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Cell-Like ‘Molecular Assembly Lines’ of Programmable Reaction Sequences as Game-Changers in Chemical Synthesis


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Accelerated Reaction Engineering of Photo(bio)catalytic Reactions through Parallelization with an Open-Source Photoreactor

Author(s): Christoph Winkler, Stefan Simić, Valentina Jurkaš, Sarah Bierbaumer, Luca Schmermund, Silvan Poschenrieder, Sarah A. Berger, Elisa Kulterer, Robert Kourist, and Wolfgang Kroutil
Published in: ChemPhotoChem, 2021, ISSN 2367-0932
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cptc.202100109

Overcoming Deactivation of Amine-Based Catalysts: Access to Fluoroalkylated γ-Nitroaldehydes

Author(s): Martin Schnurr; Jonas W. Rackl; Helma Wennemers
Published in: Journal of the American Chemical Society, 145 (42), Issue 4, 2023, ISSN 1460-4744
Publisher: Royal Society of Chemistry 2023
DOI: 10.1021/jacs.3c08198

Dynamic exchange controls the assembly structure of nucleic-acid-peptide chimeras

Author(s): Hava Sadihov-Hanoch; Anil Kumar Bandela; Agata Chotera-Ouda; Oshrat Ben David; Rivka Cohen-Luria; David G. Lynn; Gonen Ashkenasy
Published in: Soft Matter, Issue 1, 2023, ISSN 1744-6848
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sm01528e

Catalytic length-controlled oligomerization with synthetic programmable templates

Author(s): Bartosz M. Lewandowski; Dario Schmid; Rüdiger Borrmann; Dominik Zetschok; Martin Schnurr; Helma Wennemers
Published in: Nature Synthesis, 2 (4), Issue 1, 2023, ISSN 2731-0582
Publisher: Nature Synthesis
DOI: 10.1038/s44160-022-00228-9

Tripeptide Organocatalysts for Stereoselective Conjugate Addition Reactions with N‐Heterocyclic Substituents

Author(s): Jasper S. Möhler; Lena K. Beiersdörfer; Brenno Masina; Philipp Wechsler; Helma Wennemers
Published in: Advanced Synthesis & Catalysis, 364 (19), Issue 5, 2022, ISSN 1615-4169
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202200576

Organocatalytic Synthesis of Triflones Bearing Two Non‐Adjacent Stereogenic Centers

Author(s): Alena Budinská; Helma Wennemers
Published in: Angewandte Chemie. International Edition, 62 (17), Issue 4, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202300537

Collectively autocatalytic sets

Author(s): G. Ashkenasy, S. Kauffman, D. Lancet, S. Otto, K. Ruiz-Mirazo, S. Semenov, J. Xavier
Published in: Cell Reports Physical Science, Issue 4, 101594, 2023, ISSN 2666-3864
Publisher: Cell Reports Physical Science
DOI: 10.1016/j.xcrp.2023.101594

Collective adaptability in a replication network of minimal nucleobase sequences

Author(s): Sonia Vela-Gallego; Zulay Pardo-Botero; Cristian Moya; Andrés de la Escosura
Published in: Chemical Science - Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia, Issue 1, 2022, ISSN 2041-6539
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02419e

Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Author(s): Stefan Simić, Erna Zukić, Luca Schmermund, Kurt Faber, Christoph K. Winkler, and Wolfgang Kroutil
Published in: Chemical Reviews, 2021, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00574

Amine Catalysis with Substrates Bearing N ‐Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction

Author(s): Jasper S. Möhler, Tobias Schnitzer, Helma Wennemers
Published in: Chemistry – A European Journal, Issue 26/67, 2020, Page(s) 15623-15628, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202002966

Synergistic Peptide and Gold Catalysis: Enantioselective Addition of Branched Aldehydes to Allenamides

Author(s): Helma Wennemers, Leo Nicholls
Published in: Chemistry - A European Journal, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103197

Strategies for Transferring Photobiocatalysis to Continuous Flow Exemplified by Photodecarboxylation of Fatty Acids

Author(s): """Stefan Simić, Miglė Jakštaitė, Wilhelm T. S. Huck, Christoph K. Winkler and Wolfgang Kroutil"""
Published in: ACS Catalysis, 2022, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.2c04444

Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks

Author(s): Anil Kumar Bandela; Nathaniel Wagner; Hava Sadihov; Sara Morales-Reina; Agata Chotera-Ouda; Kingshuk Basu; Rivka Cohen-Luria; Andrés de la Escosura; Gonen Ashkenasy
Published in: Proc Natl Acad Sci U S A, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2015285118

The protometabolic nature of prebiotic chemistry

Author(s): Noemí Nogal; Marcos Sanz-Sánchez; Sonia Vela-Gallego; Kepa Ruiz-Mirazo; Andrés de la Escosura
Published in: Chemical Society Reviews, Issue 1, 2023, ISSN 1460-4744
Publisher: Royal Society of Chemistry 2023
DOI: 10.1039/d3cs00594a

Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-Of-Equilibrium Enzymatic Reactions

Author(s): Michael Teders, Aleksandr A. Pogodaev, Glenn Bojanov, Wilhelm T. S. Huck
Published in: Journal of the American Chemical Society, 2021, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c12956

Reversible Photoswitchable Inhibitors Enable Wavelength-Selective Regulation of Out-of-Equilibrium Bi-Enzymatic Systems

Author(s): Michael Teders, Nicholas M. Murray, Wilhelm T. S. Huck
Published in: ChemSystemsChem, 2021, ISSN 2570-4206
Publisher: Wiley-VCH GmbH
DOI: 10.1002/syst.202100020

The Systems Chemistry of Nucleic-acid-Peptide Networks

Author(s): A.K. Bandela, H. Sadihov‐Hanoch, R. Cohen‐Luria, C. Gordon, A. Blake, G. Poppitz, D.G. Lynn, G. Ashkenasy
Published in: Israel Journal of Chemistry, Issue 2022, 62, 2022, ISSN 1869-5868
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ijch.202200030

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