Projektbeschreibung
Hochselektive Antibiotika gegen hochresistente menschliche Krankheitserreger?
Antibiotika (wörtlich übersetzt: „gegen das Lebendige“) töten Bakterien. Da in unserem Körper viele „gute“ Bakterien leben, müssen Antibiotika selektiv arbeiten. In den Ribosomen findet die Proteinsynthese statt und dort setzen auch die neuen Therapeutika an, die NEXTER entwickelt. Dabei müssen bestimmte Abschnitte der Ribosomen angegriffen werden, die für einzelne Bakterienarten jeweils spezifisch sind. Mithilfe dieser Strategie konnten die Forschenden das Wachstum eines multiresistenten Stamms des Staphylococcus aureus (S. Aureus) aufhalten. Dieser wichtige Krankheitserreger verursacht sowohl in Krankenhäusern als auch in privater Umgebung Infektionen im menschlichen Körper. Diese synthetischen Therapeutika sind zudem abbaubar, das heißt, die Kontamination der Umwelt sinkt und damit auch die Entwicklung weiterer resistenter Bakterienstämme. Aktuell arbeitet das Team an der Bekämpfung weiterer Krankheitserreger und will die revolutionäre Technologie demnächst auf den Markt bringen.
Ziel
The rapid emergence and spread of Multi-drug Antimicrobial Resistance (AMR), alongside the negligible efforts of the major pharmaceuticals companies in the development of new antibiotics, result in a major global concern of modern medicine. Moreover, the currently clinically used antibiotics contaminate the environment and may harm the human microbiome, causing unpredictable health concerns. We discovered that by targeting species-specific ribosome unique structural motifs, identified by us, using our designed degradable novel synthetic lead compounds, it is possible to inhibit protein biosynthesis in bacteria. Our approach should enable distinction between pathogenic and non-pathogenic bacteria and between bacterial and human ribosome. This drug selectivity should decrease resistance, preserve the beneficial microbiome and allow usage of lower antibiotics dozes. Furthermore, the designed degradable lead compounds should prevent additional environmental contamination. Hence, our approach allows designing innovative powerful selective antibiotics that escape the existing resistance mechanisms. Several of the primary designed compounds shown to stop the growth of the multi-resistant S. aureus human pathogen were delivered into the bacterial cells by attaching specific chemical moieties to them. In this PoC we plan to design similar compounds for other human pathogens, such as Enterococcus and Pseudomonas species, where revolutionary effective antibiotic drugs against their resistant strains is desperately needed. In addition to the technological PoC in this project, we will attempt pre-commercialization studies aiming at perfecting the commercialization strategy, protecting the IP and strengthen the network for best possible commercialization outcome. The general objective is to establish at least one strategic partnership with a pharma company which has the capacity to further test, develop and commercialize antibiotics that exploit ribosomal novel unique targets.
Wissenschaftliches Gebiet
- natural sciencesbiological sciencesmicrobiologybacteriology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Finanzierungsplan
ERC-POC - Proof of Concept GrantGastgebende Einrichtung
7610001 Rehovot
Israel