Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation.

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NeutroCure newsletter No.3
Set-up of NeutroCure web page/ design of consortium’s Logo

Design of consortium’s Logo; set-up of NeutroCure web page that should include consortium’s Logo

NeutroCure newsletter No2

A symposium with participation of the supervisory board

A symposium with participation of the supervisory board (Prof. Dr. C. Hackenberger, Leibniz Research Institute for Molecular Pharmacology and Prof. Dr. R. Voll, University Medical Center Freiburg): report with agenda, list of participants, and executive summary of the meeting.

Setup of in vitro assays to assess ROS production, NET formation and killing of cancerous cells mediated by neutrophils

Publications

The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients.

Auteurs: Andrii Rabets; Galyna Bila; Roman Grytsko; Markian Samborskyy; Yuriy Rebets; Sandor G. Vari; Quentin Pagneux; Alexandre Barras; Rabah Boukherroub; Sabine Szunerits; Rostyslav Bilyy
Publié dans: Springer Nature, Numéro 2, 2021, ISSN 1661-4917
Éditeur: Springer
DOI: 10.1007/s00005-021-00607-8

3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo

Auteurs: Insa Klemt, Oleg Varzatskii, Roman Selin, Serhii Vakarov, Vladyslava Kovalska, Galyna Bila, Rostyslav Bilyy, Yan Voloshin, Itziar Cossío Cuartero, Andrés Hidalgo, Benjamin Frey, Ina Becker, Bernhard Friedrich, Rainer Tietze, Ralf P. Friedrich, Christoph Alexiou, Elena-Laura Ursu, Alexandru Rotaru, Iris Solymosi, M. Eugenia Pérez-Ojeda, and Andriy Mokhir
Publié dans: Journal of the American Chemical Society, Numéro 2, 2023, ISSN 0002-7863
Éditeur: American Chemical Society
DOI: 10.1021/jacs.3c08827

Neutrophils as Main Players of Immune Response towards Nondegradable Nanoparticles

Auteurs: Rostyslav Bilyy, Galyna Bila, Oleg Vishchur, Volodymyr Vovk, Martin Herrmann
Publié dans: Nanomaterials, Numéro 10/7, 2020, Page(s) 1273, ISSN 2079-4991
Éditeur: MDPI
DOI: 10.3390/nano10071273

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers

Auteurs: Hong-Gui Xu; Viktor Reshetnikov; Marit Wondrak; Lisa Eckhardt; Leoni A. Kunz-Schughart; Christina Janko; Rainer Tietze; Christoph Alexiou; Hannes Borchardt; Achim Aigner; Wenjie Gong; Michael Schmitt; Leopold Sellner; Steffen Daum; Hülya Gizem Özkan; Andriy Mokhir
Publié dans: Cancers, Numéro 1, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010208

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Auteurs: Hülya Gizem Özkan; Vanrajsinh Thakor; Hong‐Gui Xu; Galyna Bila; Rostyslav Bilyy; Daria Bida; Martin Böttcher; Dimitrios Mougiakakos; Rainer Tietze; Andriy Mokhir
Publié dans: Chemistry, Eur. J., Numéro 3, 2022, ISSN 1521-3765
Éditeur: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/chem.202104420

An endoplasmic reticulum – specific pro‐amplifier of reactive oxygen species in cancer cells

Auteurs: Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Publié dans: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100054

Transcriptional Insights of Oxidative Stress and Extracellular Traps in Lung Tissues of Fatal COVID-19 Cases

Auteurs: Hans-Uwe Simon; Timothée Fettrelet; Aref Hosseini; Darko Stojkov; Shida Yousefi; Rostyslav Bilyy
Publié dans: International journal of molecular sciences, Numéro 2, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032646

Periodontitis-Derived Dark-NETs in Severe Covid-19

Auteurs: Ljubomir Vitkov, Jasmin Knopf, Jelena Krunić, Christine Schauer, Janina Schoen, Bernd Minnich, Matthias Hannig, Martin Herrmann
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2022.872695

A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Auteurs: Jeeshan Singh; Irmgard Herrmann; Aparna Mahajan; Christine Schauer; Xiaomei Shan; Arndt Hartmann; Ralf J. Rieker; Katja Evert; Christina Falkeis; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Georg Schett; Martin Herrmann; Jasmin Knopf
Publié dans: International Journal of Molecular Sciences; Volume 23; Numéro 23; Pages: 15126, Numéro 2, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232315126

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex

Auteurs: Simon Lind, Claes Dahlgren, Rikard Holmdahl, Peter Olofsson, Huamei Forsman
Publié dans: Journal of Leukocyte Biology, 2020, ISSN 0741-5400
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1002/jlb.2hi0520-317r

Neutrophil extracellular traps: from physiology to pathology.

