Cell-Like ‘Molecular Assembly Lines’ of Programmable Reaction Sequences as Game-Changers in Chemical Synthesis

Risultati finali

Planned activities to reach the general public, including an infographic, science slams and open days; first activities by M13 and 25 accomplished.

Dissemination and Exploitation Plan

The Dissemination and Exploitation Plan (DEP) is due at the end of the first reporting period and is updated every reporting period.

CLASSY Scientific Symposium

Final project event presenting the research results and newly developed technologies to the scientific community and industries.

Project website and logo

Set up and maintain a project website that serves as an information resource for the general public, the scientific community and other stakeholders and includes a secured area for consortium internal exchange of documents.

Pubblicazioni

Accelerated Reaction Engineering of Photo(bio)catalytic Reactions through Parallelization with an Open-Source Photoreactor

Autori: Christoph K. Winkler, Stefan Simić, Valentina Jurkaš, Sarah Bierbaumer, Luca Schmermund, Silvan Poschenrieder, Sarah A. Berger, Elisa Kulterer, Robert Kourist, and Wolfgang Kroutil
Pubblicato in: ChemPhotoChem, 2021, ISSN 2367-0932
Editore: Wiley-VCH GmbH
DOI: 10.1002/cptc.202100109

Catalytic templated length-controlled oligomerization

Autori: Bartosz Lewandowski; Rebecca J. B. Schäfer; Etienne Cotter; Dora Harangozo; Helma Wennemers
Pubblicato in: Faraday Discussions, 2023, ISSN 1359-6640
Editore: Royal Society of Chemistry
DOI: 10.1039/d3fd00002h

Overcoming Deactivation of Amine-Based Catalysts: Access to Fluoroalkylated γ-Nitroaldehydes

Autori: Martin Schnurr; Jonas W. Rackl; Helma Wennemers
Pubblicato in: Journal of the American Chemical Society, 2023, ISSN 1460-4744
Editore: Royal Society of Chemistry
DOI: 10.1021/jacs.3c08198

Dynamic exchange controls the assembly structure of nucleic-acid-peptide chimeras

Autori: Hava Sadihov-Hanoch; Anil Kumar Bandela; Agata Chotera-Ouda; Oshrat Ben David; Rivka Cohen-Luria; David G. Lynn; Gonen Ashkenasy
Pubblicato in: Soft Matter, Numero 1, 2023, ISSN 1744-6848
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sm01528e

Catalytic length-controlled oligomerization with synthetic programmable templates

Autori: Bartosz M. Lewandowski; Dario Schmid; Rüdiger Borrmann; Dominik Zetschok; Martin Schnurr; Helma Wennemers
Pubblicato in: Nature Synthesis, 2023, ISSN 2731-0582
Editore: Nature
DOI: 10.1038/s44160-022-00228-9

Stereoselective peptide catalysis in complex environments – from river water to cell lysates

Autori: Tobias Schnitzer, Jonas W. Rackl, Helma Wennemers
Pubblicato in: Chemical Science, 2022, ISSN 2041-6539
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02044k

Tripeptide Organocatalysts for Stereoselective Conjugate Addition Reactions with N‐Heterocyclic Substituents

Autori: Jasper S. Möhler; Lena K. Beiersdörfer; Brenno Masina; Philipp Wechsler; Helma Wennemers
Pubblicato in: Advanced Synthesis & Catalysis, 2022, ISSN 1615-4169
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202200576

Organocatalytic Synthesis of Triflones Bearing Two Non‐Adjacent Stereogenic Centers

Autori: Alena Budinská; Helma Wennemers
Pubblicato in: Angewandte Chemie - International Edition, 2023, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202300537

Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems

Autori: S. Ghosh, M. G. Baltussen, N. M. Ivanov, R. Haije, M Jakštaité, T. Zhou, W. T.S. Huck
Pubblicato in: Chemical Reviews, 2023, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00681

Collectively autocatalytic sets

Autori: G. Ashkenasy, S. Kauffman, D. Lancet, S. Otto, K. Ruiz-Mirazo, S. Semenov, J. Xavier
Pubblicato in: Cell Reports Physical Science, Numero 4, 101594, 2023, ISSN 2666-3864
Editore: Cell Reports Physical Science
DOI: 10.1016/j.xcrp.2023.101594

Collective adaptability in a replication network of minimal nucleobase sequences

Autori: Sonia Vela-Gallego; Zulay Pardo-Botero; Cristian Moya; Andrés de la Escosura
Pubblicato in: Chemical Science, 2022, ISSN 2041-6539
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02419e

Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Autori: Stefan Simić, Erna Zukić, Luca Schmermund, Kurt Faber, Christoph K. Winkler, and Wolfgang Kroutil
Pubblicato in: Chemical Reviews, 2021, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00574

Modifying the Catalytic Activity of Lipopeptide Assemblies with Nucleobases

Autori: Sonia Vela-Gallego, Bartosz Lewandowski, Jasper Möhler, Alonso Puente, David Gil-Cantero, Helma Wennemers, Andrés de la Escosura
Pubblicato in: Chemistry - A European Journal, 2023, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202303395

Amine Catalysis with Substrates Bearing N ‐Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction

Autori: Jasper S. Möhler, Tobias Schnitzer, Helma Wennemers
Pubblicato in: Chemistry – A European Journal, Numero 26/67, 2020, Pagina/e 15623-15628, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202002966

Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition

Autori: Jasper S. Möhler; Mathias Pickl; Tamara Reiter; Stefan Simić; Jonas W. Rackl; Wolfgang Kroutil; Helma Wennemers
Pubblicato in: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Editore: Wiley-VCH GmbH
DOI: 10.1002/ange.202319457

Synergistic Peptide and Gold Catalysis: Enantioselective Addition of Branched Aldehydes to Allenamides

Autori: Leo D. M. Nicholls, Helma Wennemers
Pubblicato in: Chemistry - A European Journal, 2021, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103197

Selectivity in the chiral self-assembly of nucleobase-arylazopyrazole photoswitches along DNA templates

Autori: N. Nogal, S. Guisán, D. Dellemme, M. Surin, A. de la Escosura
Pubblicato in: Journal of Materials Chemistry B, 2024, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/d4tb00041b

Strategies for Transferring Photobiocatalysis to Continuous Flow Exemplified by Photodecarboxylation of Fatty Acids

Autori: Stefan Simić, Miglė Jakštaitė, Wilhelm T. S. Huck, Christoph K. Winkler and Wolfgang Kroutil
Pubblicato in: ACS Catalysis, 2022, ISSN 2155-5435
Editore: American Chemical Society
DOI: 10.1021/acscatal.2c04444

Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks

Autori: Anil Kumar Bandela; Nathaniel Wagner; Hava Sadihov; Sara Morales-Reina; Agata Chotera-Ouda; Kingshuk Basu; Rivka Cohen-Luria; Andrés de la Escosura; Gonen Ashkenasy
Pubblicato in: Proceedings of the National Academy of Sciences USA, 2021, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2015285118

The protometabolic nature of prebiotic chemistry

Autori: Noemí Nogal; Marcos Sanz-Sánchez; Sonia Vela-Gallego; Kepa Ruiz-Mirazo; Andrés de la Escosura
Pubblicato in: Chemical Society Reviews, Numero 1, 2023, ISSN 1460-4744
Editore: Royal Society of Chemistry 2023
DOI: 10.1039/d3cs00594a

Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-Of-Equilibrium Enzymatic Reactions

Autori: Michael Teders, Aleksandr A. Pogodaev, Glenn Bojanov, Wilhelm T. S. Huck
Pubblicato in: Journal of the American Chemical Society, 2021, ISSN 1520-5126
Editore: American Chemical Society
DOI: 10.1021/jacs.0c12956

Reversible Photoswitchable Inhibitors Enable Wavelength-Selective Regulation of Out-of-Equilibrium Bi-Enzymatic Systems

Autori: Michael Teders, Nicholas R. Murray, Wilhelm T. S. Huck
Pubblicato in: ChemSystemsChem, 2021, ISSN 2570-4206
Editore: Wiley-VCH GmbH
DOI: 10.1002/syst.202100020

The Systems Chemistry of Nucleic-acid-Peptide Networks

Autori: A.K. Bandela, H. Sadihov‐Hanoch, R. Cohen‐Luria, C. Gordon, A. Blake, G. Poppitz, D.G. Lynn, G. Ashkenasy
Pubblicato in: Israel Journal of Chemistry, Numero 2022, 62, 2022, ISSN 1869-5868
Editore: Wiley-VCH GmbH
DOI: 10.1002/ijch.202200030

A Bayesian Approach to Extracting Kinetic Information from Artificial Enzymatic Networks

Autori: Mathieu G. Baltussen, Jeroen van de Wiel, Cristina Lía Fernández Regueiro, Miglė Jakštaitė , and Wilhelm T. S. Huck
Pubblicato in: Analytical Cheimstry, 2022, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.2c00659

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