolecules, Edición 14, 2025, Página(s) 236, ISSN 2218-273X
Editor: MDPI AG
DOI: 10.3390/biom14020236

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Autores: Jeeshan Singh, Xiaomei Shan, Aparna Mahajan, Martin Herrmann, Christine Schauer, Jasmin Knopf, Luis E. Muñoz
Publicado en: JoVE Journal, 2022, ISSN 2689-3649
Editor: JoVE Journal
DOI: 10.3791/63890

Neutrophil Extracellular Traps and DNases Orchestrate Formation of Peritoneal Adhesions

Autores: Julia Elrod, Annika Heuer, Jasmin Knopf, Janina Schoen, Lavinia Schönfeld, Magdalena Trochimiuk, Carolin Stiel, Birgit Appl, Laia Pagerols Raluy, Ceren Saygi, Leticija Zlatar, Sami Hosari, Dmytro Royzman, Thomas H. Winkler, Günter Lochnit, Moritz Leppkes, Robert Grützmann, Georg Schett, Christian Tomuschat, Konrad Reinshagen, Martin Herrmann, Tobias A. Fuchs, Michael Boettcher
Publicado en: IScience, 2023, ISSN 2589-0042
Editor: CellPress
DOI: 10.2139/ssrn.4336831

Metabolic reprogramming promotes apoptosis resistance in acute lymphoblastic leukemia through CASP3 lactylation

Autores: Zhi Lin, Fei Long, Jiao Liu, Rui Kang, Daniel J. Klionsky, Guido Kroemer, Daolin Tang, Minghua Yang
Publicado en: Molecular Cancer, Edición 24, 2025, ISSN 1476-4598
Editor: BioMed Central
DOI: 10.1186/s12943-025-02392-w

RIPK1 inhibition in malignant cells potentiates immunotherapy and radiotherapy outcome

Autores: Jonathan G. Pol, Andrea Checcoli, Manuela Lizarralde-Guerrero, Guido Kroemer
Publicado en: OncoImmunology, Edición 13, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2024.2425465

Breaking the Gingival Barrier in Periodontitis

Autores: Ljubomir Vitkov; Jeeshan Singh; Christine Schauer; Bernd Minnich; Jelena Krunić; Hannah Oberthaler; Sonja Gamsjaeger; Martin Herrmann; Jasmin Knopf; Matthias Hannig
Publicado en: International Journal of Molecular Sciences, Edición 1, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054544

A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells <i>versus</i> neutrophils selectivity of camptothecin

Autores: Insa Klemt, Viktor Reshetnikov, Subrata Dutta, Galyna Bila, Rostyslav Bilyy, Itziar Cossío Cuartero, Andrés Hidalgo, Adrian Wünsche, Maximilian Böhm, Marit Wondrak, Leoni A. Kunz-Schughart, Rainer Tietze, Frank Beierlein, Petra Imhof, Sabrina Gensberger-Reigl, Monika Pischetsrieder, Marlies Körber, Tina Jost, Andriy Mokhir
Publicado en: RSC Medicinal Chemistry, Edición 15, 2024, Página(s) 1189-1197, ISSN 2632-8682
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d3md00609c

Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds

Autores: Rostyslav Bilyy, Quentin Pagneux, Nathan François, Galyna Bila, Roman Grytsko, Yuri Lebedin, Alexandre Barras, Jean Dubuisson, Sandrine Belouzard, Karin Séron, Rabah Boukherroub, Sabine Szunerits
Publicado en: Pathogens, Edición 10, 2025, Página(s) 861, ISSN 2076-0817
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070861

Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma

Autores: Liwei Zhao, Zhe Shen, Guido Kroemer, Oliver Kepp
Publicado en: OncoImmunology, Edición 13, 2024, ISSN 2162-402X
Editor: Informa UK Limited
DOI: 10.1080/2162402x.2024.2360275

Correction: Bilyy et al. Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds. Pathogens 2021, 10, 861