Auteurs: Andrés Hidalgo; Peter Libby; Oliver Soehnlein; Oliver Soehnlein; Iker Valle Aramburu; Venizelos Papayannopoulos; Carlos Silvestre-Roig
Publié dans: Cardiovasc Res, Numéro 1, 2022, ISSN 1755-3245
Éditeur: Cardiovascular Research
DOI: 10.1093/cvr/cvab329

A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism

Auteurs: Khushboo Borah, Olivia J. Rickman, Nikol Voutsina, Isaac Ampong, Dan Gao, Emma L. Baple, Irundika HK. Dias, Andrew H. Crosby, Helen R. Griffiths
Publié dans: Redox Biology, Numéro 36, 2020, Page(s) 101595, ISSN 2213-2317
Éditeur: Elsevier BV
DOI: 10.1016/j.redox.2020.101595

Neutrophil swarm control: what goes up must come down

Auteurs: Uderhardt, Stefan; Knopf, Jasmin; Herrmann, Martin
Publié dans: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021), Numéro 1, 2021, ISSN 2059-3635
Éditeur: Springer Nature
DOI: 10.1038/s41392-021-00836-5

Patients with COVID-19: in the dark-NETs of neutrophils

Auteurs: Maximilian Ackermann, Hans-Joachim Anders, Rostyslav Bilyy, Gary L. Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andrés Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J. Kaplan, Jason S. Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A. Manfredi, Christian Maueröder, Norma Maugeri, Ioannis Mitr
Publié dans: Nature, 2021, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds.

Auteurs: Rostyslav Bilyy; Quentin Pagneux; Nathan François; Galyna Bila; Roman Grytsko; Yuri Lebedin; Alexandre Barras; Jean Dubuisson; Sandrine Belouzard; Karin Séron; Rabah Boukherroub; Sabine Szunerits
Publié dans: https://hal.archives-ouvertes.fr/hal-03348197, Numéro 1, 2021, ISSN 2076-0817
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070861

Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction

Auteurs: Maximilian Dölling, Markus Eckstein, Jeeshan Singh, Christine Schauer, Janina Schoen, Xiaomei Shan, Aline Bozec, Jasmin Knopf, Georg Schett, Luis E Muñoz, Martin Herrmann
Publié dans: Frontiers in Immunology, 2022, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.726153

Datasets of whole cell and mitochondrial oxysterols derived from THP-1, SH-SY5Y and human peripheral blood mononuclear cells using targeted metabolomics

Auteurs: Khushboo Borah; Olivia J. Rickman; Nikol Voutsina; Emma L. Baple; Irundika H.K. Dias; Andrew H. Crosby; Helen R. Griffiths
Publié dans: Data in Brief, Numéro 2, 2020, ISSN 2352-3409
Éditeur: Elsevier BV
DOI: 10.1016/j.dib.2020.106382

FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner

Auteurs: Fei He; Apple H.M. Tay; Ahmed Calandigary; Enana Malki; Sayaka Suzuki; Tianjie Liu; Qi Wang; Carlos Fernández-Moro; Marina Kaisso; Peter Olofsson-Sahl; Marit Melssen; Siu Kwan Sze; Mikael Björnstedt; Matthias J. Löhr; Mikael C.I. Karlsson; Rainer Heuchel; Dhifaf Sarhan
Publié dans: Cancer Research, Numéro 1, 2023, ISSN 0008-5472
Éditeur: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-2932

Neutrophils as drivers of vascular injury in sickle cell disease

Auteurs: Lidiane S Torres, Andrés Hidalgo
Publié dans: Immunological Reviews, 2022, ISSN 0105-2896
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/imr.13146

