Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation.

Informazioni relative al progetto

NeutroCure

ID dell’accordo di sovvenzione: 861878

DOI

10.3030/861878

Data della firma CE 30 Agosto 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Ottobre 2025

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale

€ 2 999 998,75

Contributo UE

€ 2 999 998,75

Coordinato da

FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (4)

NeutroCure newsletter No.3
Set-up of NeutroCure web page/ design of consortium's Logo

Design of consortium’s Logo; set-up of NeutroCure web page that should include consortium’s Logo

NeutroCure newsletter No.2
NeutroCure newsletter No.1

Documents, reports (2)

A symposium with participation of the supervisory board

A symposium with participation of the supervisory board (Prof. Dr. C. Hackenberger, Leibniz Research Institute for Molecular Pharmacology and Prof. Dr. R. Voll, University Medical Center Freiburg): report with agenda, list of participants, and executive summary of the meeting.

Setup of in vitro assays to assess ROS production, NET formation and killing of cancerous cells mediated by neutrophils

Pubblicazioni

Peer reviewed articles (34)

The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients.

Autori: Andrii Rabets; Galyna Bila; Roman Grytsko; Markian Samborskyy; Yuriy Rebets; Sandor G. Vari; Quentin Pagneux; Alexandre Barras; Rabah Boukherroub; Sabine Szunerits; Rostyslav Bilyy
Pubblicato in: Springer Nature, Numero 2, 2021, ISSN 1661-4917
Editore: Springer
DOI: 10.1007/s00005-021-00607-8

3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo

Autori: Insa Klemt, Oleg Varzatskii, Roman Selin, Serhii Vakarov, Vladyslava Kovalska, Galyna Bila, Rostyslav Bilyy, Yan Voloshin, Itziar Cossío Cuartero, Andrés Hidalgo, Benjamin Frey, Ina Becker, Bernhard Friedrich, Rainer Tietze, Ralf P. Friedrich, Christoph Alexiou, Elena-Laura Ursu, Alexandru Rotaru, Iris Solymosi, M. Eugenia Pérez-Ojeda, and Andriy Mokhir
Pubblicato in: Journal of the American Chemical Society, Numero 2, 2023, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.3c08827

Neutrophils as Main Players of Immune Response towards Nondegradable Nanoparticles

Autori: Rostyslav Bilyy, Galyna Bila, Oleg Vishchur, Volodymyr Vovk, Martin Herrmann
Pubblicato in: Nanomaterials, Numero 10/7, 2020, Pagina/e 1273, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano10071273

Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers

Autori: Hong-Gui Xu; Viktor Reshetnikov; Marit Wondrak; Lisa Eckhardt; Leoni A. Kunz-Schughart; Christina Janko; Rainer Tietze; Christoph Alexiou; Hannes Borchardt; Achim Aigner; Wenjie Gong; Michael Schmitt; Leopold Sellner; Steffen Daum; Hülya Gizem Özkan; Andriy Mokhir
Pubblicato in: Cancers, Numero 1, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14010208

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Autori: Hülya Gizem Özkan; Vanrajsinh Thakor; Hong‐Gui Xu; Galyna Bila; Rostyslav Bilyy; Daria Bida; Martin Böttcher; Dimitrios Mougiakakos; Rainer Tietze; Andriy Mokhir
Pubblicato in: Chemistry, Eur. J., Numero 3, 2022, ISSN 1521-3765
Editore: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/chem.202104420

An endoplasmic reticulum – specific pro‐amplifier of reactive oxygen species in cancer cells

Autori: Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Pubblicato in: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100054

Transcriptional Insights of Oxidative Stress and Extracellular Traps in Lung Tissues of Fatal COVID-19 Cases

Autori: Hans-Uwe Simon; Timothée Fettrelet; Aref Hosseini; Darko Stojkov; Shida Yousefi; Rostyslav Bilyy
Pubblicato in: International journal of molecular sciences, Numero 2, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24032646

