Cell-Like ‘Molecular Assembly Lines’ of Programmable Reaction Sequences as Game-Changers in Chemical Synthesis

Rezultaty

Planned activities to reach the general public, including an infographic, science slams and open days; first activities by M13 and 25 accomplished.

Dissemination and Exploitation Plan

The Dissemination and Exploitation Plan (DEP) is due at the end of the first reporting period and is updated every reporting period.

CLASSY Scientific Symposium

Final project event presenting the research results and newly developed technologies to the scientific community and industries.

Project website and logo

Set up and maintain a project website that serves as an information resource for the general public, the scientific community and other stakeholders and includes a secured area for consortium internal exchange of documents.

Publikacje

Accelerated Reaction Engineering of Photo(bio)catalytic Reactions through Parallelization with an Open-Source Photoreactor

Autorzy: Christoph K. Winkler, Stefan Simić, Valentina Jurkaš, Sarah Bierbaumer, Luca Schmermund, Silvan Poschenrieder, Sarah A. Berger, Elisa Kulterer, Robert Kourist, and Wolfgang Kroutil
Opublikowane w: ChemPhotoChem, 2021, ISSN 2367-0932
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/cptc.202100109

Catalytic templated length-controlled oligomerization

Autorzy: Bartosz Lewandowski; Rebecca J. B. Schäfer; Etienne Cotter; Dora Harangozo; Helma Wennemers
Opublikowane w: Faraday Discussions, 2023, ISSN 1359-6640
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d3fd00002h

Overcoming Deactivation of Amine-Based Catalysts: Access to Fluoroalkylated γ-Nitroaldehydes

Autorzy: Martin Schnurr; Jonas W. Rackl; Helma Wennemers
Opublikowane w: Journal of the American Chemical Society, 2023, ISSN 1460-4744
Wydawca: Royal Society of Chemistry
DOI: 10.1021/jacs.3c08198

Dynamic exchange controls the assembly structure of nucleic-acid-peptide chimeras

Autorzy: Hava Sadihov-Hanoch; Anil Kumar Bandela; Agata Chotera-Ouda; Oshrat Ben David; Rivka Cohen-Luria; David G. Lynn; Gonen Ashkenasy
Opublikowane w: Soft Matter, Numer 1, 2023, ISSN 1744-6848
Wydawca: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sm01528e

Catalytic length-controlled oligomerization with synthetic programmable templates

Autorzy: Bartosz M. Lewandowski; Dario Schmid; Rüdiger Borrmann; Dominik Zetschok; Martin Schnurr; Helma Wennemers
Opublikowane w: Nature Synthesis, 2023, ISSN 2731-0582
Wydawca: Nature
DOI: 10.1038/s44160-022-00228-9

Stereoselective peptide catalysis in complex environments – from river water to cell lysates

Autorzy: Tobias Schnitzer, Jonas W. Rackl, Helma Wennemers
Opublikowane w: Chemical Science, 2022, ISSN 2041-6539
Wydawca: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02044k

Tripeptide Organocatalysts for Stereoselective Conjugate Addition Reactions with N‐Heterocyclic Substituents

Autorzy: Jasper S. Möhler; Lena K. Beiersdörfer; Brenno Masina; Philipp Wechsler; Helma Wennemers
Opublikowane w: Advanced Synthesis & Catalysis, 2022, ISSN 1615-4169
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/adsc.202200576

Organocatalytic Synthesis of Triflones Bearing Two Non‐Adjacent Stereogenic Centers

Autorzy: Alena Budinská; Helma Wennemers
Opublikowane w: Angewandte Chemie - International Edition, 2023, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202300537

Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems

Autorzy: S. Ghosh, M. G. Baltussen, N. M. Ivanov, R. Haije, M Jakštaité, T. Zhou, W. T.S. Huck
Opublikowane w: Chemical Reviews, 2023, ISSN 0009-2665
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00681

Collectively autocatalytic sets

Autorzy: G. Ashkenasy, S. Kauffman, D. Lancet, S. Otto, K. Ruiz-Mirazo, S. Semenov, J. Xavier
Opublikowane w: Cell Reports Physical Science, Numer 4, 101594, 2023, ISSN 2666-3864
Wydawca: Cell Reports Physical Science
DOI: 10.1016/j.xcrp.2023.101594

Collective adaptability in a replication network of minimal nucleobase sequences

Autorzy: Sonia Vela-Gallego; Zulay Pardo-Botero; Cristian Moya; Andrés de la Escosura
Opublikowane w: Chemical Science, 2022, ISSN 2041-6539
Wydawca: Royal Society of Chemistry (RSC)
DOI: 10.1039/d2sc02419e

Shortening Synthetic Routes to Small Molecule Active Pharmaceutical Ingredients Employing Biocatalytic Methods