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex

Auteurs: Simon Lind; Rikard Holmdahl; Peter Olofsson; Claes Dahlgren; Huamei Forsman
Publié dans: Journal of Leukocyte Biology, Numéro 4, 2020, ISSN 0741-5400
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1101/2020.05.20.106310

Behavioural immune landscapes of inflammation

Auteurs: Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D Castillo, Heidi C E Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E Smithgall, Mauro Di Pila
Publié dans: Nature, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-021-04263-y

A consensus statement

Auteurs: Daniela F. Quail; Borko Amulic; Monowar Aziz; Betsy J. Barnes; Evgeniy Eruslanov; Zvi G. Fridlender; Helen S. Goodridge; Zvi Granot; Andrés Hidalgo; Anna Huttenlocher; Mariana J. Kaplan; Ilaria Malanchi; Taha Merghoub; Etienne Meylan; Vivek Mittal; Mikael J. Pittet; Andrea Rubio-Ponce; Irina A. Udalova; Timo K. van den Berg; Denisa D. Wagner; Ping Wang; Arturo Zychlinsky; Karin E. de Visser; Mika
Publié dans: Journal of Experimental Medicine, Numéro 5, 2022, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220011

Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA

Auteurs: Han Wang; Antonia Margarethe Stehr; Jeeshan Singh; Leticija Zlatar; Arndt Hartmann; Katja Evert; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Jasmin Knopf; Michael Stürzl; Martin Herrmann
Publié dans: International Journal of Molecular Sciences, Numéro 2, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24044101

Neutrophils Orchestrate the Periodontal Pocket

Auteurs: Ljubomir Vitkov, Luis E Muñoz, Janina Schoen, Jasmin Knopf, Christine Schauer, Bernd Minnich, Martin Herrmann, Matthias Hannig
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2021.788766

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Auteurs: Jeeshan Singh, Xiaomei Shan, Aparna Mahajan, Martin Herrmann, Christine Schauer, Jasmin Knopf, Luis E. Muñoz
Publié dans: JoVE Journal, 2022, ISSN 2689-3649
Éditeur: JoVE Journal
DOI: 10.3791/63890

Breaking the Gingival Barrier in Periodontitis

Auteurs: Ljubomir Vitkov; Jeeshan Singh; Christine Schauer; Bernd Minnich; Jelena Krunić; Hannah Oberthaler; Sonja Gamsjaeger; Martin Herrmann; Jasmin Knopf; Matthias Hannig
Publié dans: International Journal of Molecular Sciences, Numéro 1, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054544

Neutrophils' Extracellular Trap Mechanisms: From Physiology to Pathology

Auteurs: Janina Schoen, Maximilien Euler, Christine Schauer, Georg Schett, Martin Herrmann, Jasmin Knopf, Kursat Oguz Yaykasli
Publié dans: MDPI, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232112855

NET Formation in Systemic Lupus Erythematosus: Changes during the COVID-19 Pandemic

Auteurs: Jasmin Knopf, Johanna Sjöwall, Martina Frodlund, Jorma Hinkula, Martin Herrmann, Christopher Sjöwall
Publié dans: MDPI, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11172619

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Auteurs: Stephan Culemann; Katharina Knab; Maximilien Euler; Anja Wegner; Hilal Garibagaoglu; Jochen Ackermann; Kim Fischer; Deborah Kienhöfer; Georgiana Crainiciuc; Jonas Hahn; Anika Grüneboom; Falk Nimmerjahn; Stefan Uderhardt; Andrés Hidalgo; Georg Schett; Markus H. Hoffmann; Gerhard Krönke
Publié dans: Journal of Experimental Medicine, Numéro 4, 2023, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20220525

Nano- and Microparticles and Their Role in Inflammation and Immune Response: Focus on Neutrophil Extracellular Traps

Auteurs: Galyna Bila, Andrii Rabets, Rostyslav Bilyy
Publié dans: 2021, ISBN 978-3-030-76234-6
Éditeur: Springer Nature

Aminoferrocene- or ferrocenylaniline-based ROS amplifiers with anticancer activity

Auteurs: Honggui Xu
Publié dans: 2022
Éditeur: FAU

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