Periodontitis-Derived Dark-NETs in Severe Covid-19

Autori: Ljubomir Vitkov, Jasmin Knopf, Jelena Krunić, Christine Schauer, Janina Schoen, Bernd Minnich, Matthias Hannig, Martin Herrmann
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.872695

A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Autori: Jeeshan Singh; Irmgard Herrmann; Aparna Mahajan; Christine Schauer; Xiaomei Shan; Arndt Hartmann; Ralf J. Rieker; Katja Evert; Christina Falkeis; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Georg Schett; Martin Herrmann; Jasmin Knopf
Pubblicato in: International Journal of Molecular Sciences; Volume 23; Numero 23; Pages: 15126, Numero 2, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232315126

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex

Autori: Simon Lind, Claes Dahlgren, Rikard Holmdahl, Peter Olofsson, Huamei Forsman
Pubblicato in: Journal of Leukocyte Biology, 2020, ISSN 0741-5400
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1002/jlb.2hi0520-317r

Neutrophil extracellular traps: from physiology to pathology.

Autori: Andrés Hidalgo; Peter Libby; Oliver Soehnlein; Oliver Soehnlein; Iker Valle Aramburu; Venizelos Papayannopoulos; Carlos Silvestre-Roig
Pubblicato in: Cardiovasc Res, Numero 1, 2022, ISSN 1755-3245
Editore: Cardiovascular Research
DOI: 10.1093/cvr/cvab329

A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism

Autori: Khushboo Borah, Olivia J. Rickman, Nikol Voutsina, Isaac Ampong, Dan Gao, Emma L. Baple, Irundika HK. Dias, Andrew H. Crosby, Helen R. Griffiths
Pubblicato in: Redox Biology, Numero 36, 2020, Pagina/e 101595, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2020.101595

Neutrophil swarm control: what goes up must come down

Autori: Uderhardt, Stefan; Knopf, Jasmin; Herrmann, Martin
Pubblicato in: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021), Numero 1, 2021, ISSN 2059-3635
Editore: Springer Nature
DOI: 10.1038/s41392-021-00836-5

Patients with COVID-19: in the dark-NETs of neutrophils

Autori: Maximilian Ackermann, Hans-Joachim Anders, Rostyslav Bilyy, Gary L. Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andrés Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J. Kaplan, Jason S. Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A. Manfredi, Christian Maueröder, Norma Maugeri, Ioannis Mitr
Pubblicato in: Nature, 2021, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-021-00805-z

Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds.

Autori: Rostyslav Bilyy; Quentin Pagneux; Nathan François; Galyna Bila; Roman Grytsko; Yuri Lebedin; Alexandre Barras; Jean Dubuisson; Sandrine Belouzard; Karin Séron; Rabah Boukherroub; Sabine Szunerits
Pubblicato in: https://hal.archives-ouvertes.fr/hal-03348197, Numero 1, 2021, ISSN 2076-0817
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens10070861

Hypoxia Promotes Neutrophil Survival After Acute Myocardial Infarction

Autori: Maximilian Dölling, Markus Eckstein, Jeeshan Singh, Christine Schauer, Janina Schoen, Xiaomei Shan, Aline Bozec, Jasmin Knopf, Georg Schett, Luis E Muñoz, Martin Herrmann
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2022.726153

Datasets of whole cell and mitochondrial oxysterols derived from THP-1, SH-SY5Y and human peripheral blood mononuclear cells using targeted metabolomics

Autori: Khushboo Borah; Olivia J. Rickman; Nikol Voutsina; Emma L. Baple; Irundika H.K. Dias; Andrew H. Crosby; Helen R. Griffiths
Pubblicato in: Data in Brief, Numero 2, 2020, ISSN 2352-3409
Editore: Elsevier BV
DOI: 10.1016/j.dib.2020.106382

FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner

Autori: Fei He; Apple H.M. Tay; Ahmed Calandigary; Enana Malki; Sayaka Suzuki; Tianjie Liu; Qi Wang; Carlos Fernández-Moro; Marina Kaisso; Peter Olofsson-Sahl; Marit Melssen; Siu Kwan Sze; Mikael Björnstedt; Matthias J. Löhr; Mikael C.I. Karlsson; Rainer Heuchel; Dhifaf Sarhan
Pubblicato in: Cancer Research, Numero 1, 2023, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-2932

Neutrophils as drivers of vascular injury in sickle cell disease

Autori: Lidiane S Torres, Andrés Hidalgo
Pubblicato in: Immunological Reviews, 2022, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.13146

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex

Autori: Simon Lind; Rikard Holmdahl; Peter Olofsson; Claes Dahlgren; Huamei Forsman
Pubblicato in: Journal of Leukocyte Biology, Numero 4, 2020, ISSN 0741-5400
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1101/2020.05.20.106310

Behavioural immune landscapes of inflammation

Autori: Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D Castillo, Heidi C E Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E Smithgall, Mauro Di Pila
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-04263-y

Targeting Lysosomal Thiols for Immunogenic Cancer Cell Death

Autori: Anton Arkhypov, Insa Klemt, Galyna Bila, Dina Attia, Svitlana Chernii, Rostyslav Bilyy, Andriy Mokhir
Pubblicato in: Angewandte Chemie, Numero 137, 2025, ISSN 0044-8249
Editore: Wiley
DOI: 10.1002/ange.202417509

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

Autori: Michael Raucheisen, Dina Attia, Marlies Körber, Alejandra Aroca Crevillén, Andrés Hidalgo, Frank Beierlein, Petra Imhof, Andriy Mokhir
Pubblicato in: ChemCatChem, Numero 17, 2025, ISSN 1867-3880
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202500054

A consensus statement

Autori: Daniela F. Quail; Borko Amulic; Monowar Aziz; Betsy J. Barnes; Evgeniy Eruslanov; Zvi G. Fridlender; Helen S. Goodridge; Zvi Granot; Andrés Hidalgo; Anna Huttenlocher; Mariana J. Kaplan; Ilaria Malanchi; Taha Merghoub; Etienne Meylan; Vivek Mittal; Mikael J. Pittet; Andrea Rubio-Ponce; Irina A. Udalova; Timo K. van den Berg; Denisa D. Wagner; Ping Wang; Arturo Zychlinsky; Karin E. de Visser; Mika
Pubblicato in: Journal of Experimental Medicine, Numero 5, 2022, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20220011

Anti-DNA-IgM Favors the Detection of NET-Associated Extracellular DNA

Autori: Han Wang; Antonia Margarethe Stehr; Jeeshan Singh; Leticija Zlatar; Arndt Hartmann; Katja Evert; Elisabeth Naschberger; Saskia von Stillfried; Peter Boor; Luis E. Muñoz; Jasmin Knopf; Michael Stürzl; Martin Herrmann
Pubblicato in: International Journal of Molecular Sciences, Numero 2, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24044101

Neutrophils Orchestrate the Periodontal Pocket

Autori: Ljubomir Vitkov, Luis E Muñoz, Janina Schoen, Jasmin Knopf, Christine Schauer, Bernd Minnich, Martin Herrmann, Matthias Hannig
Pubblicato in: Frontiers in Immunology, 2021, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.788766

Synthesis of a lysosome-targeting aminoferrocene-based prodrug NCure2

Autori: Maximilian Dill, Attia Dina, Mokhir Andriy
Pubblicato in: Arkivoc, Numero 2025, 2025, ISSN 1551-7012
Editore: ARKAT USA, Inc.
DOI: 10.24820/ark.5550190.p012.322