Autores: Rostyslav Bilyy, Quentin Pagneux, Nathan François, Galyna Bila, Roman Grytsko, Yuri Lebedin, Alexandre Barras, Jean Dubuisson, Sandrine Belouzard, Karin Séron, Rabah Boukherroub, Sabine Szunerits
Publicado en: Pathogens, Edición 12, 2023, Página(s) 1411, ISSN 2076-0817
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12121411

Neutrophils' Extracellular Trap Mechanisms: From Physiology to Pathology

Autores: Janina Schoen, Maximilien Euler, Christine Schauer, Georg Schett, Martin Herrmann, Jasmin Knopf, Kursat Oguz Yaykasli
Publicado en: MDPI, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232112855

Calpain-1 weakens the nuclear envelope and promotes the release of neutrophil extracellular traps

Autores: Jeeshan Singh, Leticija Zlatar, Marco Muñoz-Becerra, Günter Lochnit, Irmgard Herrmann, Felix Pfister, Christina Janko, Jasmin Knopf, Moritz Leppkes, Janina Schoen, Luis E. Muñoz, Georg Schett, Martin Herrmann, Christine Schauer, Aparna Mahajan
Publicado en: Cell Communication and Signaling, Edición 22, 2024, ISSN 1478-811X
Editor: BioMed Central
DOI: 10.1186/s12964-024-01785-6

Formation and Clearance of NETs in Health and Disease

Autores: Jasmin Knopf, Aparna Mahajan, Luis E. Muñoz, Martin Herrmann
Publicado en: Cells, Edición 11, 2025, Página(s) 4022, ISSN 2073-4409
Editor: MDPI AG
DOI: 10.3390/cells11244022

Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections

Autores: Israel Cotzomi-Ortega, Emily E. Rosowski, Xin Wang, Yuriko I. Sanchez-Zamora, Jeimy M. Lopez-Torres, Gamaliel Sanchez-Orellana, Rachel Han, Gabriela Vásquez-Martínez, Gabriel Mayoral Andrade, Gregory Ballash, Hanna Cortado, Birong Li, Yusuf Ali, Raul Rascon, Frank Robledo-Avila, Santiago Partida-Sanchez, Eduardo Pérez-Campos, Peter Olofsson-Sahl, Diana Zepeda-Orozco, John David Spencer, Brian B
Publicado en: Mucosal Immunology, Edición 18, 2025, Página(s) 402-417, ISSN 1933-0219
Editor: Nature Publishing Group
DOI: 10.1016/j.mucimm.2024.12.010

NET Formation in Systemic Lupus Erythematosus: Changes during the COVID-19 Pandemic

Autores: Jasmin Knopf, Johanna Sjöwall, Martina Frodlund, Jorma Hinkula, Martin Herrmann, Christopher Sjöwall
Publicado en: MDPI, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11172619

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Autores: Stephan Culemann; Katharina Knab; Maximilien Euler; Anja Wegner; Hilal Garibagaoglu; Jochen Ackermann; Kim Fischer; Deborah Kienhöfer; Georgiana Crainiciuc; Jonas Hahn; Anika Grüneboom; Falk Nimmerjahn; Stefan Uderhardt; Andrés Hidalgo; Georg Schett; Markus H. Hoffmann; Gerhard Krönke
Publicado en: Journal of Experimental Medicine, Edición 4, 2023, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220525

Neutrophils in Physiology and Pathology

Autores: Alejandra Aroca-Crevillén, Tommaso Vicanolo, Samuel Ovadia, Andrés Hidalgo
Publicado en: Annual Review of Pathology: Mechanisms of Disease, Edición 19, 2024, Página(s) 227-259, ISSN 1553-4006
Editor: Annual Reviews, Inc.
DOI: 10.1146/annurev-pathmechdis-051222-015009

Nano- and Microparticles and Their Role in Inflammation and Immune Response: Focus on Neutrophil Extracellular Traps

Autores: Galyna Bila, Andrii Rabets, Rostyslav Bilyy
Publicado en: Biomedical Nanomaterials, 2021, Página(s) 149-170, ISBN 978-3-030-76234-6
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-76235-3_6

Aminoferrocene- or ferrocenylaniline-based ROS amplifiers with anticancer activity

Autores: Honggui Xu
Publicado en: 2022
Editor: FAU

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