Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation.

Información del proyecto

NeutroCure

Identificador del acuerdo de subvención: 861878

DOI

10.3030/861878

Fecha de la firma de la CE 30 Agosto 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Octubre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coste total

€ 2 999 998,75

Aportación de la UE

€ 2 999 998,75

Coordinado por

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (4)

NeutroCure newsletter No.3
Set-up of NeutroCure web page/ design of consortium's Logo

Design of consortium’s Logo; set-up of NeutroCure web page that should include consortium’s Logo

NeutroCure newsletter No.2
NeutroCure newsletter No.1

Documents, reports (2)

A symposium with participation of the supervisory board

A symposium with participation of the supervisory board (Prof. Dr. C. Hackenberger, Leibniz Research Institute for Molecular Pharmacology and Prof. Dr. R. Voll, University Medical Center Freiburg): report with agenda, list of participants, and executive summary of the meeting.

Setup of in vitro assays to assess ROS production, NET formation and killing of cancerous cells mediated by neutrophils

Publicaciones

Peer reviewed articles (34)

The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients.

Autores: Andrii Rabets; Galyna Bila; Roman Grytsko; Markian Samborskyy; Yuriy Rebets; Sandor G. Vari; Quentin Pagneux; Alexandre Barras; Rabah Boukherroub; Sabine Szunerits; Rostyslav Bilyy
Publicado en: Springer Nature, Edición 2, 2021, ISSN 1661-4917
Editor: Springer
DOI: 10.1007/s00005-021-00607-8

3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo

Autores: Insa Klemt, Oleg Varzatskii, Roman Selin, Serhii Vakarov, Vladyslava Kovalska, Galyna Bila, Rostyslav Bilyy, Yan Voloshin, Itziar Cossío Cuartero, Andrés Hidalgo, Benjamin Frey, Ina Becker, Bernhard Friedrich, Rainer Tietze, Ralf P. Friedrich, Christoph Alexiou, Elena-Laura Ursu, Alexandru Rotaru, Iris Solymosi, M. Eugenia Pérez-Ojeda, and Andriy Mokhir
Publicado en: Journal of the American Chemical Society, Edición 2, 2023, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.3c08827

Neutrophils as Main Players of Immune Response towards Nondegradable Nanoparticles

Autores: Rostyslav Bilyy, Galyna Bila, Oleg Vishchur, Volodymyr Vovk, Martin Herrmann
Publicado en: Nanomaterials, Edición 10/7, 2020, Página(s) 1273, ISSN 2079-4991
Editor: MDPI
DOI: 10.3390/nano10071273

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers

Autores: Hong-Gui Xu; Viktor Reshetnikov; Marit Wondrak; Lisa Eckhardt; Leoni A. Kunz-Schughart; Christina Janko; Rainer Tietze; Christoph Alexiou; Hannes Borchardt; Achim Aigner; Wenjie Gong; Michael Schmitt; Leopold Sellner; Steffen Daum; Hülya Gizem Özkan; Andriy Mokhir
Publicado en: Cancers, Edición 1, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010208

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Autores: Hülya Gizem Özkan; Vanrajsinh Thakor; Hong‐Gui Xu; Galyna Bila; Rostyslav Bilyy; Daria Bida; Martin Böttcher; Dimitrios Mougiakakos; Rainer Tietze; Andriy Mokhir
Publicado en: Chemistry, Eur. J., Edición 3, 2022, ISSN 1521-3765
Editor: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/chem.202104420

An endoplasmic reticulum – specific pro‐amplifier of reactive oxygen species in cancer cells

Autores: Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Publicado en: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100054

Transcriptional Insights of Oxidative Stress and Extracellular Traps in Lung Tissues of Fatal COVID-19 Cases

Autores: Hans-Uwe Simon; Timothée Fettrelet; Aref Hosseini; Darko Stojkov; Shida Yousefi; Rostyslav Bilyy
Publicado en: International journal of molecular sciences, Edición 2, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032646

Periodontitis-Derived Dark-NETs in Severe Covid-19

Autores: Ljubomir Vitkov, Jasmin Knopf, Jelena Krunić, Christine Schauer, Janina Schoen, Bernd Minnich, Matthias Hannig, Martin Herrmann
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.872695

A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Autores: Jeeshan Singh; Irmgard Herrmann; Aparna Mahajan; Christine Schauer; Xiaomei Shan; Arndt Hartmann; Ralf J. Rieker; Katja Evert; Christina Falkeis; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Georg Schett; Martin Herrmann; Jasmin Knopf
Publicado en: International Journal of Molecular Sciences; Volume 23; Edición 23; Pages: 15126, Edición 2, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232315126

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex

Autores: Simon Lind, Claes Dahlgren, Rikard Holmdahl, Peter Olofsson, Huamei Forsman
Publicado en: Journal of Leukocyte Biology, 2020, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1002/jlb.2hi0520-317r

Neutrophil extracellular traps: from physiology to pathology.

