Cell-Like ‘Molecular Assembly Lines’ of Programmable Reaction Sequences as Game-Changers in Chemical Synthesis

Deliverables

Planned activities to reach the general public, including an infographic, science slams and open days; first activities by M13 and 25 accomplished.

Dissemination and Exploitation Plan

The Dissemination and Exploitation Plan (DEP) is due at the end of the first reporting period and is updated every reporting period.

CLASSY Scientific Symposium

Final project event presenting the research results and newly developed technologies to the scientific community and industries.

Project website and logo

Set up and maintain a project website that serves as an information resource for the general public, the scientific community and other stakeholders and includes a secured area for consortium internal exchange of documents.

Publications

Accelerated Reaction Engineering of Photo(bio)catalytic Reactions through Parallelization with an Open-Source Photoreactor

Author(s): Christoph Winkler, Stefan Simić, Valentina Jurkaš, Sarah Bierbaumer, Luca Schmermund, Silvan Poschenrieder, Sarah A. Berger, Elisa Kulterer, Robert Kourist, and Wolfgang Kroutil
Published in: ChemPhotoChem, 2021, ISSN 2367-0932
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cptc.202100109

Catalytic templated length-controlled oligomerization

Author(s): Bartosz Lewandowski; Rebecca J. B. Schäfer; Etienne Cotter; Dora Harangozo; Helma Wennemers
Published in: Faraday Discussions, 2023, ISSN 1359-6640
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3fd00002h

Overcoming Deactivation of Amine-Based Catalysts: Access to Fluoroalkylated γ-Nitroaldehydes

Author(s): Martin Schnurr; Jonas W. Rackl; Helma Wennemers
Published in: Journal of the American Chemical Society, 145 (42), Issue 4, 2023, ISSN 1460-4744
Publisher: Royal Society of Chemistry 2023
DOI: 10.1021/jacs.3c08198

Dynamic exchange controls the assembly structure of nucleic-acid-peptide chimeras

Author(s): Hava Sadihov-Hanoch; Anil Kumar Bandela; Agata Chotera-Ouda; Oshrat Ben David; Rivka Cohen-Luria; David G. Lynn; Gonen Ashkenasy
Published in: Soft Matter, Issue 1, 2023, ISSN 1744-6848
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sm01528e

Catalytic length-controlled oligomerization with synthetic programmable templates

Author(s): Bartosz M. Lewandowski; Dario Schmid; Rüdiger Borrmann; Dominik Zetschok; Martin Schnurr; Helma Wennemers
Published in: Nature Synthesis, 2 (4), Issue 1, 2023, ISSN 2731-0582
Publisher: Nature Synthesis
DOI: 10.1038/s44160-022-00228-9

Stereoselective peptide catalysis in complexenvironments – from river water to cell lysates

Author(s): Tobias Schnitzer, Jonas W. Rackl, Helma Wennemers
Published in: Chemical Science, 2022, ISSN 2041-6539
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02044k

Tripeptide Organocatalysts for Stereoselective Conjugate Addition Reactions with N‐Heterocyclic Substituents

Author(s): Jasper S. Möhler; Lena K. Beiersdörfer; Brenno Masina; Philipp Wechsler; Helma Wennemers
Published in: Advanced Synthesis & Catalysis, 364 (19), Issue 5, 2022, ISSN 1615-4169
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202200576

Organocatalytic Synthesis of Triflones Bearing Two Non‐Adjacent Stereogenic Centers

Author(s): Alena Budinská; Helma Wennemers
Published in: Angewandte Chemie. International Edition, 62 (17), Issue 4, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202300537

Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems

Author(s): S. Ghosh, M. G. Baltussen, N. M. Ivanov, R. Haije, M Jakštaité, T. Zhou, W. T.S. Huck
Published in: Chemical Reviews, 2023, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00681

Collectively autocatalytic sets

Author(s): G. Ashkenasy, S. Kauffman, D. Lancet, S. Otto, K. Ruiz-Mirazo, S. Semenov, J. Xavier
Published in: Cell Reports Physical Science, Issue 4, 101594, 2023, ISSN 2666-3864
Publisher: Cell Reports Physical Science
DOI: 10.1016/j.xcrp.2023.101594

