Cell-Like ‘Molecular Assembly Lines’ of Programmable Reaction Sequences as Game-Changers in Chemical Synthesis

Resultado final

Planned activities to reach the general public, including an infographic, science slams and open days; first activities by M13 and 25 accomplished.

Dissemination and Exploitation Plan

The Dissemination and Exploitation Plan (DEP) is due at the end of the first reporting period and is updated every reporting period.

CLASSY Scientific Symposium

Final project event presenting the research results and newly developed technologies to the scientific community and industries.

Project website and logo

Set up and maintain a project website that serves as an information resource for the general public, the scientific community and other stakeholders and includes a secured area for consortium internal exchange of documents.

Publicaciones

Accelerated Reaction Engineering of Photo(bio)catalytic Reactions through Parallelization with an Open-Source Photoreactor

Autores: Christoph K. Winkler, Stefan Simić, Valentina Jurkaš, Sarah Bierbaumer, Luca Schmermund, Silvan Poschenrieder, Sarah A. Berger, Elisa Kulterer, Robert Kourist, and Wolfgang Kroutil
Publicado en: ChemPhotoChem, 2021, ISSN 2367-0932
Editor: Wiley-VCH GmbH
DOI: 10.1002/cptc.202100109

Catalytic templated length-controlled oligomerization

Autores: Bartosz Lewandowski; Rebecca J. B. Schäfer; Etienne Cotter; Dora Harangozo; Helma Wennemers
Publicado en: Faraday Discussions, 2023, ISSN 1359-6640
Editor: Royal Society of Chemistry
DOI: 10.1039/d3fd00002h

Overcoming Deactivation of Amine-Based Catalysts: Access to Fluoroalkylated γ-Nitroaldehydes

Autores: Martin Schnurr; Jonas W. Rackl; Helma Wennemers
Publicado en: Journal of the American Chemical Society, 2023, ISSN 1460-4744
Editor: Royal Society of Chemistry
DOI: 10.1021/jacs.3c08198

Dynamic exchange controls the assembly structure of nucleic-acid-peptide chimeras

Autores: Hava Sadihov-Hanoch; Anil Kumar Bandela; Agata Chotera-Ouda; Oshrat Ben David; Rivka Cohen-Luria; David G. Lynn; Gonen Ashkenasy
Publicado en: Soft Matter, Edición 1, 2023, ISSN 1744-6848
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sm01528e

Catalytic length-controlled oligomerization with synthetic programmable templates

Autores: Bartosz M. Lewandowski; Dario Schmid; Rüdiger Borrmann; Dominik Zetschok; Martin Schnurr; Helma Wennemers
Publicado en: Nature Synthesis, 2023, ISSN 2731-0582
Editor: Nature
DOI: 10.1038/s44160-022-00228-9

Stereoselective peptide catalysis in complex environments – from river water to cell lysates

Autores: Tobias Schnitzer, Jonas W. Rackl, Helma Wennemers
Publicado en: Chemical Science, 2022, ISSN 2041-6539
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02044k

Tripeptide Organocatalysts for Stereoselective Conjugate Addition Reactions with N‐Heterocyclic Substituents

Autores: Jasper S. Möhler; Lena K. Beiersdörfer; Brenno Masina; Philipp Wechsler; Helma Wennemers
Publicado en: Advanced Synthesis & Catalysis, 2022, ISSN 1615-4169
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202200576

Organocatalytic Synthesis of Triflones Bearing Two Non‐Adjacent Stereogenic Centers

Autores: Alena Budinská; Helma Wennemers
Publicado en: Angewandte Chemie - International Edition, 2023, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202300537

Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems

Autores: S. Ghosh, M. G. Baltussen, N. M. Ivanov, R. Haije, M Jakštaité, T. Zhou, W. T.S. Huck
Publicado en: Chemical Reviews, 2023, ISSN 0009-2665
Editor: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00681

Collectively autocatalytic sets

Autores: G. Ashkenasy, S. Kauffman, D. Lancet, S. Otto, K. Ruiz-Mirazo, S. Semenov, J. Xavier
Publicado en: Cell Reports Physical Science, Edición 4, 101594, 2023, ISSN 2666-3864
Editor: Cell Reports Physical Science
DOI: 10.1016/j.xcrp.2023.101594

Collective adaptability in a replication network of minimal nucleobase sequences

Autores: Sonia Vela-Gallego; Zulay Pardo-Botero; Cristian Moya; Andrés de la Escosura
Publicado en: Chemical Science, 2022, ISSN 2041-6539
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02419e

Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Autores: Stefan Simić, Erna Zukić, Luca Schmermund, Kurt Faber, Christoph K. Winkler, and Wolfgang Kroutil
Publicado en: Chemical Reviews, 2021, ISSN 0009-2665
Editor: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00574

Modifying the Catalytic Activity of Lipopeptide Assemblies with Nucleobases

Autores: Sonia Vela-Gallego, Bartosz Lewandowski, Jasper Möhler, Alonso Puente, David Gil-Cantero, Helma Wennemers, Andrés de la Escosura
Publicado en: Chemistry - A European Journal, 2023, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202303395

Amine Catalysis with Substrates Bearing N ‐Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction

Autores: Jasper S. Möhler, Tobias Schnitzer, Helma Wennemers
Publicado en: Chemistry – A European Journal, Edición 26/67, 2020, Página(s) 15623-15628, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202002966

Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition

Autores: Jasper S. Möhler; Mathias Pickl; Tamara Reiter; Stefan Simić; Jonas W. Rackl; Wolfgang Kroutil; Helma Wennemers
Publicado en: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Editor: Wiley-VCH GmbH
DOI: 10.1002/ange.202319457

Synergistic Peptide and Gold Catalysis: Enantioselective Addition of Branched Aldehydes to Allenamides

Autores: Leo D. M. Nicholls, Helma Wennemers
Publicado en: Chemistry - A European Journal, 2021, ISSN 0947-6539
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103197

Selectivity in the chiral self-assembly of nucleobase-arylazopyrazole photoswitches along DNA templates

Autores: N. Nogal, S. Guisán, D. Dellemme, M. Surin, A. de la Escosura
Publicado en: Journal of Materials Chemistry B, 2024, ISSN 2050-7518
Editor: Royal Society of Chemistry
DOI: 10.1039/d4tb00041b

Strategies for Transferring Photobiocatalysis to Continuous Flow Exemplified by Photodecarboxylation of Fatty Acids

Autores: Stefan Simić, Miglė Jakštaitė, Wilhelm T. S. Huck, Christoph K. Winkler and Wolfgang Kroutil
Publicado en: ACS Catalysis, 2022, ISSN 2155-5435
Editor: American Chemical Society
DOI: 10.1021/acscatal.2c04444

Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks

Autores: Anil Kumar Bandela; Nathaniel Wagner; Hava Sadihov; Sara Morales-Reina; Agata Chotera-Ouda; Kingshuk Basu; Rivka Cohen-Luria; Andrés de la Escosura; Gonen Ashkenasy
Publicado en: Proceedings of the National Academy of Sciences USA, 2021, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2015285118

The protometabolic nature of prebiotic chemistry

Autores: Noemí Nogal; Marcos Sanz-Sánchez; Sonia Vela-Gallego; Kepa Ruiz-Mirazo; Andrés de la Escosura
Publicado en: Chemical Society Reviews, Edición 1, 2023, ISSN 1460-4744
Editor: Royal Society of Chemistry 2023
DOI: 10.1039/d3cs00594a

Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-Of-Equilibrium Enzymatic Reactions

Autores: Michael Teders, Aleksandr A. Pogodaev, Glenn Bojanov, Wilhelm T. S. Huck
Publicado en: Journal of the American Chemical Society, 2021, ISSN 1520-5126
Editor: American Chemical Society
DOI: 10.1021/jacs.0c12956

Reversible Photoswitchable Inhibitors Enable Wavelength-Selective Regulation of Out-of-Equilibrium Bi-Enzymatic Systems

Autores: Michael Teders, Nicholas R. Murray, Wilhelm T. S. Huck
Publicado en: ChemSystemsChem, 2021, ISSN 2570-4206
Editor: Wiley-VCH GmbH
DOI: 10.1002/syst.202100020

The Systems Chemistry of Nucleic-acid-Peptide Networks

Autores: A.K. Bandela, H. Sadihov‐Hanoch, R. Cohen‐Luria, C. Gordon, A. Blake, G. Poppitz, D.G. Lynn, G. Ashkenasy
Publicado en: Israel Journal of Chemistry, Edición 2022, 62, 2022, ISSN 1869-5868
Editor: Wiley-VCH GmbH
DOI: 10.1002/ijch.202200030

A Bayesian Approach to Extracting Kinetic Information from Artificial Enzymatic Networks

Autores: Mathieu G. Baltussen, Jeroen van de Wiel, Cristina Lía Fernández Regueiro, Miglė Jakštaitė , and Wilhelm T. S. Huck
Publicado en: Analytical Cheimstry, 2022, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.2c00659

Resultado final

Publicaciones

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