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Autori: Jeeshan Singh, Xiaomei Shan, Aparna Mahajan, Martin Herrmann, Christine Schauer, Jasmin Knopf, Luis E. Muñoz
Pubblicato in: JoVE Journal, 2022, ISSN 2689-3649
Editore: JoVE Journal
DOI: 10.3791/63890

Breaking the Gingival Barrier in Periodontitis

Autori: Ljubomir Vitkov; Jeeshan Singh; Christine Schauer; Bernd Minnich; Jelena Krunić; Hannah Oberthaler; Sonja Gamsjaeger; Martin Herrmann; Jasmin Knopf; Matthias Hannig
Pubblicato in: International Journal of Molecular Sciences, Numero 1, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24054544

A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells <i>versus</i> neutrophils selectivity of camptothecin

Autori: Insa Klemt, Viktor Reshetnikov, Subrata Dutta, Galyna Bila, Rostyslav Bilyy, Itziar Cossío Cuartero, Andrés Hidalgo, Adrian Wünsche, Maximilian Böhm, Marit Wondrak, Leoni A. Kunz-Schughart, Rainer Tietze, Frank Beierlein, Petra Imhof, Sabrina Gensberger-Reigl, Monika Pischetsrieder, Marlies Körber, Tina Jost, Andriy Mokhir
Pubblicato in: RSC Medicinal Chemistry, Numero 15, 2024, Pagina/e 1189-1197, ISSN 2632-8682
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d3md00609c

Neutrophils' Extracellular Trap Mechanisms: From Physiology to Pathology

Autori: Janina Schoen, Maximilien Euler, Christine Schauer, Georg Schett, Martin Herrmann, Jasmin Knopf, Kursat Oguz Yaykasli
Pubblicato in: MDPI, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232112855

Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections

Autori: Israel Cotzomi-Ortega, Emily E. Rosowski, Xin Wang, Yuriko I. Sanchez-Zamora, Jeimy M. Lopez-Torres, Gamaliel Sanchez-Orellana, Rachel Han, Gabriela Vásquez-Martínez, Gabriel Mayoral Andrade, Gregory Ballash, Hanna Cortado, Birong Li, Yusuf Ali, Raul Rascon, Frank Robledo-Avila, Santiago Partida-Sanchez, Eduardo Pérez-Campos, Peter Olofsson-Sahl, Diana Zepeda-Orozco, John David Spencer, Brian B
Pubblicato in: Mucosal Immunology, Numero 18, 2025, Pagina/e 402-417, ISSN 1933-0219
Editore: Nature Publishing Group
DOI: 10.1016/j.mucimm.2024.12.010

NET Formation in Systemic Lupus Erythematosus: Changes during the COVID-19 Pandemic

Autori: Jasmin Knopf, Johanna Sjöwall, Martina Frodlund, Jorma Hinkula, Martin Herrmann, Christopher Sjöwall
Pubblicato in: MDPI, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11172619

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Autori: Stephan Culemann; Katharina Knab; Maximilien Euler; Anja Wegner; Hilal Garibagaoglu; Jochen Ackermann; Kim Fischer; Deborah Kienhöfer; Georgiana Crainiciuc; Jonas Hahn; Anika Grüneboom; Falk Nimmerjahn; Stefan Uderhardt; Andrés Hidalgo; Georg Schett; Markus H. Hoffmann; Gerhard Krönke
Pubblicato in: Journal of Experimental Medicine, Numero 4, 2023, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20220525

Monographic books (1)

Nano- and Microparticles and Their Role in Inflammation and Immune Response: Focus on Neutrophil Extracellular Traps

Autori: Galyna Bila, Andrii Rabets, Rostyslav Bilyy
Pubblicato in: 2021, ISBN 978-3-030-76234-6
Editore: Springer Nature

Thesis and dissertations (1)

Aminoferrocene- or ferrocenylaniline-based ROS amplifiers with anticancer activity

Autori: Honggui Xu
Pubblicato in: 2022
Editore: FAU