Autores: Andrés Hidalgo; Peter Libby; Oliver Soehnlein; Oliver Soehnlein; Iker Valle Aramburu; Venizelos Papayannopoulos; Carlos Silvestre-Roig
Publicado en: Cardiovasc Res, Edición 1, 2022, ISSN 1755-3245
Editor: Cardiovascular Research
DOI: 10.1093/cvr/cvab329

A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism

Autores: Khushboo Borah, Olivia J. Rickman, Nikol Voutsina, Isaac Ampong, Dan Gao, Emma L. Baple, Irundika HK. Dias, Andrew H. Crosby, Helen R. Griffiths
Publicado en: Redox Biology, Edición 36, 2020, Página(s) 101595, ISSN 2213-2317
Editor: Elsevier BV
DOI: 10.1016/j.redox.2020.101595

Neutrophil swarm control: what goes up must come down

Autores: Uderhardt, Stefan; Knopf, Jasmin; Herrmann, Martin
Publicado en: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021), Edición 1, 2021, ISSN 2059-3635
Editor: Springer Nature
DOI: 10.1038/s41392-021-00836-5

Patients with COVID-19: in the dark-NETs of neutrophils

Autores: Maximilian Ackermann, Hans-Joachim Anders, Rostyslav Bilyy, Gary L. Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andrés Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J. Kaplan, Jason S. Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A. Manfredi, Christian Maueröder, Norma Maugeri, Ioannis Mitr
Publicado en: Nature, 2021, ISSN 1350-9047
Editor: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds.

Autores: Rostyslav Bilyy; Quentin Pagneux; Nathan François; Galyna Bila; Roman Grytsko; Yuri Lebedin; Alexandre Barras; Jean Dubuisson; Sandrine Belouzard; Karin Séron; Rabah Boukherroub; Sabine Szunerits
Publicado en: https://hal.archives-ouvertes.fr/hal-03348197, Edición 1, 2021, ISSN 2076-0817
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070861

Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction

Autores: Maximilian Dölling, Markus Eckstein, Jeeshan Singh, Christine Schauer, Janina Schoen, Xiaomei Shan, Aline Bozec, Jasmin Knopf, Georg Schett, Luis E Muñoz, Martin Herrmann
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.726153

Datasets of whole cell and mitochondrial oxysterols derived from THP-1, SH-SY5Y and human peripheral blood mononuclear cells using targeted metabolomics

Autores: Khushboo Borah; Olivia J. Rickman; Nikol Voutsina; Emma L. Baple; Irundika H.K. Dias; Andrew H. Crosby; Helen R. Griffiths
Publicado en: Data in Brief, Edición 2, 2020, ISSN 2352-3409
Editor: Elsevier BV
DOI: 10.1016/j.dib.2020.106382

FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner

Autores: Fei He; Apple H.M. Tay; Ahmed Calandigary; Enana Malki; Sayaka Suzuki; Tianjie Liu; Qi Wang; Carlos Fernández-Moro; Marina Kaisso; Peter Olofsson-Sahl; Marit Melssen; Siu Kwan Sze; Mikael Björnstedt; Matthias J. Löhr; Mikael C.I. Karlsson; Rainer Heuchel; Dhifaf Sarhan
Publicado en: Cancer Research, Edición 1, 2023, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-2932

Neutrophils as drivers of vascular injury in sickle cell disease

Autores: Lidiane S Torres, Andrés Hidalgo
Publicado en: Immunological Reviews, 2022, ISSN 0105-2896
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imr.13146

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex

Autores: Simon Lind; Rikard Holmdahl; Peter Olofsson; Claes Dahlgren; Huamei Forsman
Publicado en: Journal of Leukocyte Biology, Edición 4, 2020, ISSN 0741-5400
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1101/2020.05.20.106310

Behavioural immune landscapes of inflammation

Autores: Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D Castillo, Heidi C E Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E Smithgall, Mauro Di Pila
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-04263-y

Targeting Lysosomal Thiols for Immunogenic Cancer Cell Death

Autores: Anton Arkhypov, Insa Klemt, Galyna Bila, Dina Attia, Svitlana Chernii, Rostyslav Bilyy, Andriy Mokhir
Publicado en: Angewandte Chemie, Edición 137, 2025, ISSN 0044-8249
Editor: Wiley
DOI: 10.1002/ange.202417509

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

Autores: Michael Raucheisen, Dina Attia, Marlies Körber, Alejandra Aroca Crevillén, Andrés Hidalgo, Frank Beierlein, Petra Imhof, Andriy Mokhir
Publicado en: ChemCatChem, Edición 17, 2025, ISSN 1867-3880
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202500054

A consensus statement

Autores: Daniela F. Quail; Borko Amulic; Monowar Aziz; Betsy J. Barnes; Evgeniy Eruslanov; Zvi G. Fridlender; Helen S. Goodridge; Zvi Granot; Andrés Hidalgo; Anna Huttenlocher; Mariana J. Kaplan; Ilaria Malanchi; Taha Merghoub; Etienne Meylan; Vivek Mittal; Mikael J. Pittet; Andrea Rubio-Ponce; Irina A. Udalova; Timo K. van den Berg; Denisa D. Wagner; Ping Wang; Arturo Zychlinsky; Karin E. de Visser; Mika
Publicado en: Journal of Experimental Medicine, Edición 5, 2022, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220011

Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA

Autores: Han Wang; Antonia Margarethe Stehr; Jeeshan Singh; Leticija Zlatar; Arndt Hartmann; Katja Evert; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Jasmin Knopf; Michael Stürzl; Martin Herrmann
Publicado en: International Journal of Molecular Sciences, Edición 2, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24044101

Neutrophils Orchestrate the Periodontal Pocket

Autores: Ljubomir Vitkov, Luis E Muñoz, Janina Schoen, Jasmin Knopf, Christine Schauer, Bernd Minnich, Martin Herrmann, Matthias Hannig
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2021.788766

Synthesis of a lysosome-targeting aminoferrocene-based prodrug NCure2

Autores: Maximilian Dill, Attia Dina, Mokhir Andriy
Publicado en: Arkivoc, Edición 2025, 2025, ISSN 1551-7012
Editor: ARKAT USA, Inc.
DOI: 10.24820/ark.5550190.p012.322

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Autores: Jeeshan Singh, Xiaomei Shan, Aparna Mahajan, Martin Herrmann, Christine Schauer, Jasmin Knopf, Luis E. Muñoz
Publicado en: JoVE Journal, 2022, ISSN 2689-3649
Editor: JoVE Journal
DOI: 10.3791/63890

Breaking the Gingival Barrier in Periodontitis

Autores: Ljubomir Vitkov; Jeeshan Singh; Christine Schauer; Bernd Minnich; Jelena Krunić; Hannah Oberthaler; Sonja Gamsjaeger; Martin Herrmann; Jasmin Knopf; Matthias Hannig
Publicado en: International Journal of Molecular Sciences, Edición 1, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054544

A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells <i>versus</i> neutrophils selectivity of camptothecin

Autores: Insa Klemt, Viktor Reshetnikov, Subrata Dutta, Galyna Bila, Rostyslav Bilyy, Itziar Cossío Cuartero, Andrés Hidalgo, Adrian Wünsche, Maximilian Böhm, Marit Wondrak, Leoni A. Kunz-Schughart, Rainer Tietze, Frank Beierlein, Petra Imhof, Sabrina Gensberger-Reigl, Monika Pischetsrieder, Marlies Körber, Tina Jost, Andriy Mokhir
Publicado en: RSC Medicinal Chemistry, Edición 15, 2024, Página(s) 1189-1197, ISSN 2632-8682
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d3md00609c

Neutrophils' Extracellular Trap Mechanisms: From Physiology to Pathology

Autores: Janina Schoen, Maximilien Euler, Christine Schauer, Georg Schett, Martin Herrmann, Jasmin Knopf, Kursat Oguz Yaykasli
Publicado en: MDPI, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232112855

Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections

Autores: Israel Cotzomi-Ortega, Emily E. Rosowski, Xin Wang, Yuriko I. Sanchez-Zamora, Jeimy M. Lopez-Torres, Gamaliel Sanchez-Orellana, Rachel Han, Gabriela Vásquez-Martínez, Gabriel Mayoral Andrade, Gregory Ballash, Hanna Cortado, Birong Li, Yusuf Ali, Raul Rascon, Frank Robledo-Avila, Santiago Partida-Sanchez, Eduardo Pérez-Campos, Peter Olofsson-Sahl, Diana Zepeda-Orozco, John David Spencer, Brian B
Publicado en: Mucosal Immunology, Edición 18, 2025, Página(s) 402-417, ISSN 1933-0219
Editor: Nature Publishing Group
DOI: 10.1016/j.mucimm.2024.12.010

NET Formation in Systemic Lupus Erythematosus: Changes during the COVID-19 Pandemic

Autores: Jasmin Knopf, Johanna Sjöwall, Martina Frodlund, Jorma Hinkula, Martin Herrmann, Christopher Sjöwall
Publicado en: MDPI, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11172619

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Autores: Stephan Culemann; Katharina Knab; Maximilien Euler; Anja Wegner; Hilal Garibagaoglu; Jochen Ackermann; Kim Fischer; Deborah Kienhöfer; Georgiana Crainiciuc; Jonas Hahn; Anika Grüneboom; Falk Nimmerjahn; Stefan Uderhardt; Andrés Hidalgo; Georg Schett; Markus H. Hoffmann; Gerhard Krönke
Publicado en: Journal of Experimental Medicine, Edición 4, 2023, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20220525

Monographic books (1)

Nano- and Microparticles and Their Role in Inflammation and Immune Response: Focus on Neutrophil Extracellular Traps

Autores: Galyna Bila, Andrii Rabets, Rostyslav Bilyy
Publicado en: 2021, ISBN 978-3-030-76234-6
Editor: Springer Nature

Thesis and dissertations (1)

Aminoferrocene- or ferrocenylaniline-based ROS amplifiers with anticancer activity

Autores: Honggui Xu
Publicado en: 2022
Editor: FAU