Collective adaptability in a replication network of minimal nucleobase sequences

Author(s): Sonia Vela-Gallego; Zulay Pardo-Botero; Cristian Moya; Andrés de la Escosura
Published in: Chemical Science - Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia, Issue 1, 2022, ISSN 2041-6539
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02419e

Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Author(s): Stefan Simić, Erna Zukić, Luca Schmermund, Kurt Faber, Christoph K. Winkler, and Wolfgang Kroutil
Published in: Chemical Reviews, 2021, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00574

Modifying the catalytic activity of lipopeptide assemblies with nucleobases

Author(s): Sonia Vela-Gallego, Bartosz Lewandowski, Jasper Möhler, Alonso Puente, David Gil-Cantero, Helma Wennemers, Andrés de la Escosura
Published in: Chemistry Europe, 2023, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202303395

Amine Catalysis with Substrates Bearing N ‐Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction

Author(s): Jasper S. Möhler, Tobias Schnitzer, Helma Wennemers
Published in: Chemistry – A European Journal, Issue 26/67, 2020, Page(s) 15623-15628, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202002966

Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition

Author(s): Jasper S. Möhler; Mathias Pickl; Tamara Reiter; Stefan Simić; Jonas W. Rackl; Wolfgang Kroutil; Helma Wennemers
Published in: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ange.202319457

Synergistic Peptide and Gold Catalysis: Enantioselective Addition of Branched Aldehydes to Allenamides

Author(s): Helma Wennemers, Leo Nicholls
Published in: Chemistry - A European Journal, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103197

Selectivity in the chiral self-assembly of nucleobase-arylazopyrazole photoswitches along DNA templates

Author(s): N. Nogal, S. Guisán, D. Dellemme, M. Surin, A. de la Escosura
Published in: Journal of Materials Chemistry B, 2024, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4tb00041b

Strategies for Transferring Photobiocatalysis to Continuous Flow Exemplified by Photodecarboxylation of Fatty Acids

Author(s): """Stefan Simić, Miglė Jakštaitė, Wilhelm T. S. Huck, Christoph K. Winkler and Wolfgang Kroutil"""
Published in: ACS Catalysis, 2022, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.2c04444

Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks

Author(s): Anil Kumar Bandela; Nathaniel Wagner; Hava Sadihov; Sara Morales-Reina; Agata Chotera-Ouda; Kingshuk Basu; Rivka Cohen-Luria; Andrés de la Escosura; Gonen Ashkenasy
Published in: Proc Natl Acad Sci U S A, 2021, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2015285118

The protometabolic nature of prebiotic chemistry

Author(s): Noemí Nogal; Marcos Sanz-Sánchez; Sonia Vela-Gallego; Kepa Ruiz-Mirazo; Andrés de la Escosura
Published in: Chemical Society Reviews, Issue 1, 2023, ISSN 1460-4744
Publisher: Royal Society of Chemistry 2023
DOI: 10.1039/d3cs00594a

Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-Of-Equilibrium Enzymatic Reactions

Author(s): Michael Teders, Aleksandr A. Pogodaev, Glenn Bojanov, Wilhelm T. S. Huck
Published in: Journal of the American Chemical Society, 2021, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c12956

Reversible Photoswitchable Inhibitors Enable Wavelength-Selective Regulation of Out-of-Equilibrium Bi-Enzymatic Systems

Author(s): Michael Teders, Nicholas M. Murray, Wilhelm T. S. Huck
Published in: ChemSystemsChem, 2021, ISSN 2570-4206
Publisher: Wiley-VCH GmbH
DOI: 10.1002/syst.202100020

The Systems Chemistry of Nucleic-acid-Peptide Networks

Author(s): A.K. Bandela, H. Sadihov‐Hanoch, R. Cohen‐Luria, C. Gordon, A. Blake, G. Poppitz, D.G. Lynn, G. Ashkenasy
Published in: Israel Journal of Chemistry, Issue 2022, 62, 2022, ISSN 1869-5868
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ijch.202200030

a bayesian approach to extracting kinetic information from artificial enzymatic networks

Author(s): Mathieu G. Baltussen, Jeroen van de Wiel, Cristina Lía Fernández Regueiro, Miglė Jakštaitė , and Wilhelm T. S. Huck
Published in: Analytical Cheimstry, 2022, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.2c00659

Deliverables

Publications

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