Autorzy: Stefan Simić, Erna Zukić, Luca Schmermund, Kurt Faber, Christoph K. Winkler, and Wolfgang Kroutil
Opublikowane w: Chemical Reviews, 2021, ISSN 0009-2665
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00574

Modifying the Catalytic Activity of Lipopeptide Assemblies with Nucleobases

Autorzy: Sonia Vela-Gallego, Bartosz Lewandowski, Jasper Möhler, Alonso Puente, David Gil-Cantero, Helma Wennemers, Andrés de la Escosura
Opublikowane w: Chemistry - A European Journal, 2023, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202303395

Amine Catalysis with Substrates Bearing N ‐Heterocyclic Moieties Enabled by Control over the Enamine Pyramidalization Direction

Autorzy: Jasper S. Möhler, Tobias Schnitzer, Helma Wennemers
Opublikowane w: Chemistry – A European Journal, Numer 26/67, 2020, Strona(/y) 15623-15628, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202002966

Peptide and Enzyme Catalysts Work in Concert in Stereoselective Cascade Reactions—Oxidation followed by Conjugate Addition

Autorzy: Jasper S. Möhler; Mathias Pickl; Tamara Reiter; Stefan Simić; Jonas W. Rackl; Wolfgang Kroutil; Helma Wennemers
Opublikowane w: Angewandte Chemie International Edition, 2024, ISSN 1521-3773
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/ange.202319457

Synergistic Peptide and Gold Catalysis: Enantioselective Addition of Branched Aldehydes to Allenamides

Autorzy: Leo D. M. Nicholls, Helma Wennemers
Opublikowane w: Chemistry - A European Journal, 2021, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103197

Selectivity in the chiral self-assembly of nucleobase-arylazopyrazole photoswitches along DNA templates

Autorzy: N. Nogal, S. Guisán, D. Dellemme, M. Surin, A. de la Escosura
Opublikowane w: Journal of Materials Chemistry B, 2024, ISSN 2050-7518
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4tb00041b

Strategies for Transferring Photobiocatalysis to Continuous Flow Exemplified by Photodecarboxylation of Fatty Acids

Autorzy: Stefan Simić, Miglė Jakštaitė, Wilhelm T. S. Huck, Christoph K. Winkler and Wolfgang Kroutil
Opublikowane w: ACS Catalysis, 2022, ISSN 2155-5435
Wydawca: American Chemical Society
DOI: 10.1021/acscatal.2c04444

Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks

Autorzy: Anil Kumar Bandela; Nathaniel Wagner; Hava Sadihov; Sara Morales-Reina; Agata Chotera-Ouda; Kingshuk Basu; Rivka Cohen-Luria; Andrés de la Escosura; Gonen Ashkenasy
Opublikowane w: Proceedings of the National Academy of Sciences USA, 2021, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2015285118

The protometabolic nature of prebiotic chemistry

Autorzy: Noemí Nogal; Marcos Sanz-Sánchez; Sonia Vela-Gallego; Kepa Ruiz-Mirazo; Andrés de la Escosura
Opublikowane w: Chemical Society Reviews, Numer 1, 2023, ISSN 1460-4744
Wydawca: Royal Society of Chemistry 2023
DOI: 10.1039/d3cs00594a

Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-Of-Equilibrium Enzymatic Reactions

Autorzy: Michael Teders, Aleksandr A. Pogodaev, Glenn Bojanov, Wilhelm T. S. Huck
Opublikowane w: Journal of the American Chemical Society, 2021, ISSN 1520-5126
Wydawca: American Chemical Society
DOI: 10.1021/jacs.0c12956

Reversible Photoswitchable Inhibitors Enable Wavelength-Selective Regulation of Out-of-Equilibrium Bi-Enzymatic Systems

Autorzy: Michael Teders, Nicholas R. Murray, Wilhelm T. S. Huck
Opublikowane w: ChemSystemsChem, 2021, ISSN 2570-4206
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/syst.202100020

The Systems Chemistry of Nucleic-acid-Peptide Networks

Autorzy: A.K. Bandela, H. Sadihov‐Hanoch, R. Cohen‐Luria, C. Gordon, A. Blake, G. Poppitz, D.G. Lynn, G. Ashkenasy
Opublikowane w: Israel Journal of Chemistry, Numer 2022, 62, 2022, ISSN 1869-5868
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/ijch.202200030

A Bayesian Approach to Extracting Kinetic Information from Artificial Enzymatic Networks

Autorzy: Mathieu G. Baltussen, Jeroen van de Wiel, Cristina Lía Fernández Regueiro, Miglė Jakštaitė , and Wilhelm T. S. Huck
Opublikowane w: Analytical Cheimstry, 2022, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.2c00659

Rezultaty

Publikacje

Udostępnij tę stronę Udostępnij tę stronę w mediach społecznościowych

Pobierz Pobierz zawartość strony