Project description DEENESFRITPL New method to achieve zero waste in chemical synthesis The process of chemical synthesis is vital for a wide range of substances essential for daily life. The several process steps needed for effective synthesis during pharmaceutical drug production generates extensive amounts of unsustainable waste. The EU-funded CLASSY project envisages a method that will eliminate many process steps aiming towards generating no waste and becoming the ‘chemical factory of the future’. The project intends to develop an advanced chemical reactor inspired by how living systems regulate catalytic activity. It will radically change the manufacturing of chemical and pharmaceutical products and eliminate waste generation. The project is developed by a specialised consortium keen to produce new scientific knowledge on eco-friendly options for renewability, energy efficiency and sustainability. Show the project objective Hide the project objective Objective Chemical synthesis requires several process steps, produces vast amounts of waste today, for example 25–100 kg of waste per kg of product for pharmaceutical drugs, and is thus inefficient and not sustainable. Our vision is to become a real game-changer for chemical synthesis and eliminate many process steps, resulting in close to zero waste streams and a sustainable ‘chemical factory of the future’. To make this vision come true, the overarching aim of CLASSY is to develop a radically new type of chemical reactor inspired by the way in which living systems manage to modulate catalytic activity. The idea is that these reactors can self-regulate and perform multiple programmable reaction sequences by compartmentalisation of individual steps of the reaction sequence and replication of the molecular effectors that control the reactor’s catalytic activity. The use of microfluidic technology to compartmentalise individual steps of the reaction sequence and replicating molecular effectors to control the reactor activity constitute unique and highly innovative tools toward the project goals.CLASSY will result in new flow reactors that act as cell-like molecular assembly lines, being able to synthesise a multitude of complex products in a single chemical reactor. These will have the capability to revolutionise the way chemical products, for example, fine chemicals and pharmaceutical drugs, are manufactured today. CLASSY brings together 5 leading scientists in systems chemistry, replicating peptides, complex reaction networks, and peptide/enzyme catalysis. Their expertise will be combined with new microfluidic technology developed by a high-tech SME and an SME specialised in dissemination and exploitation of results. This highly interdisciplinary consortium will generate new scientific knowledge and novel technologies to support essential pillars for Europe`s future, such as renewability, sustainability, zero waste emissions and energetic efficiency. Fields of science natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencescatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords Systems chemistry supramolecular chemistry biological chemistry cell-like systems replication networks compartmentalisation peptide self-assembly and replication Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking Call for proposal H2020-FETOPEN-2018-2020 See other projects for this call Sub call H2020-FETOPEN-2018-2019-2020-01 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSIDAD AUTONOMA DE MADRID Net EU contribution € 492 083,75 Address Calle einstein 3 ciudad univ cantoblanco rectorado 28049 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all BEN-GURION UNIVERSITY OF THE NEGEV Israel Net EU contribution € 385 396,25 Address . 84105 Beer sheva See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland Net EU contribution € 585 388,75 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STICHTING RADBOUD UNIVERSITEIT Netherlands Net EU contribution € 490 000,00 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAET GRAZ Austria Net EU contribution € 519 600,00 Address Universitatsplatz 3 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ACCELOPMENT SCHWEIZ AG Switzerland Net EU contribution € 229 431,25 Address Seefeldstrasse 198 8008 Zurich See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MICRONIT HOLDING BV Participation ended Netherlands Net EU contribution € 62 848,09 Address Colosseum 15 7521 PV Enschede See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MICRONIT BV Netherlands Net EU contribution € 313 325,66 Address Colosseum 15 7521 PV Enschede See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
